Gene 21183 (Tetrahymena)
21183
Sequence
Protein domains of 21183.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 21183.AA | PLK-Unclassified | 62-266 | 54 | 1.6e-143 | 483.1 | In-house | 52-264 (264) | Show / Hide |
Range on Protein: 62-266 Range on HMM: 52-264/264 Sequence Identity: 54% (116 aa) LHSQLDHPNIVKILKRFEDNEYVYMMLEYCPGGSLFDYIVYINFQLFEKTRLNEDEARDISYQIVQGLEYLHKNKIIHRDLKPGNILLTGNNSVKICDFG .|..|.|.||||....|||.|.||..|||||.|.|..||...|||||||.||.|.|.....|||||.|.|||.|.|||||||.|||.|..|..||||||| IHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEKKRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFG LAVRVTNYESERDTFCGTPNYIAPEK-------YGIQSDCWSFGCILYTIATGRPPFETVSIQQTLKMLQ-KKNKVEYPSHLSKSLVDLIDHILDWNQDT ||....|......|.||||||||||. .....|||||||||||...|.|||||....||.|... .......|.|.|....|||.|||.||.|. LATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYTLLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQ RYNISQIKSHPFY |..|.||..|||| RPTIDQIMMHPFY |
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| Kinase | 21183.AA | PLK | 62-266 | 48 | 1.1e-126 | 414.47 | In-house | 52-258 (258) | Show / Hide |
Range on Protein: 62-266 Range on HMM: 52-258/258 Sequence Identity: 48% (103 aa) LHSQLDHPNIVKILKRFEDNEYVYMMLEYCPGGSLFDYIVYINFQLFEKTRLNEDEARDISYQIVQGLEYLHKNKIIHRDLKPGNILLTGNNSVKICDFG .|.||.||||||. ..|||.|.||..||||...||..|. .. ..||.|.|.|.. |||||||.|||...|||||||.||..|. |. |||.||| IHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRR------AKRLTEPEVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFG LAVRVTNYESERDTFCGTPNYIAPEK-------YGIQSDCWSFGCILYTIATGRPPFETVSIQQTLKMLQKKNKVEYPSH--LSKSLVDLIDHILDWNQD ||.|..... ...|.|||||||||| .....||||.|||.||. .|.||||| ....|.|. . .|. ..|.| .|... |||...|.||.| LATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKPPFETKDVKETYKRIK-HNHYSFPEHCPISDEAKDLIQKMLNWNPD TRYNISQIKSHPFY .|..|.|| .|||. ERPTIDQILQHPFF |
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| S_TKc | 21183.AA | S_TKc | 35-266 | 34 | 1.4e-73 | 251.71 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 35-266 Range on HMM: 1-231/231 Sequence Identity: 34% (90 aa) FKITLTLGRGAGSCVFLIEEYKSGSLY--------------LHSQLDHPNIVKILKRFEDNEYVYMMLEYCPG--GSLFDYIVYINFQLFEKTRLNEDEA ..| ..|.|| ..|.. . |.| .. .... .||||||.. |.| ...|| .|||.| |.|||||. . . ...| .| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR-FPFPE-HA RDISYQIVQGLEYLHKNKIIHRDLKPGNILLTGNNSVKICDFGLAVRVTNYESERDTFCGTPNYIAPE--KYGI-QSDCWSFGCILYTIATGRPPFETVS | . |||...|||.|...|||||||| ||||. .|||||||| .. .||||||.|.||| .|| .| ||.||||| ..|.|||. RFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP--Q IQQTLKMLQKKNKVEYPSHLSKSLVDLIDHILDWNQDTRYNISQIKS-------HPFY .|...|.. |... |.|...|... . |. . .. ||. MQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 21183.AA | CAMK | 65-266 | 26 | 9.7e-72 | 230.22 | In-house | 94-425 (425) | Show / Hide |
Range on Protein: 65-266 Range on HMM: 94-425/425 Sequence Identity: 26% (89 aa) QLDHPNIVKILKRFED-------------------NEYVYMML---EYCPGG----SLFDYIVYINF---------QLFEKTRLNEDEARDISYQIVQGL .||||||.|.. .|| ....|| . |||.|| |||||| . |. |..|.||| . ||.... KLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAV EYLHKNKIIHRDLKPGNILLTGN-----------------NSVKICDFGLAVRVTNYESERD-----------------------TFCGTPNYIA-PE-- .|.|...|.|||||| ||||. | | .||.|||.| ... |.... |||||| |.| || HYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVL -K----------------YGIQSDCWSFGCILYTIATGRPPFETVSIQQTLK----------MLQKKNKVEY--PSH----------------------- . || ..|.|| |.|||. .|.|||. . ..... ...| | .| |.. NGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH -LSKSLVDLIDHILDWNQDTRYNISQIKSHPFY .|.. ||| ..| . . |..|.|...||.. FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | 21183.AA | CAMKL | 62-266 | 34 | 1.6e-71 | 227.51 | In-house | 65-297 (297) | Show / Hide |
Range on Protein: 62-266 Range on HMM: 65-297/297 Sequence Identity: 34% (82 aa) LHSQLD---HPNIVKILKRFEDNEY------VYMMLEYCPGGS--LFDYIVYINFQLFEKTRLNEDEARDISYQIVQGLEYLHKNKIIHRDLKPGNILLT ....|. ||||.|.. .|. |. .|. .|||.||. |||||| |. |.||| . ||| ...|.|...|.|||.|| ||||. IMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRR---GRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLD GNNS--VKICDFGLAVR---V-TNYESERDTFCGTPNYIAPE------K--YGIQSDCWSFGCILYTIATGRPPFETVSI------QQTLKMLQKKNKVE |.. .||.|||.. . ... .||||.|.| ||| | .| . |.|| | |||.. .|. ||. .. . ....... . ENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-Y YPS---HLSKSLVDLIDHILDWNQDTRYNISQIKSHPFY || |.| .. ||| ..| | . |..| ||..||.. YPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | 21183.AA | Ciliate-E2 | 35-266 | 23 | 1.7e-71 | 243.81 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 35-266 Range on HMM: 1-365/365 Sequence Identity: 23% (88 aa) FKITLTLGRGAGSCVFLIEEYKSGSLY-----------------------------------LHS----------------------QLDHPNIVKILKR .|. .|.|. ..|.. . .| . .. . . ||.||||.|. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FE--DNEYVYMMLEYCPGGSLFDYIVYINFQLFEK----TRLNEDEARDISYQIVQ---------------GLEYLHKNK-IIHRDLKPGNILLTGNNSV |. |....|. .||| ||.||||| . . ... ...| |...|..||.| .|||||... |||||.|| |||. . FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I KICDFGLAVRVT-------------NYESER-------------------DTFCGTPNYIAP----EK----------YGIQSDCWSFGCILYTIATGRP ||.||||. ... .| . .|.||||.| || | |. ..| ||.|.||| .|.| KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP PFETVSIQQTLKMLQKKN-KVEYP------------------SHLSKSLVDLIDH----ILDWNQDTRYN-ISQIKSHPFY || . |.|. |...| ..|.. ||| .|. ... |.. ..||. ||. PF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 21183.AA | Ciliate-E2-Unclassified | 35-266 | 25 | 3.7e-67 | 229.43 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 35-266
Range on HMM: 1-352/352
Sequence Identity: 25% (89 aa)
FKITLTLGRGAGSCVFLIEEYKSGSLY-----LH------------------------------------------SQLDHPNIVKILKRFEDNEYVYMM
.|| ..|.|. ..|.. .. | . .| .. ....||.||| . |.| ...|.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV
LEYCPGGSLFDYIVYINF----------QLFEKTRLNEDEAR-----DISYQIVQGLEYLHKNK-IIHRDLKPGNILLTGNN---SVKICDFGLAV----
.|||.||.|..|| .. .. .. .. | .|. .. .||.|||||||... |||||.|| |||.. |. .||.|||..
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ
----RVTN--------YESERDTFCGTPNYI----APE-----KYG----IQSDCWSFGCILYTIATGRPPFETVSIQQ---------------TLKMLQ
. || .. . .||||||||. ||| .|. ...|.||.|.||| . .|..||. . | |. .
NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI
KKNKVEYPS--------HLSKSLVDLID----HILDWNQDTRYNISQIKSHPFY
|......|. |.|.. |.| .|..|.. |....||. ||.
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
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| Kinase | 21183.AA | Pkinase | 60-266 | 35 | 2.9e-65 | 227.91 | Pfam | 51-293 (293) | Show / Hide |
Range on Protein: 60-266 Range on HMM: 51-293/293 Sequence Identity: 35% (88 aa) LYLHSQLDHPNIVKILKRFEDNEYVYMMLEYCPGG----SLFDYIVYINFQLFEKTRL--NEDEARDISYQIVQGLEYLHKNKIIHRDLKPGNILLTGNN .... |.|||||... |||. ..|| .|||.|| .||||| ..... |.|.... |||..||||.|...|||||||| |||. |. IQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNG SV----KICDFGLAVR--VTNYESERDTFCGTPNYIAPEK------YGIQSDCWSFGCILYTIATGRPPFETV-------SIQQTLKMLQKKNKVEYPSH . |||||||| |.. .||||||.|.||| || .| ||.||||| ..||||| .| . ...... ..| HIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWW LS-------------------KSLVDLIDHILDWNQDTRYNISQIKSHPFY | ... |.|. .|... |... ||. ||. CSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 21183.AA | ULK | 65-266 | 29 | 1.1e-58 | 201.34 | In-house | 66-329 (329) | Show / Hide |
Range on Protein: 65-266
Range on HMM: 66-329/329
Sequence Identity: 29% (79 aa)
QLD--------HPNIVKILKRFEDN--EYVYMMLEYCPGGSLFDYIV---YINFQLFE-KTRLNEDEARDISYQIVQGLEYLHKNKIIHRDLKPGNILLT
.|. |||||| .. ||. ..|...|||.|| |..|| . . . | | ||.|.||. . .||..|. .|||..|||||.|| |||..
KLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDT-EEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIH
GNN------------SVKICDFGLAVRVTNY---ESERDTFC------GTPNYIAPE---------KYG-IQSDCWSFGCILYTIATGRPPFETVSIQQT
.. .||.|||.| |.| . |. ||| | ||. .|. .| ||.|||.| . .|.|||.. ....
NGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQ
L-----KMLQK---------KNKVEYP-----SHLSKSLVDLIDHILDWNQDTRYNISQIKSHPFY
| ... |.. ..| ..|. . ||| | ... | .. .. .||.
YLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
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| Kinase | 21183.AA | ULK | 65-266 | 29 | 2.1e-58 | 200.33 | In-house | 66-324 (324) | Show / Hide |
Range on Protein: 65-266
Range on HMM: 66-324/324
Sequence Identity: 29% (78 aa)
QLD---HPN--IVKILKRFEDN--EYVYMMLEYCPGGSLFDYIVYINFQLFEKT----RLNEDEARDISYQIVQGLEYLHKNKIIHRDLKPGNILLTGNN
.|. ||| ||| .. ||. ..|...|||.|| |..|| | | | | ||.|.||. . .||..|. .|||..|||||.|| |||.. ..
KLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIK-KNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQ
------------SVKICDFGLAVRVTNYESERDTFC----------GTPNYIAPE---------KYG-IQSDCWSFGCILYTIATGRPPFETVSIQQTL-
.||.|||.| .. ..... .. | ||| | ||. .|. . .| ||.|||.| . .|..||.. ....
PKTDSKKVHPNGVLKIADFGFA-KHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYL
---KMLQK---------KNKVEYP-----SHLSKSLVDLIDHILDWNQDTRYNISQIKSHPFY
|.... ......| ..|. . ||| | ... | .. .| .||.
YIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
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| Kinase | 21183.AA | STE | 62-266 | 25 | 8e-58 | 198.42 | In-house | 81-359 (359) | Show / Hide |
Range on Protein: 62-266 Range on HMM: 81-359/359 Sequence Identity: 25% (74 aa) LHSQLD--HPNIVKILKRFEDN-------EYVYMMLEYCPGGSLFDYIVYINFQLFEKT-------RLNEDEARDISYQIVQG-LEYLHKNKIIHRDLKP ...... |||||| . .... ..... .||..|||| | | ... . |..|.. . | .||..| |.|||...|||||.|| IMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKP GNILLTGNNSVKICDFGLAVRVTN----------------YESERDTFCGTPNYIAPEK-----------YGIQSDCWSFGCILYTIATGRPPFETVSIQ .|||| ||.||||.. ..|. ..|.||.||| . ||| |....| ||.|| . |||.||. . . ANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPM QTLKMLQKK---------------NKVEYPS-------------------HLSKSLVDLIDHILDWNQDTRYNISQIKS--HPFY . . | ... . |. ..|... | |.. |. . . | . || . ||| RAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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| Kinase | 21183.AA | SAK | 62-266 | 42 | 1.6e-56 | 190.88 | In-house | 52-254 (254) | Show / Hide |
Range on Protein: 62-266 Range on HMM: 52-254/254 Sequence Identity: 42% (90 aa) LHSQLDHPNIVKILKRFEDNEYVYMMLEYCPGGSLFDYIVYINFQLFEKTRLNEDEARDISYQIVQGLEYLHKNKIIHRDLKPGNILLTGNNSVKICDFG .|.|| || |... . |||| |||..|| | | . |. . . | |.|||.. ||| |. ||| |.|||| ||||| . .|| ||| IHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHR-MRPFT-----EEEARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFG LAVRVTNYESERDTFCGTPNYIAPE-----KYGIQSDCWSFGCILYTIATGRPPFETVSIQQTLKMLQKKNKVEYPSHLSKSLVDLIDHILDWNQDTRYN || . . |.|||||||.|| |.||| || ||.|||. .|||||.| ....|| . . |.||| |||...| | | LATQLKMPHEKHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTLLIGRPPFDTDAVKNTLNKVMMAE-YIMPAHLSMEAQDLIHKMLRKNPHERIT ISQIKSHPFY .| . ||| LSTVLCHPFM |
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| Kinase | 21183.AA | Pkinase_Tyr | 64-234 | 32 | 1.2e-21 | 73.98 | Pfam | 58-240 (270) | Show / Hide |
Range on Protein: 64-234 Range on HMM: 58-240/270 Sequence Identity: 32% (61 aa) SQL-DHPNIVKILKRFE-DNEY--VYMMLEYCPGGSLFDYIVYINFQLFEKTRLNEDEARDISYQIVQGLEYLHKNKIIHRDLKPGNILLTGNNSVKICD .|| .|||||. . . | .|. .||.|.|.| || .| .|. . ....|| .|.|||. ...||||| |.|.| || ||||| KQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR---EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICD FGLAVRVTN---Y-ESERDTFCGTPNYIAPE-----KYGIQSDCWSFGCILYTIAT-GRPP-FETVSIQQTLKML-QKKNKVEYPSH |||| ..| | . .. ||| |. ..|| |||| .. | | |. | .. .| .. .... .. . . | . FGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPEN |
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| Kinase | 21183.AA | TyrKc | 39-266 | 23 | 7e-16 | 34.09 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 39-266
Range on HMM: 1-280/280
Sequence Identity: 23% (67 aa)
LTLGRGAGSCVF---------------LIEEYKSGSLYLH-----SQL--DHPNIVKILKRFEDN-------EYVYMMLEYCPGGSLFDYI-VYINFQLF
.|||. |.. | . |.. .. ..| .|||||... . | ... .||.|.|.| ||. . .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---
EKTRLNEDEARDISYQIVQGLEYLHKNKIIHRDLKPGNILLTGNNSVKICDFGLAVRVTNY----ESERDTFC----GTP-----NYIAPE-----KYGI
|. .. ....|| .| ||||....||||| |.|.. |. |||.||||. .... ||. |. ||| |. .
----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT
QSDCWSFGCILYTIAT-GRPPFET-----VSIQQTLKMLQKKNKVEYPSH--------LSKSLVDLIDHILDWNQDTRYNISQIKSHPFY
.|| |||| .. | | | .| . .| |. .. ... . . | . .. . ... . . . | . |.| | .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
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| Kinase | 21183.AA | Pkinase | 35-51 | 29 | 5.331275 | 1.08 | Pfam | 1-17 (293) | Show / Hide |
Range on Protein: 35-51 Range on HMM: 1-17/293 Sequence Identity: 29% (5 aa) FKITLTLGRGAGSCVFL ..| ..|.|. .||.. YHIGRKIGSGSFGCVYK |
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