Gene 12330 (Tetrahymena)
12330
Group:
TKL
Family:
TKL-ciliate3
Sequence
Protein domains of 12330.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| MORN | 12330.AA | MORN | 85-107 | 47 | 1.3e-08 | 35.98 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 85-107 Range on HMM: 1-23/23 Sequence Identity: 47% (11 aa) YEGDWSNDLRHGKGKYFYRNGDI |||.|.|...||.|.| . .|| YEGEWKNGKMHGHGVYTWPDGDR |
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| MORN | 12330.AA | MORN | 106-127 | 40 | 2.8e-08 | 34.76 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 106-127 Range on HMM: 1-22/22 Sequence Identity: 40% (9 aa) DIYDGSWVKGKKEGKGRMTYYN |.|.|.|..||. |.|.....| DRYEGEWHNGKRHGHGVYWWAN |
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| MORN | 12330.AA | MORN | 83-104 | 54 | 5.5e-08 | 33.77 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 83-104 Range on HMM: 1-22/22 Sequence Identity: 54% (12 aa) ERYEGDWSNDLRHGKGKYFYRN ||||.| |..|||.|.| . | DRYEGEWHNGKRHGHGVYWWAN |
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| MORN | 12330.AA | MORN | 37-58 | 50 | 3.7e-07 | 31.03 | SMART | 8-29 (22) | Show / Hide |
Range on Protein: 37-58 Range on HMM: 8-29/22 Sequence Identity: 50% (11 aa) DKYEGEWYNNLRQGQGKQYYYN |.||||| |..|.|.|. ...| DRYEGEWHNGKRHGHGVYWWAN |
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| MORN | 12330.AA | MORN | 39-61 | 43 | 8e-06 | 25.98 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 39-61 Range on HMM: 1-23/23 Sequence Identity: 43% (10 aa) YEGEWYNNLRQGQGKQYYYNGDF ||||| |....|.|. .. .|| YEGEWKNGKMHGHGVYTWPDGDR |
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| MORN | 12330.AA | MORN | 108-130 | 34 | 1.8e-05 | 24.64 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 108-130 Range on HMM: 1-23/23 Sequence Identity: 34% (8 aa) YDGSWVKGKKEGKGRMTYYNNEE |.|.|..||..|.|..|. . YEGEWKNGKMHGHGVYTWPDGDR |
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| MORN | 12330.AA | MORN | 60-81 | 45 | 1.9e-05 | 25.37 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 60-81 Range on HMM: 1-22/22 Sequence Identity: 45% (10 aa) DFYTGSWNKDKKEGHGQYFYSN | |.|.| ..|. ||| | ..| DRYEGEWHNGKRHGHGVYWWAN |
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| MORN | 12330.AA | MORN | 62-84 | 39 | 0.000104 | 21.86 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 62-84 Range on HMM: 1-23/23 Sequence Identity: 39% (9 aa) YTGSWNKDKKEGHGQYFYSNNER | |.| ..|..||| | ... | YEGEWKNGKMHGHGVYTWPDGDR |
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| MORN | 12330.AA | MORN | 21-38 | 38 | 0.009376 | 14.76 | Pfam | 6-23 (23) | Show / Hide |
Range on Protein: 21-38 Range on HMM: 6-23/23 Sequence Identity: 38% (7 aa) KQGARHGQGMMHYNNGDK |.| .||.| ... .||. KNGKMHGHGVYTWPDGDR |
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| MORN | 12330.AA | MORN | 131-141 | 54 | 0.293641 | 9.33 | Pfam | 1-11 (23) | Show / Hide |
Range on Protein: 131-141 Range on HMM: 1-11/23 Sequence Identity: 54% (6 aa) YDGDWLNDKKH |.|.| |.|.| YEGEWKNGKMH |
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| Sam7 | 12330.AA | sam7 | 322-384 | 23 | 2.6e-14 | 48.78 | In-house | 1-70 (70) | Show / Hide |
Range on Protein: 322-384 Range on HMM: 1-70/70 Sequence Identity: 23% (17 aa) WNTGHICKWLDSIGL---GEFSPSFESNQI-----CGQSICMLTEQELEQSIGMKALGKRKIFLKYQEMLK |.. ..| ||..||. ... ..| .. | |. .| .||..|.. .|.. .| || ... .... WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLME-MGITRPGHRKKIWNHIQQMR |
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| SAM | 12330.AA | SAM | 319-386 | 30 | 3.3e-10 | 41.15 | SMART | 1-67 (67) | Show / Hide |
Range on Protein: 319-386 Range on HMM: 1-67/67 Sequence Identity: 30% (21 aa) LREWNTGHICKWLDSIGLGEFSPSFESNQICGQSICMLTEQELEQSIGMKALGKRKIFLKYQEMLKKY | .| ||.|||... . |..|.| |. ||..|. ...|....| || .|| . .|. VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ |
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| SAM_2 | 12330.AA | SAM_2 | 319-383 | 26 | 3.7e-10 | 37.7 | Pfam | 1-71 (71) | Show / Hide |
Range on Protein: 319-383 Range on HMM: 1-71/71 Sequence Identity: 26% (19 aa) LREWNTGHICKWLDSIGL-GEFSPSFESNQICG-QSI-CMLTEQEL--EQSIGMKALGK-RKIFLKYQEML |.. .| ||.|||. ... ..|....| | . . .|...| . .|. ..| .|| | |.|. VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK |
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| SAM_1 | 12330.AA | SAM_1 | 320-384 | 27 | 2.8e-09 | 35.86 | Pfam | 1-66 (66) | Show / Hide |
Range on Protein: 320-384 Range on HMM: 1-66/66 Sequence Identity: 27% (18 aa) REWNTGHICKWLDSIGLGEFSPSF-ESNQICGQSICMLTEQELEQSIGMKALGKRKIFLKYQEMLK .| .| ||.|||... ..| ... | .. . .|...|.. .|.. .| || .. .||| DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK |
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| Kinase | 12330.AA | TKL-Unique | 1010-1266 | 40 | 7.29999999999e-144 | 484.24 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 1010-1266 Range on HMM: 1-290/290 Sequence Identity: 40% (119 aa) FGKKIGEGSYGQVFKGTWAKTQVAIKQFGKQNSKFHLRKVQDFISEVRVINNLR-HPNIVLYMGVCF----YQSQYFMITEYLQEGSLYDHLH------- |..|||||.||||.||.|....|||||| . |........|.|..||.....|. |||||.|||.|. |........||...|||||.|| FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN --IKHTAFSEAKQIDMIEDMALGMVYLHGRK--VMHCDLKSSNVLIDEN-----WNVKLCDFGLSRIKSTLNKKKNARK----NEGLIGTPQWMAPEIMR .... .. .....|..|.|.|| ||| .. ..|.||||||.|.|.| ||.|.||||||...|. ||..| .. |.. .|...|||||..| NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR R--EQYQEHSDVYSFGMIMWEIATRKV------PYLGLSHQQIYGTVGYD-ENYQVEIPVRGIPRYLNLMKKCLRRNPQERPTFQEVVEEI . .||.|.|||||||...|||||||. || |....|.. .| |. |||...|| . ...| .|...| ...|..||.|.|..... MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
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| Kinase | 12330.AA | TKL | 1014-1266 | 26 | 2.8e-99 | 336.14 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 1014-1266
Range on HMM: 1-364/364
Sequence Identity: 26% (97 aa)
IGEGSYGQVFKGTWAK----------TQVAIKQFGKQNSKFHLRKVQD-----------------------FISEVRVINNLRHPNIVLYMGVCFYQSQ-
||.|..|.|.||.| . ||.|.| ..|.... .. |. .. |......|||||||..||.|.. ..
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------YFMITEYLQEGSLYDHLHIKHTAFSEAKQIDMIEDMALGMVYLHGRK--------VMHCDLKSSNVLIDENWN--------------V
.....|| . |||...|| . .... |.|.|| ||| .. . |.||||.|.|.||||. .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC
KLCDFGLSRIKSTLNKKKNARKNEG--------------LIGTPQWMAPEIMRRE----------------QYQEHSDVYSFGMIMWEIATRKVPYL-GL
|.||||||| .|. .... .... .|||.|||||..| . .| | .||||||...|||.||..||
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP
SHQQIYG-------TVGYDENYQVEIP------------VRGIPRYLNLMKKCLRRNPQERPTFQEVVEEI
. ..| . . .|.... .|| |.. .||..| .|..||.|||.....
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | 12330.AA | Dicty4 | 1008-1269 | 36 | 1.3e-84 | 282.08 | In-house | 1-277 (277) | Show / Hide |
Range on Protein: 1008-1269 Range on HMM: 1-277/277 Sequence Identity: 36% (103 aa) LDFGKKIGEGSYGQVFKGTWAKTQVAIKQFGKQNSKFHLRKVQDFISEVRVINNLRHPNIVLYMGVCF---YQSQYFMI-TEYLQEGSLYDHLHI----- ......||.||.|.|.|||| ..||.| . | .| . ..| || ..|||||.| || | .. ..| |||. |.|| || INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ -KHTAFS--EAKQ-IDMIEDMALGMVYLHGRK--VMHCDLKSSNVLIDENWNVKLCDFGLSR-IKSTLNKKKNARKNEGLIGTPQWMAPEIMRREQYQEH . . . |. . | | |.|| .||.. . | ||||.| |.|.||.|| ||||||. .| ..| |. . .||| |||||.|. . | | QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQ---MTACGTPCWMAPEVMMHQPYNEK SDVYSFGMIMWEIATRKVPYL--GLSHQQIYGTVGYDENYQVEIPVRGIPRYLNLMKKCLRRNPQERPTFQEVVEE-IFKI .||||||.. |||.||. ||. . . |.. |. .. .|| . |.. |...|. .|| ||.|.|.... | ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVC-NKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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| Kinase | 12330.AA | DRK | 1008-1268 | 38 | 2e-75 | 254.91 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 1008-1268 Range on HMM: 1-258/258 Sequence Identity: 38% (102 aa) LDFGKKIGEGSYGQVFKGTWAKTQVAIKQFGKQNSK-FHLRKVQDFISEVRVINNLRHPNIVLYMGVCFYQSQYFMITEYLQEGSLYDHLHIKHTAFSEA | || |.||.|| ||| ||||.| | . ...| |. .. .||||||...|| | . ..||. |||| || . IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENF--LNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWP KQIDMIEDMALGMVYLHGRK--VMHCDLKSSNVLIDENWNVKLCDFGLSRIKST-LNKKKNARKNEGLIGTPQWMAPEIMRREQYQEHSDVYSFGMIMWE . | | | || |||.. ..| |||| | |.||.| || |||| || | | .||| | |||. | . | | |||||. . || LMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGL----STRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWE IATRKVPYLGLSHQQIYGTVGYDENYQVEIPVRGIPRYLNLMKKCLRRNPQERPTFQEVVEEIFK ..||. || | |. || . .| . | | ||. |. .|| ||..||..| . CVTRQDPYFGMPTFQVVFSVGR-HGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA |
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| Kinase | 12330.AA | Pkinase | 1008-1266 | 25 | 1.1e-73 | 255.9 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 1008-1266 Range on HMM: 1-293/293 Sequence Identity: 25% (75 aa) LDFGKKIGEGSYGQVFKGTWAKTQ--VAIKQFGKQNSKFHLRKVQDFI-SEVRVINNLRHPNIVLYMGVCFYQSQYFMITEYLQEG----SLYDHLH-IK . .|.|||.||.|.|.|... .|. ||.|.. |. .. . ..... ||... ..|.||||| . ... . . . |..||.. | .|.|... . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR HTAF--SEAKQIDMIEDMALGMVYLHGRKVMHCDLKSSNVLIDENWNV----KLCDFGLSRIKSTLNKKKNARKNEGLIGTPQWMAPEIMR-REQYQEHS |..| || .... .. |. |.| ....|.|||..|.|||.| .. |.|||||.. .. | . . .. ||| .||||. | .. | . HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV DVYSFGMIMWEIATRKVPYLGL------SHQQIYGTVGY---DENYQVEIPVRGI---------------PRYLNLMKKCLRRNPQERPTFQEVVEE--I |..|.| |..| .... |. | ...|.. ... ..... ..... . . ..|.||...|..|||...... . DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 12330.AA | S_TKc | 1008-1268 | 24 | 2.1e-67 | 231.15 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1008-1268
Range on HMM: 1-231/231
Sequence Identity: 24% (69 aa)
LDFGKKIGEGSYGQVFKGTWAK--TQVAIKQFGKQNSKFHLRKVQDFISEVRVINNLRHPNIVLYMGVCFYQSQYFMITEYLQE--GSLYDHLHIKHTA-
....|||.|..|.|.|... | .||||. .....|... . .||||| . .|. . ..|..||. |.|.|... . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG
----FSEAKQIDMIEDMALGMVYLHGRKVMHCDLKSSNVLIDENWNVKLCDFGLSRIKSTLNKKKNARKNEGLIGTPQWMAPEIMRREQYQE-HSDVYSF
|.| .. ..... |.| ....|.||| .|.|.|| ..|.|||||.|. ..||| .||||.. .| .|..|.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC
GMIMWEIATRKVPYLGLSHQQIYGTVGYDENYQVEIPVRGIPRYLNLMKKCLRRNPQERPTFQEVVE-------EIFK
| |..| .... |. .|... .| | .....|||...|..||| |. . .
GCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 12330.AA | Pkinase_Tyr | 1008-1266 | 34 | 6e-63 | 213.81 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 1008-1266 Range on HMM: 1-270/270 Sequence Identity: 34% (95 aa) LDFGKKIGEGSYGQVFKGTWA------KTQVAIKQFGKQNSKFH-LRKVQDFISEVRVINNL-RHPNIVLYMGVCF-YQSQ--YFMITEYLQEGSLYDHL . ||||.|||..|.|.|||| |..||.| |... . . . .||..|... .| .||||| ..||| . . .....|| . |.|.|.| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL HIK---HTAFSEAKQIDMIEDMALGMVYLHGRKVMHCDLKSSNVLIDENWNVKLCDFGLSRIKSTLNKKKNA-RKNEGLIGTPQWMAPEIMRREQYQEHS . . ... ..| . | || ||. .. | || |.|..|| || |||||.| .. . || .| ||||| .. . . | RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKS DVYSFGMIMWEIAT-RKVP-YLGLSHQQIYGTVGYDENYQVEIPVRGIPRYLNLMKKCLRRNPQERPTFQEVVEEI ||.||| |||| | . | | |.| ...| . |...|. ..| . .|||.| . .|..||||.|..|.. DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI-YEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | 12330.AA | LISK | 1013-1208 | 33 | 2.2e-62 | 201.43 | In-house | 1-236 (296) | Show / Hide |
Range on Protein: 1013-1208 Range on HMM: 1-236/296 Sequence Identity: 33% (80 aa) KIGEGSYGQVFKGTWA--KTQVAIKQFGKQNSKFHLRKVQDFIS-EVRVINNLRHPNIVLYMGVCFY-QSQYFMITEYLQEGSLYDHLHI---KHTAFSE .||.|..|.|.|||. . .|||. .| .. .. | |. || ...|||||||| .|||| ..|....||| . | | . |. . .. EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW AKQIDMIEDMALGMVYLHGRKVMHCDLKSSNVLIDEN----WNVKLCDFGLSRIKSTLN------------------------KKKNARKNEGL-----I . .. | |.|| ||| ....| |||| |.|..|| |..|.||||. |. . | |.. .. | . PQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRMTIC GTPQWMAPEIMRREQYQEHSDVYSFGMIMWEIATRK ||| |||||... ..| | .||.|||... || ||. GTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRV |
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| Kinase | 12330.AA | MLK | 1008-1266 | 30 | 1.2e-60 | 207.85 | In-house | 1-291 (291) | Show / Hide |
Range on Protein: 1008-1266 Range on HMM: 1-291/291 Sequence Identity: 30% (91 aa) LDFGKKIGEGSYGQVFKGTWAKTQ-----VAIKQFG-----KQNSKFHLRKVQDFISEVRVINNLR-HPNIVLYMGVCFYQ-SQYFMITEYLQEGSLYDH ..| ..||.||.|.|.||.| .. ||.|.. |. . .... .. ..|... . ||.|. .||| . .... ..||...||||. IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV LHIKHT-------------AFSEAKQIDMIEDMALGMVYLHGRK---VMHCDLKSSNVLIDE------NWNVKLCDFGLSRIKSTL--NKKKNARKNEGL || . . . . .. ..| || ||| . . | ||||.|.|||| . ..| ||||.|| ... |. .|| LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNA------ IGTPQWMAPEIM---RREQYQEHSDVYSFGMIMWEIATRKVPYL-GLSHQQIYGTVGYDENYQVEIPVRGIPRYLNLMKKCLRRNPQERPTFQEVVEEI ||. |||||. | |.| | .||.|.|...||. ||.||| ... .| |.| .. . || .. .|||.| .| .||.|...|.. -GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAY-NGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | 12330.AA | RAF | 1008-1268 | 30 | 2.7e-56 | 180.89 | In-house | 1-282 (282) | Show / Hide |
Range on Protein: 1008-1268 Range on HMM: 1-282/282 Sequence Identity: 30% (87 aa) LDFGKKIGEGSYGQVFKGTWAKTQVAIKQFG-KQNSKFHLRKVQDFISEVRVINNLRHPNIVLYMGVCFYQSQ---YFMITEYLQEGSLYDHLHIKHT-- .. ...||.||.| |..| | .||.| .. . .. | || | . || ||.|.|| . . | | .|.. . ||| |.|.. | VMVMTRIGSGSFGTVYRGHWH-GDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMG-YMSKPQTNTYAIVTQWCEHSSLYHHIHVQETRE AFSEAKQIDMIEDMALGMVYLHGRKVMHCDLKSSNVLIDENWNVKLCDFGLSRIKSTLN--KKKNARKNEGLIGTPQWMAPEIMR--------------R | . || ...|| ||| ....| |||| |.. .| || |||| ..|. . .. . . | |||||. | . KFDMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWI---LWMAPEVIRNLMIDWRGDVLMQDE EQYQEHSDVYSFGMIMWEIATRKVPY-LGLSHQ-QIYGTVGYDENYQ-VEIPVRGIPRYLN-LMKKCLRRNPQERPTFQEVVEEIFK | |||||||..|.|. ||. || ... || .| . . . .|. . ||. |. ...||| ||.....| NPYSFQSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV |
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| Kinase | 12330.AA | TyrKc | 1008-1266 | 33 | 3.2e-56 | 194.0 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1008-1266 Range on HMM: 1-280/280 Sequence Identity: 33% (96 aa) LDFGKKIGEGSYGQVFKGTWAKTQVAIKQFGKQNSKFHLRKVQDFISEVRVINNL--RHPNIVLYMGVCFYQ-------SQYFMITEYLQEGSLYDHLHI . .|||.||| .|.|.|||| .|||.| . ..||..| |. .| .||||| ||| | ......|| |.| |.|. ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK KHTAFSEAKQIDMIEDMALGMVYLHGRKVMHCDLKSSNVLIDENWNVKLCDFGLSRIKSTL----NKKKNARKNE--GLI--GTPQWMAPEIMRREQYQE .. .. .. ... . | || ||| ... | || |.|..|| || .|||||| |. || | | ||||| .. . . HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT HSDVYSFGMIMWEIATR-KVPYLG-----LSHQQIYGTVGYDENYQVEIPVR--------GIPRYLNLMKKCLRRNPQERPTFQEVVEEI |||.||| |||| |. . || | .| |... | .. | ..| . ..||.| ...| .||||.|..|.. KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV--KQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 12330.AA | TKL-ciliate2 | 1008-1267 | 33 | 1.1e-55 | 184.1 | In-house | 1-273 (273) | Show / Hide |
Range on Protein: 1008-1267
Range on HMM: 1-273/273
Sequence Identity: 33% (94 aa)
LDFGKKIGEGSYGQVFKGTWAKTQVAIKQFGKQNSKFHLR-KVQDFISEVRVINNLRHPNIVLYMGVCFYQSQYFMITEYLQEGSLYDHLHIKHTAFSEA
|. || || || ..| | . ||.|.| . . ...||..| . |||||||...| | . .| || | |||. | . .
LEIQNKITEGGYGIIYKAKWREIVVAVKKF---KMDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWE
KQIDMIEDMALGMVYLHGRK--VMHCDLK--------------------SSNVLIDENWNVKLCDFGLSRIKSTLNKKKNARKNEGLIGTPQWMAPEIMR
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DRRRIALDIARGVHYLHSSNPPIIHRDLKRQIKHKEKNLINIITLIKINSLNVLVDDNFRCKLTDFGWTRVKPQDNYMTNK------IGTYQWMAPEVIK
REQYQEHSDVYSFGMIMWEIATRKVPYLGLSHQQIYGTVGYDENYQVEIPVRGIPRYLNLMKKCLRRNPQERPTFQEVVEEIF
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AFYYTEKADVFSYSIILWEIASREPPYRNKKGDVVAEKV-MCNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
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| Kinase | 12330.AA | LRRK | 1008-1211 | 27 | 1.4e-54 | 187.69 | In-house | 81-363 (351) | Show / Hide |
Range on Protein: 1008-1211 Range on HMM: 81-363/351 Sequence Identity: 27% (81 aa) LDFGKKIGEGSYG-QVFKGTWAK----------------------------TQVAIKQFGK------------------------------QNSKFHLRK | ....||.|..| |....| . . ||||.. . ||. . .|. LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA VQDFISEVRVINNLRHPNIVLYMGVCFYQSQYFMITEYLQEGSLYDHLHIKH-TA-------FSEAKQIDMIEDMALGMVYLHGRK--VMHCDLKSSNVL . | || ....|.||||| .|.|. . . |..||.. |.||..|| |. .. .| .. . | || ||| .. . |.|||| |.| FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNIL I---D---------ENWNVKLCDFGLSR----IKSTLNKKKNARKNEGLIGTPQWMAPEIMR---REQYQEHSDVYSFGMIMWEIATRK-VPY . . .. ..|..|||.|| ..... | |. |.|.|||||||| .|.| | .|.||||||.||. ||. |. LWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAK--------GCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPF |
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| Kinase | 12330.AA | STE | 1008-1261 | 21 | 2.3e-54 | 186.94 | In-house | 1-350 (359) | Show / Hide |
Range on Protein: 1008-1261 Range on HMM: 1-350/359 Sequence Identity: 21% (77 aa) LDFGKKIGEGSYGQVFKGTWA------KTQ-----------VAIKQFGKQNSKF-------------HLRKVQDFISEVRVINNLR--HPNIVLYMGVCF ... .|||.|..|.|.|. ||. .|||| ..|.. . ..|... |... .... ||||| | | .| WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF YQ-------SQYFMITEYLQEGSLYDHLHIKH-------------TAFSEAKQIDMIEDMALG-MVYLHGRKVMHCDLKSSNVLIDENWNVKLCDFGLSR . .. ... ||. ||| | .. |. . |.| . .. . | . ||| ...| |.|..|.|. |||||||.. KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG IKSTLNKKK-----------NARKNEGLIGTPQWMAPEIMRR------EQYQEHSDVYSFGMIMWEIATRKVPYLG-LSHQQIYGTV--GYDEN-----Y . . . .. .. |. ..||| |||||.... .| . .|..|.| ..| || |.|. .. .. . .. .. . QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC QVEIPVRGIPR------------------------YLNLMKKCLRRNPQERPTFQE .|. | .| . ..|||...|..||| .. IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ |
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| Kinase | 12330.AA | LRRK | 1239-1268 | 26 | 4.8e-08 | 24.53 | In-house | 322-351 (351) | Show / Hide |
Range on Protein: 1239-1268 Range on HMM: 322-351/351 Sequence Identity: 26% (8 aa) PRYLNLMKKCLRRNPQERPTFQEVVEEIFK ..|..|...| .|..||.|...|. . HMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
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| Kinase | 12330.AA | LISK | 1239-1266 | 35 | 1.7e-05 | 13.63 | In-house | 269-296 (296) | Show / Hide |
Range on Protein: 1239-1266 Range on HMM: 269-296/296 Sequence Identity: 35% (10 aa) PRYLNLMKKCLRRNPQERPTFQEVVEEI | .| |. .| . .| .||.| |.|. . PPFLDLCFDCCKYDPKNRPSFKEIVQWL |
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