Gene 19549 (Tetrahymena)
19549
Group:
Other
Family:
Ciliate-E5
Sequence
Protein domains of 19549.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 19549.AA | Ciliate-E5 | 73-252 | 40 | 1.8e-109 | 357.56 | In-house | 1-232 (271) | Show / Hide |
Range on Protein: 73-252
Range on HMM: 1-232/271
Sequence Identity: 40% (93 aa)
LLTDQILGKGGFGMVVKGYSVPLKKYVAIKIIKFKTQKQFFDNLLEFNNQQDLKQKNILQSIQIMNFN--ELQIQFIVMDLCKTDLVEYLNYFLSQKKWL
....|||||||.|||.||.|....|..||||.|.|.|||..||..|||.........|....||.... ....|||.|..||.||..|||....|.||.
IIENQILGKGGSGMVMKGCSEWNDKPIAIKIMKCKNQKQCEDNQREFNILKQFNSPHIIKVYQIYQYQYENMNYQFIIMERCKCDLHTYLNKIIYQMKWQ
KNLEILQLWLQLVQGLKYLHSQNILHLDIKPANILLGIDNFWKYNDFGLS----FVLRDGQESTT-----------------------------------
|...|.|..||||.||...|..||.||||||||||||.||.|||.|.|.| .|.||.|.|..
KHQDIYQICLQLVKGLQDIHQKNIIHLDIKPANILLGYDNKWKYIDMGISRKFKHVVRDKQVSEQRQNSSETIEENMIKFIKIIPYFFQREYPKLHNKNR
-----------DTKGFTSTYSSPEQYLLHQFK
..||||..||||||| . ...
KKLRYQIPHTCNLKGFTQCYSSPEQYQCYHNQ
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| Kinase | 19549.AA | Ciliate-A1 | 73-249 | 29 | 3e-40 | 134.7 | In-house | 1-194 (301) | Show / Hide |
Range on Protein: 73-249 Range on HMM: 1-194/301 Sequence Identity: 29% (58 aa) LLTDQILGKGGFGMVVKGYSVPLKK-YVAIKIIKFKTQKQFFDNLLEFNNQQDLKQKNILQSIQIMNFNEL--QIQFIVMDLCKTDLVEYLNYFLSQKKW . | ..||.|| | . | . .| |...|||. .. .|. .|. |. . . . | . . | . .|. ..||.| |. . | . |... YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFEQYKNNIQEYRKCKQINHNNVIKNYQQLYYNTNNKECMFIIMEYCQYGN---LFNYCYQNDY LKNLEILQLWLQLVQGLKYLHSQNILHLDIKPANILLGIDNFWKYNDFGLSFVLRDGQ-----------------ESTTDTKGFTSTYSSPEQYLLH .| || . .|...|. .|..||||.|.|| |||.. |. || |.|.| .| | . | || . | ||||| .| MKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMH |
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| Kinase | 19549.AA | Ciliate-B2 | 72-245 | 31 | 2.3e-36 | 82.96 | In-house | 1-174 (197) | Show / Hide |
Range on Protein: 72-245 Range on HMM: 1-174/197 Sequence Identity: 31% (56 aa) YLLTDQILGKGGFGMVVKGY---SVPLKKYVAIKIIKF--KTQKQFFDNLLEFNNQQDLKQKNILQSIQIMNFNELQIQFIVMDLCKTDLVEYLNYFLSQ | |.. ...|||.|.. .|| |. .. .|.|| ..|. ... .. . .. |. . | . || .|. ..|. |. .| . |. | YYLCK-YINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFE-YNINVVKYIDHIQINE-TIDVLIMEKCECSLKQELQKIQKQ KKWLKNLEILQLWLQLVQGLKYLHSQNILHLDIKPANILLGIDNFWKYNDFGLSFVLRDGQESTTDTKGFTSTYSSPEQ .| .| ..|. ||. || ... |||||||||.|||. . .| ||| | . . ... |||| | |||| QKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKK--DNQQIKIKGFTKKYASPEQ |
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| Kinase | 19549.AA | Ciliate-E1 | 79-260 | 28 | 8e-35 | 110.84 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 79-260 Range on HMM: 1-202/202 Sequence Identity: 28% (58 aa) LGKGGFGMVVKGYSVPLK-KYVAIKIIKFK---TQKQFFDNLLEFN-NQQDLK-QKNILQSIQIMNFNELQIQFIVMDLCKTDLVEYLN---------YF .|.|.|..|.|... . . ||.|||. . .| .| |.. | . .. .| ...|.| |.. ...|. |....|. | .||. . IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC LSQKKWLKNLEILQLWLQLVQGLKYLHSQNILHLDIKPANILLGIDNFWKYNDFGLSFVLRDGQESTTDTKGFTSTYSSPEQYL------LHQFKLGISV ....... ....|. ||..|| .||..||.|.||||.||| .. .|.|||.| .| |..... ||.|. |..|||| .. | .. . QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKS FIN | DIY |
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| Kinase | 19549.AA | Ciliate-E3 | 73-253 | 30 | 3.5e-31 | 94.67 | In-house | 1-187 (202) | Show / Hide |
Range on Protein: 73-253 Range on HMM: 1-187/202 Sequence Identity: 30% (59 aa) LLTDQILGKGGFGMVVKGYSVPLKKYVAIKIIKFKTQKQ------FFDNLLEFNNQQDLKQKNILQSIQIMNFNELQIQFIVMDLCKT-DLVEYLNYFLS . ||||.|.|| | |... ... |||| | . |. | . ||.| |... .|... ... ... |||...| || .|. YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQINSQNVVKCHDQYYDQQNKMIFIVQEYCSNGDLYHYI----- QKKWLKNLEILQLWLQLVQGLKYLHSQNILHLDIKPANILLGIDN---FWKYNDFGLSFVLRDGQ--ESTTDTKGFTSTYSSPEQYLLHQFKL .. . .|... |..||. .|..|| | |||| |||.. | | |||.| || .| .. |.|. |..||| |... KQQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQ-GWTPFYAAPEQNDQQQISK |
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| Kinase | 19549.AA | S_TKc | 73-315 | 22 | 3.8e-22 | 80.83 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 73-315
Range on HMM: 1-231/231
Sequence Identity: 22% (61 aa)
LLTDQILGKGGFGMVVKGYSVPLKKYVAIKIIKFKTQKQFFDNLLEFNNQQDLKQKNILQSIQIMNFNELQIQFIVMDLCKT---DLVEYLNYFLSQK--
...|||.|| | |.. . ...||||||| . . | . . . .|| . . .. . ..||..| . || .|. ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR
KWLKNLEILQLWLQLVQGLKYLHSQNILHLDIKPANILLGIDNFWKYNDFGLSFVLRDGQESTTDTKGFTSTYSSPEQYLLHQF-K--------------
... .. . |....|.|.||..|.| |.||.|||| | ||||. .| .| | | .|| . . |
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEML
LGISVFINNQSYSKQRNINKTKCYNDEYSDLNEQIIKKMLKTNPQKRITLDQLES---VIQENIQI
| | | . ..| ... . .|.|.|. .|.||.| .. .| .
CGYPPFP--QMQMMFKKIG--------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 19549.AA | CMGC | 73-206 | 17 | 3.3e-21 | 65.61 | In-house | 1-217 (513) | Show / Hide |
Range on Protein: 73-206 Range on HMM: 1-217/513 Sequence Identity: 17% (39 aa) LLTDQILGKGGFGMVVKGYS--------------VPLKKYVAIKIIK---FKTQKQ--------FFDNLLEFNNQQDLK-----------------QKNI .. .|.| .|.|.|.. ...||||.|| ...|.. . | | . |. .|| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI LQSIQIMNFNE---------------LQIQFIVMDLCKTDLVEYLNYFLS-----QKKWLKNLE------------ILQLW------LQLVQGLK--YLH .. . | ... .. ..|.... .|| .|. ... |. . | . |. .||| |.| VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH SQN--ILHLDIKPANILL |.. |.| |.||.|||. SHWGNIIHRDLKPENILI |
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| Kinase | 19549.AA | STE | 74-220 | 20 | 6.3e-21 | 70.71 | In-house | 1-194 (359) | Show / Hide |
Range on Protein: 74-220 Range on HMM: 1-194/359 Sequence Identity: 20% (41 aa) LTD-QILGKGGFGMVVKGYSV------PLKKY---------VAIKIIKFKTQ-----------------KQFFDNLLEFNNQQDLK--QKNILQSIQIMN ... ...|||.|| |.|.. . . .. .|||....... ... . | | . .... .|| . . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF FN-----ELQIQFIVMDLCK-TDLVEYLN-YFLSQK---------KWLKNLEILQLWLQLVQG-LKYLHSQNILHLDIKPANILLGIDNFWKYNDFGLS . . . .|.| .. | . .. .. .| .... .| |...| |.||||..| | ||||||||| | |||.. KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC |
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| Kinase | 19549.AA | CAMK | 78-244 | 17 | 7.8e-21 | 63.21 | In-house | 1-290 (425) | Show / Hide |
Range on Protein: 78-244 Range on HMM: 1-290/425 Sequence Identity: 17% (50 aa) ILGKGGFGMVVKGYSVPLK------------KYVAIKIIKFKTQK------------------------------QFFDNLLEFNNQQD-----LKQKNI .||.|.|| | ... . . ||||||. | | ... . .| .. |. .|| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI LQSIQIMN-----------------FNE-LQIQFIVM---DLCKT-DLVEYLNYFLSQKKW---------------LKNLEILQLWLQLVQGLKYLHSQN .. .... | . . ..|| ..| .| ..| .. ... .. | .. |......|.||.| IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN ILHLDIKPANILLGID-----------------NFWKYNDFGLSFVLRDGQEST----------------------TDTKGFTSTYSS-PE | |.|.|| |||| . | | |||.. ....|.... | | | . || IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE |
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| Kinase | 19549.AA | Pkinase | 73-240 | 25 | 2.7e-20 | 72.85 | Pfam | 1-175 (293) | Show / Hide |
Range on Protein: 73-240 Range on HMM: 1-175/293 Sequence Identity: 25% (47 aa) LLTDQILGKGGFGMVVKGYSVPLKKYVAIKIIKFKTQKQFFD--NLL--EFNNQQDLKQKNILQSIQIM-NFNELQIQFIVMDLCKTDLVEYLNYF--LS . . ...|.|.|| | |.. . | ||.|||| ...| .| ... | . |. .||.. . .. . ... .||..| .| . | .| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY---MVMEYCEGGLY-VMDLFDYIS --QKKWL--KNLEILQLWLQLVQGLKYLHSQNILHLDIKPANILLGIDNFW----KYNDFGLSFVLRDGQESTTDTKGFTSTY ..... |. ..|...||.|.||..|.| |.||.|||. .. | ||||. ... . . ...|. |. TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTP |
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| Kinase | 19549.AA | Ciliate-E2 | 73-220 | 22 | 1.7e-18 | 60.13 | In-house | 1-203 (365) | Show / Hide |
Range on Protein: 73-220
Range on HMM: 1-203/365
Sequence Identity: 22% (48 aa)
LLTDQILGKGGFGMVVKGYSVPLKKYVAIKIIKFKT---------QKQFFDNLLEFNNQQDLKQKNILQSIQ----------------------IMNFNE
...|.|.|| | |. .| .|||||. . .|... .. ....| .|.... .. |... |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE
LQI--Q----FIVMDLCKT-DLVEYLNYF-LSQKKWLK------NLEILQLWLQLVQ---------------GLKYLHSQN-ILHLDIKPANILLGIDNF
. . ..||..|. || .|.. . ..... .. ||... |..| .|.||||.| |.| |||| |||.
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----
WKYNDFGLS
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IKIIDFGLS
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| Kinase | 19549.AA | PLK-Unclassified | 147-231 | 36 | 6.3e-16 | 55.66 | In-house | 76-165 (264) | Show / Hide |
Range on Protein: 147-231 Range on HMM: 76-165/264 Sequence Identity: 36% (33 aa) IVMDLCKT-DLVEYLNYF---LSQKKWLKNLEILQLWLQLVQGLKYLHSQNILHLDIKPANILLGIDNFWKYNDFGLSFVLRD-GQESTT |.. .| .| ||. . | .|| | .| .|.||.|||||. .| | | |..||.|. .. | ||||. .| |.. | ILLEYCPNGTLMEYIKRRNFQLFEKKRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKT |
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| Kinase | 19549.AA | TyrKc | 73-309 | 20 | 1.3e-07 | -99.73 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 73-309
Range on HMM: 1-280/280
Sequence Identity: 20% (58 aa)
LLTDQILGKGGFGMVVKGYSVPLKKYVAIKIIKFKTQKQFFDNLLEFNNQQDL--KQKNILQSIQIMNFN-----ELQIQFIVMDLCKT-DLVEYLNYFL
. ...|| | || |.|| ||.| .| . | . | . | . .||.. . . . . .||| ... || .|| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR
SQKKWLKNLEILQLWLQLVQGLKYLHSQNILHLDIKPANILLGIDNFWKYNDFGLSFVLRDG------QESTT-----DTKG-FTSTYSSPEQYLLH---
. |.. . |. .| .| ||||.|. | |. |.|.| .. | ||||| . |. .. . ..|. . .|| .
PK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT
--------------------QFKLG---ISVFINNQSYSKQRNINKTKCYND-------EYSDLNEQIIKKMLKTNPQKRITLDQLESVI
| | . | . . . .. . .. . . .| ||.|. . .| .| | .. . .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | 19549.AA | CAMK | 273-304 | 30 | 0.000134 | 9.95 | In-house | 379-418 (425) | Show / Hide |
Range on Protein: 273-304 Range on HMM: 379-418/425 Sequence Identity: 30% (12 aa) TKCYNDEYSDL--------NEQIIKKMLKTNPQKRITLDQ .... |. || . |.|||...|.||.|..| GPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQ |
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| Kinase | 19549.AA | Ciliate-E2 | 286-305 | 44 | 0.000412 | 9.99 | In-house | 335-359 (365) | Show / Hide |
Range on Protein: 286-305 Range on HMM: 335-359/365 Sequence Identity: 44% (11 aa) QIIKK----MLKTNPQKRIT-LDQL ..||| ||. .|.|||| .|. DLIKKFGKRMLQKDPEKRITGWEQI |
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| Kinase | 19549.AA | Ciliate-A1 | 287-315 | 27 | 0.001285 | 8.11 | In-house | 276-301 (301) | Show / Hide |
Range on Protein: 287-315 Range on HMM: 276-301/301 Sequence Identity: 27% (8 aa) IIKKMLKTNPQKRITLDQLESVIQENIQI .|.||. .|. |. |.|. |.. .. LIFKMMQYEPNNRCSLQQC---IDCLYIF |
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| Kinase | 19549.AA | CMGC | 288-304 | 58 | 0.006294 | 4.42 | In-house | 490-506 (513) | Show / Hide |
Range on Protein: 288-304 Range on HMM: 490-506/513 Sequence Identity: 58% (10 aa) IKKMLKTNPQKRITLDQ .||||. .|.|||| .| LKKMLQYDPDKRITAEQ |
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| Kinase | 19549.AA | PLK-Unclassified | 74-104 | 38 | 0.00798 | 6.84 | In-house | 2-32 (264) | Show / Hide |
Range on Protein: 74-104 Range on HMM: 2-32/264 Sequence Identity: 38% (12 aa) LTDQILGKGGFGMVVKGYSVPLKKYVAIKII . |||||| ... .. || |.||| HRGHFLGKGGFAKCYQVKNIETKKIYAAKII |
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| Kinase | 19549.AA | PLK-Unclassified | 281-305 | 40 | 0.017384 | 5.58 | In-house | 234-258 (264) | Show / Hide |
Range on Protein: 281-305 Range on HMM: 234-258/264 Sequence Identity: 40% (10 aa) SDLNEQIIKKMLKTNPQKRITLDQL || .|.. |..||..| |.||. SDNAKDLIQHILNWNPDQRPTIDQI |
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| Kinase | 19549.AA | Pkinase | 286-305 | 40 | 0.097182 | 7.23 | Pfam | 268-287 (293) | Show / Hide |
Range on Protein: 286-305 Range on HMM: 268-287/293 Sequence Identity: 40% (8 aa) QIIKKMLKTNPQKRITLDQL ..||..|. .|.||.| .|. DFIKWCLCKDPKKRPTAEQI |
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