Gene 17911 (Tetrahymena)

17911

Species: Tetrahymena
Alias: 301, PreTt17911, 3745.m00024, 168.m00079, TTHERM_00933120, 17911
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: YSK

Sequence

Name Sequence Type Origin Length Description Download
17911.AA Protein None 496 None Fasta, JSON
17911.kin_dom Protein Kinase Domain None 178 None Fasta, JSON
17911.NA RNA None 1491 None Fasta, JSON

Protein domain

Protein domains of 17911.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 17911.AA YSK 1-178 59 2.4e-151 459.2 In-house 76-257 (257) Show / Hide 
Range on Protein: 1-178
Range on HMM: 76-257/257
Sequence Identity: 59% (108 aa)

MEYCGGGSLAQLIKKK--GQFQEPYITIILKEILQALSYLHSNQMVHRDIKSANILIQKDGKVKLCDFGVSSKITNNSQKLQTFVGTPYYMAPEVIQK--
||||||||...|.|.|  |||.|.||.|||.|||..|.||||....|||||.||.|....|.||||||||...||....|..|||||||.||||||..  
MEYCGGGSCLDLMKPKYVGQFDEKYIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEV

SEYDFKADIWSVGITAIEMATGHPPYYDKKPEIAMSRIVSEEPPSLSKETSSTMLINFVNCCLKYNPEQRQSAKQLLSHSFI
|.|||||||||.||||.|||.|.|||.|..|...|..|....||.|.....|.|...||.|||...||||.|||.||.|.||
SYYDFKADIWSLGITAYEMAKGEPPYCDYHPMRVMFLIPKNNPPKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase 17911.AA STE20 1-178 49 2.6e-106 359.47 In-house 87-288 (288) Show / Hide 
Range on Protein: 1-178
Range on HMM: 87-288/288
Sequence Identity: 49% (99 aa)

MEYCGGGSLAQLIK---KKGQ------FQEPYITIILKEILQALSYLHSNQMVHRDIKSANILIQKDGKVKLCDFGVSSKITN-----NSQKLQTFVGTP
||||||||| ...|   |.|.      ..|..|  |..|.||.|.|||||...|||||..|||. .||.|||.||||....|.     ...| .||||||
MEYCGGGSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTP

YYMAPEVIQK-----SEYDFKADIWSVGITAIEMATGHPPYYDKKPEIAMSRIV--SEEPPSLS---KETSSTMLINFVNCCLKYNPEQRQSAKQLLSHS
|.|||||||.     ..||.|.||||.||||||||.|.|||.|  |  || .|   ...|| |.   ... |. . .||. || ..||.| .|.|||.|.
YWMAPEVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHP

FI
||
FI
Kinase 17911.AA STE 1-178 37 1.5e-91 310.41 In-house 116-359 (359) Show / Hide 
Range on Protein: 1-178
Range on HMM: 116-359/359
Sequence Identity: 37% (93 aa)

MEYCGGGSLAQLIK---KKGQ-----------FQEPYITIILKEILQA-LSYLHSNQMVHRDIKSANILIQKDGKVKLCDFGVSSKITN-----------
|||..|||| ..||   ..|.           |.|. | .|...||.. |.||||.. .|||||.||||.     ||||||||....|.           
MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNII

-----NSQKLQTFVGTPYYMAPEVIQK------SEYDFKADIWSVGITAIEMATGHPPYYDKKPEIAMSRIVSE---------------EPPSLSK----
     ..|| .|||||| .|||||||.      ..||.|.||||.|.|.||||||.||. | .|  || .|  .               .||.|      
DCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQ

--------------ETSSTMLINFVNCCLKYNPEQRQSAKQLLS--HSFI
              .  |  ...|.| ||...|..| .|.|||.  |.||
NEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 17911.AA MST 1-178 52 6.9e-83 263.28 In-house 75-254 (254) Show / Hide 
Range on Protein: 1-178
Range on HMM: 75-254/254
Sequence Identity: 52% (94 aa)

MEYCGGGSLAQLIKKKGQ-FQEPYITIILKEILQALSYLHSNQMVHRDIKSANILIQKDGKVKLCDFGVSSKITNNSQKLQTFVGTPYYMAPEVIQKSEY
|||||.||.. ..|  .. . |  |  ||.  || | |||.|  .|||||..|||. ..|  || |||||.  |.   | .|..||||.|||||||.. |
MEYCGMGSVCDIMKITQRTLNEQQIACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKY

DFKADIWSVGITAIEMATGHPPYYDKKPEIAMSRIVSEEPPSLSK-ETSSTMLINFVNCCLKYNPEQRQSAKQLLSHSFI
| |||||| |||||||| |.||| | .|  ||  | .  ||.... |  |. ...||  ||  ||||| .|.|||.|.||
DCKADIWSLGITAIEMAEGMPPYSDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase 17911.AA PAKA 1-178 42 1.6e-72 247.24 In-house 77-260 (260) Show / Hide 
Range on Protein: 1-178
Range on HMM: 77-260/260
Sequence Identity: 42% (79 aa)

MEYCGGGSLAQLIKKKGQ-----FQEPYITIILKEILQALSYLHSNQMVHRDIKSANILIQKDGKVKLCDFGVSSKITNNSQKLQTFVGTPYYMAPEVIQ
||| .||.|  .|..  .     ..|  |  ...|.||.|...||.. .|||||| |||. .||.||. |||    .|   || .| |||||.||||||.
MEYMEGGCLTDVITQCCNIQCNYMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIR

KSEYDFKADIWSVGITAIEMATGHPPYYDKKPEIAMSRIVSE-EPPSLSKETSSTMLINFVNCCLKYNPEQRQSAKQLLSHSFI
. .|| | |||| || ||||. | ||| . .|  ||  | ..  |. ....  |  . .|.. ||. ....| ||..||.| |.
RKQYDEKVDIWSLGIMAIEMIEGEPPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase 17911.AA STE11 1-178 37 5.1e-69 235.6 In-house 92-303 (303) Show / Hide 
Range on Protein: 1-178
Range on HMM: 92-303/303
Sequence Identity: 37% (80 aa)

MEYCGGGSLAQLIK-KKGQ--FQEPYITIILKEILQALSYLHSNQMVHRDIKSANILIQKDGK-VKLCDFGVSSKITNNSQKLQT----------FVGTP
|||| ||||..... | |   |.|. | .  | ||..|.||||.. .||||| ||||. .||  .|| ||| . .. .. .. ..          . |||
MEYCPGGSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTP

Y--------YMAPEVIQKSE---YDFKADIWSVGITAIEMATGHPPYYDKK--PEIAMSRIV-S-EEPPSLSKETSS-----TMLINFVNCCLKYNPEQR
|        .|||||| ..    |. ||||||.| | |||||| ||... .  .  || .|. .   .| .  . |.       . .|.. |....|. |
YNSMMGTPMWMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKR

QSAKQLLSHSFI
 .| ||| |.||
PTANQLLQHPFI
Kinase 17911.AA Pkinase 1-178 30 6.5e-67 233.42 Pfam 79-293 (293) Show / Hide 
Range on Protein: 1-178
Range on HMM: 79-293/293
Sequence Identity: 30% (67 aa)

MEYCGGG----SLAQLIK--KKGQF--QEPYITIILKEILQALSYLHSNQMVHRDIKSANILIQKDGKV----KLCDFGVSSKI-TNNSQKLQTFVGTPY
||||.||    .|. .|.  ..| |  .|  .  ....||..| |.||.  .|||.|..|||| ..| .    |.||||.. .. . |.. ..||.|||.
MEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW

YMAPEVIQ-KSEYDFKADIWSVGITAIEMATGHPPYYDK------KPEIAMSRIVSEEPPSLSKETSS-------------------TMLINFVNCCLKY
|||||||.  ..|. |.|.||.|.. .||..|.||....       .   . || . .... . ...|                     .. |...||..
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

NPEQRQSAKQLLSHSFI
.|..| .|.|.| | ..
DPKKRPTAEQILQHPWF
Kinase 17911.AA Dicty2 1-178 46 1.4e-64 220.89 In-house 82-264 (264) Show / Hide 
Range on Protein: 1-178
Range on HMM: 82-264/264
Sequence Identity: 46% (85 aa)

MEYCGGGSLAQLIKKKGQFQEPYITIILKEILQALSYLHSNQMVHRDIKSANILIQKDGK---VKLCDFGVSSKIT-NNSQKLQTFVGTPYYMAPEVIQK
.||  .|||.  ||| | |.|. ..| .. .|. | |||..  .|||||.||||| |.||   .|| |||| ..|    ...  |.||||| ||||||| 
LEYIENGSLSKIIKKFGCFPESLCCIYIYQVLKGLVYLHRQGVIHRDIKAANILITKEGKSGVIKLADFGVATHIDYSDDDSRYTVVGTPYWMAPEVIQM

SE--YDFKADIWSVGITAIEMATGHPPYYDKKPEIAMSRIVSEEPPSLSKETSSTMLINFVNCCLKYNPEQRQSAKQLLSHSFI
|      . ||||.| | ||. || |||.|  |  || |.|..  | | .  |.  . .|   | .  |.|| .|||||.|  |
SGNHCCTACDIWSLGCTIIELLTGNPPYWDLNPMHAMFRMVQDDHPPLPNDISPECK-DFLMQCFCKDPNQRMTAKQLLHHPWI
Kinase 17911.AA STE11-Unclassified 1-178 35 4.3e-64 219.23 In-house 86-308 (308) Show / Hide 
Range on Protein: 1-178
Range on HMM: 86-308/308
Sequence Identity: 35% (80 aa)

MEYCGGGSLAQLIKKKGQFQEPYITIILKEILQALSYLHSNQMVHRDIKSANILIQKDGKVKLCDFGVSSKIT------------------NNSQKL---
|||. |||......| | | |. |..  |.||. |.||||.  .||||| ||||| .|| .|| ||| . .|                   ...|..   
MEYMPGGSIWSMLNKYGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQ

----QTFVGTPY---YMAPEVIQ---KSEYDFKADIWSVGITAIEMATGHPPYYDKKP---EIAMSRIV-SEEPPSLSKETS----------STMLINFV
    ..  ||||   .||||||    .  .. |.||||.| | |||||| .|......   ..|.  || | ..| .   .|          |. . .| 
QNHCKSMQGTPYQPFWMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFL

NCCLKYNPEQRQSAKQLLSHSFI
. |....|. | .| |||.|.||
RKCFQIDPKKRPTANQLLQHPFI
Kinase 17911.AA PAKL 1-178 44 2.9e-62 213.16 In-house 76-256 (256) Show / Hide 
Range on Protein: 1-178
Range on HMM: 76-256/256
Sequence Identity: 44% (80 aa)

MEYCGGGSLAQLIKKKGQ-FQEPYITIILKEILQALSYLHSNQMVHRDIKSANILIQKDGKVKLCDFGVSSKITNNSQ-KLQTFVGTPYYMAPEVIQKSE
|.||  ||   ...  .  ..|  | .||.  |  | |||| . .|||||.||||.  |. ||. |||||...           .||||.||||.| |  
MDYCSLGSINDMMESCCKTLNEKQISVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINKQN

YDFKADIWSVGITAIEMATGHPPYYDKKPEIAMSRIVSEEPPSLSK-ETSSTMLINFVNCCLKYNPEQRQSAKQLLSHSFI
|. |.|||| |||||||| | || ||  |  ||  |    || .|.    |  . .|.  |.   ||.| |. .||.| ||
YNNKCDIWSLGITAIEMADGFPPHYDMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase 17911.AA Ciliate-E2-Unclassified 1-178 29 9.8e-60 204.77 In-house 100-352 (352) Show / Hide 
Range on Protein: 1-178
Range on HMM: 100-352/352
Sequence Identity: 29% (74 aa)

MEYCGGGSLAQLIKKKGQ----------------FQEPYITI------ILKEILQALSYLHSNQ-MVHRDIKSANILIQKDG---KVKLCDFGVSSKITN
|||| ||.| | |||...                  . . ..      ....|||.|.|||...  .|||||  |||....|   ..|..||| |.|. .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

N---------------SQKLQTFVGTPYYM----APEVIQKSEYD----FKADIWSVGITAIEMATGHPPYYDKKPEI---------------AMSRIVS
|               .|...||.|||.||    ||||.|. .||    .|.||||.|. . || .| .|.||.. |.                . ..  
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

EEPPSLSK-------ETSSTMLINFVN----CCLKYNPEQRQSAKQLLSHSFI
. ... .|        ..|   ..|.|    ..||.||..| ...|.| | ..
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 17911.AA S_TKc 1-178 24 2.6e-39 137.81 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-178
Range on HMM: 1-231/231
Sequence Identity: 24% (63 aa)

M-----------------------------------------------------------------EYCGG--GSLAQLIKKKGQ------FQEPYITII
                                                                  |||.|  |.| ..|||.|       | |  .  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

LKEILQALSYLHSNQMVHRDIKSANILIQKDGKVKLCDFGVSSKITNNSQKLQTFVGTPYYMAPEVIQKSEYDF-KADIWSVGITAIEMATGHPPYYDKK
...|..|| |.||.. .|||.| .|||. .   .|.||||.. ..        ||.|||.||||||.    |.. |.|.||.|.. .||..| ||..   
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---

PEIAMSRIVSEEPPSLSKETSSTMLINFVNCCLKYNPEQRQSAKQLLS-------HSFI
 . .| ...            |  ...|.. ||...||.| .| ..|        | ..
QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 17911.AA Pkinase_Tyr 1-128 29 9.5e-18 60.74 Pfam 86-222 (270) Show / Hide 
Range on Protein: 1-128
Range on HMM: 86-222/270
Sequence Identity: 29% (40 aa)

MEYCGGGSLAQLIKK----KGQFQEPYITIILKEILQALSYLHSNQMVHRDIKSANILIQKDGKVKLCDFGVSSKI--TNNS-QKLQTFVGTPYYMAPEV
|||. .|.|    .|    |...  . .  .  .| ....||.|....|||.   |.|. ....|| |||| .  |  . .  .| .        ||||.
MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPEC

IQKSEYDFKADIWSVGITAIEMAT-GHPP-YYDKKPE
|. ...  | |.|| |..  |. | |  | |.. ..|
INYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNE
Kinase 17911.AA TyrKc 1-178 15 3.5e-11 -41.88 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-178
Range on HMM: 1-280/280
Sequence Identity: 15% (43 aa)

M-----------------------------------------------------------------------------EYCGGGSLAQLIKKKGQ-FQEP
                                                                              ||. .|.| . ..|..  .. .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

YITIILKEILQALSYLHSNQMVHRDIKSANILIQKDGKVKLCDFGVSSKITNN-------SQKLQTF-VGTP-----YYMAPEVIQKSEYDFKADIWSVG
    .   | .  .||||.. .|||.   |.|. ... || .||| | .|..        . . ..   |.        ||||.|..... .| |.|| |
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFG

ITAIEMAT-GHPPYYD-----KKPEIAMSRIVSEEPPSLSKE-------TSSTMLINFVNCCLKYNPEQRQSAKQLLSHSFI
..  |. | | .||..     .... .. .. . . .   ..       . .. . .   .| ...||.| . ...  |...
VCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF