Gene 13030 (Tetrahymena)
13030
Group:
Other
Family:
Ciliate-E5
Sequence
Protein domains of 13030.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 13030.AA | Ciliate-E5 | 77-274 | 38 | 3.3e-113 | 369.89 | In-house | 3-271 (271) | Show / Hide |
Range on Protein: 77-274
Range on HMM: 3-271/271
Sequence Identity: 38% (103 aa)
SNRLLGKTPSTKILRALNKQ-GKSVAIKILKCNSMKDYEKNQNEFKLMKLFNSDYIIKVQELLEYRTQDKLLHFLIMERCLYDLHSQL----MLMTVNQS
.|..||| | .... .. |..||||.||...|..|.||.||...| |||..||||.....|..... ..|.|||||..|||..| . |. .|.
ENQILGKGGSGMVMKGCSEWNDKPIAIKIMKCKNQKQCEDNQREFNILKQFNSPHIIKVYQIYQYQYENMNYQFIIMERCKCDLHTYLNKIIYQMK-WQK
HPDIYKICLDLIRGLQDIHNKNTVHLDIKPHNIVLGADNKWKFIDMGIS---------NQLSTNDG----------------------------------
|.|||.|||.|..||||||.||..||||||.||.||.|||||.|||||| .|.|....
HQDIYQICLQLVKGLQDIHQKNIIHLDIKPANILLGYDNKWKYIDMGISRKFKHVVRDKQVSEQRQNSSETIEENMIKFIKIIPYFFQREYPKLHNKNRK
-------YVSKLKGLTLNYCSPEQYQQFYGIN-----------------KVKATKSSDTFSLGLVFLKLT
....|||.| .|.||||||...... |.|.||.||..|||.|||.||
KLRYQIPHTCNLKGFTQCYSSPEQYQCYHNQMFYILIRNLPDIKYIQSFKKKITKQSDIYSLGIVFLELT
|
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| Kinase | 13030.AA | Ciliate-A1 | 75-332 | 27 | 1.6e-71 | 242.77 | In-house | 1-301 (301) | Show / Hide |
Range on Protein: 75-332 Range on HMM: 1-301/301 Sequence Identity: 27% (84 aa) TFSNRLLGKTPSTKILRALNKQGKS--VAIKILKCNSMKDYEKNQNEFKLMKLFNSDYIIKVQELLEYRTQDKLLHFLIMERCLYDLHSQLMLMTVNQSH . |..| ..|| . |.. ...||..| . | | .|....|. |. . ||. ..|.|.|..|. |.||| |.| . .... . YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFEQYKNNIQEYRKCKQINHNNVIKNYQQLYYNTNNKECMFIIMEYCQYGNLFNYCYQNDYMKK PDIYKICLDLIRGLQDIHNKNTVHLDIKPHNIVLGADNKWKFIDMGISNQLSTND-----------------GYVSKLKGLTLNYCSPEQYQQFY---GI .|| ||. .| |. ||| .| .|.|.|| ||... |.|||..|.|.| || | | . ||..| |.|||||| .| . EEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRDQMF NKVKATKSSDTFSLGLVFLKLTG-----------VTIPKSDVEK------------SKQESYNYVSFFNPKFPELNIIINQMLSQIPDQRPQLIEIEENL . | | || .|||.... |.. | |. .|. .. ....|.| ||...|..|.. | .| .| .. . | IENKIYKQSDMYSLGCIICFLCYKEDSHPYVGTIVNIFGNNMQNDQSIHFCKSVNAIKK--IIFPPMQEPRFEELQNLIFKMMQYEPNNRCSLQQCIDCL KKI . . YIF |
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| Kinase | 13030.AA | Ciliate-B2 | 94-267 | 29 | 1e-37 | 86.21 | In-house | 24-197 (197) | Show / Hide |
Range on Protein: 94-267 Range on HMM: 24-197/197 Sequence Identity: 29% (53 aa) NKQGKSVAIKILKCNSMKDYEKNQNEFKLMKLFNSDYIIKVQELLEYRTQDKLLHFLIMERCLYDLHSQLM---LMTVNQSHPDIYKICLDLIRGLQDIH ... . .|.||. | | |.| | ||.| .| |.| ..... .. . ||||.| ..| . | .. . .|.. .|| || .. IREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMF--EYNINVVKYIDHIQINETIDVLIMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFR NKNTVHLDIKPHNIVLGADNKWKFIDMGISNQLSTNDGYVSKLKGLTLNYCSPEQYQQF-YGINKVKATKSSDTFSLG .| .|||||| || . .. .. | ||| . | | ||.| | |||| ... . || .|.| MYNILHLDIKPQNILFMQNGNYVYCDFGISSIKK--DNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG |
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| Kinase | 13030.AA | Ciliate-E1 | 81-264 | 25 | 1.2e-27 | 87.2 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 81-264 Range on HMM: 1-202/202 Sequence Identity: 25% (52 aa) LGKTPSTKILRA--LNKQGKSVAIKILKCN---SMKDYEKNQNEFK-LMKLFN-SDYIIKVQELLEYRTQDKLLHFLIMERCLYDLHSQL---------- .|. . ...| | . ..||.|| .|. .. .......| . .|| |. .|||.... .. .. ... .|.| | . |. .| IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI--DQNYICIIIFECCCCSLKDYLQNHNRLEYWQ MLMTVNQSHPDI--YKICLDLIRGLQDIHNKNTVHLDIKPHNIVLGADNKWKFIDMGISNQLSTNDGYVSKLKGLTLNYCSPEQYQ---QFYGINKVKAT .... .... . .| .|| ||...|..| |.||||.||. ... .. | ||| .| |. . .. || | .|..||||. | . ... | . QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKIN KSSDTF . || . YKSDIY |
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| Kinase | 13030.AA | Ciliate-E3 | 100-274 | 32 | 5.7e-25 | 75.01 | In-house | 27-202 (202) | Show / Hide |
Range on Protein: 100-274 Range on HMM: 27-202/202 Sequence Identity: 32% (60 aa) VAIKILKCNSMKD------YEKNQNEFKLMKLFNSDYIIKVQELLEYRTQDKLLHFLIMERCLYDLHSQLMLMTVNQSHPDIYKICLDLIRGLQDIHNKN |||| . | .. | |.||.. . .|| .. |... . | | |.. |...| | . . |.. ||.|| .|.|. .|| || VAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQINSQNVVKCHDQY-YDQQNKMI-FIVQEYCSNGDLYHYIK-QQNKTQNIIYDICIQIIQGMIAIHEKN TVHLDIKPHNIVLGADN---KWKFIDMGISNQLSTNDGYVSKL-KGLTLNYCSPEQYQQFYGINKVKATKSSDTFSLGLVFLKLT | |||| || .. | |. | | | ||. | |. . . |.| | .||| .| . | || |.| ||. | IIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQ------QQISKESDYYSVGAVFCQLC |
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| Kinase | 13030.AA | TKL | 156-329 | 15 | 4.4e-17 | 58.05 | In-house | 126-364 (364) | Show / Hide |
Range on Protein: 156-329
Range on HMM: 126-364/364
Sequence Identity: 15% (39 aa)
LYDLHSQLMLMTVNQSHPDIYKICLDLIRGLQDIHN--------KNTVHLDIKPHNIVLGADNK--------------WKFIDMGIS--NQLSTNDGYV-
|..|| .. . ...|| ||.. |. .. .| |.|..|| . ... | |.|.| .. |.|.
LHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTM
---------------SKLKGLTLNYCSPEQ------YQQFYGI----NKVKATKSSDTFSLGLVFLKLTGVTIPKSDVEKSKQE---------SYNYVSF
. .. |.....|| |.. .|| .. ......| .| |.|. . .| .| . .. ..... .
TTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKG
FNPKFP-----------------ELNIIINQMLSQIPDQRPQLIEIEENL
| | .. .. . .. |..|| || . |
LRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | 13030.AA | Pkinase | 97-320 | 19 | 1.4e-15 | 56.12 | Pfam | 24-282 (293) | Show / Hide |
Range on Protein: 97-320 Range on HMM: 24-282/293 Sequence Identity: 19% (53 aa) GKSVAIKILKCNSMKDYEKNQN----EFKLMKLFNSDYIIKVQELLEYRTQDKLLHFLIMERCLY-----DLHSQLM-LMTVNQ--SHPDIYKICLDLIR || ||.||.| . |. .. .. | ..|| .|...|.. . |. .. .. ..|| | ||.. .. . . | .. .... ..| GKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---KDHIY-MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILR GLQDIHNKNTVHLDIKPHNIVLGADNKW----KFIDMGISNQL-STNDGYVSKLKGLTLNYCSPEQYQQFYGIN-KVKATKSSDTFSLGLVFLKLTGVTI ||. .|... .| |.|| || . .. | .| |.. |. |.. . . | |..|..|| |. . ....| .|.|... . GLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCG-TPWYMAPEV------IRGGQYYGPKVDMWSCGCILYEMLCGRP PKSDV---------EKSKQESYNYVSFFNPKF---------------------PELNIIINQMLSQIPDQRP | .. .. .. . ..| |. .|. .|. .| . | .|| PFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP |
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| Kinase | 13030.AA | S_TKc | 75-333 | 19 | 7.6e-15 | 40.77 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 75-333
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)
TFSNRLLGKTPSTKILRALNKQ-GKSVAIKILKCNSMKDYEKNQNEFKLMKLFNSDYIIKVQELLEYRTQDKLLHFLIMERCLY---DLHSQLMLMTVN-
|..|| | .. .| |. |||||.| |. ..| ...| . ..|.| . . ...|| | ||.. . . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHG
----QSHPDIYKICLDLIRGLQDIHNKNTVHLDIKPHNIVLGADNKWKFIDMGISNQLSTNDGYVSKLKGLTLNYCSPEQYQQFYGINKVKATK-SSDTF
. .. ... ....|. .|... .| |.|| || | | .| |.. || . |..|..|| . .| ..|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---------GYGKCKCDWW
SLGLVFLKLTGVTIPKSDVEKSKQESYNYVSFFNPKFPELNIIINQMLSQIPDQRPQLIEIEE-----NLKKII
|.| .. . | . |. .. . ||. .|...| |..|| |. . .. .
SCGCILYEMLCGYPPFP----QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 13030.AA | C8 | 89-270 | 24 | 3e-12 | 38.92 | In-house | 15-226 (226) | Show / Hide |
Range on Protein: 89-270 Range on HMM: 15-226/226 Sequence Identity: 24% (53 aa) ILRALN-KQGKSVAIKILKCNSMKDYEKNQNEFKLMKLFNSDYIIKVQELL--EYRTQDKLLHFLIMERCL-----------YDLHS---------QLML .|.| | |. . ...|..|| .. ...||. ..|| . . ... . . || .. . . | | ..... || . VLKAKNVKDNREIVLKFQKC---QNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELCEQNLKQLYD MTVNQSHP----DIYKICLDLIRGLQDIHNKNTVHLDIKPHNIVLGADNKW----KFIDMGISNQLSTNDGYVSKLK----GLTLNYCSPEQYQQFYGIN |. . . .| . .| |. || || .| ||||||. . .|.. | |.|.. |.| | | | |. | ||. .. . ERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCG-TWAYFAPEIEKKQDNQY KVKATKSSDTFSLGLVF | . .. || ||.||| K-QYRIQSDLFSVGLVL |
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| Kinase | 13030.AA | STE | 177-248 | 26 | 2.1e-10 | 33.07 | In-house | 155-236 (359) | Show / Hide |
Range on Protein: 177-248 Range on HMM: 155-236/359 Sequence Identity: 26% (24 aa) KICLDLIRG-LQDIHNKNTVHLDIKPHNIVLGADNKWKFIDMGISNQLS----------------TNDGYVSKLKGLTLNYCSPEQYQQ .|| ....| |. .|... .| |||| || | | .| |.. ||. |... . | . .|| || YICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPEVIQQ |
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| Kinase | 13030.AA | MSN | 149-228 | 34 | 6.4e-10 | 28.7 | In-house | 78-159 (265) | Show / Hide |
Range on Protein: 149-228 Range on HMM: 78-159/265 Sequence Identity: 34% (28 aa) FLIMERCLYDLHSQLMLMTVNQSHPD--IYKICLDLIRGLQDIHNKNTVHLDIKPHNIVLGADNKWKFIDMGISNQLSTNDG ...|| | |. || .|| . | || ...|||. .| . .| ||| |..| . . | .| |.| ||. | WMVMEFCGAGSVTDLVKMTKGQSLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVG |
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| Kinase | 13030.AA | Ciliate-E6 | 177-267 | 26 | 1.1e-09 | 27.32 | In-house | 57-154 (154) | Show / Hide |
Range on Protein: 177-267 Range on HMM: 57-154/154 Sequence Identity: 26% (26 aa) KICLDLIRGLQDIHNKNTVHLDIKPHNIVLGADNKWKFIDMGISNQLSTNDGY---VSKLKGLTLNYCSPEQYQ----QFYGINKVKATKSSDTFSLG |.|..| ... .| || |. |.. || | . . |. | |.. .| . .. .. . ||.|||. | ||. |...| .|.. KFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICDFGFQQCIIPNQQTKEFMAQKNQNKYHYCPPEQFDYSKDQQSKHYKVNWTQEGDIWSVC |
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| Kinase | 13030.AA | TyrKc | 75-329 | 19 | 1.1e-07 | -98.67 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 75-329 Range on HMM: 1-280/280 Sequence Identity: 19% (57 aa) TFSNRLLGKTPSTKILRALNKQGKSVAIKILKCNSMKDYEKNQNEFKLMKLF--NSDYIIKVQELLEYRTQDK------LLHFLIMERCLY-DLHSQLML .. || .. .. | ||.| || .. | .| ..|. . . . |.. |. . ||.. ....|| . . ||.. | ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVR---LYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK MTVNQSHPDIYKICLDLIRGLQDIHNKNTVHLDIKPHNIVLGADNKWKFIDMGISNQLSTN-------DGYVS----KLKG-LTLNYCSPEQYQQFYGIN . ...| ..|.. .| . .| || .| |. |. .|... | | | | . | |.. |. | . ..|| | HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI------N KVKATKSSDTFSLGLV-----------FLK-----LTGVTIPKSDVEKSKQESYNYVSFFNP-----KFPELNIIINQMLSQIPDQRPQLIEIEENL . | | || .| | . .. . . . . .. | .|. |. | |..|| || | . YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 13030.AA | STE | 91-133 | 16 | 0.000557 | 10.09 | In-house | 17-94 (359) | Show / Hide |
Range on Protein: 91-133 Range on HMM: 17-94/359 Sequence Identity: 16% (13 aa) RALNK----------------QGKSVAIKILKCNSM-----------------KDYEKNQNEFKLMKLFN--SDYIIK .|.|. .|. .|||... .. .. .. ..| |.|| .| ...|.| KAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVK |
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| Kinase | 13030.AA | TKL | 81-133 | 11 | 0.087482 | 2.22 | In-house | 1-89 (364) | Show / Hide |
Range on Protein: 81-133 Range on HMM: 1-89/364 Sequence Identity: 11% (10 aa) LGKTPSTKILRALNKQ---------GKSVAIKILKCNS---------------------------MKDYEKNQNEFKLMKLFNSDYIIK .|. . .. .. .. || ||.|..| .. .. .. .| ..|. .. . |.. IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQ |
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