Gene 20648 (Tetrahymena)
20648
Group:
Other
Family:
Ciliate-E4
Sequence
Protein domains of 20648.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 20648.AA | Ciliate-E4 | 22-171 | 42 | 1.3e-71 | 236.65 | In-house | 1-150 (150) | Show / Hide |
Range on Protein: 22-171 Range on HMM: 1-150/150 Sequence Identity: 42% (64 aa) YITVKNIQDEKYGEGVLMQNKLTGAYCLLKEYNSTDDYEFEKAYSKYKKRQELKHENIVMLLGIAQKKESQLCSTFYKLYVLYEYVNDNLEQHIQLHQQT | . ..| || | | .| . . .. .||.|.||||.|......|||.|.||..|.||...||....|.|||..|.|. YRKIESVKDIHYGDIQIMEHKIQKQIIVMKIRKFQNETKARQQQQQFRRRQDLNHENIIMVYEYFHKKEDQFCSSIYRLYWFMEYLQKDLQQHIKQHKQQ GQHFIESELWDILMQSVSALSYLQQKGITHQNIKPSNIFFDQNQMVKIAD ||||.|||.|.|......|..||||..|||...|||||||||..|||||| GQHFDESEIWQIAFCCINAMYYLQQVNITHGDLKPSNIFFDQYFMVKIAD |
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| Kinase | 20648.AA | Ciliate-A5 | 32-294 | 29 | 1.7e-47 | 162.65 | In-house | 1-275 (275) | Show / Hide |
Range on Protein: 32-294 Range on HMM: 1-275/275 Sequence Identity: 29% (82 aa) KYGEGVLMQNKLTGAYCLLKEYNSTDDYEFEKAYSKYKKRQELKHENIVMLLGIAQKKESQLCSTFYKLYVLYEYVNDNLEQHIQLHQQTG--QHFIESE ||. .. | .. | | . | .. . . .|..|.| ||| |... ..|....||.|||. .|||. |||| .| .| . |.| FYGCMKIWKNQHQQEYYICKQKQIQDEDRQKHFQQYFEQRMQLQHPNIVKLIDFHTHKKEEFCSQFYKVNCYYEYHDNNLEQEMQMRKQCQKDIFYNEQE LWDILMQSVSALSYLQQKGITHQNIKPSNIFFDQNQMVKIADSQ----VIQQMNTFSLVATNPKEPPKNS-YLSPALIEALAQNN----WSPNHDTSKSD || |. .|...||||..| | .|.|.||. |. ||..|. | | | . . |. |||| . .... . |.|. ||| LWYIMDCLISVCMYLQQNNICHGDIRPQNICLTQDGQVKLMDMNESKDFFYQINWSSYKQYQHHMSTENKQYLSPMQWYQMMHRDEQNIQRPEHNWYKSD IFSLGMTIISAGLLEDLDSCYIYYPEPAFQEDIFKQKFNQFKS-NYSSKLTNILGIMTSLGEETRPDFNQLWNQL .|.|||.. ...| |. | . |. .. |.|. || ..|.. | . |. |||| |. .| VFCLGMICLEMCTMRDCTQFYYDYETFQIQNNQLIKQLIQMKEKKYSEQFINFIKQMLQFEENKRPDFHQIYQYL |
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| Kinase | 20648.AA | CDC2 | 72-171 | 27 | 3.9e-14 | 39.34 | In-house | 55-146 (301) | Show / Hide |
Range on Protein: 72-171 Range on HMM: 55-146/301 Sequence Identity: 27% (28 aa) QELK-HENIVMLLGIAQKKESQLCSTFYKLYVLYEYVNDNLEQHIQLHQQTGQHFIESELWDILMQSVSALSYLQQKGITHQNIKPSNIFFDQNQMVKIA .||| |.|||.| . . .||| ||.. .| . .....|. .. . ....| ....... |..| | ..||.||. | . .||| KELKDHPNIVKLHDVIHQ---------NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIA D | D |
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| Kinase | 20648.AA | Ciliate-E1 | 60-222 | 16 | 1.6e-13 | 40.8 | In-house | 28-202 (202) | Show / Hide |
Range on Protein: 60-222 Range on HMM: 28-202/202 Sequence Identity: 16% (30 aa) EFEKAYSKYKKRQELKHENIVMLLGIAQKKESQLCSTFY-KLY----VLYEYVNDNLEQHIQ---------LHQQTGQHFIESELWDILMQSVSALSYLQ . . .|.. .. .|.| .. .| . ... |.. ... ... . |.....|.. .| ..||. . | . .. | .| . .|..|. NCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELH QKGITHQNIKPSNIFFDQNQMVKIADSQVIQQMNTFSLVATNPKEPPKNSYLSPALIEALAQNNWSPNHDTSKSDIF |..|.|..|||.|| .... ...| .. .. . .. .. | .. | .. . . . . .. .. ||||. QYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKINYKSDIY |
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| Kinase | 20648.AA | Ciliate-E6 | 101-171 | 31 | 3.7e-11 | 32.1 | In-house | 26-96 (154) | Show / Hide |
Range on Protein: 101-171 Range on HMM: 26-96/154 Sequence Identity: 31% (23 aa) YVLYEYVNDNLEQHIQLHQQTGQHFIESE--LWDILMQSVSALSYLQQKGITHQNIKPSNIFFDQNQMVKIAD ... | . ||...| || . |.. . ... | ..|..|| .|.. .|||.. ||| |.|. .||.| FIVMERCEMNLQDWI--HQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICD |
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| Kinase | 20648.AA | S_TKc | 22-297 | 18 | 6.6e-11 | -16.96 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 22-297 Range on HMM: 1-231/231 Sequence Identity: 18% (54 aa) YITVKNIQDEKYGEGVLMQNKLTGAYCLLKEYNSTDDYEFEKAYSKYKKRQELKHENIVMLLGIAQKKESQLCSTFYKLYVLYEYVND---NLEQHIQLH | .. | .|. . ..| || .. .|. . .. . | . | .|.||| |... | .||. ||.. .| ..|. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK------HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYIKKR QQTGQH--FIESELWDILMQSVSALSYLQQKGITHQNIKPSNIFFDQNQMVKIAD---SQVIQQMNTFSLVATNPKEPPKNSYLSPALIEALAQNNWSPN . | . | | . . .. | ..|| |. ..|| | .||.||..|. .||.| . .. ... | |..| .. GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPW-------YMAPEVL----------G HDTSKSDIFSLGMTIISAGLLEDLDSCYIYYPEPAFQEDIFKQKFNQFKSNYSSKLTNILGIMTSLGEETRPDFNQLWN------QLQQF ... |.|. |.| ... | . .. .. .||. |. . ... . | || .. . . . | YGKCKCDWWSCGCILYEM-----LCGYPPFP----QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 20648.AA | WEE | 110-171 | 25 | 1.8e-10 | 31.4 | In-house | 92-175 (297) | Show / Hide |
Range on Protein: 110-171 Range on HMM: 92-175/297 Sequence Identity: 25% (21 aa) NLEQHIQLHQQTGQH-FIESELWDILMQSVSALSYLQQK-GITHQNIKPSNIFFDQNQ--------------------MVKIAD || | .. . ..| . |...|.||.. . .|... .. |. | |||.|||. .. | ||.| NLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGD |
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| Kinase | 20648.AA | Ciliate-E2 | 99-171 | 26 | 2.3e-10 | 31.74 | In-house | 108-199 (365) | Show / Hide |
Range on Protein: 99-171 Range on HMM: 108-199/365 Sequence Identity: 26% (26 aa) KLYVLYEYVND-NLEQHIQLH-QQTGQH------FIESELWDILMQSVS---------------ALSYLQQKG-ITHQNIKPSNIFFDQNQMVKIAD ..| ||.. .|...|. . .. ... | | | .| | .. || || .|. | | .|||.||.| .||.| NIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIID |
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| Kinase | 20648.AA | CDK | 72-171 | 25 | 1.1e-09 | 27.03 | In-house | 63-156 (284) | Show / Hide |
Range on Protein: 72-171
Range on HMM: 63-156/284
Sequence Identity: 25% (28 aa)
QELKHENIVMLLGIAQKKESQ--LCSTF--YKLYVLYEYVNDNLEQHIQLHQQTGQHFIESELWDILMQSVSALSYLQQKGITHQNIKPSNIFFDQNQM-
.|| |.||| |. . |.. .. ||| ||. | . . ...| ..|.|. ...| | .||.|| . |
KEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFEYMDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEV
----VKIAD
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KCGRLKIAD
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| Kinase | 20648.AA | CAMKK | 123-171 | 19 | 1.1e-09 | 26.46 | In-house | 150-242 (396) | Show / Hide |
Range on Protein: 123-171 Range on HMM: 150-242/396 Sequence Identity: 19% (18 aa) QHFIESE---------------------LWDILMQSVSALSYLQ-QKG-------------------ITHQNIKPSNIFFDQNQ---MVKIAD ... | . .| .. ... .| || ... | | |||.|| .|.. .||||| SIMSEQQSISEFINQVVKQDQYFIHEDYAWKYFRDCIKGLEYLHNYQKACSYIIIYINEFIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIAD |
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| Kinase | 20648.AA | NEK | 110-171 | 35 | 1.8e-09 | 29.96 | In-house | 93-166 (286) | Show / Hide |
Range on Protein: 110-171 Range on HMM: 93-166/286 Sequence Identity: 35% (26 aa) NLEQH---IQLHQQTGQHFIESELWDILMQSVSALSYLQQK-----GITHQNIKPSNIFFDQNQM----VKIAD .|.|. |. ..| |..| |.. ||.. | ..|| |. .. | | |||.||| . | . ||| | DLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGD |
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| Kinase | 20648.AA | Pkinase | 72-171 | 26 | 3.2e-09 | 33.68 | Pfam | 55-155 (293) | Show / Hide |
Range on Protein: 72-171 Range on HMM: 55-155/293 Sequence Identity: 26% (29 aa) QELKHENIVMLLGIAQKKESQLCSTFYKLYVLYEYVNDNLEQHIQLH----QQTGQHF--IESELWDILMQSVSALSYLQQKGITHQNIKPSNIFFDQNQ ..|.|.||| |... . ..|. ||.. |. .. |. . . | | |. ... | ...| |. ..|| | .||.||..|.| KRLNHPNIVRLYDWFED--------KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNG MV----KIAD . ||.| HIDACVKICD |
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| Kinase | 20648.AA | TyrKc | 37-294 | 16 | 1.5e-05 | -132.87 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 37-294 Range on HMM: 1-280/280 Sequence Identity: 16% (55 aa) VLMQNKL-TGAYC--------------LLKEYNSTDDYEFEKAYSKYKKR--------QEL--KHENIVMLLGIAQKKESQLCSTF---YKLYVLYEYVN . . || ||.. |||. .. .| .|.||| |.|.. ... . | |... ||. ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMP D-NLEQHIQLHQQTGQHFIESELWDILMQSVSALSYLQQKGITHQNIKPSNIFFDQNQMVKIAD---SQVIQQM-----NTFSLVAT---NPK--EPPKN .| .... |. . . ..| .. | . .|| .|.. | . |. . |. |||.| | | .. ... . | | . HGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR- SYLSPALIEALAQNNWSPNHD--TSKSD----------IFSLGMT---------IISAGLLEDLDSCYIYYPEPA----FQEDIFKQKFNQFKSNYSSKL ..| |.. |. |.||| ||..|.. . . ..|.... | . | | .... -WMAP---ECI-------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------F-VCCPDEM TNILGIMTSLGEETRPDFNQLWNQL .| | || |... .. YQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 20648.AA | WEE | 218-228 | 81 | 0.004838 | 6.13 | In-house | 216-226 (297) | Show / Hide |
Range on Protein: 218-228 Range on HMM: 216-226/297 Sequence Identity: 81% (9 aa) KSDIFSLGMTI |.||||||.|| KADIFSLGITI |
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| Kinase | 20648.AA | Ciliate-E6 | 216-225 | 40 | 0.056634 | 2.5 | In-house | 145-154 (154) | Show / Hide |
Range on Protein: 216-225 Range on HMM: 145-154/154 Sequence Identity: 40% (4 aa) TSKSDIFSLG | ..||.|.. TQEGDIWSVC |
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| MORN | 20648.AA | MORN | 1098-1120 | 47 | 7.4e-08 | 33.28 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 1098-1120 Range on HMM: 1-23/23 Sequence Identity: 47% (11 aa) YDGEWKDNKMNGRGVLYYASGKI |.||||..||.|.||.....| YEGEWKNGKMHGHGVYTWPDGDR |
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| MORN | 20648.AA | MORN | 1096-1117 | 40 | 2.1e-07 | 31.81 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 1096-1117 Range on HMM: 1-22/22 Sequence Identity: 40% (9 aa) GLYDGEWKDNKMNGRGVLYYAS |.|||...|. |.||...|. DRYEGEWHNGKRHGHGVYWWAN |
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| MORN | 20648.AA | MORN | 1075-1097 | 47 | 1.9e-05 | 24.52 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 1075-1097 Range on HMM: 1-23/23 Sequence Identity: 47% (11 aa) YEGEKMNGLRHGQGRFFYQDGGL |||| ||..||.|.. . ||. YEGEWKNGKMHGHGVYTWPDGDR |
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| MORN | 20648.AA | MORN | 1073-1094 | 50 | 0.000237 | 21.5 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 1073-1094 Range on HMM: 1-22/22 Sequence Identity: 50% (11 aa) SRYEGEKMNGLRHGQGRFFYQD .||||| ||.|||.|.. . . DRYEGEWHNGKRHGHGVYWWAN |
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| MORN | 20648.AA | MORN | 1120-1141 | 36 | 0.009544 | 9.49 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 1120-1141 Range on HMM: 1-22/22 Sequence Identity: 36% (8 aa) IAYDGYWEEDKFHGFGALFNEN |.| | ..|.||.| . | DRYEGEWHNGKRHGHGVYWWAN |
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| MORN | 20648.AA | MORN | 1122-1135 | 50 | 0.099888 | 11.03 | Pfam | 1-14 (23) | Show / Hide |
Range on Protein: 1122-1135 Range on HMM: 1-14/23 Sequence Identity: 50% (7 aa) YDGYWEEDKFHGFG |.| | ..|.||.| YEGEWKNGKMHGHG |
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| MORN | 20648.AA | MORN | 1164-1186 | 34 | 1.4e-05 | 25.06 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 1164-1186 Range on HMM: 1-23/23 Sequence Identity: 34% (8 aa) YDGEFKDDNKDGFGTLYLSNGER |.||.|.. ..|.|... ..| | YEGEWKNGKMHGHGVYTWPDGDR |
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| MORN | 20648.AA | MORN | 1162-1183 | 27 | 0.001039 | 16.7 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 1162-1183 Range on HMM: 1-22/22 Sequence Identity: 27% (6 aa) IKYDGEFKDDNKDGFGTLYLSN .|.||.... ..|.|... .| DRYEGEWHNGKRHGHGVYWWAN |
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| MORN | 20648.AA | MORN | 1187-1209 | 30 | 0.014616 | 14.06 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 1187-1209 Range on HMM: 1-23/23 Sequence Identity: 30% (7 aa) FEGSFKNDFVCGPGSFYKINGEK .||..||.. .| | .. .| . YEGEWKNGKMHGHGVYTWPDGDR |
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| MORN | 20648.AA | MORN | 1185-1206 | 31 | 0.029243 | 5.85 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 1185-1206 Range on HMM: 1-22/22 Sequence Identity: 31% (7 aa) ERFEGSFKNDFVCGPGSFYKIN | ||...|. .| | .. | DRYEGEWHNGKRHGHGVYWWAN |
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