Gene 11603 (Tetrahymena)

11603

Species: Tetrahymena
Alias: 942, 1.m00651, PreTt11603, TTHERM_00005920, 11603
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-Unique
Subfamily: Ciliate-E2b

Sequence

Name Sequence Type Origin Length Description Download
11603.AA Protein None 403 None Fasta, JSON
11603.kin_dom Protein Kinase Domain None 150 None Fasta, JSON
11603.NA RNA None 1212 None Fasta, JSON

Protein domain

Protein domains of 11603.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 11603.AA Ciliate-E2b 231-383 67 9.1e-115 350.08 In-house 1-156 (272) Show / Hide 
Range on Protein: 231-383
Range on HMM: 1-156/272
Sequence Identity: 67% (106 aa)

LIFIKKLGFGQFGSVYLVRN-KDSGALYALKSVSKAQIIEQNLEKHLLQEKQVLETVNFTFIMQFIRTFKDNQSVYFLVEFISGMELFDVIRDIG--LLS
.|.|||||||||||||||.| |.. ..||.|..||.|||.||.|||.||||.|||..|..|||.|||.|||.|..||..||..|||||||||.||  |||
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLS

TSDSQFYIGTLILCMEYLHSRNIIYRDIKPENIMVDSKGYMYMIDMGTAKILKQGK
|.||||||....||.||||..|||||||||||||||.||||..|||||||.... .
TYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKN
Kinase 11603.AA AGC 231-386 27 2.8e-57 145.58 In-house 1-212 (395) Show / Hide 
Range on Protein: 231-386
Range on HMM: 1-212/395
Sequence Identity: 27% (59 aa)

LIFIKKLGFGQFGSVYLVRNK------DSGALYALKSVSKAQ-IIEQN--LEKHLLQE------------KQVLETVN----------FTFIMQ-FIRTF
  |.| .| | || ||||| |      |.| .||.| ..|.  |.. .   ..| . |            ...||..|            || .    .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

KDNQS--VYFLVEFIS----------GMELFDVIR---DIGLLSTSDSQFYIGT-------LILCMEYLHS-RNIIYRD-IKPENIMVDSKGYMYMIDMG
.|..   .||. |...          |.|||  ..   . | .. . ..||.         ..|..||||| ..||.|| .|||||. |..|.    | |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

TAKILKQGKHPG
 .|........|
LCKEGMNDGEKG
Kinase 11603.AA Ciliate-E2 231-381 28 2.4e-51 174.5 In-house 1-208 (365) Show / Hide 
Range on Protein: 231-381
Range on HMM: 1-208/365
Sequence Identity: 28% (61 aa)

LIFIKKLGFGQFGSVYLVRN-----------------------KDSGALYALKSVSKAQIIEQNLEKHLL----------QEKQVLETVNFTFIMQFIRT
 .||||.|.|.|||||....                       |. . .||.|...| ||.... |.|..          .||..||..|. .|.... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FK--DNQSVYFLVEFISGMELFD-------------------VIRDIGLLSTSDSQ-------FYIGTLILCMEYLHSRN-IIYRDIKPENIMVDSKGYM
|.  |....|.  |...|..|||                   ... |. ...   |       |||. .||..|||||.| ||.||||||||..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

YMIDMGTAKILKQ
  ||.|..|....
KIIDFGLSKKYDD
Kinase 11603.AA PKA 231-380 38 3.8e-46 159.61 In-house 1-152 (263) Show / Hide 
Range on Protein: 231-380
Range on HMM: 1-152/263
Sequence Identity: 38% (59 aa)

LIFIKKLGFGQFGSVYLVRNKDSGALYALKSVSKAQIIEQNLEKHLLQEKQVLETVNFTFIM-QFIRTFKDNQSVYFLVEFISGMELFDVIRDIGLLSTS
  .|. || | || |.|.|.|.||  ||.|  .|..|.  . . | . ||..|  ... ||  . . ||.|..  |.. |...| |.|. .|  | .| .
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

DSQFYIG-TLILCMEYLHSRNIIYRDIKPENIMVDSKGYMYMIDMGTAKILK
...||.    .|  ||||| |||||| |||||. |..|.  . | | || ..
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVD
Kinase 11603.AA AktR 232-377 38 9.3e-44 151.7 In-house 2-150 (268) Show / Hide 
Range on Protein: 232-377
Range on HMM: 2-150/268
Sequence Identity: 38% (57 aa)

