Gene MAST2 (Sea Urchin)

MAST2

Species: Sea Urchin
Alias: SPU_022164, MAST2, Spk009
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: AGC
Family: MAST
Subfamily: MAST

Sequence

Name Sequence Type Origin Length Description Download
MAST2.AA Protein None 1246 None Fasta, JSON
MAST2.kin_dom Protein Kinase Domain None 274 None Fasta, JSON

Protein domain

Protein domains of MAST2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF1908 MAST2.AA DUF1908 14-89 52 3e-31 113.64 Pfam 1-94 (369) Show / Hide 
Range on Protein: 14-89
Range on HMM: 1-94/369
Sequence Identity: 52% (49 aa)

PLESPR-VPIHPHAHFAFNSVR-------QADGRRWSLASLPSSGYGTNTPSSAVS------ERL----HQLPYQPTPEDLQLLSQHFSSSESN
|..||| .     ..|.|  .|       .|||||||.|||||||||||.||| ||      |||    ||||.||| .||..||.||...|||
PIDSPRNFSTSSMMNFPFVPIRRITNCRDRADGRRWSVASLPSSGYGTNPPSSNVSSQCSSQERLNQLPHQLPFQPTQDDLHFLSKHFCCTESN
DUF1908 MAST2.AA DUF1908 92-241 44 7.7e-50 176.7 Pfam 168-323 (369) Show / Hide 
Range on Protein: 92-241
Range on HMM: 168-323/369
Sequence Identity: 44% (70 aa)

GDQED----GRRSPSCRPRSRSL-SGASSPLVGSTDHEMLHMNSLYKERFPKAKQQMETKLTDFINKYS--MDMSQEGHDAIYAFLVHQTVELARDCLEK
.. ||    |.|||  ||||||| |   |. .   | |   || .|||||||| |||| .| .||....   . |    | .  |  || ||.|||||.|
CQDEDNNFCGCRSPHHRPRSRSLSSPSRSCIT--FDNEIVMMNHVYKERFPKATQQMEERLQHFIHHFKNIPCDSLRLADPVVRFIHHQVVEMARDCLHK

SQEDQVSHIYFTEVSHKVQMLAEDAENRS-QVSAKSFTRVVRDLLMILARPARLLECL
|..  .   || | . |   |  .| .||    .   | |.. ||.| .|||||||||
SHAKLITSRYFYEMQEKLERLLHEAHERSESEEVPFITHVIKKLLIIISRPARLLECL
Kinase MAST2.AA MAST 258-531 51 1.7e-220 681.3 In-house 1-337 (337) Show / Hide 
Range on Protein: 258-531
Range on HMM: 1-337/337
Sequence Identity: 51% (175 aa)

FENIKIISNGAYGAVYLVRHKASLQRFAMKKICKQNIALRNQREQVFAERDILTFAENPFVVALYCSFET--KKYLCMVMEYVEGGDVATLIKHIG-PLP
||.||.||.|||||||||.|| . .|||||.|..|.....|| .|||.||.|||...||||| ...||.|  ||||||||||.||||.|.|....| ..|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

LETARLYFAEAVLAIEYLHSYGIVHRDIKPDNMLITSTGHIKLTDFGLSKIGIMSLTTNLYEG---------------NIDRDTKQFQ------------
 . |..|.|| ||..||||||||||||.|||||||.|.||||||||||||.|.|..|||.|||               .|.....|||            
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGKNHFNEYHIQKNYQQFQQDFGINGNTNKN

------------------------DQQVCGTPQYIAPEVILRQG-YGKPVDWWSMGVVLYEILVGCPPFFGETPEE-LFAQTIN--VMIEWPDG-----D
                        ..|.||||.||||||||.|| |||||||||||...||.|||||||.|.|||| .|...||   .||||..     |
QIQQQQEQPQCQQQNEMRPHNIHQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDD

DALSDEAMELINGFLQQDPLFRLGTGGSEDVKGHRFF
|..|.||..||. .||..|. |||..|....| |.||
DCMSPEAQDLIKKLLQPNPKKRLGANGADEIKQHPFF
Kinase MAST2.AA MAST 258-531 49 7.29999999999e-203 660.23 In-house 1-334 (334) Show / Hide 
Range on Protein: 258-531
Range on HMM: 1-334/334
Sequence Identity: 49% (164 aa)

FENIKIISNGAYGAVYLVRHKASLQRFAMKKICKQNIALRNQREQVFAERDILTFAENPFVVALYCSFETKKYLCMVMEYVEGGDVATLIKHIGPLPLET
|| ||.||.||||.||||.|| . .|||||.|.|.. ...|. .||..||.||....||||| ...||.||.||||||||.||||.|.|....|... ..
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

ARLYFAEAVLAIEYLHSYGIVHRDIKPDNMLITSTGHIKLTDFGLSKIGIMSLTTNLYEG---------------NIDRDTKQFQ---------------
|..|.|| ||..|||||.||||||.|||||||.|.||||||||||||.|.|......|||               ....|..||.               
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQ

--------------------DQQVCGTPQYIAPEVILRQG-YGKPVDWWSMGVVLYEILVGCPPFFGETPEELFAQTINVM---IEWPDG-----DDALS
                    ..|.||||.||||||||.|| .||||||||||...||.|||||||...||||.|....| .   ||||.|     |.|.|
QQQEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMS

DEAMELINGFLQQDPLFRLGTG-GSEDVKGHRFF
 ||..||. .||.||. |||.. |...|| |.||
PEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase MAST2.AA AGC 258-531 30 1.4e-165 432.08 In-house 1-395 (395) Show / Hide 
Range on Protein: 258-531
Range on HMM: 1-395/395
Sequence Identity: 30% (122 aa)

FENIKIISNGAYGAVYLVRHK------ASLQRFAMKKICKQN--------IALRNQREQ-------VFAERDILTFAE----------NPFVVA-LYCSF
|| .|.|. |..| |||||.|      .. . .|||.. |.            ....|.       |..||.||. .           .||.|  |..||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETKKY--LCMVMEYVE---------GG-DVATLIK---HIGPLPLETARLYFAE-------AVLAIEYLHS-YGIVHRD-IKPDNMLITSTGHIKLTDFG
..|..  |..||||..         || .  . ..   . | .. |.|| |.||        |||.|||||  ||.||| .||.|.|... |||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKIGIMS-----------LTTNLYEG---------------NIDRDT----------KQFQDQQVCG--TPQYIAPEVILRQGYGKPVDWWS--MGVVL
|.|.|...           .... ...               |..|.           |... .  ||  ||.|.|||..    |||..||||  .|...
LCKEGMNDGEKGQQSQSNMKFHW-HNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLM

YEILVGCPPFFGETPE----------ELFAQTI------NVMIEWP-------DGDDALSDEAMELINGFLQQDPLFRLGTG-------GSEDVKGHRFF
|| |.|.|||.|..|.          |.| . .      |  ...|       ..|. .|.||. ||...|. ||  |||.|       | |..| | .|
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase MAST2.AA S_TKc 258-531 34 3.3e-96 326.85 SMART 1-231 (231) Show / Hide 
Range on Protein: 258-531
Range on HMM: 1-231/231
Sequence Identity: 34% (98 aa)

FENIKIISNGAYGAVYLVRHKASLQRFAMKKICKQNIALRNQREQVFAERDILTFAENPFVVALYCSFETKKYLCMVMEYVEG--GDVATLIKHIGP---
.| ...|  ||.| ||..||| . ...|.|.|           |..  |..||     |..| || .|.. ..|.|||||..|  ||. ..||. |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPLETARLYFAEAVLAIEYLHSYGIVHRDIKPDNMLITSTGHIKLTDFGLSKIGIMSLTTNLYEGNIDRDTKQFQDQQVCGTPQYIAPEVILRQGYG
   .|  .|| |... ..|.||.|| ||.|||.||.| |...  |||..||||...                         .|||| |.||||.   |||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------------TTFCGTPWYMAPEVL---GYG

K-PVDWWSMGVVLYEILVGCPPFFGETPEELFAQTINVMIEWPDGDDALSDEAMELINGFLQQDPLFRLGTGGSED----VKGHRFF
| ..|||| |..||| |.|.|||   .....| .               |.|| ..|.. || ||  |..          .| | .|
KCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAST2.AA SGK 258-531 37 2.8e-92 285.23 In-house 1-283 (283) Show / Hide 
Range on Protein: 258-531
Range on HMM: 1-283/283
Sequence Identity: 37% (112 aa)

FENIKIISNGAYGAVYLVRHKAS------------------LQRFAMKKICKQNIA-------LRNQREQVFAER-DILTFAENPFVVALYCSFETKKYL
|. .|.|  | .| ||.|.||.                    . .||| . || |         ...   . ||| .||     || | |  .| ||..|
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CMVMEYVEGGDVATLIKHIGPLPLETARLYFAEAVLAIEYLHSYGIVHRDIKPDNMLITSTGHIKLTDFGLSKIGIMSLTTNLYEGNIDRDTKQFQDQQV
 .||.||.||.    ..  . .|   || | || |.|.|||||  |..|| ||.| |  . ||..||||||.| ||   .|          |. |     
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDT----------TFTF-----

CGTPQYIAPEVILRQGYGKPVDWWSMGVVLYEILVGCPPFFGETPEELFAQTINVMIEWPDGDDALSDEAMELINGFLQQDPLFRLGTG-GSEDVKGHRF
|||| | ||||.. |.... ||||..| |||| ..| |||.    .... . ||  .  | .    | .| .||.| || ||  ||||  .....| | |
CGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQ---MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPF

F
|
F
Kinase MAST2.AA AktR 258-531 36 3.3e-90 305.98 In-house 1-268 (268) Show / Hide 
Range on Protein: 258-531
Range on HMM: 1-268/268
Sequence Identity: 36% (105 aa)

FENIKIISNGAYGAVYLVRHK-ASLQRFAMKKICKQNIALRNQREQVFAERDILT-FAENPFVVALYCSFETKKYLCMVMEYVEGGDVATLIKHIGPLPL
|. .|.. .||.| ||||..|  . . .||| | |..|  |||....  ||.|.   . .|| | |. .|.||..|  .|||..||.  . .|... .  
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

ETARLYFAEAVLAIEYLHSY-GIVHRDIKPDNMLITSTGHIKLTDFGLSKIGIMSLTTNLYEGNIDRDTKQFQDQQ------VCGTPQYIAPEVILR-QG
|.|| |||. .||.||||.   |. ||.||.| |. . ||.|.|||||||                    ||..        .||||.|.|||.|.. .|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK-------------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKG

YGKPVDWWSMGVVLYEILVGCPPFFGETPEELFAQTINVM-IEWPDGDDALSDEAMELIN-GFLQQDPLFRLG--TGGSEDVKGHRFF
..|.||||. |...||...|||||. .  ...|   .. . .. |.  . .|.....||. . |...|  |||  . | |..| | .|
HNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSY-FSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase MAST2.AA RSK-Unclassified 258-531 36 4.7e-85 267.05 In-house 1-283 (283) Show / Hide 
Range on Protein: 258-531
Range on HMM: 1-283/283
Sequence Identity: 36% (104 aa)

FENIKIISNGAYGAVYLVRHKASLQRFAMKKICKQNIALRNQREQVFAERDILTFAENPFVVALYCSFETKKYLCMVMEYVEGGDVATLIK--HIGPLPL
|. .. |  |  | ||||| | . | .|||   |. .  .|    |  |..|.   . ||.| || || |. || ..|||  |||            .  
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

ETARLYFAEAVLAIEYLHSYGIVHRDIKPDNMLITSTGHIKLTDFGLSKIG------IMS--LTTNLYEGNIDRDTKQFQDQQVCGTPQYIAPEVILRQG
. .| | .| ..| ||||  ... || |||| .    ||..||||.||. .      .|       . .  |  .   |  .  |||  |.|||.| | |
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHG--FRTNSFCGTEEYLAPEMIRRCG

YGKPVDWWSMGVVLYEILVGCPPFFGETPEELFAQTINVMIEWPDGDDALSDEAMELINGFLQQDPLFRLGTG-G-SEDVKGHRFF
 .| |||| .|.|.||.|.||||. |.  .|.|       .  |. |  .| .. .||   ||. |  ||| . |  .|.| | ||
HTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPH-DSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase MAST2.AA RSK 261-531 34 9.6e-85 287.84 In-house 1-278 (278) Show / Hide 
Range on Protein: 261-531
Range on HMM: 1-278/278
Sequence Identity: 34% (100 aa)

IKIISNGAYGAVYLVRHK---ASLQRFAMKKICKQNIALRNQ-REQVFAERDILTFAE-NPFVVALYCSFETKKYLCMVMEYVEGGDVATLIKHIGP---
.|    |.||.|.|.| .   .. | .||| . |  |. |.   . ...||.||   .  ||.| |. .|.|...| ..|||..||.  | ... .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPLETARLYFAEAVLAIEYLHSYGIVHRDIKPDNMLITS---TGHIKLTDFGLSKIGIMSLTTNLYEGNIDRDTKQFQDQQVCGTPQYIAPEVIL----R
.  ..|. |.|| |||.|.||. ||.|||.||.|.| ..    |||||||||..|..  . .  ..                |.| .|.|||..     .
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMT--------------FCYTIEYMAPEMLKRANQQ

QGYGKPVDWWSMGVVLYEILVGCPPFFG---ETPEELFAQTINVMIEWPDGD--DALSDEAMELINGFLQQDPLFRLG--TGGSEDVKGHRFF
 |..| .|||| ||..|| |.||||| |   ....|....  .  .  ....  . ||.|| .||.. |. ||  |||   .. |..| | .|
GGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFS-LTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MAST2.AA NDR 258-407 50 5.5e-75 230.55 In-house 1-155 (350) Show / Hide 
Range on Protein: 258-407
Range on HMM: 1-155/350
Sequence Identity: 50% (79 aa)

FENIKIISNGAYGAVYLVRHKASLQRFAMKKICKQNIALRNQREQVFAERDILTFAE--NPFVVALYCSFETKKYLCMVMEYVEGGDVAT---LIKHIGP
|| ||||. ||.| |.|||.| . . .|||.. |. .  .||  .| |||||.. |   ||.|| ||.||  |.||. ||||. |||  |   |..  . 
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

LPLETARLYFAEAVLAIEYLHSYGIVHRDIKPDNMLITSTGHIKLTDFGLSKIGI
.. . || | || |.|||..|..|..|||||||| || . ||||||||||.. |.
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGM
Kinase MAST2.AA Pkinase 258-531 30 5.7e-75 260.18 Pfam 1-293 (293) Show / Hide 
Range on Protein: 258-531
Range on HMM: 1-293/293
Sequence Identity: 30% (94 aa)

FENIKIISNGAYGAVYLVRHKASLQRFAMKKICKQNIALRNQREQVF-AERDILTFAENPFVVALYCSFETKKYLCMVMEYVEGG----DVATLIK--HI
.. ...|  |..| ||. .|| . ...|.|.|.|...    ... .  .|  |.     |..| ||..||.|....|||||.|||    | ...|.    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GPL--PLETARLYFAEAVLAIEYLHSYGIVHRDIKPDNMLITSTGHI----KLTDFGLSKIGIMSLTTNLYEGNIDRDTKQFQDQQVCGTPQYIAPEVIL
|..  . .... |. . . ..||.|| ||.|||.||.| || ..|||    |..||||.|                   ..   . .|||| |.|||||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--------------Y-NNS-MTTFCGTPWYMAPEVIR

-RQGYGKPVDWWSMGVVLYEILVGCPPFFGE------TPEELFAQTIN--VMIEWPDGDD----------------ALSDEAMELINGFLQQDPLFRLGT
 .|.||..||.||.|..||| | | ||| |.      .. ......    .. .||  ..                ..|.|. ..|.. |..||  |.. 
GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-

GGSEDVKGHRFF
   |... | .|
--AEQILQHPWF
Kinase MAST2.AA Akt 258-409 40 4.6e-54 171.17 In-house 1-154 (264) Show / Hide 
Range on Protein: 258-409
Range on HMM: 1-154/264
Sequence Identity: 40% (63 aa)

FENIKIISNGAYGAVYLVRHKASLQRF-AMKKICKQNIALRNQREQVFAERDILTFAENPFVVALYCSFETKKYLCMVMEYVEGGDVATLIKHIGPLPLE
|. .|..  |..| |.||. |.. . . ||| . |. |  .|| |....|| ||    .||.| |. || |...|..||.|. ||.  ..... .  . .
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

TARLYFAEAVLAIEYLHSYGIVHRD-IKPDNMLITSTGHIKLTDFGLSKIGIMS
.|| | || .||||.||| .|. ||  || | |. ..|||.||||||.| .|..
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIK
Kinase MAST2.AA PKA 258-404 44 8.9e-51 175.01 In-house 1-149 (263) Show / Hide 
Range on Protein: 258-404
Range on HMM: 1-149/263
Sequence Identity: 44% (67 aa)

FENIKIISNGAYGAVYLVRHKASLQRFAMKKICKQNIALRNQREQVFAERDILTFAENPFVVA-LYCSFETKKYLCMVMEYVEGGDVATLIKHIGPLPLE
|| |. . .| .| |.|.||| | . .||| . || |  ..| | |  |. ||.  ..||.|  .| .| . .|| ||||||.||.. . . . | ..  
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

TARLYFA-EAVLAIEYLHSYGIVHRDIKPDNMLITSTGHIKLTDFGLSK
.|..| | . |||.|||||  |..|| || | || . ||||.|||| .|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAK
Kinase MAST2.AA NDR 433-531 42 2.3e-42 128.04 In-house 243-350 (350) Show / Hide 
Range on Protein: 433-531
Range on HMM: 243-350/350
Sequence Identity: 42% (46 aa)

GTPQYIAPEVILR-QGYGKPVDWWSMGVVLYEILVGCPPFFGETPEELFAQTINVMIEW-----PDGDDA-LSDEAMELINGFLQQDPLFRLG-TG-GSE
|||.|.||||... .||.. .|||| |...|| ||| |||...||.| .   .|  . |      .. .| ||.||  ||  ..  ||  |||  | | .
GTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVD

DVKGHRFF
..| | ||
EIKSHPFF
Kinase MAST2.AA Akt 431-531 39 1.6e-36 114.19 In-house 162-264 (264) Show / Hide 
Range on Protein: 431-531
Range on HMM: 162-264/264
Sequence Identity: 39% (41 aa)

VCGTPQYIAPEVILRQGYGKPVDWWS-MGVVLYEILVGCPPFFGETPEELFAQTINVMIEWPDGDDALSDEAMELINGFLQQDPLFRLG--TGGSEDVKG
.|||| |.|||... .|..|.||||.  |.|.|| . | |||. .  ...| .  |  .. ||  |..|.|.  ||.| |. ||  |||   .. ...| 
FCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDK-DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKR

HRFF
| .|
HPWF
Kinase MAST2.AA PKA 431-531 38 5.3e-33 115.95 In-house 158-263 (263) Show / Hide 
Range on Protein: 431-531
Range on HMM: 158-263/263
Sequence Identity: 38% (42 aa)

VCGTPQYIAPEVILRQ-GYGKPVDWWSMGVVLYEILVGCPPFFGE--TPEELFAQTINVMIEWPDGDDALSDEA---MELINGFLQQDPLFRLGT--GGS
.||||.|.|||.|..  |.||.||||. |.. || |.| |||. .  .| ...   .|  |..|  .|     |     ||.  || |.  |.|.  .|.
LCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFDS---DANYFKDLIKKLLQVDLTKRYGNMKNGV

EDVKGHRFF
.|.| |..|
NDIKNHKWF
Kinase MAST2.AA TyrKc 258-531 21 1.5e-12 -19.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 258-531
Range on HMM: 1-280/280
Sequence Identity: 21% (66 aa)

FENIKIISNGAYGAVYLVRHKASLQRFAMKKICKQNIALRNQREQVFAERDILTFA--ENPFVVALYCSFETK-------KYLCMVMEYVEGGDVATLI-
 . .|.. .||.| ||. . |   .  | |.. .        ||    |  |..    ..| .|.||    ..       . |..||||...||    . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KHIGPLPLETARLYFAEAVLAIEYLHSYGIVHRDIKPDNMLITSTGHIKLTDFGLSKIGIMSLTTNLYEG-NIDRDTKQFQDQQVC----GTPQ-----Y
|| . |....   .   .    ||||| ...|||.   | |... ...| .|||||.        ..|.. .        .|  .     |.        
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSR--------DIYDDDQQG----ESKDYYRKKEHKGGKTMLPIRW

IAPEVILRQGYGKPVDWWSMGVVLYEILVGCPPFFGE------TPEELFAQTINVMIEWPDGDDA------LSDEAMELINGFLQQDPLFRLGTGGSEDV
 |||.|    .    | || ||...||.  . .   .      ...|....  . .   .  .|        .||  ...    . ||  |      ...
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP---TFSEI

KGHRFF
  |..|
--HECF
Kinase MAST2.AA Pkinase_Tyr 330-404 29 1.4e-08 29.7 Pfam 81-159 (270) Show / Hide 
Range on Protein: 330-404
Range on HMM: 81-159/270
Sequence Identity: 29% (23 aa)

YLCMVMEYVEGGDVATLIKH----IGPLPLETARLYFAEAVLAIEYLHSYGIVHRDIKPDNMLITSTGHIKLTDFGLSK
....||||...||  .  .      .||....   . ..   . |||.| ...|||.   | |.|.....| .||||..
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase MAST2.AA S_TK_X 532-591 20 6.1e-05 18.88 SMART 1-79 (79) Show / Hide 
Range on Protein: 532-591
Range on HMM: 1-79/79
Sequence Identity: 20% (17 aa)

QGVDWNGLLR----QKADFIPQLE----GEDDTSYFD--ARSERYNHELDSDDDEDIPEIGN------------FSTFSPRF
 |.||..|..     .. |.|..     .. |||.||    .|      ...||. . .. .            |  |. .|
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM---LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase MAST2.AA Pkinase_Tyr 439-482 32 3.82594 1.11 Pfam 182-227 (270) Show / Hide 
Range on Protein: 439-482
Range on HMM: 182-227/270
Sequence Identity: 32% (15 aa)

APEVILRQGYGKPVDWWSMGVVLYEILVGC-PP-FFGETPEELFAQ
|||.|    .    | || ||...||.  .  | . | ..||....
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEY
PDZ MAST2.AA PDZ 884-961 20 2e-12 48.55 SMART 1-80 (80) Show / Hide 
Range on Protein: 884-961
Range on HMM: 1-80/80
Sequence Identity: 20% (19 aa)

KTMGFHMQAIKVYLGESNIYTLHHLVRHVEEGSPAYEAG------LRPGDLVTHINN-APVEGLIHREIVELIMS--------DTQVVIHAVP
. .|| ..              .... .|..|.||. ||      ||||| .. .|.  |||.. | ..|... .          ....   .
GGLGFSIVG-------------GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG
PDZ MAST2.AA PDZ 909-956 23 8e-06 22.53 Pfam 31-81 (86) Show / Hide 
Range on Protein: 909-956
Range on HMM: 31-81/86
Sequence Identity: 23% (12 aa)

VRHVEEG-SPAYEAG-LRPGDLVTHINNAPVEGLIHREIVELIMSDTQ-VV
. .| .| ..|  .| ...|| .. ||. ..... | ..|..|..  . .|
ISEVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEV