Gene RSK2 (Sea Urchin)
RSK2
Sequence
Protein domains of RSK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | RSK2.AA | RSK | 99-186 | 45 | 7.9e-51 | 175.18 | In-house | 177-271 (271) | Show / Hide |
Range on Protein: 99-186 Range on HMM: 177-271/271 Sequence Identity: 45% (43 aa) VNDRGHSQISNYFSLSTVQYEMLTGALPFQGQHRKETMALILKAKLGM-------PQFLSAEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF ....||.|.....|.....||||||..|||...|...|..|...|||| ..|.|.||..||||...|.|.|||||||||...||.|..| LKRQGHDQACDWWSFGVLMYEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF |
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| Kinase | RSK2.AA | RSK | 99-186 | 42 | 1.5e-41 | 144.38 | In-house | 180-278 (278) | Show / Hide |
Range on Protein: 99-186 Range on HMM: 180-278/278 Sequence Identity: 42% (42 aa) VN----DRGHSQISNYFSLSTVQYEMLTGALPFQG---QHRKETMALILKAK--LGMP--QFLSAEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF .. ..||.. ..|| . ||||||..|||| ..|||.|. |.|.| |.|| |.||.||..|.|....|.|..|||.||.....||.|..| LKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | RSK2.AA | AGC | 110-186 | 28 | 1.8e-38 | 95.84 | In-house | 286-395 (395) | Show / Hide |
Range on Protein: 110-186 Range on HMM: 286-395/395 Sequence Identity: 28% (31 aa) YFS--LSTVQYEMLTGALPFQGQ----------HRKETMALIL------KAKLGMP----------QFLSAEAQSLLRMLFKRNPQNRLGAGPN-----G . | | . |||||| ||.|. ...|.. .|. . |. .| ...| ||..|...|....| .|||.|.| | WWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKG INDIKSHAFF ...||.| .| AEEIKNHPWF |
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| Kinase | RSK2.AA | Akt | 118-186 | 33 | 3.8e-25 | 77.25 | In-house | 194-264 (264) | Show / Hide |
Range on Protein: 118-186 Range on HMM: 194-264/264 Sequence Identity: 33% (24 aa) YEMLTGALPFQGQHRKETMALILKAKLGMP--QFLSAEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF |||..|..|| | ... . .|. ... .| ..| |...|.. | ...| .|||.|||....||.| .| YEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF |
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| Kinase | RSK2.AA | p70 | 103-186 | 44 | 1e-24 | 86.48 | In-house | 214-299 (299) | Show / Hide |
Range on Protein: 103-186 Range on HMM: 214-299/299 Sequence Identity: 44% (38 aa) GHSQISNYFSLSTVQYEMLTGALPFQGQHRKETMALILKAK--LGMPQFLSAEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF ||.. ..|| | ||||. || | ||.|. |||.| | .| |..|. |.. | ||.|. |.||||. . ||..|.|| GHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF |
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| Kinase | RSK2.AA | RSK-Unclassified | 103-186 | 36 | 4.1e-23 | 68.99 | In-house | 198-283 (283) | Show / Hide |
Range on Protein: 103-186 Range on HMM: 198-283/283 Sequence Identity: 36% (32 aa) GHSQISNYFSLSTVQYEMLTGALPFQGQHRKETMALILKAKLGMP--QFLSAEAQSLLRMLFKRNPQNRLGAGPNG-INDIKSHAFF || . | | |||| | |. | . || |.|... .| ...| ....|.. | .||| |||.. | .||| | || GHTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCK-MGDADDIKRHPFF |
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| Kinase | RSK2.AA | SGK | 111-186 | 31 | 6.6e-19 | 54.58 | In-house | 209-283 (283) | Show / Hide |
Range on Protein: 111-186 Range on HMM: 209-283/283 Sequence Identity: 31% (24 aa) FSLSTVQYEMLTGALPFQGQHRKETMALILKAKLGMPQFLSAEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF ..| .| |||..|. || . ... |.. .| .|.. |..| .|. | ...|..|||. .. .||.| || WCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF |
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| Kinase | RSK2.AA | AGC-Unique | 118-186 | 34 | 1.7e-17 | 59.09 | In-house | 202-270 (270) | Show / Hide |
Range on Protein: 118-186 Range on HMM: 202-270/270 Sequence Identity: 34% (24 aa) YEMLTGALPFQGQHRKETMALILKAKLGMPQFLSAEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF ..|.|. || . |.. . .. || ||| ..| .. | | | ||| .|.| .|||| .| CDMRTDRSPFDASNRNDMYDSMIQKRPRMPMFLSPDEQDFVNKLIVRDPNQRLGNSPQGFEEIKSHDMF |
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| Kinase | RSK2.AA | RSK | 30-92 | 44 | 1.9e-17 | 59.01 | In-house | 44-106 (271) | Show / Hide |
Range on Protein: 30-92 Range on HMM: 44-106/271 Sequence Identity: 44% (28 aa) SRIKQKNQRSILMKVYHDFFSSFCYAFQTEGKLYLILDFLKGGDLFTRLSKEVVFIMNEIKIY .|.. .. | || . | | |.||.|||.|.|.||..|||||.||.|...| .|.|.| DRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSEREVKFY |
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| Kinase | RSK2.AA | AktR | 118-186 | 32 | 3.4e-16 | 59.02 | In-house | 196-268 (268) | Show / Hide |
Range on Protein: 118-186 Range on HMM: 196-268/268 Sequence Identity: 32% (24 aa) YEMLTGALPFQGQHRKETMALILKAK-LGMPQF--LSAEAQSLLR-MLFKRNPQNRLGAGPNGINDIKSHAFF |||.|| ||. . ... .|.. . |. .| ....|. |...||..||| . ||. .|||| .| YEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF |
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| Kinase | RSK2.AA | p70 | 38-84 | 51 | 1.5e-14 | 49.26 | In-house | 79-125 (299) | Show / Hide |
Range on Protein: 38-84 Range on HMM: 79-125/299 Sequence Identity: 51% (24 aa) RSILMKVYHDFFSSFCYAFQTEGKLYLILDFLKGGDLFTRLSKEVVF |.|| | | | |||||.|||||||..| || ||. | .. .. RNILEEVKHPFICDLHYAFQTNGKLYLILEYLHGGELFMHLERHGIW |
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| Kinase | RSK2.AA | RSK | 38-88 | 50 | 2.1e-14 | 49.37 | In-house | 51-103 (278) | Show / Hide |
Range on Protein: 38-88 Range on HMM: 51-103/278 Sequence Identity: 50% (27 aa) RSILMKVY-HDFFSSFCYAFQTEGKLYLILDFLKGGDLFTRLSKEVVF-IMNE |.||. . | | . ||||||||||||.....||.|||.|.||. | . | RNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSE |
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| Kinase | RSK2.AA | AGC | 37-93 | 21 | 2.2e-14 | 32.14 | In-house | 59-152 (395) | Show / Hide |
Range on Protein: 37-93 Range on HMM: 59-152/395 Sequence Identity: 21% (20 aa) Q-----------RSILMKVY----------HDFFSS-FCYAFQTEGK--LYLILDFLK---------GG-DLFTRLS---KEVVFIMNEIKIYF . | ||.|. |.| . |.||.. . ||....... || .||..| || .| .....|. HWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYA |
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| Kinase | RSK2.AA | Ciliate-E2 | 118-186 | 20 | 5e-14 | 44.53 | In-house | 287-365 (365) | Show / Hide |
Range on Protein: 118-186 Range on HMM: 287-365/365 Sequence Identity: 20% (19 aa) YEMLTGALPFQGQHRKETMALILKAKLGMPQF------------------LSAEAQSLLRM----LFKRNPQNRLGAGPNGINDIKSHAFF ||||.| .|| . |.. |. |.. .| |.. |.. .....|..|.. |...|. | .| YEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF |
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| Kinase | RSK2.AA | Akt | 38-84 | 40 | 1e-11 | 33.68 | In-house | 51-97 (264) | Show / Hide |
Range on Protein: 38-84 Range on HMM: 51-97/264 Sequence Identity: 40% (19 aa) RSILMKVYHDFFSSFCYAFQTEGKLYLILDFLKGGDLFTRLSKEVVF | || ...| | . |.|||. |||...|. .||.||. |... .| RNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRF |
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| Kinase | RSK2.AA | SGK | 38-92 | 37 | 2.5e-11 | 30.77 | In-house | 75-130 (283) | Show / Hide |
Range on Protein: 38-92 Range on HMM: 75-130/283 Sequence Identity: 37% (21 aa) R-SILMKVYHDFFSSFCYAFQTEGKLYLILDFLKGGDLFTRLSKEVVFIMNEIKIY | || .. | | . |||||. |||. .|.. ||..| | .| | . ..| RNVILKNMKHPFIVNLHYAFQTKWKLYFVMDYVNGGEMFYHLQREKHFPEDRARFY |
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| Kinase | RSK2.AA | AktR | 38-81 | 37 | 1.3e-09 | 33.55 | In-house | 51-95 (268) | Show / Hide |
Range on Protein: 38-81 Range on HMM: 51-95/268 Sequence Identity: 37% (17 aa) RSILM-KVYHDFFSSFCYAFQTEGKLYLILDFLKGGDLFTRLSKE | |. .. | |. . |.|||. ||..|... .||.||. |.|. RNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKK |
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| Kinase | RSK2.AA | RSK-Unclassified | 38-92 | 31 | 7.2e-09 | 23.45 | In-house | 50-106 (283) | Show / Hide |
Range on Protein: 38-92 Range on HMM: 50-106/283 Sequence Identity: 31% (18 aa) RSILMKVYHDFFSSFCYAFQTEGKLYLILDFLKGGDLFTRLS--KEVVFIMNEIKIY . |. | | ..|||. .|||.... |||.| | || | .....| QNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCEDDVRFY |
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| Kinase | RSK2.AA | Pkinase | 118-186 | 16 | 9e-09 | 32.1 | Pfam | 203-293 (293) | Show / Hide |
Range on Protein: 118-186 Range on HMM: 203-293/293 Sequence Identity: 16% (16 aa) YEMLTGALPFQGQ------HRKETMALILKAKLGMPQFLS---------------------AEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF ||||.| .||.|. .. ...|....| . . . |...... .....|. |.. . .|. | .| YEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPWF |
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| Kinase | RSK2.AA | Ciliate-E2 | 34-89 | 24 | 1.6e-08 | 25.31 | In-house | 77-154 (365) | Show / Hide |
Range on Protein: 34-89 Range on HMM: 77-154/365 Sequence Identity: 24% (19 aa) QK--NQRSILMKVYHDFFSSFCYAFQ--TEGKLYLILDFLKGGDLFTRLS------------------KEVVFIMNEI .| | ..|| .. |.. . ..|| .. ..||......||||| .. ||. .|| .| YKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQI |
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| S_TKc | RSK2.AA | S_TKc | 1-186 | 16 | 3.4e-08 | -56.71 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1-186
Range on HMM: 1-231/231
Sequence Identity: 16% (43 aa)
VFLEDKISK------TEGRNMY--------AVSLGNPTLIANLSRIKQKNQRSILMKVYHDFFSSFCYAFQTEGKLYLILDFLKG--GDLFTRLSKEVV-
. .|| | .|. .. .. .. ..||.| |.. . ..||. ..||...... | ||||... |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH
-----FIMNEIKIYFN------------------------------------------------------IFQXVNDRGHSQ-ISNYFSLSTVQYEMLTG
| ... |. .. |.. . |. . ||||.|
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYEMLCG
ALPFQGQHRKETMALILKAKLGMPQFLSAEAQSLLRMLFKRNPQNRLGAGPNGI--NDIKSHAFF
||. .|....| . | || ...| .....|..|..| |||.| .|
YPPFP------QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | RSK2.AA | AGC-Unique | 40-81 | 34 | 2e-06 | 18.82 | In-house | 55-97 (270) | Show / Hide |
Range on Protein: 40-81 Range on HMM: 55-97/270 Sequence Identity: 34% (15 aa) ILMKVYHDFFSSFCYAFQTEGKLYLILDFLKGGDLFTRLSK-E || . | || |.||.. | ...|. |||.|. . . | ILTTMHHPFFMRMHYSFQNKDHLFMCMDYVPGGDMFHHMQNAE |
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| Kinase | RSK2.AA | Pkinase | 46-93 | 23 | 5.2e-05 | 18.8 | Pfam | 59-114 (293) | Show / Hide |
Range on Protein: 46-93 Range on HMM: 59-114/293 Sequence Identity: 23% (13 aa) HDFFSSFCYAFQTEGKLYLILDFLKGG----DLFTRLS--KEVVF--IMNEIKIYF |.. . ..|......|...... || |||...| .. .| ..|.| |. HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYM |
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