Gene 4322 (Tetrahymena)

4322

Species: Tetrahymena
Alias: 4322, 252.m00022, TTHERM_01142670, PreTt04322, 3824.m03210, 172
External Links: Tetrahymena Genome Database (TGD) ,
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: CDC15

Sequence

Name Sequence Type Origin Length Description Download
4322.AA Protein None 1203 None Fasta, JSON
4322.kin_dom Protein Kinase Domain None 258 None Fasta, JSON
4322.NA RNA None 3612 None Fasta, JSON

Protein domain

Protein domains of 4322.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 4322.AA Dicty2 16-273 65 1.7e-211 708.89 In-house 1-264 (264) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-264/264
Sequence Identity: 65% (174 aa)

YKVG-VKLGQGASGTVYKGEHIETGQVVAIKLVS----TVNIKKENIKSIKKEMHLLKKLKHENIVTYIDFIQTENHYAIILEYIESGSLYGIIKKFGPF
|..| .|.|.||.||||||.|||||..||||...    ...|..|...||..|.||||||.|.|||.||..|.||||..|||||||.|||..||||||.|
YQIGDEKIGKGAFGTVYKGLHIETGDFVAIKQINIMKKKTKISEEQHQSIMQEIHLLKKLNHHNIVKYIEHIETENHLYIILEYIENGSLSKIIKKFGCF

QESLVIIFIKQVLRGLEYLHRQGIVHRDIKGANILTTKNNKSGVIKLTDFGVATHLA-DDDKSSTQCVGTPYWMAPEVIIDSDGHISTSCDIWSLGCTII
.|||..|.|.|||.||.||||||..|||||.||||.||..|||||||.|||||||.. .||.|....||||||||||||..|..|..|.|||||||||||
PESLCCIYIYQVLKGLVYLHRQGVIHRDIKAANILITKEGKSGVIKLADFGVATHIDYSDDDSRYTVVGTPYWMAPEVIQMSGNHCCTACDIWSLGCTII

ELLTGNPPYSYGNPHHALFRMVSDQHPPLPKDVTPQCLDFLMQCFNKEPSQRMDAKSLLNHEWL
|||||||||...||.||.||||.|.|||||.|..|.|.|||||||.|.|.|||.||.||.|.|.
ELLTGNPPYWDLNPMHAMFRMVQDDHPPLPNDISPECKDFLMQCFCKDPNQRMTAKQLLHHPWI
Kinase 4322.AA STE 16-273 30 3e-110 372.55 In-house 1-359 (359) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-359/359
Sequence Identity: 30% (112 aa)

YKVGVKLGQGASGTVYKGEHIE---------------TGQVVAIKLVSTVNIKK---------------ENIKSIKKEMHLLKKLK--HENIVTYIDFIQ
..   |.|.||.|||||. ...               ||...||| ..  | ..               |....|.||. ..||..  |.|||.|..   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TE-------NHYAIILEYIESGSLYGIIK-KFGPFQ-------------ESLVIIFIKQVLRG-LEYLHRQGIVHRDIKGANILTTKNNKSGVIKLTDFG
 |       ..  |..||.. |||  ||| |.|...             ||.......|.|.| |.|||...|.|||||.||||         .||.|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFG

VATHLADD----------------DKSSTQCVGTPYWMAPEVIIDS----DGHISTSCDIWSLGCTIIELLTGNPPYSYGNPHHALFRMVSD--------
|.. |.|.                .. .. .|||| |||||||       |.. .|.||||||||||||..||.||.. ..|. |.|..           
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE

-------QHPPLPK-------------------DVTPQCLDFLMQCFNKEPSQRMDAKSLLN--HEWL
       ..||||                     ..| . ||. .|..|.|..| .|. ||.  |...
QLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 4322.AA S_TKc 16-273 33 4.3e-104 353.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-231/231
Sequence Identity: 33% (91 aa)

YKVGVKLGQGASGTVYKGEHIETGQVVAIKLVSTVNIKKENIKSIKKEMHLLKKLKHENIVTYIDFIQTENHYAIILEYIES--GSLYGIIKKFGP----
|... |.|.|| |.|||. |..||..|||| ..         ..|..|. .||| .|.|||...|..|. .|. ...||..   |.|. .||| |.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FQESLVIIFIKQVLRGLEYLHRQGIVHRDIKGANILTTKNNKSGVIKLTDFGVATHLADDDKSSTQCVGTPYWMAPEVIIDSDGHIST-SCDIWSLGC
  | |  .  ...|....|||.|..||.|||.| .||| ..     .||..|||.|..|       | ..|||..|||||.     . .. .||.||.||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGC

TIIELLTGNPPYSYGNPHHALFRMVSDQHPPLPKDVTPQCLDFLMQCFNKEPSQRMDAKSLLN-------HEWL
...|.|.| ||..    ....|...           .|...||...|..|.|..|. |  .|.       |.|.
ILYEMLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 4322.AA STE11 16-273 36 1.5e-102 346.95 In-house 1-303 (303) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-303/303
Sequence Identity: 36% (112 aa)

YKVGVKLGQGASGTVYKGEHIETGQVVAIKLVSTVNIKK------ENIKS------IKKEMHLLKKLKHENIVTYIDFIQ---TENHYAIILEYIESGSL
.. | ..|.|| |||||.  . ||...|.| . ..|...      . ..|      |..|. |.|.|.|.||| |... .    ..|. |..||.. |||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

YGIIK-KFGP--FQESLVIIFIKQVLRGLEYLHRQGIVHRDIKGANILTTKNNKSGVIKLTDFGVATHLADDDKSSTQ----------CVGTPY------
  ... |.||  |.|... ...||.|.|| ||| .||.||||||||||  .  ...|.||.||| |. || .  ....            ||||      
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDS--DGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGT

--WMAPEVII--DSDGHISTSCDIWSLGCTIIELLTGNPPYS-YGN-PHHALFRMV-S-DQHPPLPKDVT------PQCLDFLMQCFNKEPSQRMDAKSL
  |||||||    .||. ....||||||||.|| .||.||.. |.. .  |.|. . . ..|||.| ...      ..| ||| .|| ..|. |  |  |
PMWMAPEVIKQEGRDGY-GRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQL

LNHEWL
|.| ..
LQHPFI
Kinase 4322.AA STE11-Unclassified 16-273 35 6.7e-95 321.58 In-house 1-308 (308) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-308/308
Sequence Identity: 35% (111 aa)

YKVGVKLGQGASGTVYKGEHIETGQVVAIKLVSTVNIK------KEN-IKSIKKEMHLLKKLKHENIVTYIDFI--QTENHYAIILEYIESGSLYGIIKK
...|  .|.|. |.|||.  ..||...|.| . .....      ..  |.||.||| .||.| |.|||.|...   . |... |..||.. ||.   ..|
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

FGPFQESLVIIFIKQVLRGLEYLHRQGIVHRDIKGANILTTKNNKSGVIKLTDFGVATHLADD-------------D--KSSTQC----------VGTPY
.|.| |..  .. ||.| ||.||| .||.||||||||||. ..   |..|||||| |   . |             |  |.. .            ||||
YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFD---GICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPY

---WMAPEVIID--SDGHISTSCDIWSLGCTIIELLTGNPPYSYGNP---HHALFRMV-SDQHPPLPKD-----------VTPQCLDFLMQCFNKEPSQR
   |||||||    ..|| ... ||||||||.||  || .|.|  ..     |..  | |.| |..| .           ....| ||| .||   |. |
QPFWMAPEVIKNSTQTGH-CRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKR

MDAKSLLNHEWL
 .|  ||.| ..
PTANQLLQHPFI
Kinase 4322.AA Pkinase 16-273 31 4.6e-92 316.96 Pfam 1-293 (293) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-293/293
Sequence Identity: 31% (94 aa)

YKVGVKLGQGASGTVYKGEHIETGQVVAIKLVSTVNIKKENIKSIKK--EMHLLKKLKHENIVTYIDFIQTENHYAIILEYIESG----SLYGIIK--KF
|..| |.|.|..|.|||. |. ||..||.| .. ...|..  ..  .  | ...|.|.|.|||...|. ....|. ...|| | |    .|. .|.  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GPF--QESLVIIFIKQVLRGLEYLHRQGIVHRDIKGANILTTKNNKSGV---IKLTDFGVATHL-ADDDKSSTQCVGTPYWMAPEVIIDSDGHISTSCDI
|.|  .|  .. ...|.||||||.|..||.|||.| .|||    |.  .   .|..|||.| ..    .   |  .|||..||||||  .. ......|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDM

WSLGCTIIELLTGNPPYSYG----NPHHALFRMVSDQHPPLPKDVT-----------------------PQCLDFLMQCFNKEPSQRMDAKSLLNHEWL
||.||...|.|.|.||..      | |  ..... . .|||. |                         . |.||.  |..| |..|  |. .|.|.|.
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 4322.AA STE20 16-273 36 6.8e-88 298.31 In-house 1-288 (288) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-288/288
Sequence Identity: 36% (107 aa)

YKVGVKLGQGASGTVYKGEHIETGQV----VAIKLVSTVNIKK--ENIKSIKKEMHLLKKLKHENIVTYIDFIQTE----NHYAIILEYIESGSLYGIIK
|.   |.|||..|.|||. |..||..    |||| ..  . .   . ...|.||   .|..||.|||.|..  . .    ..  |. || . |||  |.|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---KFG------PFQESLVIIFIKQVLRGLEYLHRQGIVHRDIKGANILTTKNNKSGVIKLTDFGVATHLAD-----DDKSSTQCVGTPYWMAPEVIIDS
   | |      |..|. .    ..||.||.|||...|.|||||..||| |..   | .||.||||.  | .     ...     ||||||||||||   
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTED---GEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCM

D---GHISTSCDIWSLGCTIIELLTGNPPYSYGNPHHALFRMVSDQHPPL------PKDVTPQCLDFLMQCFNKEPSQRMDAKSLLNHEWL
.   .   . ||||||| |.||...|.|||.  .|  |.|.. . | ||.      |.  .|.  ||. .| .|.|..|  |. ||.|...
EGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase 4322.AA CAMK 21-273 19 3.2e-79 254.77 In-house 1-425 (425) Show / Hide 
Range on Protein: 21-273
Range on HMM: 1-425/425
Sequence Identity: 19% (81 aa)

KLGQGASGTVYKGEHIETG------------QVVAIKLVSTVNIK--------------------------KENIKSIKKEMHLLKK-------LKHENI
.||.|. |.|....|..|.            | |||| ...  .|                           .. |....|....||       |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VTYIDFIQ------------TENH--------YAIIL---EYIESG----SLYGIIKKFGP---------------FQESLVIIFIKQVLRGLEYLHRQG
.  .....            | ..        . ...   ||.. |     |.  |.. |.               |.|. .  ...|.. ...|.| ..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDIKGANILTTKNNKS--------------GVIKLTDFGVATHLAD-----------------------DDKSSTQCVGTPYWMA-PEVIIDS----
|||||.|  ||| ..||..              . ||..||| |... .                       ...  . ..|||. || |||.  .    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------DGHISTSCDIWSLGCTIIELLTGNPPYS------------YGNPHHALFRMVSDQHPP-LPKDVTP-----------------------QCL
           .. .||.||.|.    .|.| ||.              |.  . ||...        |. ..|                       .| 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DFLMQCFNKEPSQRMDAKSLLNHEWL
|.. .. ...|..|| ..  |||.|.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 4322.AA Ciliate-E2 16-273 23 1.4e-76 260.77 In-house 1-365 (365) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-365/365
Sequence Identity: 23% (89 aa)

YKVGVKLGQGASGTVYKGEHIETGQV------------------VAIKLVSTVNIKKENIKSIKKEMHLLK----------------KLKHENIVTYIDF
||.  |.|||. |.|||........                   |.||..   ..|| .|..||.| |...                .|.| ||. ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IQ--TENHYAIILEYIESGSLYGIIKKF-----------GPFQESLVIIFIKQVLR---------------GLEYLHRQG-IVHRDIKGANILTTKNNKS
 |  ..|.. ...||.. |.|. .||..           ..| |  .. ..||.|.               .||||| .. |.|||||  |||       
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

GVIKLTDFGVATHLADDDKSSTQ-------------------------------CVGTPYWMAPEVIIDSD------GH-ISTSCDIWSLGCTIIELLTG
  ||..||| .. . || .  |.                               ..|||. ||||..   .      ..  ...|||||||... |.|.|
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

NPPYSYGNPHHALFRMVSDQHPPLP------------------KDVTPQCLDFLMQ----CFNKEPSQRMD-AKSLLNHEWL
.||.         ..   ..   .|                  |.....| |.. .    ...|.|..|.. .. .|||.|.
KPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 4322.AA ULK 16-273 29 2.6e-76 259.86 In-house 1-324 (324) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-324/324
Sequence Identity: 29% (96 aa)

YKVGVKLGQGASG-TVYKGEHIET---GQVVAIKLVS---TVNIKKEN-----IKSIKKEMHLLKKLK---HEN--IVTYIDFIQTE--NHYAIILEYIE
| .  .||.|. | .||||....|   .|.||.| ..     ..|.|.     ....|.|  ..||||   |.|  || ..|. .|   |.. ||.|| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

SGSLYGIIKKFGP---------FQESLVIIFIKQVLRGLEYLHRQGIVHRDIKGANILTTKNNKS---------GVIKLTDFGVATHLADDDKSSTQC--
 | |  .||| ..         . |. .|.|.|| . |. .|| ..|.||||| .||| .... .         ||.|..||| | |. ..... ..|  
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

-V------GTPYWMAPEVIIDS--DGHISTS-CDIWSLGCTIIELLTGNPPY--SYGNPHH----ALFRM-------VSDQHPPLP---KDVT--PQCLD
 |      |||. |||... .     . ... |||||||| . |.|.| .|.  .  |.       | ..       . .|  . |   ||.   |.| |
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

FLMQCFNKEPSQRMDAKSLLNHEWL
...... .....|..   ..||.|.
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 4322.AA ULK 16-273 29 2e-75 256.87 In-house 1-329 (329) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-329/329
Sequence Identity: 29% (98 aa)

YKVGVKLGQGASGTVYKGEHIET----GQVVAIKLVS--TVNIKKEN------IKSIKKEMHLLKKLK--------HENIVTYIDFIQTE--NHYAIILE
| .  .||.|. |.||||....|    ...||.| ..  . |.|. .      ....|.|  ..||||        |.||| ..|. .|   |.. ||.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YIESGSLYGIIKKFGP----------FQESLVIIFIKQVLRGLEYLHRQGIVHRDIKGANILTTKNNKS---------GVIKLTDFGVATHLADD---DK
| . | |  .||| ..          . |. .|.|.|| | |. .|| ..|.||||| .||| .... .         ||.|..||| | |. .|   ..
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

SSTQCV------GTPYWMAPEVIIDS--DGHISTS-CDIWSLGCTIIELLTGNPP-YSYGNPHHALFRMVSDQH-------------PPLPKD-----VT
  . ||      |||. |||... .     . ... |||||||| . |.|.| || |.. .    |  . .                .  |||     . 
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

PQCLDFLMQCFNKEPSQRMDAKSLLNHEWL
|.| |.. ... .....|..   |.||.|.
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 4322.AA PAKA 16-273 36 2.5e-73 249.92 In-house 1-260 (260) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-260/260
Sequence Identity: 36% (97 aa)

YKVGVKLGQGASGTVYKGEHIETGQV--VAIKLVSTVNIKKENIK-SIKKEMHLLKKLKHENIVTYID-FIQTENHYAIILEYIESGSLYGIIKKFG---
||.  |.||||||.||... |.|.|   ||||   . |.|... |  |. |. ..|. ||.||| ||| ..  .    ...|| | |.|  .|...    
YKFMEKIGQGASGEVYVATNIKTNQEENVAIK---QMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLV-DDELWVVMEYMEGGCLTDVITQCCNIQ

--PFQESLVIIFIKQVLRGLEYLHRQGIVHRDIKGANILTTKNNKSGVIKLTDFGVATHLADDDKSSTQCVGTPYWMAPEVIIDSDGHISTSCDIWSLGC
  ...|. .   ....|.|||..|.....|||||  |||    .. | .|.|||| .. | . . . .  ||||||||||||   .   .   |||||| 
CNYMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILL---GMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQ--YDEKVDIWSLGI

TIIELLTGNPPYSYGNPHHALFRMVSDQHPPL--PKDVTPQCLDFLMQCFNKEPSQRMDAKSLLNHEWL
 .||.. | ||| . .|  |..   .   |..  |  ....  ||| .| .... .| .|..||.|. |
MAIEMIEGEPPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase 4322.AA Pkinase_Tyr 16-218 29 1.2e-30 104.4 Pfam 1-216 (270) Show / Hide 
Range on Protein: 16-218
Range on HMM: 1-216/270
Sequence Identity: 29% (65 aa)

YKVGVKLGQGASGTVYKGEHI----ETGQVVAIKLVSTVNIKKEN--IKSIKKEMHLLKKL-KHENIVTYIDFIQ-TENH--YAIILEYIESGSLYGIIK
 . | |||.|| |.||||.      .|.. ||.| .   .  .|.  ...  .|. ..|.| .|.||| ..  .   . .  . |..|| . |.|.   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----FGPFQESLVIIFIKQVLRGLEYLHRQGIVHRDIKGANILTTKNNKSGVIKLTDFGVATHLADDD---KSSTQCVGTPYWMAPEVIIDSDGHISTS
|     .|.  .  . .  |. .|.|||......|||.   |.| |.   ..|.| .||| |  . .||   .... .     |||||.| ..    .| 
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK--FTTK

CDIWSLGCTIIELLT-GNPP-Y
 |.|| | .. |..| |  | |
SDVWSFGVLMWEIFTYGEQPTY
Kinase 4322.AA TyrKc 16-273 25 3.4e-28 100.9 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-280/280
Sequence Identity: 25% (74 aa)

YKVGVKLGQGASGTVYKGEHIETGQVVAIKLVSTVNIKKENIKSIKKEMHLLKKL--KHENIVTYIDFIQTE-------NHYAIILEYIESGSLYGIIKK
 . | ||| || |.||||. .   . ||.| .         .. . .|. ...||  .|.|||  .  . ..         . |..|| . |.|   ..|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

FGP-FQESLVIIFIKQVLRGLEYLHRQGIVHRDIKGANILTTKNNKSGVIKLTDFGVATHLADDDKS----STQCV----GTP-----YWMAPEVIIDSD
 .| .. .  . |  |. .| ||||.....|||.   |.| ..|.   ..| .||| .  . |||..    ..  .    |.       |||||.|   .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NY

GHISTSCDIWSLGCTIIELLT-GNPPYSY-----GNPHHALFRMVSDQHPPLPKD--------VTPQCLDFLMQCFNKEPSQRMDAKSLLNHEWL
|  .|  |.|| | .. |..| | .||.       .. ... .  .   .| |..         ..   .   || . .|..|   . .  || .
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF