Gene 29587 (Tetrahymena)
29587
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 29587.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 29587.AA | Ciliate-C7 | 78-240 | 81 | 1.3e-125 | 404.47 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 78-240 Range on HMM: 1-164/164 Sequence Identity: 81% (134 aa) FRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQ-GTLTQILERNQNKRLN ||||||| |||||||||.|||||||||||||||.|||.|.|.||.|.||..|||.|.||||||.|..|||||||.||||.||| |||.||.||||||||| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN EISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINKSGYAMNQYM ||||||||.||||||||||||.|.|||||||||||||.|||||.||||||||..||.|..|||| EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM |
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| Pkinase | 29587.AA | Pkinase | 75-249 | 28 | 2.7e-27 | 97.6 | Pfam | 1-181 (293) | Show / Hide |
Range on Protein: 75-249 Range on HMM: 1-181/293 Sequence Identity: 28% (53 aa) YSDFRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQG-----TLTQILER | | .|.| | | .... .|. ..|.| . .|. . |. . .. .|..|.|.. ..|..| |.| || . |.|. |.| | .... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST NQNKRL--NEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNA----VVSDFGLADNL-INKSGYAMNQYMGNFLYQAPE ..... | ...|. |..||.|.||.... ||| .||||| .|. ..||||| . . ... |. . | | ||| WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPE |
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| Kinase | 29587.AA | CAMK | 80-249 | 18 | 2.1e-24 | 74.92 | In-house | 1-290 (425) | Show / Hide |
Range on Protein: 80-249 Range on HMM: 1-290/425 Sequence Identity: 18% (54 aa) FLGQGVQGLVLLAKDSKTN------------MRYAIKGVQV----------------RDPQGNLD------EDLNNRVKQEVEILKKCR------DSPYV ||.| | | |... .|. ..||| . .| ... . . .|..|.||.||.. | | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VSLIDQFEG-------------------QQFSYLVL---TECQGT------LTQILERNQN------------KRLNEISAIKYANDIAQGLYYIHSKSC ..|.. .| ... |.|. |.| . | |. .. .|..| | .| |.... |.||. IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI LVNDLKMDNILIDYH-----------------GNAVVSDFGLADNLINKS----------------------GYAMNQYMGNFLYQA-PE ||| .|||.|.. .| ..|||.| .. .. | |. . | | | || VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE |
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| Kinase | 29587.AA | Ciliate-E1 | 81-250 | 20 | 1.5e-23 | 73.8 | In-house | 1-181 (202) | Show / Hide |
Range on Protein: 81-250 Range on HMM: 1-181/202 Sequence Identity: 20% (38 aa) LGQGVQGLVLLAKDSKTN-MRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQ--FSYLVLTECQGTLTQILE--------- .|.| ...|. || ..| .|.| ..... . ...... |.. .|.| . |.. .||... .| ........|. .|.. |. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNY--NQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ --RNQNKRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINKSGYAMNQYMGNFLYQAPEC ..... ... .. . .. .|| ..|.. . |.|..||||. || | .|||....|.|.. . ... |. ||. QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQ |
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| Kinase | 29587.AA | CAMKL | 75-251 | 26 | 5.1e-23 | 70.17 | In-house | 1-205 (297) | Show / Hide |
Range on Protein: 75-251 Range on HMM: 1-205/297 Sequence Identity: 26% (54 aa) YSDFRFLGQGVQGLVLLAKD-SKTNMRYAIKGVQVR----DPQGNLD------EDLNNRVKQEVEILKKCR--DSPYVVSLIDQFEGQQF------SYLV | . ||.| | | ||.. . |. ..||| . . ||. . |. |...|..|.|. . | ...| . .| ... ||| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV LTECQGT---LTQILERNQNKR--LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHG--NAVVSDFGLADNLI---NKSGYAMNQYMGNFLY . |.| | . .... ..| . | | .| | ...|.||. |.| .|||.|..| |. ..|||.. . ...| .. | | MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY QAPECF .||| | MAPEIF |
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| Kinase | 29587.AA | Ciliate-E2-Unclassified | 75-252 | 21 | 9.7e-23 | 75.72 | In-house | 1-239 (352) | Show / Hide |
Range on Protein: 75-252 Range on HMM: 1-239/352 Sequence Identity: 21% (51 aa) YSDFRFLGQGVQGLVLLAKDSKTN----MRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILK---------------KCRDSPYVVSLIDQFEGQQFSYLV | . .||| .| | .....|.. | |..| .. . | . . .. ..|....| . ..|..| ....|. .| |.| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LTEC-QGTLTQILE---------------RNQNKRLNEISAI-----KYANDIAQGLYYIHSKS-CLVNDLKMDNILIDYHG---NAVVSDFGLADNLIN . | .|.| |... ..|.|.. | |. .|. | ||| |.|.| .. |.| .|||.| | . ..|||.. .... MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ KSGYA--------------MNQYMGNFLYQ----APECFD ... |.. .|. |. |||... NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ |
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| S_TKc | 29587.AA | S_TKc | 75-338 | 21 | 2.8e-22 | 81.25 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 75-338
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)
YSDFRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQG---TLTQILERNQ
| | .|.| | | .... ||. ..||| . .....|..|||| . |..| |.| |. .. |.|. | | .| .......
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG
NKR----LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINKSGYAMNQYMGNFLYQAPECFDPADP-----------
.. ..| | .|. |...| |.||. . ||| .|||.| . ..||||| | . . | | ||| . . ..
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCI
----FIGKV----YHDEYQKLGVSVRQQPSNRGIDFSLAQNKHKPLKYDGEFQNFVYHKQLKYIIDGLTNFVPKDRMPIKEALI-----ILKGII
. |. .. ..|.| ...| .|... .. |..|. . ||| . .
LYEMLCGYPPFPQMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 29587.AA | Ciliate-E2 | 75-251 | 18 | 6.3e-22 | 72.04 | In-house | 1-259 (365) | Show / Hide |
Range on Protein: 75-251 Range on HMM: 1-259/365 Sequence Identity: 18% (50 aa) YSDFRFLGQGVQGLVLLAKDSKTNMRYAIK-------------GVQ-VRDPQGNLDEDLNNRVKQEVEILKKCR---------------DSPYVVSLIDQ | . .||| .| | ..|. |.. ..||| .|. .. .. . .||| |... . ..|... ... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FE--GQQFSYLVLTECQG-TLTQILERN----------QNKRLNEISAIKYANDIAQ---------------GLYYIHSKS-CLVNDLKMDNILIDYHGN |. .. |||. ||| .| .... | . |...| .... |.| .| |.||| .. |.| .|||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- AVVSDFGLADNLINK---------SGYAMNQY----------------------MGNFLYQAPECF ..||||. .. .. .. |. |. |.||| . IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEIL |
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| Kinase | 29587.AA | ULK | 75-249 | 24 | 1.4e-19 | 65.09 | In-house | 1-221 (329) | Show / Hide |
Range on Protein: 75-249 Range on HMM: 1-221/329 Sequence Identity: 24% (54 aa) YSDFRFLGQGVQGLVLLAKDSKT----NMRYAIKGVQ----VRDPQ---GNLDEDLNNRVKQEVEILKKCRD---SPY----VVSLIDQFEGQQF--SYL |. . ||.| | | ... || | .|.| .. .... | . . . .|.|..|.|| . ... .| |.| || ... |. YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEG---QYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYI VLTECQG-TLTQILERNQN--------KRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAV------------VSDFGLADNLINK-- .. |.| .| |....|.. |||.| ||.. .|..|. ..|.. . |.| .||||. . ..|||.| . | IMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNM SGYAMNQYM------GNFLYQAPE . | . | || ||. EQQMMMTCVNEKRLCGTPLYMAPQ |
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| Kinase | 29587.AA | ULK | 75-225 | 25 | 2.7e-19 | 65.18 | In-house | 1-185 (324) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-185/324 Sequence Identity: 25% (48 aa) YSDFRFLGQGVQG-LVLLAKDSKT---NMRYAIKGVQ--------VRDPQGNLDEDLNNRVKQEVEILKKCR--DSPY--VVSLIDQFEGQ--QFSYLVL |. . ||.| | | ... || | .|.| .. ... | . . . |.|..|.|| .|. .| |.| || . . |... YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQE-G---QYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIM TECQG-TLTQILERNQN-------KRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAV------------VSDFGLA |.| .| |....|.. |||.| ||.. .|..|. ..|.. . |.| .|||| . ..|||.| EYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 29587.AA | STE | 75-249 | 18 | 1.4e-18 | 62.27 | In-house | 1-232 (359) | Show / Hide |
Range on Protein: 75-249 Range on HMM: 1-232/359 Sequence Identity: 18% (45 aa) YSDFRFLGQGVQGLVLLAKDSK---------------TNMRYAIKGVQVRDPQGNLDE------------DLNNRVKQEVEILKKCRD-SPYVVSLIDQF . . ...|.| | | .|.. | |. ..||| . ... . . | . .....|..|.|||.. .|..| .. . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY EGQ-------QFSYLVLTECQ-GTLTQILE------RNQN------KRLNEISAIKYANDIAQG-LYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLA . . .... . |.|..|.. ...| .|..| .... .| .| |||.||. |.| .|||. . .|||.. FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC DNLIN---------------KSGYAMNQYMGNFLYQAPE .|.. .. | | . ||| GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE |
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| Kinase | 29587.AA | CMGC | 75-225 | 18 | 6.4e-17 | 51.25 | In-house | 1-251 (513) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-251/513 Sequence Identity: 18% (47 aa) YSDFRFLGQGVQGLVLLAKDSKTNMR--------------YAIKGVQVRDPQGN------LDEDLNNRVKQEVEILKKCR----------------DSPY | . .|.| | | ..| .|| . .||| . . . . . .. | |..|||. . . .. YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN VVSLIDQFEGQQFS-----------------YLVLTECQGTLTQILERNQ-------NKRLNEIS------------AIKYA------NDIAQGLY--YI .|.|.| | . ||| .. .| |....|| .. |.| .. | .|| |. IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC HSKS--CLVNDLKMDNILIDYHGNA--------------------VVSDFGLA ||. . ||| ||||. . . ||||| HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA |
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| Kinase | 29587.AA | TyrKc | 75-334 | 17 | 4.1e-07 | -107.61 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 75-334
Range on HMM: 1-280/280
Sequence Identity: 17% (54 aa)
YSDFRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKC-RDSPYVVSLIDQFEGQQ------FSYLVLTE--CQGTLTQ
. . || | | | ... . . |.| .. .| .|..| . | .| |. |. .....| . | | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
ILERNQNKRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLINK------SGYAMNQY--MGNFL----YQAPECF--
| ....| |. .... .||.| |.||| | || |.|.. . . .|||||. .. .. . | . . |... ||||.
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY
---------------------DPADPFIG-----KVYHDEYQKLGVS-VRQQPSN----RGIDFSLAQNKHKPLKYDGEFQNFVYHKQLKYIIDGLTNFV
. . | | . . .... . || | | .. . |. ..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------F--VCCPDEMYQIMKQCWHED
PKDRMPIKEALIIL
|.|| .| ..
PEDRPTFSEIHECF
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