Gene 14911 (Tetrahymena)
14911
Group:
Other
Family:
Ciliate-E1
Sequence
Protein domains of 14911.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 14911.AA | Ciliate-C5 | 51-310 | 35 | 9.3e-48 | 155.16 | In-house | 2-260 (260) | Show / Hide |
Range on Protein: 51-310 Range on HMM: 2-260/260 Sequence Identity: 35% (92 aa) ILTSFIGQVGLGTIFEAQKGNEFFAIKCLITHNPDDIQKEINLLNQFKMNSSYFQTFKEGFYSEKCHIYFYIAEKLSCNLQKVQETYLSNNQQLCYYSIL |||.| | | | .|||. .| |.|| . | . |. | .... | |.. .| | || |. |. . ||||. . . . . . | |. YLTSYISQGGFGCVFEAKYNEEIVAVKCSKP-NFEKIKEEEKIMKLLKDTPYVFKSIEE-FLNEKKSKYYQISKRYSCNLKDIMQSFFDQKKTLPLNQII AIAIQISKGLCILEENNIYHNEVIPENIMYDSKLKTFKLGDVGIS-QIKKNIVIQQTHREIHKYFAPEKVKQIKEISLQSDIYSLGLILVELTCGRFLTV .|||.| ....||. | .| ||||.|||. | |.| | | | . | .. . || ||| . . .. ||| ||.||.||| |.|| GFAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNLCDYGESKSFKDGSKTYDLKGFTRKYAAPEITDDNGFFNIKYDIYGLGIILLELTLGKFLED EETDLIRKGFLEQYLNQEESFKDLNQLIKQMLCINKANRFKPRELEEQLYSLQRIEEIKFQ |. .||.| | .|. ... ..|.||.| .|| . || || || |. | .| EDCTFIRNGKLPNYISKNALYQDINQIIIKMLEKMPQNRIDSFELTKQLNELRLKLESQFI |
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| Kinase | 14911.AA | Ciliate-E1 | 56-232 | 21 | 1e-20 | 64.47 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 56-232 Range on HMM: 1-202/202 Sequence Identity: 21% (44 aa) IGQVGLGTIFEA--QKGN------EFFAIKCLIT--HNPDDIQKEINLLNQFKMNSSYFQTFKEGFYSEKCHIYFYIAEKLSCNLQKVQE---------T ||. . . .|.| |. | .. ... .. |. | |........ || . ...| .. ...... |. | |...|.|.. .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDY-IKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQ YLSNNQQLCYYSILAIAIQISKGLCILEENNIYHNEVIPENIMYDSKLKTFKLGDVGISQ--IKKNIVIQQTHREIHKYFAPEKVK-------QIKEISL . .|..|. ...|..|. .||..|. .||.| .|.|| .... . ... | |||. ..... .| ..|.| ||... . ..|. CQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINY QSDIY .|||| KSDIY |
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| Kinase | 14911.AA | Ciliate-B2 | 50-235 | 27 | 3.2e-14 | 29.75 | In-house | 1-197 (197) | Show / Hide |
Range on Protein: 50-235 Range on HMM: 1-197/197 Sequence Identity: 27% (57 aa) YILTSFIGQVGLGTIFEAQKGNEFF-----AIKCLIT---HNPDDIQKEINLLNQFKMNSSYFQTFKEGFYSEKCHIYFYIAEKLSCNLQKVQETYLSNN |.|. .|.. | | |.| | . .. |.| . . ..||.||. . | .| .. .|. .. | || | |. || . . YYLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDV--LIMEKCECSLK--QELQKIQK QQLCYYS--ILAIAIQISKGLCILEENNIYHNEVIPENIMYDSKLKTFKLGDVGISQIKK---NIVIQQTHREIHKYFAPEKVKQI------KEISLQSD || |. . .. . | || . .|| | .. |.|| .. ... | ||| ||| .| | . . || || .... .| ||| QQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILF-MQNGNYVYCDFGISSIKKDNQQIKIKG---FTKKYASPEQMECDHNQTFVTNIDFQSD IYSLG |||.| IYSMG |
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| Kinase | 14911.AA | Ciliate-E3 | 50-242 | 25 | 2.9e-13 | 38.0 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 50-242 Range on HMM: 1-202/202 Sequence Identity: 25% (53 aa) YILTSFIGQVGLGTIFEA--QKGNEFFAIKCLITHNPDD---------IQKEINLLNQFKMNSSYFQTFKEGFYSEKCHIYFYIAEKLSC-NLQKVQETY | .|. . | . | . | ||| .|. | . |.|... |. || . .. .| .. .| . | | .|. .| YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQI--NSQNVVKCHDQYYDQQNKMIFIVQEYCSNGDLY----HY LSNNQQLCYYSILAIAIQISKGLCILEENNIYHNEVIPENIMYDSKLK--TFKLGDVGIS-QIKKNIVIQQTH-REIHKYFAPEKVKQIKEISLQSDIYS . | . |. |.||| .|. .. | || | |.|| |. . . | .| | | | .|| .| ..|. . . ||. ||.|| IK-QQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQISKESDYYS LGLILVELT .| .. .| VGAVFCQLC |
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| Kinase | 14911.AA | S_TKc | 50-300 | 16 | 3e-13 | 17.33 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 50-300 Range on HMM: 1-231/231 Sequence Identity: 16% (45 aa) YILTSFIGQVGLGTIFEAQKGN--EFFAIKCLITHNPDDIQKEINLLNQFKMNSSYFQTFKEGFYSEKCHIYFYIAEKLSC---NLQKVQETYLS--NNQ | . ||. . |. . ... . . .|||.. ..|..||..| . . . .... |.. . .. . | .. .| .. . . . ... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF QLCYYSILAIAIQISKGLCILEENNIYHNEVIPENIMYDSKLKTFKLGDVGISQIKKNIVIQQTHREIHKYFAPEKVKQIKEISL-QSDIYSLGLILVEL .. . .. || ..| . ...| | . ||||. |. . |..| |.. . . | | ||| . . .|..|.| || |. PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL--TTFCGTPW----YMAPEVL----GYGKCKCDWWSCGCILYEM TCGRFLTVEETDLIRKGFLEQYLNQEESFKDLNQLIKQMLCINKANRFKPRELEE-------QLYS ||. . . ... | . ... ..|...|. . ..| |. . . LCGYPPFP-QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 14911.AA | C8 | 75-238 | 23 | 3.6e-11 | 35.12 | In-house | 28-226 (226) | Show / Hide |
Range on Protein: 75-238 Range on HMM: 28-226/226 Sequence Identity: 23% (47 aa) AIKCLITHNPDDIQKEINLLNQFKMNSSYFQTFKEGFYSEKCHIYFYIAE---KLS-----------CNLQK-------VQETYLSNNQQLCY---YSIL ..| .. | .|||... . ...| || .. ..| | . | | | .. ... |. .. . . VLKFQKCQNKQDIQNIESIMKEYEMP-QVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELCEQNLKQLYDERRNKQQQFSKEMKE AIAIQISKGLCILEENNIYHNEVIPENIM--YDSKLK-TFKLGDVGIS-QIKKNIVIQQTHR----EIHKYFAPEKVKQ----IKEISLQSDIYSLGLIL ||||. |. .. || | .. |.|.. | . . || | |.. |..|| |.. .||||| |. |. . |||..|.||.| IIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | 14911.AA | Ciliate-A1 | 225-301 | 23 | 9e-10 | 29.38 | In-house | 205-301 (301) | Show / Hide |
Range on Protein: 225-301 Range on HMM: 205-301/301 Sequence Identity: 23% (23 aa) ISLQSDIYSLGLILVELTC--------GRFLTVEETDLIR--------------KGFLEQYLNQEESFKDLNQLIKQMLCINKANRFKPRELEEQLYSL |. |||.||||.|. .|. | . . .. |. .. || .|..|. ||..|. . || . .. ..|| . IYKQSDMYSLGCIICFLCYKEDSHPYVGTIVNIFGNNMQNDQSIHFCKSVNAIKKIIFPPM--QEPRFEELQNLIFKMMQYEPNNRCSLQQCIDCLYIF |
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| Kinase | 14911.AA | Ciliate-E2-Unclassified | 152-294 | 22 | 3.6e-09 | 27.98 | In-house | 148-346 (352) | Show / Hide |
Range on Protein: 152-294
Range on HMM: 148-346/352
Sequence Identity: 22% (45 aa)
IAIQISKGLCILEENN-IYHNEVIPENIMYDSKLK--TFKLGDVGISQ-------------IKKNIVIQQTHREI--HKYF-----APEKVKQIKEISLQ
.. || .||. | ..| | | ||||..|.. | |. | ||| |..| .|| . .. ||| | | .. . .
YFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPE-VLQGQNYDHS
----SDIYSLGLILVELTCGRFLTVEETDLI-------------RKGFLEQYLNQEESFKDLN-----------------QLIKQMLCINKANRFKPREL
.||.||| || |. |.. ... . || .... .... .|. . .|...|| | .| . ..
KAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQI
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| Kinase | 14911.AA | Ciliate-E2 | 50-294 | 15 | 1.3e-08 | 25.67 | In-house | 1-359 (365) | Show / Hide |
Range on Protein: 50-294
Range on HMM: 1-359/365
Sequence Identity: 15% (58 aa)
YILTSFIGQVGLGTIFEA---QKGNEF----------------------FAIKCLITHNPDDIQKEINLL--------------NQFKMNSSYFQTFKEG
|.. ||| . |..... .....| .|.|... . | .||... .....|. . ..|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC
FYSEKCHIYFYIAEKLSCN--LQKVQETYLSNNQQLC------YYSILAIAIQISK---------------GLCILEENN-IYHNEVIPENIMYDSKLKT
|.... . .... | .. . .. .. ... |... . |. | || . .| | ..| | | ||||..
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------
FKLGDVGISQIKKNIVIQQTHREIHK--------------------------------YFAPEKVKQIKE--------ISLQSDIYSLGLILVELTCGRF
|. | |.|.. .. ...|| ..| | ||| .. |. . ..||.||| || |. .|..
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP
LTVEETDLIRKGFLEQYLNQEESFKDLN-----------------------QLIKQ----MLCINKANRFK-PREL
..| .... .| . .|||. ||. . .|. . ..
PF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI
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| Kinase | 14911.AA | GIN4 | 155-299 | 28 | 5.4e-08 | 21.18 | In-house | 142-293 (293) | Show / Hide |
Range on Protein: 155-299 Range on HMM: 142-293/293 Sequence Identity: 28% (44 aa) QISKGLCILEENNIYHNEVIPENIMYDSKLKTFKLGDVGISQIKKNIVIQQTHREIHKYFAPEKVKQIKEISLQSDIYSLGLILVELTCGRFLTVEETDL || |. || | .. |||.. |.| . |. | |. .. . . .| | ||| | | ||..| |.|| | |. || QIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIADFGMAALETDNKLLETSCGSPHYAAPEIVMGIPYHGFASDVWSCGVILFALLTGHLPFDEEDGN IRKGFLE------QYLNQEESFKDLNQLIKQMLCINKANRFKPRE-LEEQLY ||| | . ...| .. ||...| . | | |. |. | IRKLLLKVQKGKYEMPSDDEISREAQDLIRKILVVDPEKRIKTRDILKHPLI |
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| Kinase | 14911.AA | MEK5 | 152-246 | 32 | 1.2e-07 | 24.03 | In-house | 98-189 (254) | Show / Hide |
Range on Protein: 152-246 Range on HMM: 98-189/254 Sequence Identity: 32% (31 aa) IAIQISKGLCILEENNIYHNEVIPENIMYDSKLKTFKLGDVGISQIKKNIVIQQTHREIHKYFAPEKVKQIKEISLQSDIYSLGLILVELTCGRF ... | ||| | . | | .| | |.. . . || | |.| | | .| | |||.. . . ||..|||. ..|. ||| MTVAIVKGLNYLWNLKIMHRDVKPSNMLVNTQGQ-IKLCDFGVSTQLVN-SITRTYIGTNAYMAPERISG-DQYGIHSDVWSLGIFFMEMATGRF |
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| Kinase | 14911.AA | TyrKc | 50-298 | 16 | 1.5e-05 | -132.93 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 50-298
Range on HMM: 1-280/280
Sequence Identity: 16% (47 aa)
YILTSFIGQVGLGTIFEAQKGNEFFAIKCLITHNPDDIQKEINLLNQF--K----MNSSYFQTFKEG--FYSEKCHIYFYIAEKLSCN--LQKVQETYLS
| .| |...... . |.|.| . |. .|.... .. . . | ... |.| | . ... ... |.| ...
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---
NNQQLCYYSILAIAIQISKGLCILEENNIYHNEVIPENIMYDSKLKTFKLGDVGISQIKKNI--------VIQQ----THR--EIHKYFAPEKVKQIKEI
|| | ...||..| |...|. | |....... | | .| | | .. .. . . . ||| . ..
----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKF
SLQSDIYSLGLILVEL-TCGRFLTVE-----------ETDLIRKGFLEQYLNQEE-----SFKDLNQLIKQMLCINKANRFKPRELEEQL
. .||..| | . |. | | . .. . . ..| | .. ... |..|| . ..| .|. |..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | 14911.AA | Pkinase | 175-247 | 26 | 0.00017 | 16.98 | Pfam | 136-211 (293) | Show / Hide |
Range on Protein: 175-247 Range on HMM: 136-211/293 Sequence Identity: 26% (21 aa) PENIMYDSKLKT---FKLGDVGISQIKKNIVIQQTHREI---HKYFAPEKVKQIKEISLQSDIYSLGLILVELTCGRFL ||||..|.. . .|..| |.. .. . .. . | ||| .. .... .|..|.|.|| |. |||.. PENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPP |
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| Kinase | 14911.AA | Ciliate-A1 | 149-197 | 32 | 0.00193 | 7.5 | In-house | 103-150 (301) | Show / Hide |
Range on Protein: 149-197 Range on HMM: 103-150/301 Sequence Identity: 32% (16 aa) ILAIAIQISKGLCILEENNIYHNEVIPENIMYDSKLKTFKLGDVGISQI | | || .|. . . || | . |.||. . | .|. | |.|.. IYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDK-WKICDLGMSKQ |
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| Kinase | 14911.AA | Pkinase | 50-98 | 13 | 7.239718 | 0.61 | Pfam | 1-58 (293) | Show / Hide |
Range on Protein: 50-98 Range on HMM: 1-58/293 Sequence Identity: 13% (8 aa) YILTSFIGQVGLGTIFEAQKGNEF--FAIKCLITHNPDDIQK-------EINLLNQFK | . . ||. . |. ..... .. .|.|.. .. .. .. || ... .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN |
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| LRR_RI | 14911.AA | LRR_RI | 428-454 | 28 | 0.412848 | 1.25 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 428-454 Range on HMM: 1-28/28 Sequence Identity: 28% (8 aa) LTNLS-LNLQNNSLNAEAAKVISSNLQN ...| |.|.|| | .| ...... |. NCSLRELWLSNNKLGDEGCRQLCEGLKH |
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| LRR_RI | 14911.AA | LRR_RI | 535-564 | 40 | 0.005081 | 14.73 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 535-564 Range on HMM: 1-28/28 Sequence Identity: 40% (12 aa) CQNLRKLNLSLHNNQIGVDGAKNLAQGLEN ..||.|.|| || .| .|.. |..||. NCSLRELWLS--NNKLGDEGCRQLCEGLKH |
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| LRR_RI | 14911.AA | LRR_RI | 591-618 | 25 | 0.157715 | 4.2 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 591-618 Range on HMM: 1-28/28 Sequence Identity: 25% (7 aa) NMIELNLDLGDNSIGLEGAKNIGYSIER |. . |.|..| .| ||.. . ... NCSLRELWLSNNKLGDEGCRQLCEGLKH |
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