Gene 11605 (Tetrahymena)
11605
Sequence
Protein domains of 11605.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 11605.AA | Ciliate-E2b | 19-123 | 66 | 1.3e-84 | 256.99 | In-house | 161-272 (272) | Show / Hide |
Range on Protein: 19-123 Range on HMM: 161-272/272 Sequence Identity: 66% (75 aa) RTFTIIGTPHYMAPEIIQ-----GKGYSYNADLWSVGICLYEFLCGGVPYAEEAEDPYEIYEEIIKK-NNVKYPSFLKDKKA-KRLIDQLLSKVPELRLG |||||||||||||||||| ||||.|..|.||||||||||.||.||.||...||||||.||||| .....||..|||.| |.|..|.|.|.||.||| RTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLG GSFAALKAHPWF ||...||.|||| GSYSWLKSHPWF |
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| Kinase | 11605.AA | AGC | 19-123 | 33 | 6.3e-48 | 120.85 | In-house | 261-395 (395) | Show / Hide |
Range on Protein: 19-123 Range on HMM: 261-395/395 Sequence Identity: 33% (47 aa) RTFTIIG--TPHYMAPEIIQGKGYSYNADLWS--VGICLYEFLCGGVP-YAEEAE-------DPYEIYEEIIK-----KNNVKYP----------SFLKD || |. | ||.||||||. |.. .| || .|...||.|.| | |... . .|.|... |.. ...||.| ... . RTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWF-S KKAKRLIDQLLSKVPELRLG--GS------FAALKAHPWF . || || .|| | || ||| |. . .|.|||| PEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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| Kinase | 11605.AA | Ciliate-E2 | 5-123 | 25 | 8.5e-37 | 123.83 | In-house | 217-365 (365) | Show / Hide |
Range on Protein: 5-123 Range on HMM: 217-365/365 Sequence Identity: 25% (42 aa) NQHIYLTIFQLSIGRTFT-------------IIGTPHYMAPEIIQGKG---------YSYNADLWSVGICLYEFLCGGVPYAEEAEDPYEIYEEIIKKNN .|. .. . . ||.. |.|||.||||||..||. |.| .|.||.|..|||.|.| |. ...||... QQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----------QQQIKQCK VKYPSFLKD-----------------KKAKRLIDQ----LLSKVPELRLGGSFAALKAHPWF ...|.. .. ...| || . .| | || |.. .. .. |||| IDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT-GWEQILNHPWF |
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| Kinase | 11605.AA | Ciliate-E2-Unclassified | 1-123 | 25 | 2.4e-28 | 95.44 | In-house | 174-352 (352) | Show / Hide |
Range on Protein: 1-123 Range on HMM: 174-352/352 Sequence Identity: 25% (46 aa) NLLI--NQ---HIYLTIFQLSI---------------------GRTFTIIGTPHYM----APEIIQGKGYS----YNADLWSVGICLYEFLCGGVPYAEE |.|. |. .| .. |..|. .. |..||| || |||..||..|. | .| ||.|..|||.| | |. . NILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDN AEDPYE-------------IYEEIIKKNNVKYPSFLK-------DKKAKRLID----QLLSKVPELRLGGSFAALKAHPWF .. .. .....||..|...|.| . ...|| .| ..| | |. |. .| .. |||| NCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI--TFEQILNHPWF |
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| Kinase | 11605.AA | RSK | 18-123 | 32 | 4.6e-27 | 96.14 | In-house | 163-278 (278) | Show / Hide |
Range on Protein: 18-123 Range on HMM: 163-278/278 Sequence Identity: 32% (38 aa) GRTFTIIGTPHYMAPEIIQ----GKGYSYNADLWSVGICLYEFLCGGVPYAE-EAEDPYEIYEEIIKKN-NVKYP--SFLKDKKAKRLIDQLLSKVPELR ..| | ..| .|||||.. ..|.. ..|.|| |. .|| | | .|.. . ... || . | |.. ... | ..| . || || ..| . |. | QWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYL-SQEAKDLIRKMLHRDPHKR LG---GSFAALKAHPWF || . . .|.|||| LGCGPQDAEEIKQHPWF |
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| Kinase | 11605.AA | Akt | 25-123 | 37 | 4.9e-27 | 83.4 | In-house | 164-264 (264) | Show / Hide |
Range on Protein: 25-123 Range on HMM: 164-264/264 Sequence Identity: 37% (39 aa) GTPHYMAPEIIQGKGYSYNADLWS-VGICLYEFLCGGVPYAEEAEDPYEIYEEIIKKNNVKYP--SFLKDKKAKRLIDQLLSKVPELRLG---GSFAALK ||| |.||||..|.|.. .| |. .|. .||..|| |. . .| . .. || ..||.| ... ....| || .||.| |..||| . .| GTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYN--QDHHQMFKK-IKNQPVKFPDKDWI-SPECKDLISGLLNKDPKKRLGGGPNDAQEIK AHPWF .|||| RHPWF |
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| Kinase | 11605.AA | MAST | 23-123 | 36 | 1.1e-26 | 78.04 | In-house | 228-337 (337) | Show / Hide |
Range on Protein: 23-123
Range on HMM: 228-337/337
Sequence Identity: 36% (41 aa)
IIGTPHYMAPEIIQGKG-YSYNADLWSVGICLYEFLCGGVPYAEEAEDPYE-IYEEIIK-KNNVKYPSF--------LKDKKAKRLIDQLLSKVPELRLG
..||| |.|||.| |.| |. .| ||.|| .||||.| .| . . | | | . ||. .... .|. . . |. ||..|| . | |||
CCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNG--DTPEEMIFQNIINHDREIEWPEEGDPNDDDCMS-PEAQDLIKKLLQPNPKKRLG
GS-FAALKAHPWF
. | || |
ANGADEIKQHPFF
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| Kinase | 11605.AA | MAST | 23-123 | 35 | 2.4e-26 | 81.64 | In-house | 224-334 (334) | Show / Hide |
Range on Protein: 23-123 Range on HMM: 224-334/334 Sequence Identity: 35% (40 aa) IIGTPHYMAPEIIQGKG-YSYNADLWSVGICLYEFLCGGVPYAEEAEDPYEIYEEIIKKN-N-VKYP--------SFLKDKKAKRLIDQLLSKVPELRLG ..||| |.|||.| |.| .. | ||.||..||||.| .| .. . ||.. |...| | ...| . . . |. ||..|| |. ||| CCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPE--EIFQNILNRNCNEIEWPEGGDINDDEAMS-PEAQDLIEKLLQPDPRKRLG GS--FAALKAHPWF . . | || | ANNGADEVKQHPFF |
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| Kinase | 11605.AA | SGK | 20-123 | 34 | 3.6e-26 | 77.44 | In-house | 182-283 (283) | Show / Hide |
Range on Protein: 20-123 Range on HMM: 182-283/283 Sequence Identity: 34% (37 aa) TFTIIGTPHYMAPEIIQGKGYSYNADLWSVGICLYEFLCGGVPYAEEAEDPYEIYEEIIKKNNVKYPSFLKDKKAKRLIDQLLSKVPELRLGGS--FAAL |||. ||| |.|||........ | |. |. |||.. | |. . . . |. ||.. . | . .|. || .|| | |. ||| |. TFTFCGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPF--YSRNKQQMYDNIINQ-PLQIPPQMS-NDAWDLIQGLLQKDPKKRLGTKRDFMEI KAHPWF | ||.| KNHPFF |
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| Kinase | 11605.AA | PKC | 25-123 | 35 | 5e-25 | 77.92 | In-house | 162-262 (262) | Show / Hide |
Range on Protein: 25-123 Range on HMM: 162-262/262 Sequence Identity: 35% (37 aa) GTPHYMAPEIIQGKGYSYNADLWSVGICLYEFLCGGVPYAEEAEDPYEIYEEIIKKNNVKYPSFLKDKKAKRLIDQLLSKVPELRLGG------SFAALK ||| |.||||.|.. |. . | |. |. .||...| | | || |. . | .. |. || | |.|. .. ... | || ||| . . . GTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPFHGEDED--ELFQSIMHD-NPHYPRWLS-KEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIR AHPWF .|| | EHPFF |
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| Kinase | 11605.AA | Pkinase | 22-123 | 27 | 6.9e-25 | 89.08 | Pfam | 170-293 (293) | Show / Hide |
Range on Protein: 22-123 Range on HMM: 170-293/293 Sequence Identity: 27% (35 aa) TIIGTPHYMAPEIIQ-GKGYSYNADLWSVGICLYEFLCGGVPYAEE----AEDPYEIYEEIIKKNNVKYPSFLKD-------------------KKAKRL |. |||.|||||.|. |..|.. .| ||.|. |||.||| |. .. |.......| .. . . . . . .| . TFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDF IDQLLSKVPELRLGGSFAALKAHPWF |. .| | |. |.. .. .. |||| IKWCLCKDPKKRPT--AEQILQHPWF |
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| Kinase | 11605.AA | S_TKc | 2-123 | 17 | 5.5e-07 | -74.48 | SMART | 19-231 (231) | Show / Hide |
Range on Protein: 2-123
Range on HMM: 19-231/231
Sequence Identity: 17% (41 aa)
LLIN-------------------------------------QHIYL----------TIFQLSIGRTF---------------------------------
.. .|.|. . |.. |
RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSHGIIHR
-------------------------TIIGTPHYMAPEIIQGKGYSY-NADLWSVGICLYEFLCGGVPYAEEAEDPYEIYEEIIKKNNVKYPSFLKDKKAK
|..|||.|||||.. ||.. .| ||.|..|||.||| |. ....... | .. ||
DLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG------------SPEAK
RLIDQLLSKVPELRLGGSFAAL-----KAHPWF
.|...| | || |.. | |.||||
DFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 11605.AA | Pkinase_Tyr | 30-65 | 34 | 9.3e-05 | 16.73 | Pfam | 181-218 (270) | Show / Hide |
Range on Protein: 30-65 Range on HMM: 181-218/270 Sequence Identity: 34% (13 aa) MAPEIIQGKGYSYNADLWSVGICLYEFLC-GGVP-YAE |||| |. . .. | || |....| . |. | |.. MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPG |
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