Gene 14879 (Tetrahymena)
14879
Group:
Other
Family:
Ciliate-E6
Sequence
Protein domains of 14879.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 14879.AA | Ciliate-E6 | 99-195 | 46 | 9.9e-53 | 166.02 | In-house | 1-97 (154) | Show / Hide |
Range on Protein: 99-195 Range on HMM: 1-97/154 Sequence Identity: 46% (45 aa) ADFLKNSNHPNIVCYIDSFQIDFYYFIVMEKCEKSLQQLVEQLTNTQIQISDDLYFNIACQTLSAIDYLHKQKYRLEELSLKTILIDRNNNVKLYNF ...|||.|||||..|.|||||..|||||||.||..||....|..|.......|..|...||...|..|||...| | ...|| | .|.| |.|. | IQNLKNCNHPNILKYMDSFQIENYYFIVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICDF |
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| Kinase | 14879.AA | Ciliate-A2 | 60-193 | 48 | 2e-46 | 159.12 | In-house | 7-145 (272) | Show / Hide |
Range on Protein: 60-193 Range on HMM: 7-145/272 Sequence Identity: 48% (67 aa) KILLAQHK--IKDTQYSVRIISLFDGSDQ-ISSQMLEIAINEADFLKNSNHPNIVCYIDSFQIDFYYFIVMEKC-EKSLQQLVEQLTNTQIQISDDLYFN ......|. .. ..| . |.|..||.|| || | | . ||.|||| |||||| | |.|||.|||||.|||| |.|||. .. | | |.| . . CVIFVEHMDNHNNEKYAIKIQSIIDGIDQKISQQKLQECKHEAQFLKNCNHPNIVKYHDEFQIGFYYFIQMEKCPECSLQDWIDKFQNQQKFIPDHQFVH IACQTLSAIDYLHKQKYRLEELSLKTILIDRNNN-VKLY .|||.|.||.||| . | | .|||. |||| .|. .||. FACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLC |
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| Kinase | 14879.AA | Pkinase | 85-171 | 24 | 4.4e-12 | 43.79 | Pfam | 35-128 (293) | Show / Hide |
Range on Protein: 85-171 Range on HMM: 35-128/293 Sequence Identity: 24% (23 aa) DQISSQMLEIAIN--EADFLKNSNHPNIVCYIDSFQIDFYYFIVMEKCEKSLQQLVEQL----TNTQIQI--SDDLYFNIACQTLSAIDYLHKQK . ..|........ |. .|. |||||| ..|.|. . .. .||| ||. | . . | . . |.. ... |.|....|.|... RHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMG |
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| Kinase | 14879.AA | STE | 75-172 | 16 | 4.2e-11 | 35.57 | In-house | 44-173 (359) | Show / Hide |
Range on Protein: 75-172
Range on HMM: 44-173/359
Sequence Identity: 16% (21 aa)
VRIISLFDGS-----------DQISSQMLEIAINEADFLKNSN--HPNIVCYIDSFQID-------FYYFIVMEKCE-KSLQQLVEQLTNTQIQIS----
. ...| . . ... .. .. ..| ...|..| ||||| |.... . . .|.|| .. || ..... .. . .
IKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQ
------DDLYFNIACQTLSA-IDYLHKQKY
.. |..|.| . .|||....
HQHRFPESQIAYICRQILKGLLYYLHSHHI
|
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| Kinase | 14879.AA | STE20 | 63-172 | 23 | 1.6e-10 | 34.97 | In-house | 17-138 (288) | Show / Hide |
Range on Protein: 63-172 Range on HMM: 17-138/288 Sequence Identity: 23% (29 aa) LAQHKIKDTQ----YSVRIISLFDGSD-QISSQMLEIAINEADFLKNSNHPNIVCYIDSFQID----FYYFIVMEKCEK-SLQQLVEQLTNTQI-----Q .| || . . . .....| . .. | ...| ..| ...|...||||| |..|.. | .|||| |. ||...... .... KAYHKPTGEYCNQRVAIKKMNLEKCDNEQ---DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKCGKNHKGHP ISDDLYFNIACQTLSAIDYLHKQKY .. . | ..| . ||||.... MNEEQIAYICREVLQGLDYLHSNHI |
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| Kinase | 14879.AA | TBCK | 125-195 | 25 | 4.8e-10 | 32.08 | In-house | 54-128 (346) | Show / Hide |
Range on Protein: 125-195 Range on HMM: 54-128/346 Sequence Identity: 25% (19 aa) IVMEKCEKSLQQLVEQLTNTQIQISDDLYFNIACQTLSAIDYLHKQKYRLEELSLKTILIDRNN----NVKLYNF .||| .. .| .| . .. .. . .|. |.|....|.||. |... |..|.|. ||| |. VVMEHYKMNLEDQIEIYAKRHTPKDCSQILCIYYQILCGLSYMHKHHIVHRFLHPHNIYLDDNGNQKLHVKLANY |
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| Kinase | 14879.AA | NEK | 93-171 | 29 | 2.1e-09 | 29.71 | In-house | 48-139 (286) | Show / Hide |
Range on Protein: 93-171 Range on HMM: 48-139/286 Sequence Identity: 29% (27 aa) EIAI-NEADFLKNSNHPNIVCYIDSFQIDF--YYFIVMEKCEK--SLQQL---VEQLTNTQIQISDDLYFNIACQTLSAIDYLHKQ-----K . |. ||. || .||||| |.|||. . . .|||| || |.|. .. .. .. . .. .| ..|..|.|.. | QNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRK |
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| Kinase | 14879.AA | CAMK-Unique | 97-171 | 22 | 9.3e-09 | 24.83 | In-house | 65-177 (363) | Show / Hide |
Range on Protein: 97-171 Range on HMM: 65-177/363 Sequence Identity: 22% (25 aa) NEADFLKNSNHPNIVCYIDS----FQIDF---------------YYFIVMEKCEKS-LQQLVEQ----------------LTNTQIQISD--DLYFNIAC .|.. .| .||||. | |. . |..|||| |.. |.... . | |.. | . .| REHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQ QTLSAIDYLHKQK ..|||. |.|.|. CLLSAVAYMHSQD |
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| Kinase | 14879.AA | Ciliate-E2 | 65-171 | 15 | 9.7e-09 | 26.11 | In-house | 28-180 (365) | Show / Hide |
Range on Protein: 65-171 Range on HMM: 28-180/365 Sequence Identity: 15% (24 aa) QHKIKDTQY------------SVRIISLFDGSDQISSQMLEIAINEAD----------FLKNSNHPNIVCYIDSFQ--IDFYYFIVMEKCEK-SLQQLVE ..||.| |. . . . .. .. . . ..| . |.. |||||. ....|| | ....||| |. .|... . AIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIK QL---------------TNTQIQISDDLYF-------NIACQTLSAIDYLHKQK . . ..|. . ..... ..|. |||... NNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKN |
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| Kinase | 14879.AA | Ciliate-E2-Unclassified | 59-192 | 19 | 1.1e-08 | 26.24 | In-house | 13-188 (352) | Show / Hide |
Range on Protein: 59-192 Range on HMM: 13-188/352 Sequence Identity: 19% (35 aa) NKILLAQHKIKDTQY-------SVRIIS-LFDGSDQISSQMLEIAINEAD-------------FLKNSNHPNIVCYIDSFQIDFYYFIVMEKCE-KSLQQ .|. ..||| .. || ...|.. . . . . ....|. |.|..||.|| ... || ... .||||.|| ..|.| GKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQ LVE-------------QLTNTQIQISDDLYF-----NIACQTLSAIDYLHKQK---YRLEELSLKTILIDRNN---NVKL . . .... .... ... | |....|||... .| . . ||.| |. ..|. YIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHR--DIKPENILFDNNGKNYYIKI |
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| Kinase | 14879.AA | CMGC | 94-171 | 14 | 1.7e-08 | 23.09 | In-house | 67-202 (513) | Show / Hide |
Range on Protein: 94-171
Range on HMM: 67-202/513
Sequence Identity: 14% (20 aa)
IAINEADFLKNSN-----------------HPNIVCYIDSFQID-----------------FYYFIVMEKCEKSLQQLVEQ------------LTNTQ--
.|. | .||. | |.|||. .|.|. . . ..|.| ....| |. .. |. .
RALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HEN
-----------IQISDDLYFNIACQTLSAID--YLHKQK
.. . .. | | ... |.|...
KHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHW
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| S_TKc | 14879.AA | S_TKc | 55-339 | 12 | 2e-06 | -82.95 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 55-339
Range on HMM: 1-231/231
Sequence Identity: 12% (40 aa)
NNNMNKI--------LLAQHKIKDTQYSVRIISLFDGSDQISSQMLEIAINEADFLKNSNHPNIVCYIDSFQIDFYYFIVMEKCEK---SLQQLVEQLTN
..|| ...|| . .. . ||. | ...| . ||. .||||| ..|.|| ....||| |. .| .. ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR
--TQIQISDDLYFNIACQTLSAIDYLHKQKYRLEELSLKTILIDRNNNVKLYNF---KKVKQDYISLLNQKDNNITENTIEPKPHDLVEDYC--------
.. ... ...|...|..|.|... | ||.|. ..|. | ... .|
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------------------TTFCGTPWYMAP
---NFAK-----------IFLLLVQKVQFKNDYLSSKEIKKLDCLNSLRAITFQGLQLNQKNEIQLFIDFLFQNLALKNPAIDRLSEHFQMRSEILQKFQ
. | .. .|. . | .. .. . |. . |
EVLGYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG---------------------------------------------------SPEAKDFI
QVLISIQRHQRIEFFQIIL-------EQYM
. . .|. .. ...
RKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 14879.AA | TPR_1 | 342-371 | 33 | 0.000592 | 17.79 | Pfam | 5-34 (34) | Show / Hide |
Range on Protein: 342-371 Range on HMM: 5-34/34 Sequence Identity: 33% (10 aa) YNQGLTYLNQGNLDSSLKCFQECRTLFRQY || |..|...||.| ..|.|.. | ... YNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| Kinase | 14879.AA | TPR | 338-371 | 26 | 0.001106 | 19.48 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 338-371 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) YMDNYNQGLTYLNQGNLDSSLKCFQECRTLFRQY . ||.|. |...|..| ..|.|.. .| ... AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| Kinase | 14879.AA | TPR_2 | 338-371 | 23 | 0.001404 | 16.75 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 338-371
Range on HMM: 1-34/34
Sequence Identity: 23% (8 aa)
YMDNYNQGLTYLNQGNLDSSLKCFQECRTLFRQY
||.|. |..||..| ....... |. ..
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
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| TPR | 14879.AA | TPR | 398-431 | 29 | 6.1e-07 | 30.3 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 398-431 Range on HMM: 1-34/34 Sequence Identity: 29% (10 aa) YSLIYNIAFIKYQQGKINKAIKLFNESLNLNPQN . ||.. . |..|....||. ....| |.|.| AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_1 | 14879.AA | TPR_1 | 398-431 | 32 | 9.6e-07 | 27.53 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 398-431 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) YSLIYNIAFIKYQQGKINKAIKLFNESLNLNPQN . ||.. . |..|. ..||. ... | |||.| AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR_1 | 14879.AA | TPR_1 | 466-499 | 32 | 3e-06 | 25.61 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 466-499 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) ATSLMLLGITFHQKGMIGQAIRSFKKCLKLDPNK | . || .....| .|| ..|.|.|.|| AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR_2 | 14879.AA | TPR_2 | 398-431 | 32 | 4e-06 | 25.74 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 398-431 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) YSLIYNIAFIKYQQGKINKAIKLFNESLNLNPQN . ||.. . |.||. .||......| |.|.| AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR_1 | 14879.AA | TPR_1 | 432-465 | 35 | 4e-06 | 25.56 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 432-465 Range on HMM: 1-34/34 Sequence Identity: 35% (12 aa) IKCYHSLAFLYQKLGMLEEAIQLLQKSLTLKPIS . . |. .| |.| ..|||. .|| | | | AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR | 14879.AA | TPR | 432-465 | 35 | 7e-06 | 26.74 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 432-465 Range on HMM: 1-34/34 Sequence Identity: 35% (12 aa) IKCYHSLAFLYQKLGMLEEAIQLLQKSLTLKPIS .... |. .| |.| ..|||. .||.|.| | AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR | 14879.AA | TPR | 466-499 | 35 | 7e-06 | 26.8 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 466-499 Range on HMM: 1-34/34 Sequence Identity: 35% (12 aa) ATSLMLLGITFHQKGMIGQAIRSFKKCLKLDPNK | . || ....| . .|| ..|.|.|||| AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_2 | 14879.AA | TPR_2 | 466-499 | 38 | 2e-05 | 23.25 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 466-499 Range on HMM: 1-34/34 Sequence Identity: 38% (13 aa) ATSLMLLGITFHQKGMIGQAIRSFKKCLKLDPNK | ...|| ..| .||. ..|.|||||| AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR_2 | 14879.AA | TPR_2 | 432-465 | 32 | 6.1e-05 | 21.56 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 432-465 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) IKCYHSLAFLYQKLGMLEEAIQLLQKSLTLKPIS .... |. .| |.| ..|||....|.| | | AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR_2 | 14879.AA | TPR_2 | 500-526 | 37 | 0.359148 | 8.23 | Pfam | 1-27 (34) | Show / Hide |
Range on Protein: 500-526 Range on HMM: 1-27/34 Sequence Identity: 37% (10 aa) QICYIHLGKVFHDKGFFDEAIELYQKV .. ||.. .| .|||||.|.|. AEAWYNLGQCYYKQGDYDEAIEYYEKA |
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| TPR_1 | 14879.AA | TPR_1 | 503-526 | 45 | 1.348444 | 6.07 | Pfam | 4-27 (34) | Show / Hide |
Range on Protein: 503-526 Range on HMM: 4-27/34 Sequence Identity: 45% (11 aa) YIHLGKVFHDKGFFDEAIELYQKV . || ... .| .||||| |||. WYNLGNCYYKMGNYDEAIECYQKA |
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