Gene 23446 (Tetrahymena)
23446
Group:
Other
Family:
Ciliate-E1
Sequence
Protein domains of 23446.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 23446.AA | Ciliate-B2 | 506-573 | 39 | 1.8e-25 | 56.8 | In-house | 79-151 (197) | Show / Hide |
Range on Protein: 506-573 Range on HMM: 79-151/197 Sequence Identity: 39% (29 aa) VMQKCQMSLHDEIQ----SK-VFNLKETLKFISTAFHLLIVLRQKYIYHSDIKPGNILKTYNNNYKLSDFGAS .|.||. || .|.| . || . .. | . || .| . | | |||| |||...|.||...||| | IMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGIS |
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| Kinase | 23446.AA | Ciliate-E1 | 439-608 | 18 | 1.5e-18 | 57.29 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 439-608 Range on HMM: 1-202/202 Sequence Identity: 18% (38 aa) LDNHSEQFLKQIFKLGDHIGGGGEADIFTNQNDDKTVFRELQEQNI------LNINSSHLIENKD-KDTKYIIHVMQKCQMSLHDEIQ------------ . | |. . ..... ... . | ...|... | ....... .... .|. .. .. . .| ....|..||.|..| IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQ --SKVFNLKETLKFISTAFHLLIVLRQKYIYHSDIKPGNILKTYNNNYKLSDFGASQ-----QVDFIDPFCDYQMHTPGFKPQ------DRVKNLPFYHD . |. .. .. | ... || |.|. |.|.|||| |||.. ..||...||| |. | . .. .. .. | . . .. .. . | QNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSD IY || IY |
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| Kinase | 23446.AA | Ciliate-C6 | 517-577 | 36 | 1.2e-10 | 34.0 | In-house | 126-188 (306) | Show / Hide |
Range on Protein: 517-577 Range on HMM: 126-188/306 Sequence Identity: 36% (23 aa) EIQSKVFNLKETLKFISTAFHLLIVLRQ-KYIYHSDIKPGNILKTYN-NNYKLSDFGASQQVD ..... |. .| ..| . .| .. | | |||| ||| . |||.|||||..|| . NYKYEHFDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQQLF |
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| Kinase | 23446.AA | LKB | 547-582 | 41 | 1.6e-08 | 21.49 | In-house | 125-160 (265) | Show / Hide |
Range on Protein: 547-582 Range on HMM: 125-160/265 Sequence Identity: 41% (15 aa) IYHSDIKPGNILKTYNNNYKLSDFGASQQVDFIDPF . | ||||||.| | .| |..||| |.. .. VVHKDIKPGNLLLTHDNTLKICDFGVAEQLHHFQRD |
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| Kinase | 23446.AA | Ciliate-A1 | 547-584 | 39 | 6.5e-08 | 22.95 | In-house | 122-159 (301) | Show / Hide |
Range on Protein: 547-584 Range on HMM: 122-159/301 Sequence Identity: 39% (15 aa) IYHSDIKPGNILKTYNNNYKLSDFGASQQVDFIDPFCD | |.|.||.||| . .|. |.| |.| . || ILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCD |
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| Kinase | 23446.AA | S_TKc | 451-660 | 14 | 1.6e-07 | -66.55 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 451-660
Range on HMM: 1-231/231
Sequence Identity: 14% (39 aa)
FKLGDHIGGGGEADIFTNQNDD-----------------KTVFRELQEQNILNINSSHLIENKDKDTKYIIHVMQKCQM---SLHDEIQSKV-------F
......|| |. . . .. . . .. . || .. . ... || | .|.| |... |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF
NLKETLKFISTAFHLLIVLRQKYIYHSDIKPGNILKTYNNNYKLSDFGASQQVDFIDPFCDYQMHTPGFKPQDRVKNLPFYH---DIYSFG---------
. .. ... . | . .. | | |.|| ||| . . |..||| . |. . . || . . . .. . |..|.|
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG
--------KTIKQLFPPQLENRPDIQIYDCLNKFIDEKICKDDENSINVDCLK-------LPRI
...|.. . . ||. .|| |. . ...|. | .
YPPFPQMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
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| Kinase | 23446.AA | Ciliate-E3 | 497-575 | 33 | 8.1e-07 | 17.62 | In-house | 73-155 (202) | Show / Hide |
Range on Protein: 497-575 Range on HMM: 73-155/202 Sequence Identity: 33% (28 aa) DKDTKYIIHVMQKCQM-SLHDEIQSKVFNLKETLKFISTAFHLLIVLRQKYIYHSDIKPGNILKTYNNN---YKLSDFGASQQ |...| | |.. | .| |.. . . .... . . .| . .| | |||||| ||| ||| | .|||.| | DQQNKMIFIVQEYCSNGDLYHYIKQQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQ |
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| Kinase | 23446.AA | Ciliate-A5 | 538-571 | 38 | 2e-06 | 18.7 | In-house | 111-144 (275) | Show / Hide |
Range on Protein: 538-571 Range on HMM: 111-144/275 Sequence Identity: 38% (13 aa) LLIVLRQKYIYHSDIKPGNILKTYNNNYKLSDFG .. .|.|. |.| ||.| ||. | .. .|| |.. VCMYLQQNNICHGDIRPQNICLTQDGQVKLMDMN |
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| Kinase | 23446.AA | CAMKK | 549-582 | 37 | 3e-06 | 15.61 | In-house | 219-255 (396) | Show / Hide |
Range on Protein: 549-582 Range on HMM: 219-255/396 Sequence Identity: 37% (14 aa) HSDIKPGNILKTYNN---NYKLSDFGASQQVDFIDPF | |||| ||| . .. . |..||| |.... .|.. HRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQT |
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| Kinase | 23446.AA | RAN | 547-571 | 53 | 4e-06 | 16.58 | In-house | 170-195 (324) | Show / Hide |
Range on Protein: 547-571 Range on HMM: 170-195/324 Sequence Identity: 53% (14 aa) IYHSDIKPGNILKT-YNNNYKLSDFG ||| |||| ||| . | .| |.| IYHCDIKPENILIDGIDWNIYLCDWG |
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| Kinase | 23446.AA | MSN | 539-577 | 48 | 8e-06 | 14.92 | In-house | 117-155 (265) | Show / Hide |
Range on Protein: 539-577 Range on HMM: 117-155/265 Sequence Identity: 48% (19 aa) LIVLRQKYIYHSDIKPGNILKTYNNNYKLSDFGASQQVD | | |. . | ||| |.| | | . || ||| | |.| LAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLD |
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| Kinase | 23446.AA | Ciliate-B2 | 592-611 | 45 | 0.064212 | 0.18 | In-house | 178-197 (197) | Show / Hide |
Range on Protein: 592-611 Range on HMM: 178-197/197 Sequence Identity: 45% (9 aa) FKPQDRVKNLPFYHDIYSFG .. | | |. | |||| | DHNQTFVTNIDFQSDIYSMG |
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