Gene 29596 (Tetrahymena)
29596
Sequence
Protein domains of 29596.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 29596.AA | MST | 21-271 | 63 | 9.5e-217 | 695.59 | In-house | 1-254 (254) | Show / Hide |
Range on Protein: 21-271 Range on HMM: 1-254/254 Sequence Identity: 63% (162 aa) FEILDLLGEGSYGQVYKALHKQTGELVAVKMVPNEGD-SALEKEIRMLKECQSEYVVKYYASYY--KDQHLWLIMEYCAAGSIIDLVKITRIQLNEQQIA |.|...||.||||.||||.|||||..||.||||...| ....|||.....|.|.|.||||.||. |..|.|..||||..||..|..|||...||||||| FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVNEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQIA SILQSTLKGLQYLHSNKIIHRDIKAGNILLDQRGNAKLADFGVSFQQIHTQAKAESKIGTPCWMAPEVIMHLKYDSKADIWSLGITAIELAEGEPPYSDV .||..||.||||||.||.||||||||||||...|..||||||||.|...|.||....||||.|||||||...|||.|||||||||||||.|||.|||||. CILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSDI KPSMVMAKIQQKPPQGLKNPSQWSQQFNDFVKQCLQQDPQKRPTAEQLLQHPFI .|...|..|.||||...|.|.||||.|||||..|||..|..|.||||||||||| HPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI |
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Kinase | 29596.AA | STE20 | 21-271 | 50 | 1.7e-159 | 536.18 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 21-271 Range on HMM: 1-288/288 Sequence Identity: 50% (144 aa) FEILDLLGEGSYGQVYKALHKQTGEL----VAVKMVPNEGD-------SALEKEIRMLKECQSEYVVKYYASYYKD----QHLWLIMEYCAAGSIIDLVK .|.|. .|.||||.|||| ||.|||. ||.|... | . ..|||...|.|.....|||| ||.|| ..||..||||..||. |..| YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK ---ITRI-----QLNEQQIASILQSTLKGLQYLHSNKIIHRDIKAGNILLDQRGNAKLADFGVSFQQIH----TQA-KAESKIGTPCWMAPEVIMH---- .. . .||.||| |.. .|.||.|||||.||||||||.||||...|..|||||||. | .. |.. | . .|||.|||||||. HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP -LKYDSKADIWSLGITAIELAEGEPPYSDVKPSMVMAKIQ--QKPPQGLKN--PSQWSQQFNDFVKQCLQQDPQKRPTAEQLLQHPFI .||.|.|||||||||||.|||||||.|. | .| .| |.|| ||. |..||..|.|||..|||.||.|||||.|||.|||| DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI |
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Kinase | 29596.AA | STE | 21-271 | 34 | 5.9e-133 | 447.99 | In-house | 1-359 (359) | Show / Hide |
Range on Protein: 21-271 Range on HMM: 1-359/359 Sequence Identity: 34% (125 aa) FEILDLLGEGSYGQVYKALHK------QTGEL---------VAVKMVPNEGDS--------------------ALEKEIRMLKECQ--SEYVVKYYASYY .|... .|.|..|.||||... .|||. .|.| .. | .. ..|||...|.|. ....|||| .|. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF KD-------QHLWLIMEYCAAGSIIDLVK---ITRIQLN----------EQQIASILQSTLKG-LQYLHSNKIIHRDIKAGNILLDQRGNAKLADFGVSF |. ..||..|||...||. |..| .. .|| |.||| |....||| |.||||..|||||||..|||| .||.||||. KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG QQIH---------------TQA-KAESKIGTPCWMAPEVIMH------LKYDSKADIWSLGITAIELAEGEPPYSDVKPSMVMAKIQQK----------- | .. |.. | . .||| |||||||. .|| |.||||||.|.||.|.|.||..| .| .| |... QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC ----PPQGLKN-----------------PSQWSQQFNDFVKQCLQQDPQKRPTAEQLLQ--HPFI || |.. |..||. |.||...||| ||.|||||.|||. |||| IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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Kinase | 29596.AA | YSK | 21-271 | 48 | 1.2e-124 | 377.39 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 21-271 Range on HMM: 1-257/257 Sequence Identity: 48% (126 aa) FEILDLLGEGSYGQVYKALHKQTGELVAVKMVPNEGDS----ALEKEIRMLKECQSEYVVKYYASYYKDQHLWLIMEYCAAGSIIDLVKITRI-QLNEQQ | ... | ||.| |||. ..|.. ||.| . | .. . .|| | .| | |. |||.|| || || |||||. ||. || | . |. |.. FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY IASILQSTLKGLQYLHSNKIIHRDIKAGNILLDQRGNAKLADFGVSFQQIHTQAKAESKIGTPCWMAPEVIMH--LKYDSKADIWSLGITAIELAEGEPP || || |||| ||||.. ||||||| |.|| |. ||.||||. | || | . .||| |||||||. .||.|||||||||||.|.| |||| IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPP YSDVKPSMVMAKIQQKPPQGLKNPSQWSQQFNDFVKQCLQQDPQKRPTAEQLLQHPFI |.|..| || | ..| |. ...| | .|| || ||..||.|..|| | || YCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI |
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Kinase | 29596.AA | PAKL | 21-271 | 50 | 1.4e-119 | 403.6 | In-house | 1-256 (256) | Show / Hide |
Range on Protein: 21-271 Range on HMM: 1-256/256 Sequence Identity: 50% (129 aa) FEILDLLGEGSYGQVYKALHKQTGELVAVKMVP-NEG-D-SALEKEIRMLKECQSEYVVKYYASYYKD-QHLWLIMEYCAAGSIIDLVKITRIQLNEQQI ||. ||.|||| ||||.|| |. |.| . | . .|||| .|| | . ..| |. | |.| |.||..||| |. ... ||| || FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQI ASILQSTLKGLQYLHSNKIIHRDIKAGNILLDQRGNAKLADFGVSFQQIHTQAK--AESKIGTPCWMAPEVIMHLKYDSKADIWSLGITAIELAEGEPPY . ||| ||||| |||| |||||||| ||||. . |.|||||| ||. . | . |||| |||||.| |..|.|||||||||||.|.|.|| SVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVS-QQLQDEYDGQANQMIGTPYWMAPEIINKQNYNNKCDIWSLGITAIEMADGFPPH SDVKPSMVMAKIQQKPPQGLKNPSQWSQQFNDFVKQCLQQDPQKRPTAEQLLQHPFI .|. | | | .|| ..|| || ||||. ||.. || ||. . .|| |||| YDMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI |
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Kinase | 29596.AA | Ste20-DD1 | 21-271 | 46 | 2.1e-101 | 343.17 | In-house | 1-268 (268) | Show / Hide |
Range on Protein: 21-271 Range on HMM: 1-268/268 Sequence Identity: 46% (125 aa) FEILDLLGEGSYGQVYKA-------LHKQTGELVAVKMVPNEG-----DSALEKEIRMLKEC-QSEYVVKYYASYYKDQHLWLIMEYCAAGSIIDLVKIT | |. | ||.| | ...|.| | .. | | ||| ||. |.||| | |. | .|||| ||| | ... FQIVEVIGQGSFGVVCTCRWMKKKDRNTNNNRVIACKFVEMNADDVEENSNLKKEIDILKNTMDCPYIVKYHGCYIKENMLMIVMEYCDGGSILDIMQMC RIQLNEQQIASILQSTLKGLQYLHSNKIIHRDIKAGNILLDQRGNAKLADFGVSFQQIHTQAKAESKIGTPCWMAPEVIMH----LKYDSKADIWSLGIT . | | ||| |. ||| |||||.|.||||||||.|... | .|||||||| . | || | ||.||.|| ||.|||||||||| SKRLIEEQIAAICYQIVKGLVYLHSNRITHRDIKAGNVLVNKEGQPKLADFGVSTIAVNQGFKMNTVIGSPYWMSPEIIMPPKGSQGYDQKADIWSLGIT AIELAEGEPPYSDVKPSMVMAKIQQKPPQGLKNPSQWSQQFNDFVKQCLQQDPQKRPTAEQLLQHPFI |||.|| || .| |. | | ..| || || || ||||.|||| .| ||| | ||| |||| AIEMAESKPPRFNVNPVRVIFVIPHQQPPTLKIPSNWSPEFNDFIKQCLNMNPDKRPSAQQLLNHPFI |
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Kinase | 29596.AA | S_TKc | 21-271 | 34 | 5e-100 | 339.54 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 21-271 Range on HMM: 1-231/231 Sequence Identity: 34% (91 aa) FEILDLLGEGSYGQVYKALHKQTGELVAVKMVPNEGDSALEKEIRMLKECQSEYVVKYYASYYKDQHLWLIMEYCAA--GSIIDLVKITRIQ-----LNE .|||...|.|..|.|||. || ||..||.|... ...||..||. . ...||.| ... .||...|||| |. |. | . . ..| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE QQIASILQSTLKGLQYLHSNKIIHRDIKAGNILLDQRGNAKLADFGVSFQQIHTQAKAESKIGTPCWMAPEVIMHLKYDS-KADIWSLGITAIELAEGEP ....... ....|.|.||..|||||.| |||||. . |..|||.. | . .||| .|||||. .|. |.|.||.|.. .|.. |.| -HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYP PYSDVKPSMVMAKIQQKPPQGLKNPSQWSQQFNDFVKQCLQQDPQKRPTAEQLLQ-------HPFI |.. . |.. || |... ||...||| ||.||||| ..|| ||.. PFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 29596.AA | PAKA | 21-271 | 41 | 6.5e-96 | 324.96 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 21-271 Range on HMM: 1-260/260 Sequence Identity: 41% (109 aa) FEILDLLGEGSYGQVYKALHKQTGEL--VAVKMVPNEGDSALEK---EIRMLKECQSEYVVKYYASYYKDQHLWLIMEYCAAGSIIDLVKITR-IQLN-- .. .. .|.|. |.||.| ..|.. ||.| . .. |. ||...|||. . .|.|. || | ||..||| ..|. |... .. ||.| YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM -EQQIASILQSTLKGLQYLHSNKIIHRDIKAGNILLDQRGNAKLADFGVSFQQIHTQAKAESKIGTPCWMAPEVIMHLKYDSKADIWSLGITAIELAEGE |.||| ... .|.||...||...|||||| ||||...|. |..||| | | | .. ||| ||||||| .|| | ||||||| |||..||| DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGE PPYSDVKPSMVMAKIQQK--PPQGLKNPSQWSQQFNDFVKQCLQQDPQKRPTAEQLLQHPFI ||| . .| | | .. |. .|.| |||.|.||...||. |...|..|..||.|||. PPYLNEPPLRAMYLIATNGKPD--IKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL |
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Kinase | 29596.AA | KHS | 21-271 | 48 | 1e-95 | 322.44 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 21-271 Range on HMM: 1-258/258 Sequence Identity: 48% (126 aa) FEILDLLGEGSYGQVYKALHKQTGELVAVKMV---PNEGDSALEKEIRMLKECQSEYVVKYYASYYKDQHLWLIMEYCAAGSIIDLVKITRIQLNEQQIA .|.| .| | ||.|||| ..|..||.|||.. |.. . . .|| |.|.|. .| |. || . ..||..|||| .||. |. ..| .|.| ||| YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVT-GPLSELQIA SILQSTLKGLQYLHSNKIIHRDIKAGNILLDQRGNAKLADFGVSFQQIHTQAKAESKIGTPCWMAPEVIMHLK---YDSKADIWSLGITAIELAEGEPPY . . ||.||.||||.. .||||| |||| ..|. |||||||| | | || | |||| |||||| . |. |||..||||||||| || YVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPM SDVKPS---MVMAKIQQKPPQGLKNPSQWSQQFNDFVKQCLQQDPQKRPTAEQLLQHPFI |. | ..|.| . .||. ||. ..|||.| .|||..| ..|.||||||.||||||. FDLHPMRALFLMTKSNFQPPK-LKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV |
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Kinase | 29596.AA | SLK | 21-271 | 45 | 1.7e-93 | 315.79 | In-house | 1-259 (259) | Show / Hide |
Range on Protein: 21-271 Range on HMM: 1-259/259 Sequence Identity: 45% (119 aa) FEILDLLGEGSYGQVYKALHKQTGELVAVKMVPNEGDSALEK---EIRMLKECQSEYVVKYYASYYKDQHLWLIMEYCAAGSIIDLVKITRIQLNEQQIA .||. ||.| .|.|||| ||... . | ||. . . || || .| ||. ..|| | .|| |..||...|.|. | . .. | |.||. WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQ SILQSTLKGLQYLHSNKIIHRDIKAGNILLDQRGNAKLADFGVSFQQIHTQAKAESKIGTPCWMAPEVIM-----HLKYDSKADIWSLGITAIELAEGEP . . .. .|..|||||.||||.||||||. . |. .||||||| .. || | .. |||| ||||||.| || |||||||||| ||.|..|| YVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEP PYSDVKPSMVMAKIQQKPPQGLKNPSQWSQQFNDFVKQCLQQDPQKRPTAEQLLQHPFI |.... | |. |||. | |..||.||..|.||.|.||..|||.|.|..||.||... PHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV |
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Kinase | 29596.AA | Pkinase | 21-271 | 30 | 5.7e-93 | 319.96 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 21-271 Range on HMM: 1-293/293 Sequence Identity: 30% (92 aa) FEILDLLGEGSYGQVYKALHKQTGELVAVKMVPNEGDSALEK-------EIRMLKECQSEYVVKYYASYYKDQHLWLIMEYCAAG----SIIDLVK-ITR ..|. .|.||.|.|||. || ||..|||| .. .... .. ||...|.......|..| ... ..|....|||| | . |... . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH IQL--NEQQIASILQSTLKGLQYLHSNKIIHRDIKAGNILLDQRGNA----KLADFGVS--FQQIHTQAKAESKIGTPCWMAPEVIM-HLKYDSKADIWS . |... ... .|.||.|.||..|||||.| |||.|..|. |..|||.. |. . . . . ||| .||||||. . .|..|.|.|| GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS LGITAIELAEGEPPYSDV----KPSMVMAKIQQKPPQGLKNPSQWS---------------------QQFNDFVKQCLQQDPQKRPTAEQLLQHPFI .|.. .|.. |.||... . |..|... . |. ...|. . . ||.| ||..||.|||||||.||||.. CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | 29596.AA | NinaC | 21-271 | 44 | 2.2e-89 | 303.29 | In-house | 1-267 (267) | Show / Hide |
Range on Protein: 21-271 Range on HMM: 1-267/267 Sequence Identity: 44% (119 aa) FEILDLLGEGSYGQVYKALHKQTGELVAVKMVP--NEGDSALEKEIRMLKE-CQSEYVVKYYASYYKDQH-----LWLIMEYCAAGSIIDLVK-ITRIQ- .|| | | || |.|.. |. |...||| .. | | | . |.. | ||..| ||| . ||..||||. ||..|.|| . . WEIYETIGKGTYGKVFKVKNKDNGQIAAVKIQHYIHDHDEEIEAEYNILRDYCDHPNVVRFYGMYYKKDKCNGDQLWFVMEYCNGGSVTDMVKGLLKCGR -LNEQQIASILQSTLKGLQYLHSNKIIHRDIKAGNILLDQRGNAKLADFGVSFQQIHTQAKAESKIGTPCWMAPEVI-----MHLKYDSKADIWSLGITA ..|. || || .. ||| ||.|..||||.| |||| . | || ||||| | | . .||||||||||| || .|.||||||| RMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPDYDARCDVWSLGITA IELAEGEPPYSDVKPSMVMAKIQQKPPQGLKNPSQWSQQFNDFVKQCLQQDPQKRPTAEQLLQHPFI |||. |.|| | | | || || | | .|.|.||||. ||| | |||. ..|.|||| IELGDGDPPFADMHPMRAMFKIPRNPPPTLMHPENWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI |
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Kinase | 29596.AA | Pkinase_Tyr | 21-271 | 26 | 2.3e-48 | 164.44 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 21-271 Range on HMM: 1-270/270 Sequence Identity: 26% (72 aa) FEILDLLGEGSYGQVYKALHK----QTGELVAVKMVPNEGDSA------LEKEIRMLKEC-QSEYVVKYYASYY-KDQH--LWLIMEYCAAGSIIDLVKI ... ||||..|.|||. | .|. |||||... .. . .|....|. . . .|..|. . .... ....|||.. |. | . ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK T---RIQLNEQQIASILQSTLKGLQYLHSNKIIHRDIKAGNILLDQRGNAKLADFGVSFQQIHTQ---AKAESKIGTPCWMAPEVIMHLKYDSKADIWSL . .|. ... .. . ||..||.|...||||. | |.|.. . .| .||| . .. |... |||||.|.. |. .| |.|| HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF GITAIELAE-GEPP-YSDVKPSMVMAKI-QQKPPQGLKNPSQWSQQFNDFVKQCLQQDPQKRPTAEQLLQHPFI |.. |. || | | ..... |...| .. .. | .. | ||| ..||..||| ... | .. GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR--MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL |
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Kinase | 29596.AA | TyrKc | 21-271 | 25 | 9.4e-34 | 119.38 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 21-271 Range on HMM: 1-280/280 Sequence Identity: 25% (73 aa) FEILDLLGEGSYGQVYKALHKQTGELVAVKMVPNEGDSALEKEIRMLKEC--QSEYVVKYYASYYKD-------QHLWLIMEYCAAGSIIDLVKITRIQL . .. |||| .|.|||. | . |||||. .. .. .|.|.... . . .|. |. .. . |...|||.. |. | . .| .| ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL NEQQIASILQSTLKGLQYLHSNKIIHRDIKAGNILLDQRGNAKLADFGVSFQQIHT-------QAKAESK-IGTP--C---WMAPEVIMHLKYDSKADIW . .. |. .| .||||...||||. | |.|.. .. .| .||| | . . . .. |. |||||.|.. |. .| |.| CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVW SLGITAIELAE-GEPPYSD-----VKPSMVMAKIQQKPPQGLKNPSQ--------WSQQFNDFVKQCLQQDPQKRPTAEQLLQHPFI | |.. |. |..||.. .... |.....| .. | .. . ||| . || .||| ... | .. SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG--YRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |