Gene RSK1 (Sea Urchin)
RSK1
Sequence
Protein domains of RSK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | RSK1.AA | RSK | 1-45 | 51 | 8.7e-26 | 89.11 | In-house | 220-271 (271) | Show / Hide |
Range on Protein: 1-45 Range on HMM: 220-271/271 Sequence Identity: 51% (27 aa) AKLGM-------PQFLSAEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF .|||| ..|.|.||..||||...|.|.|||||||||...||.|..| IKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF |
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| Kinase | RSK1.AA | AGC | 2-45 | 30 | 6.4e-24 | 57.34 | In-house | 337-395 (395) | Show / Hide |
Range on Protein: 2-45 Range on HMM: 337-395/395 Sequence Identity: 30% (18 aa) KLGMP----------QFLSAEAQSLLRMLFKRNPQNRLGAGPN-----GINDIKSHAFF |. .| ...| ||..|...|....| .|||.|.| |...||.| .| KVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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| Kinase | RSK1.AA | RSK | 1-45 | 44 | 3.1e-21 | 74.6 | In-house | 230-278 (278) | Show / Hide |
Range on Protein: 1-45 Range on HMM: 230-278/278 Sequence Identity: 44% (22 aa) AK--LGMP--QFLSAEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF .| |.|| |.||.||..|.|....|.|..|||.||.....||.|..| GKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | RSK1.AA | Ciliate-E2 | 9-45 | 21 | 1.4e-08 | 25.59 | In-house | 329-365 (365) | Show / Hide |
Range on Protein: 9-45 Range on HMM: 329-365/365 Sequence Identity: 21% (9 aa) LSAEAQSLLRM----LFKRNPQNRLGAGPNGINDIKSHAFF .| |.. |.. .....|..|.. |...|. | .| WSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF |
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| Kinase | RSK1.AA | Ciliate-E2-Unclassified | 9-45 | 18 | 1e-06 | 18.8 | In-house | 317-352 (352) | Show / Hide |
Range on Protein: 9-45 Range on HMM: 317-352/352 Sequence Identity: 18% (7 aa) LSAEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF .| ||. ... |.......... . ....|. | .| WSPEAKDFINDLLQKMLKKNPNKRI-TFEQILNHPWF |
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| Kinase | RSK1.AA | MSK | 10-40 | 29 | 7.4e-05 | 12.34 | In-house | 247-277 (277) | Show / Hide |
Range on Protein: 10-40 Range on HMM: 247-277/277 Sequence Identity: 29% (9 aa) SAEAQSLLRMLFKRNPQNRLGAGPNGINDIK |..|. |.. | ..|. |||... . . .| SPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK |
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| Kinase | RSK1.AA | CAMKL | 6-45 | 22 | 0.000717 | 8.07 | In-house | 264-297 (297) | Show / Hide |
Range on Protein: 6-45 Range on HMM: 264-297/297 Sequence Identity: 22% (9 aa) PQFLSAEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF . ..| ....|.| . ..|| | | .|..| .. WYHVS-DCRDLIRKMLQVNPEKRP-----TIHQIMNHPWM |
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| Kinase | RSK1.AA | CAMK | 6-45 | 22 | 0.003563 | 5.28 | In-house | 392-425 (425) | Show / Hide |
Range on Protein: 6-45 Range on HMM: 392-425/425 Sequence Identity: 22% (9 aa) PQFLSAEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF . |.|.|...|.| . ...|..|. | ....| .. H-FVSQECKDLIRKMLQVDPEKRM-----TIEQCLNHPWM |
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| Kinase | RSK1.AA | Pkinase | 9-45 | 18 | 0.005794 | 11.56 | Pfam | 262-293 (293) | Show / Hide |
Range on Protein: 9-45 Range on HMM: 262-293/293 Sequence Identity: 18% (7 aa) LSAEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF .| |...... .....|. |.. . .|. | .| WSEECKDFIKWCLCKDPKKRPT-----AEQILQHPWF |
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| Kinase | RSK1.AA | RSK | 143-397 | 55 | 1.9e-182 | 612.43 | In-house | 4-271 (271) | Show / Hide |
Range on Protein: 143-397 Range on HMM: 4-271/271 Sequence Identity: 55% (149 aa) XQDIGLGSYS---VCKRCTHKATGQDYAVKIIKKNTKDVR-----EEIEILLRYGHHSNVITLRDVFDDGQNVYMVMELMRGGELLDRLLKQKFLSEREA ..|| ||.| |||.|.||.|.|.||.|||||.|.||. ||..|.||||||.....|..||.|...|||.|..||||.|.|||||||..||||. HECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSEREV CEIMLTVTRTMDFLHQQKVVHRDLKPSNILYADETYSPGTLRIADFGFAKQMRADNGMLMTPCYTANFVAPEVLKKQGYDAACDIWSLGVILYTMLAGFT ...|......|..||.|..|||||||.||||.||...||...|.|||||||.|..||||||.|||||..||||||.||.|.|||.||.||..|.||.|.| KFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLTGCT PFVHKPDDSSKVILARIQEGKYTMNGGNWDNISDRAKDLISRMLHVDPFQRPST-----KQVLQHTWF ||..||.|. ..|..||..|...|..||||.|||.||||...|||.||..|... .|..||.|| PFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF |
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| Kinase | RSK1.AA | RSK | 142-397 | 42 | 1.1e-150 | 506.95 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 142-397 Range on HMM: 1-278/278 Sequence Identity: 42% (120 aa) XXQD--IGLGSYSVCKRCTHKATGQDYAVKIIKKNTKDVR--------EEIEILLRYGHHSNVITLRDVFDDGQNVYMVMELMRGGELLDRLLKQKF--- .. .| |....|..|||..||| ||.|..||.. ..| .|..||.|...| ...|| ..|.... .|..||..|||||...|.|.|. LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC LSEREACEIMLTVTRTMDFLHQQKVVHRDLKPSNILYADETYSPGTLRIADFGFAKQMRAD-NGMLMTPCYTANFVAPEVLK---KQG-YDAACDIWSLG .||.|||..| ... ....||||...||||||.||||.||. ..|.... ||||.||.|.| |...||.|||....|||.|| .|| .|.|||.|||| FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG VILYTMLAGFTPFVHKPDD-SSKVILARIQEGKYTMNGGNWDNISDRAKDLISRMLHVDPFQRPS-----TKQVLQHTWF |..|.||.|..|| . |.| ..|.|..|||.||......||...|. |||||..|||.|| .|.. .....|| || VLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | RSK1.AA | CAMK1 | 146-397 | 38 | 1.8e-111 | 325.31 | In-house | 7-276 (276) | Show / Hide |
Range on Protein: 146-397 Range on HMM: 7-276/276 Sequence Identity: 38% (105 aa) IGLGSYSVCKRCTHKAT---GQDYAVKII--KKNTKD--------VREEIEILLRYG--HHSNVITLRDVFDDGQNVYMVMELMRGGELLDRLLKQKFLS || |. |. ..|||| | |..||.|.| ||..| .. ||||. . . .| |.| . ..... .|.||||. ||||.|| .. .. . IGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVEKGNYT EREACEIMLTVTRTMDFLHQQKVVHRDLKPSNILYADETYSPG-TLR--IADFGFAKQMRADNGMLMTPCYTANFVAPEVLKK---QGYDAACDIWSLGV |..|..|| . ..|.. .||||||| |.||.|. ... ... ||||| .|. |.... |.| | .||||||. ..|| |||.|| || EKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDK--DEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGV ILYTMLAGFTPFVHKPDDS-SKVILARIQEGKYTMNGGNWDNISDR-AKDLISRMLHVDPFQRPSTKQVLQHTWF |.|..| |. || |.. . ... | ...|.. |||||| |||.|. || ||| .|.. .|.|.| |. ITYILLCGYPPFY---DENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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| Kinase | RSK1.AA | AGC | 146-397 | 22 | 4.90000000001e-108 | 279.87 | In-house | 7-395 (395) | Show / Hide |
Range on Protein: 146-397 Range on HMM: 7-395/395 Sequence Identity: 22% (88 aa) IGLGSYSVCKRCTHK------ATGQDYAVKIIKKNT----------KDVREE------------IEILLRYGH---------HSNVIT-LRDVFDDGQN- || ||.. . . .| .||. ||.|..|| . . . | .|| .. | | ... | | | .. IGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHT -VYMVMELMR---------GG-ELLDRLL---KQKFLSEREACEIMLT-------VTRTMDFLHQ-QKVVHRD-LKPSNILYADETYSPGTLRIADFGFA .|.|||.| || ||. .| |.. ..| .|. .. .. ...||. ....||| ||| ||| .. | ....|||.. YLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED----GHIKLTDFGLC KQMRAD-----------------------------------------------------NGMLMTPCYTANFVAPEVLKKQGYDAACDIWS--LGVILYT |... | . . || |....|||.| |. |||.|| ||...| KEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC-TPEYMAPEIL----YGKACDWWSFGLGCLMYE MLAGFTPFVHKPDD-------SSKVILARIQEGKYTMNGGNW------------DNISDRAKDLISRMLHVDPFQRPS----------TKQVLQHTWF ||.| .|| ..... . . . .|..|.|..| . ...|. |||||...|..|| .|. .... .| || MLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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| Kinase | RSK1.AA | CAMK | 145-397 | 24 | 1.2e-103 | 334.94 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 145-397
Range on HMM: 1-425/425
Sequence Identity: 24% (106 aa)
DIGLGSYSVCKRCTHKATG------------QDYAVKIIKK--------------------------------NTKDVREEIEILLRYG------HHSNV
.| ||... |.|.|| |. | .|.|||.| . | || ||||. . .| |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
ITLRDVFDDGQN-------------------VYMVM---ELMRGGEL----LDRLLKQKF---------------LSEREACEIMLTVTRTMDFLHQQKV
| | .|..|... .|||| |.. |||| .|.. ... ..||||. .. . ....|....
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI
VHRDLKPSNILYADETYSP-------------GTLRIADFGFAKQMRADNG-----------------------MLMTPCYTANFVA-PEVLKK------
||||||| |||. | . ... |.|||||.... ... .. |.| | ..| ||||..
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM
--------QGYDAACDIWSLGVILYTMLAGFTPFVHKPDD----------SSKVILARIQEGKYTMNGGN------------WDNISDR--------AKD
..|. .||.||.|||||.|| |. || .. |. . . .. .|..|||.. ||.||| .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD
LISRMLHVDPFQRPSTKQVLQHTWF
||..|| ||| .|.. .|.|.| |.
LIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | RSK1.AA | MAPKAPK | 140-397 | 37 | 1e-99 | 309.45 | In-house | 1-292 (292) | Show / Hide |
Range on Protein: 140-397
Range on HMM: 1-292/292
Sequence Identity: 37% (111 aa)
XXXXQDIGLGSYSVCKRCTHKATGQDYAVKIIKKN-----TKDVREEIEILLRYGHHSNVITLRDVFDD----GQNVYMVMELMRGGELLDRLLK--QKF
. .|.|.| .|.|| ||| |||||... .| .| | |.. . | |.. . |.| . .. |.|||.|.||||... . .|
KLWKEVLGEGIYGKVQTCVHKRTGQEYAVKILEDQPGHSRQK-ARREVELHWHCQGHPNIVQIIDWFENMYQFDKCFYLVMECMEGGELFQHIQQRGHKH
LSEREACEIMLTVTRTMDFLHQQKVVHRDLKPSNILYADETYSPGTLRIADFGFAKQ--------MRADNGMLMTPCYTANFVAPEVLKKQG----YDAA
.|||| .|| .. ||||. |||||| |||. | |.. .. . ||||||. .. . |||||||. ..||||. . ||
FTEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTD-TNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFKEAHTYDKS
CDIWSLGVILYTMLAGFTPFVHKPD--DSSKV-----------ILARIQEGKYTMNGGNWDNISDRAKDLISRMLHVDPFQRPSTKQVLQHTWF
||.||||||.| ||.|. ||. . . | |. .|||||.|. |..||. |||||...| .|| || ...||..| |
CDMWSLGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI
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| Pkinase | RSK1.AA | Pkinase | 140-397 | 32 | 2.1e-96 | 331.4 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 140-397
Range on HMM: 1-293/293
Sequence Identity: 32% (98 aa)
XXXXQDIGLGSYSVCKRCTHKATGQDYAVKIIKKNTKDVRE--------EIEILLRYGHHSNVITLRDVFDDGQNVYMVMELMRGG----ELLDRLL--K
. || ||......|.|| ||. .||||||| ... . ||.|..| .| |...|.|.| |....|||||...|| .| |.. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR
QKFL--SEREACEIMLTVTRTMDFLHQQKVVHRDLKPSNILYADETYSPGTLRIADFGFAKQM-RADNGMLMTPCYTANFVAPEVLK-KQGYDAACDIWS
.. . ||.|.. .|. . | ....|.....||||||.|||. .. . . ...|.|||.|||. |. ..|.| | ...||||.. |.|. ..|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS
LGVILYTMLAGFTPFVHK----PDDSSKVILARIQEGKYTMNGGNWDNIS-----------------DRAKDLISRMLHVDPFQRPSTKQVLQHTWF
.|.||| || | .|| .. . .. .....|| .... . .|..|| . .||.|...|..|| .||. .|.||| ||
