Gene 13026 (Tetrahymena)
13026
Group:
Other
Family:
Ciliate-E5
Sequence
Protein domains of 13026.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 13026.AA | Ciliate-E5 | 65-253 | 42 | 4.1e-120 | 392.72 | In-house | 1-257 (271) | Show / Hide |
Range on Protein: 65-253
Range on HMM: 1-257/271
Sequence Identity: 42% (109 aa)
IIEKGLLGSGGGGFVLKACSEWNDHLAVKLM-KYSNLEQLKINKREYDILKNINSKYVTKVYQFFTESYESNGYQFIVMERCLYDLKNYIAKKITSKKFL
|||...||.||.|.|.|.||||||....... |..|..|.. |.||..|||..||....||||.....||.. ||||.||||..||..|..|.|...|..
IIENQILGKGGSGMVMKGCSEWNDKPIAIKIMKCKNQKQCEDNQREFNILKQFNSPHIIKVYQIYQYQYENMNYQFIIMERCKCDLHTYLNKIIYQMKWQ
SHQDLYYLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKWKYADLGVS---------KVVSEQRK---------------------------------
.|||.|..||||.||||..||||||||||||||||||.|.||||.|.|.| |.|||||.
KHQDIYQICLQLVKGLQDIHQKNIIHLDIKPANILLGYDNKWKYIDMGISRKFKHVVRDKQVSEQRQNSSETIEENMIKFIKIIPYFFQREYPKLHNKNR
--------HTNNLIGLTALYSSPEQYQLAN-----------------TSVTHKVTKS
||.||.|.|..||||||||. . .|...|.||.
KKLRYQIPHTCNLKGFTQCYSSPEQYQCYHNQMFYILIRNLPDIKYIQSFKKKITKQ
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| Kinase | 13026.AA | Ciliate-A1 | 65-241 | 33 | 1.4e-41 | 139.34 | In-house | 1-193 (301) | Show / Hide |
Range on Protein: 65-241 Range on HMM: 1-193/301 Sequence Identity: 33% (66 aa) IIEKGLLGSGGGGFVLKACSEWNDH--LAVKLMKYSNLEQLKINKREYDILKNINSKYVTKVYQFFTESYESN--GYQFIVMERCLYD-LKNYIAKKITS . |...|. | |..| | |..|... .| ||.| | || ..| ||. .| |.|| |. | .||.|| |.| | ||. YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFEQYKNNIQEYRKCKQINHNNVIKNYQQLY--YNTNNKECMFIIMEYCQYGNLFNYCYQ---- KKFLSHQDLYYLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKWKYADLGVSKVVSEQR----------------KHTNNLI-GLTALYSSPEQYQL ..... . | .|.|. .|. .| .||.|.|.|| |||.. | ||| .||| ||. .. || . |.. .| ||||||. NDYMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQM |
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| Kinase | 13026.AA | Ciliate-E1 | 71-250 | 25 | 2.1e-28 | 89.72 | In-house | 1-199 (202) | Show / Hide |
Range on Protein: 71-250 Range on HMM: 1-199/202 Sequence Identity: 25% (52 aa) LGSGGGGFVLKACSEWND----HLAVKLMK--YSNLEQLKINKREYDILKNIN-SKYVTKVYQFFTESYESNGYQFIVMERCLYDLKNYIA--------K .|.|. ..|.|| ...| .. . ... |. ......| .| |.| .. .|. ...... ..| . |..| | . ||.|. . IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIK--IDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ KITSKKFLSHQD-LYYLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKWKYADLGVSKVVSEQRKHTNNLIGLTALYSSPEQYQ------LANTSVTH .. .... ... . .. || .||.||||.||||.||||.||| . . .|.|.|.||. .. ... . | | |..||||. | ... QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINY KV |. KS |
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| Kinase | 13026.AA | Ciliate-B2 | 138-247 | 34 | 2e-25 | 56.66 | In-house | 76-185 (197) | Show / Hide |
Range on Protein: 138-247 Range on HMM: 76-185/197 Sequence Identity: 34% (39 aa) QFIVMERCLYDLKNYIAKKITSKKFLSHQDLYYLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKWKYADLGVSKVVSEQRKHTNNLIGLTALYSSPE . ..||.| ..||. . | .| | || . || || ... .||.||||||.|||. . .| | |.| . ... . . |.| | ||| DVLIMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKKDNQQI--KIKGFTKKYASPE QYQLA--NTSVT | . .|.|| QMECDHNQTFVT |
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| Kinase | 13026.AA | Ciliate-E3 | 100-245 | 32 | 1.5e-23 | 70.49 | In-house | 43-186 (202) | Show / Hide |
Range on Protein: 100-245 Range on HMM: 43-186/202 Sequence Identity: 32% (49 aa) LEQLKINKREYDILKNINSKYVTKVYQFFTESYESNGYQFIVMERCLY-DLKNYIAKKITSKKFLSHQDLYYLCLQLSKGLQELHQKNIIHLDIKPANIL .||.. | . |||..| |... . . | |||.| | ||..|| . .. . .| .| |. .|. ..|.||||| |||| ||| GEQFQKTQQEFQNCQQINSQNVVKCHDQYYD--QQNKMIFIVQEYCSNGDLYHYIK-QQN----KTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNIL LGLDL---KWKYADLGVSKVVSEQRKHTNNL-IGLTALYSSPEQYQLANTS .. . | .|.| || . || . |.| .|..||| . .. | VDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQIS |
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| Kinase | 13026.AA | Ciliate-E2 | 65-240 | 20 | 2.2e-20 | 66.7 | In-house | 1-260 (365) | Show / Hide |
Range on Protein: 65-240 Range on HMM: 1-260/365 Sequence Identity: 20% (56 aa) IIEKGLLGSGGGGFVLKACS------------------------EWNDHLAVKLMKYSNLEQLKINKREYD-------------ILKNINSKYVTKVYQF .. ..|.|. | | |.. . |.| || ...||.| .... ||...|.... | | . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FTESYESNGYQFIVMERCLY-DLKNYIAKK---------------ITSKKFLSHQDLY-------YLCLQLSKGLQELHQKN-IIHLDIKPANILLGLDL | | ... . ..||| | . ||. || .. . |... | |. . . .. ..|..||.|| ||| |||| |||. FQE--KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---- KWKYADLGVSKVVSEQRK------------------------------HTNNLIGLTALYSSPEQYQ | .|.| || ...... .. | | |. | .|| .. -IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILN |
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| Kinase | 13026.AA | Pkinase | 65-237 | 24 | 2.3e-19 | 69.54 | Pfam | 1-181 (293) | Show / Hide |
Range on Protein: 65-237
Range on HMM: 1-181/293
Sequence Identity: 24% (47 aa)
IIEKGLLGSGGGGFVLKACSEWNDH-LAVKLMKYSNLEQ--LKINKR--EYDILKNINSKYVTKVYQFFTESYESNGYQFIVMERCLY-----DLKNYIA
. .. .|||. | | |.. . . ||| .|... . .... | | |.|..|.... . | .|.. ... .||| | ||. ||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS
KKITSKKFL--SHQDLYYLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKW----KYADLGVSKVVSEQRKHTNNLIGLTALYSSPE
... . | ... ..|. .||. .|...||| |.||.|||. . | .| |..|.... ... .. . | | .||
T--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPE
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| Kinase | 13026.AA | CAMK | 70-199 | 16 | 3.1e-18 | 54.7 | In-house | 1-212 (425) | Show / Hide |
Range on Protein: 70-199 Range on HMM: 1-212/425 Sequence Identity: 16% (36 aa) LLGSGGGGFVLKACSE-WN------------DHLAVKLMKYS----------------------------NLEQLKINKREYDILKN-------INSKYV ||.|. | | ... . . |.| .. . . . .| .||..|.|. .. . . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI TKVYQFFT---------ESYESNGY--------QFIVM---ERCLY-----DLKNYIAKK------------ITSKKFLSHQDLYYLCLQLSKGLQELHQ | |... . ||. . ..|| | | || .|| .. . ... .. .. .. |. ... .|. IKLYEVYEDPHYFKNTND-YET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHS KNIIHLDIKPANILL .||.|.|.|| |||| HNIVHRDLKPENILL |
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| Kinase | 13026.AA | CMGC | 65-199 | 20 | 4.2e-18 | 55.2 | In-house | 1-217 (513) | Show / Hide |
Range on Protein: 65-199
Range on HMM: 1-217/513
Sequence Identity: 20% (44 aa)
IIEKGLLGSGGGGFVLKACS---------------EWNDHLAVKLMK--YSNLEQLK----------INKREYDILKNIN-----------------SKY
. .|.| | | |. |.| . |.| .| . || | . || |||..| ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN
VTKVYQFFTESYES-------------NGYQFIVMERCLYDLKNYIAKKIT-----SKKFLSHQD------------LYYLC------LQLSKGLQ--EL
. | | .|. . . . . ..|.| . .||..|| .. . .. ||. |. |. .|| .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC
HQKN--IIHLDIKPANILL
|... ||| |.||.|||.
HSHWGNIIHRDLKPENILI
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| Kinase | 13026.AA | STE | 66-237 | 23 | 1.7e-17 | 58.43 | In-house | 1-232 (359) | Show / Hide |
Range on Protein: 66-237 Range on HMM: 1-232/359 Sequence Identity: 23% (55 aa) IEK-GLLGSGGGGFVLKACSEWND--H--------------LAVKLMKYSNL-----------------EQLKINKREYDILKNIN--SKYVTKVYQFFT |. . .|.|..| | ||. |. | |.| |...| |... ..| .|.|. | .... | | . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF ESYES---NGYQFIVMERCL-YDLKNYIA-KKITSK---------KFLSHQDLYYLCLQLSKG-LQELHQKNIIHLDIKPANILLGLDLKWKYADLGVSK . ... .|.|| . | | |... | .... . . | | |. || |. ||...||| ||||||||| | .| ||.. KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG VVSE----------------QRKHTNNLIGLTALYSSPE ... . ...| ..| . .|| QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPE |
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| Kinase | 13026.AA | S_TKc | 65-314 | 20 | 5.7e-16 | 57.32 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 65-314
Range on HMM: 1-231/231
Sequence Identity: 20% (56 aa)
IIEKGLLGSGGGGFVLKACSEW-NDHLAVKLMKYSNLEQLKINKREYDILKNINSKYVTKVYQFFTESYESNGYQFIVMERCLY---DLKNYIAKKITSK
..|.|. | | |. . . |.| .| . .|| .|||. . ... | | .| . .. ..||| | ||. || |. . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHG
KF--LSHQDLYYLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKWKYADLGVSKVVSEQRKHTNNLIGLTALYSSPEQYQLANTSVTH-KVT------
. .. . ... |. ..|. .|...||| |.||.|||| | .| |..... . ..| | | .|| . .. |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCG-TPWYMAPEVL-----GYGKCKCDWWSCGC
--------KSLTGVDVTQKWIIKEKISAHNYDKCLNPYYEEFNNCIIKKMMQYEANDRLQIEEVID------VLKRL
. . | . .|| .|. . .|.|..|.. ..|. . |. .
ILYEMLCGYPPFP----QMQMMFKKIG-----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 13026.AA | ULK | 65-199 | 29 | 1.2e-15 | 51.23 | In-house | 1-163 (329) | Show / Hide |
Range on Protein: 65-199 Range on HMM: 1-163/329 Sequence Identity: 29% (49 aa) IIEKGLLGSGGGGFVLKACSEWN-----DHLAVKLMKYSNLEQLKIN----------KREYDILKNIN----SKY----VTKVYQFFTESYESNGYQFIV .. . ||.| | | |. . . |.| . . . | . . |.| .|.| .. .|. . | | .| .| . | . .|. YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH-N-NIYII MERCLY-DLKNYIAKKIT------SKKFLSHQDLYYLCLQLSKGLQELHQKNIIHLDIKPANILL || | ||..|| |. . ||.|| | . |. |..|||..|||| ||||.|||. MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILI |
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| Kinase | 13026.AA | Ciliate-A1 | 279-314 | 44 | 5.9e-09 | 26.56 | In-house | 267-301 (301) | Show / Hide |
Range on Protein: 279-314 Range on HMM: 267-301/301 Sequence Identity: 44% (16 aa) NPYYEEFNNCIIKKMMQYEANDRLQIEEVIDVLKRL .| .|| .| .|.|||||| | |.. ...|| |. . EPRFEELQN-LIFKMMQYEPNNRCSLQQCIDCLYIF |
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| Kinase | 13026.AA | TyrKc | 65-311 | 19 | 1.7e-07 | -101.47 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 65-311
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)
IIEKGLLGSGGGGFVLKACSEWNDHLAVKLMKYSNLEQLKINKREYDILKNI--NSKYVTKVYQFFTES---YESNGYQFIVMERCLY-DLKNYIAKKIT
| . ||.| | | |. ||| .| . . . || |.... . . . . | |.. . . . .|||| . . |||.|. |.
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDF-MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP
SKKFLSHQDLYYLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKWKYADLGVSKVVSEQ--------RKHTN---NLIG-LTALYSSPEQYQLA----
|...|| . |.| ..| . ||.||.|| |. |.|.| .. | .| | |. . . ... . . | .|| .
K---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT
----------------NTSVTHKV---TKSLTGVDVTQKWIIKEKISAHNYDK------CLNPYYEEFNNCIIKKMMQYEANDRLQIEEVIDVL
. . .. .| .. . .| | | |.|. .....|| .|... .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMY-----QIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | 13026.AA | Pkinase_Tyr | 108-189 | 34 | 0.000785 | 13.6 | Pfam | 52-134 (270) | Show / Hide |
Range on Protein: 108-189 Range on HMM: 52-134/270 Sequence Identity: 34% (29 aa) REYDILKNI-NSKYVTKVYQFFTESYESNGYQFIVMERCLY-DLKNYIAKKITSKKFLSHQDLYYLCLQLSKGLQELHQKNIIH || |.|.. . . . . | |. |.| . .|||| . . ||..| |. ..|. |...|| |.| .||.. |..||.|| REAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH |
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| Kinase | 13026.AA | ULK | 289-309 | 38 | 0.018888 | 4.47 | In-house | 305-325 (329) | Show / Hide |
Range on Protein: 289-309 Range on HMM: 305-325/329 Sequence Identity: 38% (8 aa) IIKKMMQYEANDRLQIEEVID .|..|.||. .|| .||... LIRRMLQYDEKDRISWEELFN |
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