Gene 18124 (Tetrahymena)

18124

Species: Tetrahymena
Alias: 3671.m00073, 708, PreTt18124, TTHERM_00723640, 116.m00149, 18124
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: AGC-Sar
Subfamily: Ciliate-E2b

Sequence

Name Sequence Type Origin Length Description Download
18124.AA Protein None 951 None Fasta, JSON
18124.kin_dom Protein Kinase Domain None 260 None Fasta, JSON
18124.NA RNA None 2856 None Fasta, JSON

Protein domain

Protein domains of 18124.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
CNMP_binding 18124.AA cNMP_binding 268-353 29 9.7e-21 73.84 Pfam 1-91 (91) Show / Hide 
Range on Protein: 268-353
Range on HMM: 1-91/91
Sequence Identity: 29% (27 aa)

LCQTKKDQYLFKQGDKASAFFFIKSGTIAIEIDEQEKK-----QLGPGTGIGELALLYSA-PRSASIKCIVDCQFWAIDRHTFRKTVEEIVQ
. . ||....|.|||... |....||.. ..  ... .      ||||  .||.||..   ||.|... . ||. |.|.| .||. ...  .
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQNPRTATVVALTDCECWRIPREDFRQLMQQHPE
CNMP 18124.AA cNMP 250-363 28 4.7e-20 73.88 SMART 1-123 (123) Show / Hide 
Range on Protein: 250-363
Range on HMM: 1-123/123
Sequence Identity: 28% (35 aa)

VFYSLSEDQIKEVANQMFLCQTKKDQYLFKQGDKASAFFFIKSGTIAIEID---------EQEKKQLGPGTGIGELALLYSAPRSASIKCI-VDCQFWAI
.| .|.|... |....|..   .. .|.|.|||... |..| ||.. .  .         ||. . ||||  .||||||  .||.|...   ..|..| |
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL-RRPRTAAARACCECCTIWRI

DRHTFRKTVEEIVQRDSQTNRKFM
|.. |.  .... |.  .  ... 
DFQHFMQQLQQHPQHMYRMLQQLA
CNMP 18124.AA cNMP 368-481 21 1.4e-22 82.22 SMART 1-123 (123) Show / Hide 
Range on Protein: 368-481
Range on HMM: 1-123/123
Sequence Identity: 21% (27 aa)

FFSFMSDEQKDSIASALISVRFKPGDNIVSEGDRADSFYLIKEGKVSVWKN---------GVLIRNLYQSDSFGEQALYIKSTRAATVKAD-EEVKLLSL
.|. .....  ...... ......|. |. .||..|.||.| .|.| | |          ..... | . |.||| ||   ..|.|...|  | .... .
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL-RRPRTAAARACCECCTIWRI

GRDDLTRILGGKIQKIVYANKQRW
 .... ..|.   |.  .  .|. 
DFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding 18124.AA cNMP_binding 386-471 30 3e-21 75.62 Pfam 1-91 (91) Show / Hide 
Range on Protein: 386-471
Range on HMM: 1-91/91
Sequence Identity: 30% (28 aa)

SVRFKPGDNIVSEGDRADSFYLIKEGKVSVWKNGVLIR-----NLYQSDSFGEQALYIKS-TRAATVKADEEVKLLSLGRDDLTRILGGKIQ
 ...|.|. |...||..|.||....|||.| | .   |      | . | ||| ||   . .|.|||.| ........ |.|. ...    .
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQNPRTATVVALTDCECWRIPREDFRQLMQQHPE
CNMP_binding 18124.AA cNMP_binding 506-592 21 0.004768 13.05 Pfam 1-91 (91) Show / Hide 
Range on Protein: 506-592
Range on HMM: 1-91/91
Sequence Identity: 21% (20 aa)

ISNYKNGTVLYEKGDYCDTLIAVLDGNIKGEDSGQI-------LADKGQIFGDYYLPLTNQNIQFDQRIVIGSDAVLSTISFKQFHKCIGGDVL
. .|| |.|....|| || .  ||.| .| .  ..        .  .|..||.  |   .    .   .|  .|...  |. ..|....  .  
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQ--NPRTATVVALTDCECWRIPREDFRQLMQQHPE
Kinase 18124.AA Ciliate-E2b 623-882 66 1.6e-202 620.92 In-house 1-272 (272) Show / Hide 
Range on Protein: 623-882
Range on HMM: 1-272/272
Sequence Identity: 66% (180 aa)