IFIKKLGFGQFGSVYLVRNK-DSGALYALKSVSKAQIIEQNLEKHLLQEKQVLE-TVNFTFIMQFIRTFKDNQSVYFLVEFISGMELFDVIRDIGLLSTS
 ..| || | || ||||. | |.. .||.|...|  |||.|...|...|....|  .|. || ..  .|...   .|. |.. | |||.... .. .| .
HVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEE

DSQFYIGTLILCMEYLHSR-NIIYRDIKPENIMVDSKGYMYMIDMGTAK
...||.   .|. ||||.. ||||||.|||||. |. |. . .| | .|
QARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK
Kinase 11603.AA PKG 231-383 38 1.1e-40 141.47 In-house 1-154 (260) Show / Hide 
Range on Protein: 231-383
Range on HMM: 1-154/260
Sequence Identity: 38% (59 aa)

LIFIKKLGFGQFGSVYLVRNKD-SGALYALKSVSKAQIIEQNLEKHLLQEKQVLETVNFTFIMQFIRTFKDNQSVYFLVEFISGMELFDVIRDIGLLSTS
|  |  || | || | ||. .  .   .|||   |..|...  . |   ||....  .  || .  |||.|.  ||.| |   | ||  ..|| |    .
LKIIATLGVGGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDK

DSQFYIGTLILCMEYLHSRNIIYRDIKPENIMVDSKGYMYMIDMGTAKILKQGK
 ..||..  .  ..|||..|||||| ||||.| | .||. ..| | || ..||.
TTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGR
Kinase 11603.AA PDK1 232-379 33 1.8e-37 112.01 In-house 2-163 (307) Show / Hide 
Range on Protein: 232-379
Range on HMM: 2-163/307
Sequence Identity: 33% (54 aa)

IFIKKLGFGQFGSVYLVRNKDS----GALYALKSVSKAQIIEQNLEKHLLQEKQVLETVN-----FTFIMQFIRTFKDNQSVYFLVEFISGMELFDVIRD
||.| .| | ...|||.|.|..    .. ||.|  .| .|| ..  |    || ..   |     . .| .   ||.|.|. ||. |. .. .|   .. 
IFGKNIGEGSYSTVYLAREKETKNDENKMYAIKICEKRYIIREKKVKYVHREKEIMCHLNNECNGHPGIVKLYFTFQDEQCLYFVLEYCPNGDLLHYMKK

--IGLLSTSDSQFYIGTLILCMEYLHSRNIIYRDIKPENIMVDSKGYMYMIDMGTA---KIL
  .| .. ....||   .|.  |.|||..|| ||.|||||..|...    .| |||   |||
QPFGSFDMDCCRFYAAEIIDALEHLHSNGIIHRDLKPENILLDKDMHIMITDFGTAGFDKIL
Kinase 11603.AA Akt 232-367 39 1.3e-35 111.24 In-house 2-139 (264) Show / Hide 
Range on Protein: 232-367
Range on HMM: 2-139/264
Sequence Identity: 39% (54 aa)

IFIKKLGFGQFGSVYLVRNKDSGALY-ALKSVSKAQIIEQNLEKHLLQEKQVLETVNFTFIMQFIRTFKDNQSVYFLVEFISGMELFDVIRDIGLLSTSD
 |.| || | || |.||. ||.. .| |.|. .| .||..|  .| ..|. .|...|. || .    | ...  ||  ....| |||  ..  .  | . 
DFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDR

SQFYIGTLILCMEYLHSRNIIYRD-IKPENIMVDSKGY
  ||.  .||  |.|||.||||||  |||||..|..|.
ARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGH
Kinase 11603.AA Pkinase 231-398 28 1.1e-34 123.79 Pfam 1-172 (293) Show / Hide 
Range on Protein: 231-398
Range on HMM: 1-172/293
Sequence Identity: 28% (51 aa)

LIFIKKLGFGQFGSVYLVRNKDSGALYALKSVSKAQIIEQNLEKHLL-QEKQVLETVNFTFIMQFIRTFKDNQSVYFLVEFISGM----ELFDVIR--DI
. ...|.| | ||.||. ..|..| ..|.| ..|  . .. .. |.. .| |..  .|  .| .....| |....|.  |.  |     .|||.|.  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GLL--STSDSQFYIGTLILCMEYLHSRNIIYRDIKPENIMVDSKGYM----YMIDMGTAKILKQGKHPGRSINQSIYSQYV
| .  |  . .||.  ..  .||.||..||.||.|||||..|..|.       .| | || ..         |.| .. ..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------Y-NNS-MTTFC
Kinase 11603.AA SGK 232-377 29 3.7e-34 102.53 In-house 2-173 (283) Show / Hide 
Range on Protein: 232-377
Range on HMM: 2-173/283
Sequence Identity: 29% (51 aa)

IFIKKLGFGQFGSVYLVRNKDS------------------GALYALKSVSKAQII-------EQNLEKHLLQEK-QVLETVNFTFIMQFIRTFKDNQSVY
.|.|..| | || ||.|. ||                   ...||.|  .|..||         ...|| . |.  .|  ..  || .    |   .  |
DFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKLY

FLVEFISGMELFDVIRDIGLLSTSDSQFYIGTLILCMEYLHSRNIIYRDIKPENIMVDSKGYMYMIDMGTAK
|  ... | |.|  ..  . .. . . ||   ... .||||| .||||| |||||. |..|.  . | | .|
FVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCK
Kinase 11603.AA RSK 234-379 31 7.2e-34 118.84 In-house 1-157 (278) Show / Hide 
Range on Protein: 234-379
Range on HMM: 1-157/278
Sequence Identity: 31% (50 aa)

IKKLGFGQFGSVYLVRNK---DSGALYALKSVSKAQIIEQNL-EKHLLQEKQVLETVN-FTFIMQFIRTFKDNQSVYFLVEFISGMELFDVIRDIGL---
.| || | .|.|.|.| .   |.| .|| | ..|| |.  .   .| ..| ..||...   || .   .|.... .|   |...| |||. ..  .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LSTSDSQFYIGTLILCMEYLHSRNIIYRDIKPENIMVDS---KGYMYMIDMGTAKIL
.| .. .||. ...| .|.||.. ||.||.|||||. |.    |    .| | .|..
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF
Kinase 11603.AA S_TKc 231-398 20 3e-14 31.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 231-398
Range on HMM: 1-231/231
Sequence Identity: 20% (50 aa)

LIFIKKLGFGQFGSVYLVRNKDSGALYALKSVSKAQIIEQNLEKHLLQEKQVLETVNFTFIMQFIRTFKDNQSVYFLVEFISG--MELFDVIRDIGL---
  ...|.| | ||.||..|.|..| ..|.| ..          .|...| |.|.  .  .| ... .| | ...|.  |...|   .|||.|.. |    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LSTSDSQFYIGTLILCMEYLHSRNIIYRDIKPENIMVDSKGYMYMIDMGTAKIL------------------K----------------QGKHPGR-
   ..  . .||.  ... .||.||..||.||.|||||..|.      .| | |..|                  |                 |. | . 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFPQ

-----------------------------SINQSIY-------SQYV
                             .. .           ...
MQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 11603.AA TyrKc 231-397 12 4.4e-05 -140.45 SMART 1-280 (280) Show / Hide 
Range on Protein: 231-397
Range on HMM: 1-280/280
Sequence Identity: 12% (38 aa)

LIFIKKLGFGQFGSVYLVRNKDSGALYALKSVSKAQIIEQNLEKHLLQEKQVLETV--NFTFIMQFIRTFKDN-------QSVYFLVEFISGMELFDVIR
. ..|||| |.|| ||. . |      | |.. .        .. ...| ...  .  .   | ...    .        . .. ..|. ..  | | .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

DIGLLSTSDSQFYIGTLILC---------MEYLHSRNIIYRDIKPENIMVDSKG-------------YMY--------MIDM-----GT-----------
. .          . .  |.         ||||||.|.| ||.   |..|....             | .        ....     |            
KHRPK--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

--------------------------------------------AKILKQGKHPGRSIN-------------------------------QSIYSQY
                                             . .|||. . .  |                               . |... 
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF