Gene Trad (Sea Urchin)
Trad
Sequence
Protein domains of Trad.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
---|---|---|---|---|---|---|---|---|---|
I-set | Trad.AA | I-set | 181-272 | 35 | 3.7e-19 | 67.51 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 181-272 Range on HMM: 1-92/92 Sequence Identity: 35% (33 aa) PAFTLPLINQSCHLGTTATLSCQVCGRPRPMITWRDPQGDIIAP-STRTNVWERDDGMVFLEIRASCKLDNGVYTCTASNDAGSTECKALLRI | || .. .. . | ||...||| | | | ..| | ..| | | .. ...|| .|.|. .. | |.|||.|.| .|. ||.| | . PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKD-GQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
|||||||||
IGc2 | Trad.AA | IGc2 | 193-262 | 30 | 2.8e-10 | 41.39 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 193-262 Range on HMM: 1-56/56 Sequence Identity: 30% (21 aa) HLGTTATLSCQVCGRPRPMITWRDPQGDIIAPSTRTNVWERDDGMVFLEIRASCKLDNGVYTCTASNDAG | |...|| | . |.| | |.|. | .. . .|.|. . | |.|||.|.| .| HEGQSVTLTCPATGNPDPNIHWYK--GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG |
|||||||||
IG | Trad.AA | IG | 187-273 | 18 | 3.4e-07 | 31.16 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 187-273 Range on HMM: 1-58/58 Sequence Identity: 18% (17 aa) LINQSCHLGTTATLSCQVCGRPRPMITWRDPQGDIIAPSTRTNVWERDDGMVFLEIRASCKLDN---GVYTCTASNDAGSTEC--KALLRII .. .| |.||.| | |.|. |.| . | |.|.|.|. .|.... . |.. PP-VTVKEGETVTLTC-VS-----QIWWY------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
|||||||||
FN3 | Trad.AA | FN3 | 276-360 | 21 | 3e-12 | 47.96 | SMART | 1-69 (69) | Show / Hide |
Range on Protein: 276-360 Range on HMM: 1-69/69 Sequence Identity: 21% (21 aa) PGPPSI---PILCERRPH------SVTLQWEPSHNTGNAESVTYNVEYAQITHNTLHWQTSCANIAHTTHKVDALSAG----ASYKFRITAQND--VGCS ||||. . . . .. ||||.|.| |.| ..|. |..| |.||..| |. .| . PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-----------IVGYR--------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG |
|||||||||
Kinase | Trad.AA | Trio | 394-650 | 53 | 2.4e-232 | 603.66 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 394-650 Range on HMM: 1-258/258 Sequence Identity: 53% (139 aa) FNITREIGRGRFSSTHACTRSQQQRTLAAKFISKRLMDLEQVQHEASMMQPLQHPLICSLHATYETHGQYILVLDLIPDGRILEYLVSLSQVTERQVIGF .....||||||||....|......||.|||||..|.||.|||.||..|.|.||||..||||.||||...|||.|.|..||..|..|.......|..|... YTFQEEIGRGRFSVVRRCWHKATGRTCAAKFIPYRMMDKEQVYHEYEMLQHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLMRWGSYCESEVKTY IRQLVQAVNYLHSNGIIHLDIKPENVMMEKALG-RAQIKLIDFGDAMDLWSSPPPFYHELNANPEFCSPELLGGNEIDYGTDVWSIGALSYVMLSGISPF ..|...||.|||...|.||||||||.||..... |.|||..|||||..||.......|....||||..||...||...||||.||||.|.|||||||||| MWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVMLSGISPF LDESLEETNMNIIRVDYSFPEEYFKNVSQNAKHFITGLLHADSSERKTTSECLMNHWF .|||..||.|||.|.|.||||.||..|||||||||...|..|...|...||||...|| YDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF |
|||||||||
Kinase | Trad.AA | MLCK | 394-650 | 35 | 1e-98 | 260.59 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 394-650 Range on HMM: 1-257/257 Sequence Identity: 35% (92 aa) FNITREIGRGRFSSTHACTRSQQQRTLAAKFISK-RLMDLEQVQHEASMMQPLQHPLICSLHATYETHGQYILVLDLIPDGRILEYLV-SLSQVTERQVI ..|. |.|||.|. .| |. . ..|.||||| . | | |..| ..| |.|| . .|. .|| . ......| | ..|. | . |||.|| YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKCRKPKDKENVKNEIEIMNQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVI GFIRQLVQAVNYLHSNGIIHLDIKPENVMMEKALGRAQIKLIDFGDAMDLWSSPPPFYHELNANPEFCSPELLGGNEIDYGTDVWSIGALSYVMLSGISP ..||. .| ..|...|.|||.||||.|. . |||.|||| |. . .. . . |||..|| ....||.||.| ..|..|||.|| HYMRQICEGVHHMHWQNIVHLDLKPENIMC-QTRTSHQIKIIDFGLARKYDPDEKK-VKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLSP FLDESLEETNMNIIRVDYSFPEEYFKNVSQNAKHFITGLLHADSSERKTTSECLMNHWF |. .. .|| |. ... | .| |...|. || ||. || | ..| |..||| .|. FMGDNDRETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL |
|||||||||
Kinase | Trad.AA | CAMK | 399-650 | 19 | 3.5e-90 | 290.72 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 399-650 Range on HMM: 1-425/425 Sequence Identity: 19% (83 aa) EIGRGRFSSTHACTRSQQQ------------RTLAAKFISKR-----------------------------LMDLEQVQHEASMMQPLQ-------HPLI ..|||.|. . |.. . . . |.|.|.|. |...|..| ..|. || || | TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI CSLHATYE------------THGQ--------YILVL---DLIPDG----RILEYLVSLSQ---------------VTERQVIGFIRQLVQAVNYLHSNG ..|. .|| | . ...|. .... | ....|.|. .. .|||.. ..||...||.|.||.. IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN IIHLDIKPENVMMEKA--------------LGRAQIKLIDFGDAMDLWSSP----------------------PPFYHELNANPEFCS-PELLGG----- |.|.|.||||... . . ...||.|||| | . .. . ... ||... ||.| | IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN ---------NEIDYGTDVWSIGALSYVMLSGISPFLDE-------------SLEETNMNIIRVDYSFPEEYFKN------------VSQN--------AK ... .|.||.| . |.||.| .|| .. ...|. .|.. .|.||..||.. .|.. .| MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK HFITGLLHADSSERKTTSECLMNHWF ..| ..| | ..| | ..|| |. DLIRKMLQVDPEKRMTIEQCLNHPWM |
|||||||||
Kinase | Trad.AA | S_TKc | 394-650 | 25 | 2.2e-59 | 204.53 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 394-650 Range on HMM: 1-231/231 Sequence Identity: 25% (70 aa) FNITREIGRGRFSSTHACTRSQQQRTLAAKFISKRLMDLEQVQHEASMMQPLQHPLICSLHATYETHGQYILVLDLIPD--GRILEYLVSLSQ------V . | |.||.| |.. . |. .| | | |. |... | .... .|| |. |. .... . . .|..... | ..|... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF TERQVIGFIRQLVQAVNYLHSNGIIHLDIKPENVMMEKALGRAQIKLIDFGDAMDLWSSPPPFYHELNANPEFCSPELLGGNEIDY-GTDVWSIGALSYV .| .. ...|...|..|.||.|||| |.||||... . .||..||| | | . . |....||.| .. |.||.| . | PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE MLSGISPFLDESLEETNMNIIRVDYSFPEEYFKNVSQNAKHFITGLLHADSSERKTTSECLM-------NHWF ||.| || ... ...|. |. ||.|| ..|. | ..| | |.| || MLCGYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
Kinase | Trad.AA | DRAK | 397-650 | 33 | 9.6e-59 | 180.93 | In-house | 2-259 (259) | Show / Hide |
Range on Protein: 397-650 Range on HMM: 2-259/259 Sequence Identity: 33% (87 aa) TREIGRGRFSSTHACTRSQQQRTLAAKFISKRLMDL---EQVQHE-ASMMQPLQHPLICSLHATYETHGQYILVLDLIPDGRILE--YLVSLSQVTERQV .| |||.| | . . . ||||. || . . . || | .| . | . ||. ||| |||| . | | . . ..|..| AKERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEKDV IGFIRQLVQAVNYLHSNGIIHLDIKPENVMMEKALGRAQIKLIDFGDAMDLWSSPPPFYHELNANPEFCSPELLGGNEIDYGTDVWSIGALSYVMLSGIS . .|| ..| |||.. |.||| || |... ||..||| . . . |. |.. || | . | ||.|||| | ||||..|| QRCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEE--VREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLTHIS PFLDESLEETNMNIIRVDYSFPEEYFKNVSQNAKHFITGLLHADSSERKTTSECLMNHWF ||. . || .|| . ...|| | .|. | || |. . .| | ||| | PFVGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL |
|||||||||
Kinase | Trad.AA | Pkinase | 394-650 | 24 | 1.4e-56 | 199.12 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 394-650 Range on HMM: 1-293/293 Sequence Identity: 24% (73 aa) FNITREIGRGRFSSTHACTRSQQQRTLAAKFISKRLMDLEQVQH-----EASMMQPLQHPLICSLHATYETHGQYILVLDLIPDG----RILEYLV--SL . | | ||.| |.. |.. ... | | |.|| . .. |. |...|. |.|| |. |. ..|... . .|... . | .|. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH SQV--TERQVIGFIRQLVQAVNYLHSNGIIHLDIKPENVMMEKALGR-AQIKLIDFGDA--MDLWSSPPPFYHELNANPEFCSPELLG-GNEIDYGTDVW . .|.... ...|......|.||.|||| |.||||... . | .|..||| | .| . . .. . |....||.. |..... |.| GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW SIGALSYVMLSGISPFLDE------SLEETNMNIIRVDYSFPEEYFKNVS-----------------QNAKHFITGLLHADSSERKTTSECLMNH-WF |.| . | ||.| || .. . . .| . ...|.... ..| ...|.||...|. | ..| | |....| || SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-AEQILQHPWF |
|||||||||
Kinase | Trad.AA | Ciliate-E2 | 394-650 | 20 | 2.2e-54 | 185.11 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 394-650 Range on HMM: 1-365/365 Sequence Identity: 20% (79 aa) FNITREIGRGRFSSTHACTRSQQQRTLAAKFISKRL----------------------MDLEQVQHEASMMQ----------------PLQHPLICSLHA ... . ||.| |.| |.. ..|. | |.| .. ..||. | ..|. |.|| |. .. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE TYE--THGQYILVLDLIPDGRILEYLVSL-----------SQVTERQVIGFIRQLVQ---------------AVNYLHSNG-IIHLDIKPENVMMEKALG ... . . ||.... | ..|. . . ||.... ...|..| |..||||.. ||| ||||||... CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- RAQIKLIDFGDAMDLWSSPPPFYHELNA-------------------------------NPEFCSPELLGGNE---------IDYGTDVWSIGALSYVML ||.|||| . .. . .| .. .|.. .|| |.| . || |.||.| . | || ---IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML SGISPFLDESLEETNMNIIRV-DYSFPEE--------------YFKNVSQNAKHFITG----LLHADSSERKT-TSECLMNHWF .| || ...| ...||.. .|..||..|..| .| | ..| | ...| ..|| FGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
|||||||||
Kinase | Trad.AA | CAMK-Unique | 438-650 | 19 | 9.2e-49 | 158.99 | In-house | 66-363 (363) | Show / Hide |
Range on Protein: 438-650 Range on HMM: 66-363/363 Sequence Identity: 19% (57 aa) EASMMQPLQHPLICSLHAT----YETHG---------------QYILVLDLIPDGRILEYLVS--------------------LSQVTE--RQVIGFIRQ |.. .. . || | | . ... . .|......| ...... . .| .... ... EHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQC LVQAVNYLHSNGIIHLDIKPENVMMEKALG-------------RAQIKLIDFGDAMDLWSSPPP-FYHELNANPEFCSP--------------ELLGGNE |..||.|.||..|.| |.|.||.| . . . |||.||| . .. .. . .. |....| |.... LLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQC IDYGT----DVWSIGALSYVMLSGISPFLDESLE--------ETNMNIIRVDY-SFPEEYFKN---VSQNAKHFITGLLHADSSERKTTSECLMNHWF .|. | ||.|.. | ||.|..|| |. . |. .| || .|..... .||.|| |..... | . | . .| | . |. YDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI |
|||||||||
Kinase | Trad.AA | Ciliate-E2-Unclassified | 394-650 | 20 | 6.8e-44 | 150.14 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 394-650 Range on HMM: 1-352/352 Sequence Identity: 20% (74 aa) FNITREIGRGRFSSTHACTRSQQQRTLAAKFISKRLMDLEQVQHEAS---------------------------MMQPLQHPLICSLHATYETHGQYILV ..| . ||.| |.. . | ...|. ..|. . | .. | | . . .. ..||.| .. . .. ..| YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LDLIPDGRILEYLVSLSQ-----------------VTERQVI-----GFIRQLVQAVNYLHSNG-IIHLDIKPENVMMEKALGRAQIKLIDFGDAMDLWS ......| ..|. . .. .||.|.. ...|..|. .|||... ||| ||||||... . .. .||.|||| .. . . MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ S--------------PPPFYHELNANPEFC----SPELLGGNEID----YGTDVWSIGALSYVMLSGISPFLDESLEE---------------TNMNII- . .. .. .|.. .||.|.|.. | | |.|| | . | || | || |.. |. ..| NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK RVDYSFPEEYF----KNVSQNAKHFIT----GLLHADSSERKTTSECLMNHWF ...||.. . |..|..||.||. .| . ..| | .. | .|| QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
|||||||||
Kinase | Trad.AA | DAPK | 396-536 | 32 | 7.7e-41 | 110.0 | In-house | 1-152 (264) | Show / Hide |
Range on Protein: 396-536 Range on HMM: 1-152/264 Sequence Identity: 32% (49 aa) ITREIGRGRFSSTHACTRSQQQRTLAAKFISKRLMDLE-------QVQHEASMMQPLQ-HPLICSLHATYETHGQYILVLDLIPDGRILEYLVS--LSQV . .|.|||.|. |. . ||||| || . || . . .. || . .||. ||| ||.| . | . |.. . MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREECL TERQVIGFIRQLVQAVNYLHSNGIIHLDIKPENVMMEK-ALGRAQIKLIDFG .| ... |..| ..|.||||. | |||.||.|.| ||.|||| CEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFG |
|||||||||
Kinase | Trad.AA | DAPK | 556-650 | 47 | 6.6e-36 | 96.16 | In-house | 170-264 (264) | Show / Hide |
Range on Protein: 556-650 Range on HMM: 170-264/264 Sequence Identity: 47% (45 aa) PEFCSPELLGGNEIDYGTDVWSIGALSYVMLSGISPFLDESLEETNMNIIRVDYSFPEEYFKNVSQNAKHFITGLLHADSSERKTTSECLMNHWF ||. || . . || |||| . |.||||||||| . || || .| |.|.||||...|. || || || | | | ||| | PEYVAPEIVNYEPLSLATDMWSIGVITYIMLSGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI |
|||||||||
Kinase | Trad.AA | DAPK | 394-536 | 32 | 2.4e-31 | 87.57 | In-house | 1-152 (264) | Show / Hide |
Range on Protein: 394-536 Range on HMM: 1-152/264 Sequence Identity: 32% (49 aa) FNITREIGRGRFSSTHACTRSQQQRTLAAKFISKRLMDL-------EQVQHEASMMQPLQ-HPLICSLHATYETHGQYILVLDLIPDGRILEYLVSLSQV . . ||| | |. |. ||||| || . | . | | . .. || | .||. ||. .|.| |. | .| . YDMGEEIGSGQFAVVKKCREKSTGKEYAAKFIKKRRYTASRRGVSREDIEREVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKECL TERQVIGFIRQLVQAVNYLHSNGIIHLDIKPENVMMEKALGRAQ--IKLIDFG .| || | ..|...|| | |.|.||||.| . . .. ||.|||| NEEEATQFIKQILDGVHHMHSKHICHFDLKPENIML-LDRNVPNPRIKIIDFG |
|||||||||
Kinase | Trad.AA | DAPK | 573-650 | 52 | 3.2e-30 | 84.3 | In-house | 187-264 (264) | Show / Hide |
Range on Protein: 573-650 Range on HMM: 187-264/264 Sequence Identity: 52% (41 aa) TDVWSIGALSYVMLSGISPFLDESLEETNMNIIRVDYSFPEEYFKNVSQNAKHFITGLLHADSSERKTTSECLMNHWF || |||| |..||| |||| . .|| || .| | | |||||| |. || || || | | | ||| | TDMWSIGVITYILLSGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKDPKKRMTIQECLQHPWI |
|||||||||
Kinase | Trad.AA | CAMK1 | 394-536 | 30 | 2.7e-29 | 82.27 | In-house | 1-158 (276) | Show / Hide |
Range on Protein: 394-536 Range on HMM: 1-158/276 Sequence Identity: 30% (48 aa) FNITREIGRGRFSSTHACTRSQQ---QRTLAAKFIS-KRLMDL------EQVQHEASMMQ---PLQHPLICSLHATYETHGQYILVLDLIPDGRILEYLV .... ||||| || . ||. . .. | | |. |. |. |... | ..|. ..|| | ... ||. . ||..|. | ... | YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV SLSQVTERQVIGFIRQLVQAVNYLHSNGIIHLDIKPENVMMEKALGRAQIK--LIDFG . ||.. ..|...||.|.||.|| | |.|||| . ..|| ..||| EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFG |
|||||||||
Kinase | Trad.AA | CAMK1 | 556-650 | 35 | 1.9e-23 | 65.0 | In-house | 177-276 (276) | Show / Hide |
Range on Protein: 556-650 Range on HMM: 177-276/276 Sequence Identity: 35% (35 aa) PEFCSPELLGG---NEIDYGTDVWSIGALSYVMLSGISPFLDES-LEETNMNIIRVDYSFPEEYFKNVSQN-AKHFITGLLHADSSERKTTSECLMNHWF |... || | . |. |.|||| .|..| | .|| ||. .| |.. .| ||. .. |.| ||.||...| | ..| | ..|| |. PGYVAPEVLECKKDKPYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
|||||||||
Kinase | Trad.AA | TyrKc | 394-650 | 18 | 8.8e-09 | -80.63 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 394-650 Range on HMM: 1-280/280 Sequence Identity: 18% (54 aa) FNITREIGRGRFSSTHACTRSQQQRTLAAKFISKRLMDLEQVQHEASMMQPL--QHPLICSLHATYETH-------GQYILVLDLIPDGRILEYLVSLSQ ...|.| | . .| . .. | | . . .| .||..| | .|| | |.. .. ... .|. . | | ..|| . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP -VTERQVIGFIRQLVQAVNYLHSNGIIHLDIKPENVMMEKALGRAQIKLIDFGDAMDLWSS---PPPFYHELNA-----NPEF------CSPELLGGNEI .. .. . | | . .||||...|| |. |.. . . ..| ||| . |. . .. . . ..|| . .. KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG--ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF DYGTDVWSIGALSYVMLS-GISPFLD-----ESLEETNMNIIRVDYSFPEEY-----FKNVSQNAKHFITGLLHADSSERKTTSECLMNHWF .|||| | . . ... | .| . | .| .. . .. . .. | .. .. |.| ..| | ||. . | TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
|||||||||
Kinase | Trad.AA | Pkinase_Tyr | 394-511 | 20 | 1.3e-05 | 19.65 | Pfam | 1-134 (270) | Show / Hide |
Range on Protein: 394-511 Range on HMM: 1-134/270 Sequence Identity: 20% (28 aa) FNITREIGRGRFSSTHACTRS----QQQRTLAAKFI--SKRLMD--LEQVQHEASMMQPL-QHPLICSLHATYE-THGQ--YILVLDLIPDGRILEYLVS . ...|.| | . . .| ... . | | . . . .| .||..| | .|| | .|.. .. ...|. . | | |.|| . ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK ----LSQVTERQVIGFIRQLVQAVNYLHSNGIIH ..| . ... .| .. .||.|...|| HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH |