Gene ROCK (Sea Urchin)

ROCK

Species: Sea Urchin
Alias: Spk004, SPU_024526, ROCK
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: AGC
Family: DMPK
Subfamily: ROCK

Sequence

Name Sequence Type Origin Length Description Download
ROCK.AA Protein None 1540 None Fasta, JSON
ROCK.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of ROCK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ROCK.AA DMPK 72-334 66 6e-290 728.1 In-house 1-270 (270) Show / Hide 
Range on Protein: 72-334
Range on HMM: 1-270/270
Sequence Identity: 66% (179 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKRSDSAFYWEERDIMAHANSEWIVQLHYAFQDEKYLYMVMDYMPGGDLVNLMSNYE--IPEK
|...||||||.||||.|||......|||||...|.||.||...|..|||||||.|.||.||.|||||||||.||||||.|||||||..|||.||  |||.
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

WARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHLKLADFGTCMRMERDGMVRSDTAVGTPDYISPEVLKSQAGN--GQYGRECDWWSVGVFIYEM
.||||.||.|||...||.||..|||.||||||||..||.||||||.||.|.|||||||..|||||||||||||... ..  |.||.|||||||||..|||
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSCMKMNRDGMVRSKVAVGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEM

LVGDTPFYADSLVGTYSKIMDH-RNSLEFPDDIS--ISGPAKDLICKFLTDRDTRLGKNGIDEIKLHRFF
|.|.|||||||||.||.|||.| .|.|.|||| .  .|  ||||||..|.||..|||.||....| |.||
LYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGYEDFKCHPFF
Kinase ROCK.AA ROCK 72-334 85 1.5e-214 719.06 In-house 1-263 (263) Show / Hide 
Range on Protein: 72-334
Range on HMM: 1-263/263
Sequence Identity: 85% (226 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKRSDSAFYWEERDIMAHANSEWIVQLHYAFQDEKYLYMVMDYMPGGDLVNLMSNYEIPEKWA
|.|||||||||||||..||...||||||||.||||||||||||||.||||||||||||||||||||||||..|||||||||||||||||||||..|||||
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYDVPEKWA

RFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHLKLADFGTCMRMERDGMVRSDTAVGTPDYISPEVLKSQAGNGQYGRECDWWSVGVFIYEMLVGD
||||.|||||||||||||||||||||||||||..||||||||||||.|...||||.||||||||||||||||||...|.|||||||||||||||||||||
RFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTCMKMNKNGMVRCDTAVGTPDYISPEVLKSQGQDGEYGRECDWWSVGVFIYEMLVGD

TPFYADSLVGTYSKIMDHRNSLEFPDDISISGPAKDLICKFLTDRDTRLGKNGIDEIKLHRFF
||||||||||||||||||.|||.||||..|| .||||||||||||..|||.||.|.|| |.||
TPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDREQRLGRNGVDDIKQHKFF
Kinase ROCK.AA AGC 72-334 31 5.6e-177 462.26 In-house 1-395 (395) Show / Hide 
Range on Protein: 72-334
Range on HMM: 1-395/395
Sequence Identity: 31% (128 aa)

FQMIKVIGRGAFGEVKVVRER------TSKKVYAMKCLSKFE--------MIKRSDSAF-------YWEERDIMAHAN----------SEWIVQ-LHYAF
|...||||.|.||.|  ||..      ...|.||||.|.| .        |...  ...        ||||.|....|          . .||. |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDEKY--LYMVMDYMP--------GGDLVNLMSNY------EIPEKWARFYTAE-------VVLALDAIHS-MGFIHRD-VKPDNMLLDSSGHLKLADFG
||...  ||.||.|||        ||..  .....        .|..||||.||       .||||. .|| ||.|||| .||.|.|||. ||.||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

TCMRMERDG-------------------------------------------------MVRSDTAVG--TPDYISPEVLKSQAGNGQYGRECDWWS--VG
 | .. .||                                                 ..|  | .|  ||.|..||.|        ||..|||||  .|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL--------YGKACDWWSFGLG

VFIYEMLVGDTPFYADSLV----------GTYSKIMDHR----NSLEFP--------DDISISGPAKDLICKFLT-DRDTRLGKN-------GIDEIKLH
...||||.| .|||.|. .           .. |||..|    . ..||        .| ..|  ||||| |.|. |.. ||| .       |..||| |
CLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNH

RFF
 .|
PWF
Kinase ROCK.AA GEK 72-334 56 7.89999999999e-141 474.16 In-house 1-269 (269) Show / Hide 
Range on Protein: 72-334
Range on HMM: 1-269/269
Sequence Identity: 56% (152 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKRSDSAFYWEERDIMAHANSEWIVQLHYAFQDEKYLYMVMDYMPGGDLVNLMSNYE--IPEK
|...||||||||||| ||. . ...||||| | |.||.||.. | . ||||.. .  . || .||||||||.|||.||||  ||||. |.| .|  .||.
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

WARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHLKLADFGTCMRMERDGMVRSDTAVGTPDYISPEVLKS-QAGNGQYGRECDWWSVGVFIYEML
 |||| ||.|.|.|..| ....|||.||||.|||  ||..||||| |.||..||||.|  |||||||||||.|.  . |.|.||.||||||.||..||||
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMNKDGMVQSNVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEML

VGDTPFYADSLVGTYSKIMDHRNSLEFPDDIS---ISGPAKDLICKFLTDRDTRLGKNGIDEIKLHRFF
 |.|||||.||| ||.|||.|.. ..||..     .|  |||||.. .  ...|||.|||.. | | ||
YGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQDFKKHPFF
Kinase ROCK.AA CRIK 72-334 44 1.1e-122 393.08 In-house 1-272 (272) Show / Hide 
Range on Protein: 72-334
Range on HMM: 1-272/272
Sequence Identity: 44% (123 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKRSDSAFYWEERDIMAHANSEWIVQLHYAFQDEKYLYMVMDYMPGGDLVNLMSNYE--IPEK
|    .||.| ||.|.||||.    .|||| . | ..  . . .|  ||||||. .||.|. || |||||.  || .| |.|||||  ||. ..    | 
FEVKDLIGCGHFGQVQVVREKQTNDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDEN

WARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHLKLADFGTCMRMERDGMVRSDTAVGTPDYISPEVLKSQAGN----GQYGRECDWWSVGVFIY
 |||| || ..|.  .| ||..|||.||.| |.|  || ||||||    |.|...| |   ||||||. |||| .  |     | || .|||||.|.  |
MARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFGSAAKMNRNNHVNSKMPVGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAY

EMLVGDTPFYADSLVGTYSKIMD------HRNSLEFPDDISISGPAKDLICKFLTDRDTRLGKNGIDEIKLHRFF
|| .| |||  |. . |||.||.       .  | ||||  .|  . |||   |...  ||   .   .. | ||
EMMCGKTPFHEDNMHRTYSNIMNHCEESHFQRFLSFPDDPKVSPNYRDLIQSLLCNQSKRL---KYEQLCCHPFF
Kinase ROCK.AA S_TKc 72-334 33 1.4e-98 334.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 72-334
Range on HMM: 1-231/231
Sequence Identity: 33% (93 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKRSDSAFYWEERDIMAHANSEWIVQLHYAFQDEKYLYMVMDYMPG--GDLVNLMSNYE----
......||.||||.|. .|.. .....|.|...             . |..|. . . ..||.|...||| ..|||||.|..|  |||  .. ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---IPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHLKLADFGTCMRMERDGMVRSDTAVGTPDYISPEVLKSQAGNGQYGR-ECDWWSVG
   .|| .||||......||. .||.|.||||.||.| |||.  |.|..||| . ..        .| .|||.|..||||       .||. .|||||.|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCG

VFIYEMLVGDTPFYADSLVGTYSKIMDHRNSLEFPDDISISGPAKDLICKFLT-DRDTRLGKNGIDE----IKLHRFF
. .||||.| .||.   .  .. ||.              | .|||.|.| |. | . |..   . .    ||.| .|
CILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ROCK.AA RSK 75-334 37 4e-91 309.03 In-house 1-278 (278) Show / Hide 
Range on Protein: 75-334
Range on HMM: 1-278/278
Sequence Identity: 37% (106 aa)

IKVIGRGAFGEVKVVRER---TSKKVYAMKCLSKFEMIKRS-DSAFYWEERDIMAHAN-SEWIVQLHYAFQDEKYLYMVMDYMPGGDLVNLMSNYEI---
.|| |.|..|.| ..|.     ....|||| |.| ....|  | .  ..||.|... . .  ||.||||||.|..||..|.|..||.|    .. ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

-PEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDS---SGHLKLADFGTCMRMERDGMVRSDTAVGTPDYISPEVLK-SQAGNGQYGRECDWWSVG
  |. |.|| ||.|||.. .|. |.|||| ||.|.|.|.   .||.|| ||| |  .  |   . .| ..| .|. ||.||  . ..| ... ||||| |
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHDKACDWWSLG

VFIYEMLVGDTPFYA---DSLVGTYSKIMDHRNSLEFPDDISISGPAKDLICKFLT-DRDTRLG--KNGIDEIKLHRFF
| .||||.| .||..   ..   .  .|.  . ||..| . ..| .||||| | |. |   |||  .....||| | .|
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase ROCK.AA Akt 72-334 40 1.7e-87 279.77 In-house 1-264 (264) Show / Hide 
Range on Protein: 72-334
Range on HMM: 1-264/264
Sequence Identity: 40% (109 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVY-AMKCLSKFEMIKRSDSAFYWEERDIMAHANSEWIVQLHYAFQDEKYLYMVMDYMPGGDLVNLMSNYEI-PEK
|...||.|.|.|| |  |..  ..|.| ||| |.|   |..   .    || |  | |.  ||.|||.||....||.||||..||.| ....  .. .|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

WARFYTAEVVLALDAIHSMGFIHRD-VKPDNMLLDSSGHLKLADFGTCMRM-ERDGMVRSDTAVGTPDYISPEVLKSQAGNGQYGRECDWWS-VGVFIYE
 |||| ||..||... ||.. | ||  || | |.|. ||..|.||| | ..   |. .  .|  ||| |..||.|.   ||| ... .|||. .|...||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDK-TKTFCGTPEYLAPEILN---GNG-HTKAVDWWGSLGCVMYE

MLVGDTPFYADSLVGTYSKIMDHRNSLEFPDDISISGPAKDLICKFLT-DRDTRLG--KNGIDEIKLHRFF
|. |  |||..     . ||.   . ..||| . ||  .|||| . |. |.. |||  .|...||| | .|
MMCGRPPFYNQDHHQMFKKIK--NQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase ROCK.AA NDR 72-214 51 1e-82 254.87 In-house 1-149 (350) Show / Hide 
Range on Protein: 72-214
Range on HMM: 1-149/350
Sequence Identity: 51% (77 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKRSDSAFYWEERDIMAHAN--SEWIVQLHYAFQDEKYLYMVMDYMPGGDLVN---LMSNYEI
|..||.||.|||||| .||.. ....|||| . | ||...   |    |||||| |.  ..|.| | |.|||..||| ||.|.||||.     | ....|
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

-PEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHLKLADFG
 .| ||||| || |.|....|.||.||||.|||| |.|. ||.|| |||
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFG
Kinase ROCK.AA Pkinase 72-334 29 7.8e-71 246.44 Pfam 1-293 (293) Show / Hide 
Range on Protein: 72-334
Range on HMM: 1-293/293
Sequence Identity: 29% (90 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKRSDSAFYW-EERDIMAHANSEWIVQLHYAFQDEKYLYMVMDYMPGG----DLVNLMS---N
.. ...||.|.||.|.  ... . |..|.|...| .  .  | .  .  |  ||.. |.. ||.|...|.|....||||.|..||    ||  ..|   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

YEI--PEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHL----KLADFGTCMRMERDGMVRSDTAVGTPDYISPEVLKSQAGNGQYGRECDW
  .  .|. ..||  ... .|. .||||.||||.||.| |.|. ||.    |..||| .  ..    .  .| .|||.|..|||..   |.  ||...|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPKVDM

WSVGVFIYEMLVGDTPFYAD------SLVGTYSKIMDHRNSLEFPDDISIS-----------------GPAKDLICKFLT-DRDTRLGKNGIDEIKLHRF
||.|. .|||| | .||. .      .    . .||. ... ..| ..|||                  ..||.|.. |. |   |..   ...|. | .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPW

F
|
F
Kinase ROCK.AA MAST 72-214 43 9.3e-68 205.85 In-house 1-147 (337) Show / Hide 
Range on Protein: 72-214
Range on HMM: 1-147/337
Sequence Identity: 43% (65 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKR--SDSAFYWEERDIMAHANSEWIVQLHYAFQD--EKYLYMVMDYMPGGDLVNLMSNYE--
|  ||.|..||.| |  |. ..... .||| . .  .|..   |..|   ||.| . .  ...| . |.||   .|||.|||.|| |||   |...|   
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFV--ERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNC

IPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHLKLADFG
 ||  |..|.|| ||.|. .||.| .|||.||||||.|| ||.||.|||
MPEWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase ROCK.AA MAST 72-214 44 9.7e-66 210.78 In-house 1-144 (334) Show / Hide 
Range on Protein: 72-214
Range on HMM: 1-144/334
Sequence Identity: 44% (65 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKR--SDSAFYWEERDIMAHANSEWIVQLHYAFQDEKYLYMVMDYMPGGDLVNLMSNY-EIPE
|  ||.|..||.| |  |. ..... .||| . | .||..   |. .   ||.| | . ....| . |.|| ..||.|||.|| |||.  |...|   .|
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQV--ERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDE

KWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHLKLADFG
  |..|.||.||.|. .||.| .|||.||||||.||.|| ||.|||
WMAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase ROCK.AA NDR 230-334 44 2.4e-53 162.55 In-house 241-350 (350) Show / Hide 
Range on Protein: 230-334
Range on HMM: 241-350/350
Sequence Identity: 44% (50 aa)

AVGTPDYISPEVLKSQAGNGQYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHRNSL-----EFPDDISISGPAKDLICKFLT-DRDTRLGKN
.||||||. |||.. . |   |. .|||||.|.  |||||| .||..|.   |. |||. .. .     .|| .. .|  |.||| .... |.|.|||..
TVGTPDYMAPEVFQQKTG---YNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSH

G--IDEIKLHRFF
|  .|||| | ||
GKGVDEIKSHPFF
Kinase ROCK.AA MAST 231-334 43 6.4e-36 106.74 In-house 229-337 (337) Show / Hide 
Range on Protein: 231-334
Range on HMM: 229-337/337
Sequence Identity: 43% (49 aa)

VGTPDYISPEVLKSQAGNGQYGRECDWWSVGVFIYEMLVGDTPFYADSLVG-TYSKIMDHRNSLEFPDD--IS----ISGPAKDLICKFLT-DRDTRLGK
.||||||.|||.    | | ||   ||||.|. .|| ||| .|| .|.    . ..|  | . .|.|..  .     .|  |.||| |.|. .  .||| 
CGTPDYIAPEVI---LGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGA

NGIDEIKLHRFF
|| |||| |.||
NGADEIKQHPFF
Kinase ROCK.AA MAST 231-334 41 6.5e-34 106.46 In-house 225-334 (334) Show / Hide 
Range on Protein: 231-334
Range on HMM: 225-334/334
Sequence Identity: 41% (47 aa)

VGTPDYISPEVLKSQAGNGQYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHR-NSLEFPDD------ISISGPAKDLICKFLTD-RDTRLGK
.||||||.|||.. |   | .|   ||||.|. .|| ||| .||  |.   ....|  .. |  |.|..      . .| .|.||| |.|.    .||| 
CGTPDYIAPEVILGQ---GTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGA

N-GIDEIKLHRFF
| | ||.| |.||
NNGADEVKQHPFF
Kinase ROCK.AA TyrKc 72-313 20 2.9e-12 -24.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 72-313
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKRSDSAFYWEERDIMAHA--NSEWIVQLHYAFQDE-------KYLYMVMDYMPGGDLVNLMS
 ...|..|.||||||   . .   .| | |.| .         .|. .|  || .   . . ||.|. .  ..       . |..|| |||.||| .   
ITLGKKLGEGAFGEVYKGTWK--IQV-AVKMLKEDA-----REDFM-REARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NYE--IPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHLKLADFGTCMRMERD-------GMVRSDTAVGTPD-----YISPEVLKSQAGN
...  .. |    .   .    . .||...||||    | |... .. | .||| .   . |        . |. .  |. .       .||..      
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NY

GQYGRECDWWSVGVFIYEML-VGDTPFYA-----DSLVGTYSKIMDHRNSLEFPDD-----------------------ISISGPAKDLICKFL
| .  . | || || ..|..  |..| .       |    . ... ... .. |..                          . |    |....
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK-QGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase ROCK.AA Pkinase_Tyr 72-87 50 0.001913 12.29 Pfam 1-16 (270) Show / Hide 
Range on Protein: 72-87
Range on HMM: 1-16/270
Sequence Identity: 50% (8 aa)

FQMIKVIGRGAFGEVK
 ...|..|.||||||.
ITFGKKLGEGAFGEVY
Kinase ROCK.AA Pkinase_Tyr 132-159 38 0.004536 11.02 Pfam 66-96 (270) Show / Hide 
Range on Protein: 132-159
Range on HMM: 66-96/270
Sequence Identity: 38% (12 aa)

IVQLHYAFQ-DEKY--LYMVMDYMPGGDLVN
||.|. .   ...   .|.|| |||.||| .
IVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD
Kinase ROCK.AA Pkinase_Tyr 186-214 37 0.020521 8.8 Pfam 128-156 (270) Show / Hide 
Range on Protein: 186-214
Range on HMM: 128-156/270
Sequence Identity: 37% (11 aa)

HSMGFIHRDVKPDNMLLDSSGHLKLADFG
.|...||||.   | |...... | .|||
ESKNCIHRDLAARNCLVTENNVVKICDFG
Pkinase_C ROCK.AA Pkinase_C 354-399 31 5.5e-09 34.93 Pfam 1-46 (46) Show / Hide 
Range on Protein: 354-399
Range on HMM: 1-46/46
Sequence Identity: 31% (15 aa)

ELISDVDTSNFDEIEPEDHPEES-FQSPKTFAGNNLPFIGFTYNKSN
.. |. ||||||. . . .|...   ..  ..|...||.||||  ..
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
S_TK_X ROCK.AA S_TK_X 337-397 25 1.7e-07 32.16 SMART 1-79 (79) Show / Hide 
Range on Protein: 337-397
Range on HMM: 1-79/79
Sequence Identity: 25% (20 aa)

DMWTYDNIRN----TVPPVVPELI----SDVDTSNFDEIEPEDHPEESFQSPKTFAGNNLP----------FIGFTYNK
. .  |...|    . || .|..     |. ||||||. ..|  | .. ..|  ..... .          |.||||. 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Rho_Binding ROCK.AA Rho_Binding 1056-1074 42 4.316682 2.74 Pfam 1-19 (72) Show / Hide 
Range on Protein: 1056-1074
Range on HMM: 1-19/72
Sequence Identity: 42% (8 aa)

LQQDYHQLSNEKESLAAQL
|  |  .|.|||| |  ..
LTKDVANLANEKEELNNKM
Rho_Binding ROCK.AA Rho_Binding 1137-1205 41 2.2e-07 27.58 Pfam 1-72 (72) Show / Hide 
Range on Protein: 1137-1205
Range on HMM: 1-72/72
Sequence Identity: 41% (30 aa)

LNNRIMTLNTEKDELNKKLKESSEA-QEAMETK--HQEMEKQMEQNKKLLGEEKLKKEQAVSKLAEIMNRKD
|   .  |  || ||| |.|.  |  | . |..   ... .| | ..  |  |.. | ||| ||||||||||
LTKDVANLANEKEELNNKMKKQQEELQKLKEEEQQMNQIKAQFEKCRAKLQTERTLKTQAVNKLAEIMNRKD
PH ROCK.AA PH 1314-1516 9 2.9e-07 31.39 SMART 1-82 (82) Show / Hide 
Range on Protein: 1314-1516
Range on HMM: 1-82/82
Sequence Identity: 9% (19 aa)

GRLEGWLSLPGKNLRRHGWKKHFVEVSSKKILFYESEDQKAQKKPYLVLAIDKLFHVRAVTQGDVIRAEARDIPRIFQLLYAGEGENRRMVPDEANENPG
  .||||.  .    . .|||... . .. ...|...      ||  .. ....  ||  .                                       
VIKEGWLYKKS----K-RWKKRWFVLFNDCLYYYKDK------KPKGSIPLSDC-TVRE-P---------------------------------------

QDDEEGTIVHKNHKFTVVHFHMPTTCECCSKTLSHLVRPPPALECKLCRLKVHKEHYDKQEEFCPPCKVNIDAETAKHMLLMANSKEEQQRWIGKLGKQI
                                                                   ..    .    ... ..|.||.|.|.  . | |
-----------------------------------------------------------------CFEIHH-DR---TYYFQCESEEEMQEWMQAIQKAI

QDK
.. 
HNN
C1 ROCK.AA C1 1426-1477 24 3.1e-07 31.28 SMART 1-61 (61) Show / Hide 
Range on Protein: 1426-1477
Range on HMM: 1-61/61
Sequence Identity: 24% (15 aa)

HKFTVVHFHMPTTCECCSKTLSHLVRP---PPALECKLCRLKVHKEHYDKQEE-------FC
|..  . |  ||.|. | |..... ..   .....|  |..|.|| . ||  .        |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
PH ROCK.AA PH 1314-1392 20 1.9e-05 22.29 Pfam 1-63 (92) Show / Hide 
Range on Protein: 1314-1392
Range on HMM: 1-63/92
Sequence Identity: 20% (16 aa)

GRLEGWLSLPGKNLRRHGWKKHFVEVSSKKILFYESEDQKAQKKPYLVLAIDKLFHVRAVTQGDVIRAEARDIPRIFQL
 ..||||.. |   .| .|||... . ......|....    ..|  .. ....  |. |. .        . | .||.
VIKEGWLHKKG---KRKSWKKRWFVLFNNCLYYYKDDK----YRPKGSIPLSDC-QVTKVPDN--------KRPHCFQI
C1_1 ROCK.AA C1_1 1426-1468 22 0.000959 17.4 Pfam 1-43 (55) Show / Hide 
Range on Protein: 1426-1468
Range on HMM: 1-43/55
Sequence Identity: 22% (10 aa)

HKFTVV-HFHMPTTCECCSKTLSH-LVRPPPALECKLCRLKVHKE
|.. .  .| .|| |. | . ... | .  ... |  | ...|..
HHWVHHWNFKQPTFCCHCGEFCWGWLGH--QGWKCQWCHYNCHHR
PH ROCK.AA PH 1490-1514 20 0.376647 6.8 Pfam 68-92 (92) Show / Hide 
Range on Protein: 1490-1514
Range on HMM: 68-92/92
Sequence Identity: 20% (5 aa)

KHMLLMANSKEEQQRWIGKLGKQIQ
.  .. |.| || ..|.  . . . 
RTYYFQAESEEEMNDWMQAIQSACR