LIYIKKLGVGQFGSVYLVRR-KNTRELYALKSVSKGQIIEQNLEKHLISEKNVLEMIQFPFIMNFIRTFKDDQSVYFLLKFINGLELFDVIRDIG--LLS
.||||||| |||||||||.. |||...||.|..|| |||.||.|||...||||||....||||.|||.|||||..||...|.||.|||||||.||  |||
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLS

TFDSQFYVGSLILCLEYLHSRQIIYRDVKPENMMVDHTGYMYMIDMGAAKLLSKGKSIG-RTFTIIGTPHYMAPEIIK-----GKGYSYSSDLWSVGICL
| |||||..|..|||||||...|||||.||||.||||.|||..||||.||...| .... |||||||||||||||||.     ||||.|..|.|||||||
TYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICL

YEFMCGQVPYAEDAQDPYEIYEEINSK--DIKFPPFLKDRKA-KLLIEQLLQKVPELRLGGSYAALKTNPWF
||||||.||.|||.|||||||.||..|  .|.||...||..| | |..|.|||.||.||||||..||..|||
YEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLGGSYSWLKSHPWF
Kinase 18124.AA AGC 623-882 26 2.5e-107 278.03 In-house 1-395 (395) Show / Hide 
Range on Protein: 623-882
Range on HMM: 1-395/395
Sequence Identity: 26% (104 aa)

LIYIKKLGVGQFGSVYLVRRK------NTRELYALKSVSKGQ-IIEQN--LEKHLISE------------KNVLEMIQ----------FPFIMN-FIRTF
   .| .| | || |||||.|       | ..||.| ..|   |.. .   ..| ..|            .|.||...           ||| .    .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

KDDQS--VYFLLK----FIN------GLELFDVIR---DIGLLSTFDSQFYVGS-------LILCLEYLHS-RQIIYRD-VKPENMMVDHTGYMYMIDMG
.|..   .||..     ..|      |.|||  ..   . | ..   ..||          ..|.|||||| . ||.|| .||||.. |. |.    | |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

AAKLLSKGKSIG------------------------------------------------RTFTIIG--TPHYMAPEIIKGKGYSYSSDLWS--VGICLY
 .| . .....|                                                || |. |  ||.||||||.    |... | ||  .|...|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EFMCGQVP-YAEDAQ-------DPYEIYEEIN------SKDIKFP----------PFLKDRKAKLLIEQLLQKVPELRLG--GS------YAALKTNPWF
|...|. | |... |       .|.|... |       ....|||          ... .  || ||..||.| || |||  |.      .  .|  |||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWF-SPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 18124.AA Ciliate-E2 623-882 25 1.2e-88 300.83 In-house 1-365 (365) Show / Hide 
Range on Protein: 623-882
Range on HMM: 1-365/365
Sequence Identity: 25% (98 aa)

LIYIKKLGVGQFGSVYLVRRKNTRE-----------------------LYALKSVSKGQIIEQNLEKHLI----------SEKNVLEMIQFPFIMNFIRT
 . |||.| |.|||||.........                       .||.|...| ||.... |.|..           |||.|| ...|.|.... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FK--DDQSVYFLLKFINGLELFD-------------------VIRDIGLLSTFDSQ-------FYVGSLILCLEYLHSRQ-IIYRDVKPENMMVDHTGYM
|.  ||...|. . ...| .|||                   ... |. ...   |       ||....||.||||||.  ||.|| |||| ..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

YMIDMGAAK-----------------LLSKGKSIGRTFT-------------IIGTPHYMAPEIIKGKG---------YSYSSDLWSVGICLYEFMCGQV
  ||.| .|                 ..  .  . ||..             |.|||.||||||..||.         |.|..|.||.|..|||...|. 
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PYAEDAQDPYEIYEEINSKDIKFPPFLKD-----------------RKAKLLIEQ----LLQKVPELRLGGSYAALKTNPWF
|.          ...|  ..|.||.. ..                  ..| || .    .||| || |.. ..  .. .|||
PF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT-GWEQILNHPWF
Kinase 18124.AA PKA 623-882 39 2.7e-73 249.79 In-house 1-263 (263) Show / Hide 
Range on Protein: 623-882
Range on HMM: 1-263/263
Sequence Identity: 39% (105 aa)

LIYIKKLGVGQFGSVYLVRRKNTRELYALKSVSKGQIIEQNLEKHLISEKNVLEMIQFPFIMN-FIRTFKDDQSVYFLLKFINGLELFDVIRDIGLLSTF
   |. || | || |.|.| |.. . ||.|  .| .|.  . . | ..|||.|  |..||| .  . ||.||.  |... ...| |.|. .|  | .|  
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

DSQFYVG-SLILCLEYLHSRQIIYRDVKPENMMVDHTGYMYMIDMGAAKLLSKGKSIGRTFTIIGTPHYMAPEIIKGK-GYSYSSDLWSVGICLYEFMCG
...||.    .| |||||| .||||| |||| . |  |.  . | | || .       ||.|. ||| |.|||||..| |.  | | |. ||  ||.. |
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD-----RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAG

QVPYAEDAQDPYEIYEEINSKDIKFPPFLKDRKA---KLLIEQLLQKVPELRLGGSYA---ALKTNPWF
  |  ..  || .||| | . .||||... | .|   | ||..|||. .. |.|   .     |. .||
YPPFYDHNRDPMQIYEKICNGKIKFPRHF-DSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 18124.AA S_TKc 623-882 29 7.7e-73 249.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 623-882
Range on HMM: 1-231/231
Sequence Identity: 29% (82 aa)

LIYIKKLGVGQFGSVYLVRRKNTRELYALKSVSKGQIIEQNLEKHLISEKNVLEMIQFPFIMNFIRTFKDDQSVYFLLKFING--LELFDVIRDIGL---
   ..|.| | ||.||..| |.| ...|.| ..          .|...| ..|.. . |.| ... .| | ...|. . ...|   .|||.|.. |    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LSTFDSQFYVGSLILCLEYLHSRQIIYRDVKPENMMVDHTGYMYMIDMGAAKLLSKGKSIGRTFTIIGTPHYMAPEIIKGKGYSY-SSDLWSVGICL
   ..  . .||.  ... |||.||..||.||.|||| ..|.      .| | |..|          |..|||.|||||..   ||.. ..| ||.|..|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

YEFMCGQVPYAEDAQDPYEIYEEINSKDIKFPPFLKDRKAKLLIEQLLQKVPELRLGGSYAAL-----KTNPWF
||..||. |.     ....... |            .. || .|...||| || |..   |       |  |||
YEMLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 18124.AA AktR 624-882 36 8.9e-68 231.48 In-house 2-268 (268) Show / Hide 
Range on Protein: 624-882
Range on HMM: 2-268/268
Sequence Identity: 36% (97 aa)

IYIKKLGVGQFGSVYLVRRK-NTRELYALKSVSKGQIIEQNLEKHLISEKNVLE-MIQFPFIMNFIRTFKDDQSVYFLLKFINGLELFDVIRDIGLLSTF
 ..| || | || ||||..| .. ..||.|...|  |||.|...|.| |.|..| ....||| ..  .|...   .|..... | |||.... .. .|  
HVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEE

DSQFYVGSLILCLEYLHSR-QIIYRDVKPENMMVDHTGYMYMIDMGAAKLLSKGKSIGRTFTIIGTPHYMAPEIIKG-KGYSYSSDLWSVGICLYEFMCG
...||    .|.|||||..  ||||| |||| . |  |. . .| | .||. .     .. .. |||.|||||.|.  ||. .|.|.|..|| .|| . |
QARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTG

QVPYAEDAQDPYEIYEEINSKD-IKFPPFLKD-RKAKLLIE-QLLQKVPELRLG-G--SYAALKTNPWF
. |   . |   .... |..|. .|||.  .   ..| ||. .||.| |. ||| .  .   .|  |||
CPPFYHKNQN--QMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 18124.AA SGK 624-882 31 2.9e-65 200.3 In-house 2-283 (283) Show / Hide 
Range on Protein: 624-882
Range on HMM: 2-283/283
Sequence Identity: 31% (91 aa)

IYIKKLGVGQFGSVYLVRRKNT------------------RELYALKSVSKGQII-------EQNLEKHLISEK-NVLEMIQFPFIMNFIRTFKDDQSVY
...|..| | || ||.|..| .                    .||.|  .| .||         ...||  .|. ..|  .  ||| |    |  ..  |
DFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKLY

FLLKFINGLELFDVIRDIGLLSTFDSQFYVGSLILCLEYLHSRQIIYRDVKPENMMVDHTGYMYMIDMGAAKLLSKGKSIGRTFTIIGTPHYMAPEIIKG
| . ..|| |.|  ..  . ..   . ||.  ... ||||||  ||||| |||| . || |.  . | | .|.  | .    |||. ||| |.|||....
FVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTND--TTFTFCGTPEYLAPEVLRK

KGYSYSSDLWSVGICLYEFMCGQVPYAEDAQDPYEIYEEINSKDIKFPPFLKDRKAKLLIEQLLQKVPELRLGGS--YAALKTNPWF
.... . | |. |. |||.| |  |.    ..  . |. | ......||.    .|. ||..|||| |. |||     .  |  |.|
QPHDRTVDWWCLGCVLYEMMYGLPPFYS--RNKQQMYDNIINQPLQIPPQMS-NDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 18124.AA RSK 626-882 30 2.6e-63 216.64 In-house 1-278 (278) Show / Hide 
Range on Protein: 626-882
Range on HMM: 1-278/278
Sequence Identity: 30% (85 aa)

IKKLGVGQFGSVYLVRRK---NTRELYALKSVSKGQIIEQNL-EKHLISEKNVLEMIQ-FPFIMNFIRTFKDDQSVYFLLKFINGLELFDVIRDIGL---
.| || | .|.|.|.|..   .|. .|| | ..|  |.  .   .|   | |.||..|  ||| .   .|.... .|  . ...| |||. ..  .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LSTFDSQFYVGSLILCLEYLHSRQIIYRDVKPENMMVDH---TGYMYMIDMGAAKLLSKGKSIGRTFTIIGTPHYMAPEIIK----GKGYSYSSDLWSVG
.|  . .||   ..| .|.||...||.|| ||||.. |.    |    .| | .|.. . .  ..| | ..| .|||||..|    ..|.. . |.|| |
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

ICLYEFMCGQVPYAEDAQ-DPYEIYEEINSKD--IKFP--PFLKDRKAKLLIEQLLQKVPELRLG---GSYAALKTNPWF
. .||   |..|.. ... .. || . | ...   ..|  ..|  . || || ..|.. |. |||   .  . .| .|||
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYL-SQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 18124.AA Akt 624-882 36 5.3e-63 200.2 In-house 2-264 (264) Show / Hide 
Range on Protein: 624-882
Range on HMM: 2-264/264
Sequence Identity: 36% (99 aa)

IYIKKLGVGQFGSVYLVRRKNTRELY-ALKSVSKGQIIEQNLEKHLISEKNVLEMIQFPFIMNFIRTFKDDQSVYFLLKFINGLELFDVIRDIGLLSTFD
 ..| || | || |.||. |.| ..| |.|. .| .||..|  .| . |.|.|.....||| |    | . .  || . ..|| |||  ..  .  |   
DFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDR

SQFYVGSLILCLEYLHSRQIIYRD-VKPENMMVDHTGYMYMIDMGAAKLLSK-G-KSI-GRTFTIIGTPHYMAPEIIKGKGYSYSSDLWS-VGICLYEFM
  ||.  .|| .|.|||. |||||  |||| ..|..|. .. | |    |.| . ..   .| |. ||| |.||||..|.|.. ..| |. .|. .||.|
ARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFG----LCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

CGQVPYAEDAQDPYEIYEEINSKDIKFP--PFLKDRKAKLLIEQLLQKVPELRLG---GSYAALKTNPWF
||. |. .  ||  . .. | ....|||  ... . ..| ||..||.| |..|||   .    .|  |||
CGRPPFYN--QDHHQMFKKIKNQPVKFPDKDWI-SPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 18124.AA Pkinase 623-882 27 5.7e-63 220.3 Pfam 1-293 (293) Show / Hide 
Range on Protein: 623-882
Range on HMM: 1-293/293
Sequence Identity: 27% (82 aa)

LIYIKKLGVGQFGSVYLVRRKNTRELYALKSVSKGQIIEQNLEKHLI-SEKNVLEMIQFPFIMNFIRTFKDDQSVYFLLKFINGL----ELFDVIR--DI
.  ..|.| | ||.||. ..|.|....|.| ..|  . .. .. |.  ||  .. ... |.|  ....| |....|. . . .|     .|||.|.  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GLL--STFDSQFYVGSLILCLEYLHSRQIIYRDVKPENMMVDHTGYM----YMIDMGAAKLLSKGKSIGRTFTIIGTPHYMAPEIIK-GKGYSYSSDLWS
| .  |  . .||.  ..  |||.||. ||.||.|||| ..|..|.       .| | ||...   . . . |. |||.|||||.|. |..|....| ||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

VGICLYEFMCGQVPYA-E----DAQDPYEIYEEINSKDIKFPPFLKD--------------------RKAKLLIEQLLQKVPELRLGGSYAALKTNPWF
.|. |||..||. |.  .    .  |.......| .....|. . ..                    . .| .|. .|.| |. |..   . ..  |||
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT--AEQILQHPWF
Kinase 18124.AA Ciliate-E2-Unclassified 624-882 25 2.3e-60 206.84 In-house 2-352 (352) Show / Hide 
Range on Protein: 624-882
Range on HMM: 2-352/352
Sequence Identity: 25% (89 aa)

IYIKKLGVGQFGSVYLVRRKNTRELYALKSVSKGQIIEQNLEKHL---------ISEKN-------------VLEMIQFPFIMNFIRTFKDDQSVYFLLK
. ||..| |.||.||....|.. ..||.|  .| ||. |.. ..          . .|.              | ... |||.... .|.|.| .|. . 
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVME

FINGLELFDVIRDI-----------------GLLSTFDSQ-----FYVGSLILCLEYLHSRQ-IIYRDVKPENMMVDHTG---YMYMIDMGAAKLLSKGK
...|..|.. |..                    .. . ..     ||   ....|||||. . ||.|| |||| ..|  |   |   || | .| . .  
YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNN

SIGRTF--------------TIIGTPHYM----APEIIKGKGYS----YSSDLWSVGICLYEFMCGQVPY-AEDAQDPY-------------EIYEEINS
 .  |.              |..||| ||    |||...|..|.    |..| ||.|..|||.. |. |. ...  . .             ..|..|. 
NCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

KDIKFPPFLK-------DRKAKLLIEQLLQKVPELRLG--GSYAALKTNPWF
|.|.||.| .       . .|| .|..|||| .. ...   ..  ..  |||
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 18124.AA PKG 623-837 38 7.2e-58 198.56 In-house 1-211 (260) Show / Hide 
Range on Protein: 623-837
Range on HMM: 1-211/260
Sequence Identity: 38% (84 aa)

LIYIKKLGVGQFGSVYLVRRKNTR-ELYALKSVSKGQIIEQNLEKHLISEKNVLEMIQFPFIMNFIRTFKDDQSVYFLLKFINGLELFDVIRDIGLLSTF
|  |  |||| || | ||. ..   . .|||   | .|...  . | .||||...  . .||    |||.|.  ||.|.    | ||  ..|| |     
LKIIATLGVGGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDK

DSQFYVGSLILCLEYLHSRQIIYRDVKPENMMVDHTGYMYMIDMGAAKLLSKGKSIGRTFTIIGTPHYMAPEIIKGKGYSYSSDLWSVGICLYEFMCGQV
 ..||..  .  ..|||.. ||||| ||||.| |..||. ..| | || . .|.   .| |  ||| | |||||  ||   | | |. ||  .| . |. 
TTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGR---KTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGNP

PYAEDAQDPYEIYEEI
|.   . ||  .|  |
PFS--GSDPMKTYNII
Kinase 18124.AA TyrKc 623-878 19 3.8e-11 -42.45 SMART 1-280 (280) Show / Hide 
Range on Protein: 623-878
Range on HMM: 1-280/280
Sequence Identity: 19% (59 aa)

LIYIKKLGVGQFGSVYLVRRKNTRELYALKSVSKGQIIEQNLEKHLISEKNVLEMI--QFPFIMNFIRTFKDD-------QSVYFLLKFINGLELFDVIR
.  .|||| |.|| ||. . |   .  | |.. ..       .. ...| ... ..  . | | ...    ..       . .. .. .  .  | | .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

DIGLLSTFDSQFYVGSLILC---------LEYLHSRQIIYRDVKPENMMVDHTGYMYMIDMGAAKLLSKG-------KSI-------GRT-FTIIGTPHY
. .          .    |.          |||||...| ||    | .|.. . .   | | .. .  .       . .       |.| . |      
KHRPK--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI----RW

MAPEIIKGKGYSYSSDLWSVGICLYE-FMCGQVPYAEDA---QDPYEIYEEINSKDIKFPPFL--------KDRKAKLLIEQLLQKVPELRLGGSYAALK
|||| |. . ..  || || |.|..| |  || || ...    ...|..| . . .   .|             .   ...|  .  || |   |    .
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

T
 
F
Kinase 18124.AA Pkinase_Tyr 790-825 36 4e-06 21.46 Pfam 181-218 (270) Show / Hide 
Range on Protein: 790-825
Range on HMM: 181-218/270
Sequence Identity: 36% (14 aa)

MAPEIIKGKGYSYSSDLWSVGICLYEFMC-GQVP-YAE
|||| |. . ..  || || |....| .  |. | |..
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPG
Kinase 18124.AA Pkinase_Tyr 623-639 52 0.001625 12.53 Pfam 1-17 (270) Show / Hide 
Range on Protein: 623-639
Range on HMM: 1-17/270
Sequence Identity: 52% (9 aa)

LIYIKKLGVGQFGSVYL
.. .|||| |.||.||.
ITFGKKLGEGAFGEVYK