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| Kinase | RSK1.AA | S_TKc | 144-397 | 34 | 1.1e-95 | 325.07 | SMART | 5-231 (231) | Show / Hide |
Range on Protein: 144-397 Range on HMM: 5-231/231 Sequence Identity: 34% (94 aa) QDIGLGSYSVCKRCTHKATGQDYAVKIIKKNTKDVREEIEILLRYGHHSNVITLRDVFDDGQNVYMVMELMRG--GELLDRLLKQKF------LSEREAC . || |.......|.|| ||. .|.|||| ...| ||.|| . || |...| |||.| ...|||||.. | |.|.|.. |.. ..| .|. RKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR EIMLTVTRTMDFLHQQKVVHRDLKPSNILYADETYSPGTLRIADFGFAKQMRADNGMLMTPCYTANFVAPEVLKKQGYDA-ACDIWSLGVILYTMLAGFT .| . . ....|.....||||||.||| . .. |.|||.|.|. .| | | ...||||| ||. .||.||.|.||| ||.| . FYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYP PFVHKPDDSSKVILARIQEGKYTMNGGNWDNISDRAKDLISRMLHVDPFQRPSTKQVLQ-------HTWF || .... .| |. |||.|...|..|| .||. ..|| | || PFP-----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | RSK1.AA | MSK | 141-397 | 35 | 2.3e-88 | 298.83 | In-house | 1-277 (277) | Show / Hide |
Range on Protein: 141-397
Range on HMM: 1-277/277
Sequence Identity: 35% (100 aa)
XXXQ-DIGLGSYSVCKRCTHKATGQDYAVKIIK--------KNTKDVREEIEILLRYGHHSNVITLRDVFDDGQNVYMVMELMRGGELLDRLLKQKFLSE
.| |....|..|.|. ||. ||.||.. | . .. |. .|.. | |. .| ..| | |.|||. .||||. .. | . .|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE
REACEIMLTVTRTMDFLHQQKVVHRDLKPSNILYADETYSPGTLRIADFGFAKQMRAD-NGMLMTPCYTANFVAPEVLK----KQG-YDAACDIWSLGVI
|. .||. . |..|| ...|||||| |||..||. . |.... |||||. .| . . .||.| . |||.|. ..| ||.|||.||||||
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDN-GHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVI
LYTMLAGFTPFV---HKPD---DSSKVILARIQEGKYTMNGGNWDNISDRAKDLISRMLHVDPFQRPSTKQVLQHTWF
||||| | || . . |.. | ||..|. | | |.| |||||...| .|| |... ..| |
LYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
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| Kinase | RSK1.AA | Ciliate-E2 | 140-397 | 25 | 2e-76 | 260.21 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 140-397
Range on HMM: 1-365/365
Sequence Identity: 25% (98 aa)
XXXXQDIGLGSYSVCKRCTH-----------------------KATGQDYAVKIIKKN-TKDVREEIEIL---------------LRYGHHSNVITLRDV
. || |.... ..|.. |.... ||.||.||| . . || |. |. | |.| . ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC
FD--DGQNVYMVMELMRGGELLDRLL--KQKF---------LSEREACEIMLTVTR---------------TMDFLHQQK-VVHRDLKPSNILYADETYS
| | .|.|.|||. ||.|.|.. |.|. ..|.|...|| ... . .||... ..|||.||.|||.
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------
PGTLRIADFGFAKQMRADNG-------------------------------MLMTPCYTANFVAPEVLK---------KQGYDAACDIWSLGVILYTMLA
. |.|||..|. || | | |.|....|||.|. ..||| .||||||||||| ||
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF
GFTPFVHKPDDSSKVILARIQEGKYTMNGG--------------NWDNISDRAKDLISR----MLHVDPFQRPS-TKQVLQHTWF
| .|| . |...|. . .|...|. .||||.. || .|| .|.. .|.|.| ||
GKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | RSK1.AA | CAMKL | 146-397 | 30 | 3.1e-75 | 239.5 | In-house | 7-297 (297) | Show / Hide |
Range on Protein: 146-397 Range on HMM: 7-297/297 Sequence Identity: 30% (92 aa) IGLGSYSVCKRCTH-KATGQDYAVKIIKKNTKD-------------------VREEIEI--LLRYGHHSNVITLRDVFDDGQN------VYMVMELMRGG .| ||... | .|| . ||. .|.|||.|. . .| ||.| .|. | | |.| | .|... .. .|.|||. || LGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGG E--LLDRLLKQKF----LSEREACEIMLTVTRTMDFLHQQKVVHRDLKPSNILYADETYSPGTLRIADFGFAKQMRA----DNGMLMTPCYTANFVAPEV | |.|.. |.. ..|.||. . . ....|....||||.|| ||| . . .. |.||||. ..| .. .|.| | . .. |||. EMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEI LKK--QGYD-AACDIWSLGVILYTMLAGFTPFVHKPD-----DSSKVILARIQEGKYTMNGGNWDNISDRAKDLISRMLHVDPFQRPSTKQVLQHTWF ... . || . ||||.|||||.|. | || .. | . .| .| | .. | .| ...|||..|| |.| .||. .|...| |. FQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPP--IWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | RSK1.AA | Ciliate-E2-Unclassified | 140-397 | 25 | 1.3e-67 | 230.95 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 140-397
Range on HMM: 1-352/352
Sequence Identity: 25% (91 aa)
XXXXQDIGLGSYSVCKRCTHKATGQDYAVKIIKKNTKDV-----------REEIEILLRY-----------------GHHSNVITLRDVFDDGQNVYMVM
. || |.... ..| || ..| || |..||. .. .|..|. . | ... . ..| | ||.|.||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM
ELMRGGELLDRLLKQKF-----------------LSEREAC-----EIMLTVTRTMDFLHQQK-VVHRDLKPSNILYADETYSPGTLRIADFGFAKQMRA
|...||.|.. . |.|. ..|..|. .. . ..||... ..|||.||.|||. .. . . ..|.|||..|.
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKYQQ
DNG---------------MLMTPCYTANFV----APEVLKKQGYD----AACDIWSLGVILYTMLAGFTPFVHKPDDSSKV-------------ILARIQ
.|. |. | | | |. |||||..|.|| .||||||||||| || | || . ...... .. |.
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK
EGKYTMNGGNW----DNISDRAKDLIS----RMLHVDPFQRPSTKQVLQHTWF
.... . .| ...|. |||.|. .|| ..| .|.. .|.|.| ||
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
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| Kinase | RSK1.AA | Pkinase_Tyr | 167-327 | 26 | 1.5e-19 | 66.79 | Pfam | 32-205 (270) | Show / Hide |
Range on Protein: 167-327 Range on HMM: 32-205/270 Sequence Identity: 26% (48 aa) AVKIIKKNTKDV-------REEIEILLRYGHHSNVITLRDVFD-DGQN--VYMVMELMRGGELLDRLLK----QKFLSEREACEIMLTVTRTMDFLHQQK |||..| .. . .|..|. .||| |.. | | .|. .|.|||.| .| ||| | | .. |. . ... . . . |..|.... AVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN VVHRDLKPSNILYADETYSPGTLRIADFGFAKQM-------RADNGMLMTPCYTANFVAPEVLKKQGYDAACDIWSLGVILY .|||| |.| .. ... .|.||| |. . |. | . . |||... . . |.|| || .. CIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKFTTKSDVWSFGVLMW |
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| Kinase | RSK1.AA | TyrKc | 144-397 | 21 | 2.7e-16 | 40.65 | SMART | 5-280 (280) | Show / Hide |
Range on Protein: 144-397 Range on HMM: 5-280/280 Sequence Identity: 21% (63 aa) QDIGLGSYSVCKRCTHKATGQDYAVKIIK--KNTKDVREEIEILLRYG-HHSNVITLRDVFDDG-------QNVYMVMELMRGGELLDRLLKQK-FLSER . .| | . . ..| | .. ||| .| . .| ..|..|. ..| || |.. | | .. . ...|||.| .| |.|.| | . |. . KKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK EACEIMLTVTRTMDFLHQQKVVHRDLKPSNILYADETYSPGTLRIADFGFAKQMRAD------NGMLMT----PC---YTANFVAPEVLKKQGYDAACDI . ..... . . |..||.....|||| |.|.... | .|.||| .. | . .. . |||.... . . |. DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV WSLGVILYTMLA-GFTPFVH---KPDDSSKVILARIQEGKYTMNGGNWDN--------ISDRAKDLISRMLHVDPFQRPSTKQVLQHTWF || || .. .. | .| . . | . .......|.. . .| .| ..... | || .||. ... | | WSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQP---PNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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