Gene TTBK (Sea Urchin)

TTBK

Species: Sea Urchin
Alias: Spk118, TTBK, SPU_021174
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
TTBK.AA Protein None 329 None Fasta, JSON
TTBK.kin_dom Protein Kinase Domain None 215 None Fasta, JSON

Protein domain

Protein domains of TTBK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TTBK.AA TTBK 16-271 77 4.5e-208 697.53 In-house 1-257 (257) Show / Hide 
Range on Protein: 16-271
Range on HMM: 1-257/257
Sequence Identity: 77% (199 aa)

WKVTKKIGGGGFGEIYEALDQVID-ECVAIKLESALQPKQVLKMEVAVLKKLQGRDHICKFIGCGRNDQFNYVVMTVQGQNLAELRRAQPRGTFSVSTML
|||.||||||||||||||.|.... |.||||.||| ||||||||||||||||||.||.|.||||||||.|||.||..||.|||.|||.||||.||.||.|
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

RLGVQILESIESIHEVGFLHRDIKPSNFAIGKAAANTRKVYMLDFGLARQYTNSQGQVRTPRPVAGFRGTVRYASVNAHRNREMGRHDDLWSLFYMLVEF
|||||||.||||||.||||||||||||||.|......||.|||||||||||||..|.||.||.||||||||||||.||||||||||||||||||||||||
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEF

VIGQLPWRKIKDKEQVGLLKEKYDHRLLLKHMPMEFKQILEQFQSLEYADKPDYKCI
|.|||||||||||.||| .|||||||.||||.| ||.| ..  .||.|.|.|||. |
VQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase TTBK.AA CK1 16-271 33 4.3e-119 401.94 In-house 1-339 (339) Show / Hide 
Range on Protein: 16-271
Range on HMM: 1-339/339
Sequence Identity: 33% (114 aa)

WKVTKKIGGGGFG-EIYEA-----LDQVID-----ECVAIKLESALQPKQ-VLKMEVAVLKKL---------------------QGRDHICKFIGCGRND
|||.||||.|||| .||..      |   .     |..|.|.|.. . .|  ..||.....|.                     .|. |.|... .|..|
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

Q-FNYVVMTVQGQNLAELRR--AQPRGTFSVSTMLRLGVQILESIESIHEVGFLHRDIKPSNFAIGKA------------AANTRKVYMLDFGLAR-QYT
. .||.|||  | || .||.  ..... ||..| |....|.||..| .|. ||.||||||.||..| .              . |.|||.|||.|| .|.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

NSQGQV------------RTPRP---VAGFRG-TVRYASVNAHRNREMGRHDDLWSLFYMLVEFVIGQ--LPWRKIKDKEQ-----VGLLKEKYDHRLLL
...|..            |.||.    .|||| |.||.|.|.|...|.||.|||||.||||.|.. |.  |||...||...     |.  |... .. ..
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

------------KHMPMEFKQILEQFQSLEYADKPDYKCI
            ...| || .|..   ||.| |.|||. |
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase TTBK.AA Worm6 16-271 41 2.1e-112 379.76 In-house 1-279 (279) Show / Hide 
Range on Protein: 16-271
Range on HMM: 1-279/279
Sequence Identity: 41% (117 aa)

WKVTKKIGGGGFGEIYEALDQVIDE--CVAIKLES--ALQPKQVLKMEVAVLKKLQGRD--HICKFIGCGRNDQ--FNYVVMTVQGQNLAELRRAQPRGT
|||||||| |||| .|...|    .   .|.|.|.  .  ..|.||||..|||..  .   | ||.. .|. |.  |||.|||  | ||..||...| . 
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FSVSTMLRLGVQILESIESIHEVGFLHRDIKPSNFAIG----KAAANTRKVYMLDFGLAR--QYTNSQGQVRTPR-PVAGFRGTVRYASVNAHRNREMGR
||..| |... | ||.||  | .||.|||.||.||.||    |   . ...||||||..|  .| | ....|||| ...|||||||||....|...|..|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

HDDLWSLFYMLVEFVIGQLPWRKIKDKEQVG-LLKEKYDHR------LLLKHMPM-EFKQILEQFQSLEYADKPDYKCI
 ||. | |||.||.. |.||||..||. .|. . |......      ....  |. ||. |.. . .. | |.|||| |
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase TTBK.AA TTBKL 16-275 38 4.7e-112 378.56 In-house 1-288 (288) Show / Hide 
Range on Protein: 16-275
Range on HMM: 1-288/288
Sequence Identity: 38% (110 aa)

WKVTKKIGGGGFGEIYEALDQVI-DECVAIKLESALQPK--QVLKMEVAVLKKLQ--GRDHICKFIGCGRNDQFNYVVMTVQGQNLAELRRAQPRGT-FS
|...|.||.||||..|.. | .  ..| | | |.  . .  ...|||| ||.|||  |  |..|....|.....|..|||  | ||  ||.  |..  ||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

VSTMLRLGVQILESIESIHEVGFLHRDIKPSNFAIGKAAAN---TRKVYMLDFGLARQYTNSQG-----------QVRTPRP---VAGFRGTVRYASVNA
..| .|.|.|.|...  .|..||.|||.||.|...|  . .    | || .|||.|||| ...|           ..|.||.    |.||||.||.|.|.
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HRNREMGRHDDLWSLFYMLVEFVIGQLPWRKIKDKEQVGLLKEKYDHRLLLKH------MPMEFKQILEQFQSLEYADKPDYKCIHSLL
|. .| ||||||||..||..|.. | |||. ..||.... .|..  . .| |       .|.||  . .   ||.|.| |||  |  ..
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase TTBK.AA CK1 16-269 34 4.7e-56 191.45 In-house 1-271 (271) Show / Hide 
Range on Protein: 16-269
Range on HMM: 1-271/271
Sequence Identity: 34% (95 aa)

WKVTKKIGGGGFGEIYEALDQVIDEC---VAIKLESALQPKQVLKMEVAVLKKLQG------RDHICKFIGCGRNDQ--FNYVVMTVQGQNLAELRRAQP
 .|..||| | ||.||.. .   ..    ||||||.. .  . |. |. ..| |||        .| . . ||...|  .|..||.  |..| .|     
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCN

RGTFSVSTMLRLGVQILESIESIHEVGFLHRDIKPSNFAIGKAAANTRKVYMLDFGLARQYT-NSQGQVRTPRPVAGFRGTVRYASVNAHRNREMGRHDD
|  ||. | | .. |... || .|. .|.|||||| || .|    .  .||. ||||| .|   . .|    |   .. ||.||||.|.|  .| .| ||
R-KFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD

LWSLFYMLVEFVIGQLPWRKIKDK------EQVGLLKEKYDHRLLLKH-MPMEFKQILEQFQSLEYADKPDYK
. || |.|. |  |.|||  .| .      |. .  | .. .  | |   | || . |.   .|....||||.
MESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase TTBK.AA CK1-D 16-271 36 1.3e-49 171.13 In-house 1-261 (261) Show / Hide 
Range on Protein: 16-271
Range on HMM: 1-261/261
Sequence Identity: 36% (97 aa)

WKVTKKIGGGGFGEIYEALDQVIDECVAIKLESALQPKQVLKMEVAVLKKLQGRDHICKFIGCGRNDQFNYVVMTVQGQNLAELRRAQPRGTFSVSTMLR
... .|||.| ||.||   .   .| ||||||..      |..|  . | .||   | .   ||.. ..| .|| . |  | .|     |  ||. |.| 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHR-KFSLKTVLM

LGVQILESIESIHEVGFLHRDIKPSNFAIGKAAANTRKVYMLDFGLARQYTNSQGQVRTP-RPVAGFRGTVRYASVNAHRNREMGRHDDLWSLFYMLVEF
|. |..  || ||   |.|||||| || .|        ||..|||||..|  .. .   | |      || ||||.| |.  |  | ||| || |.|. |
LADQMICRIEYIHCRNFIHRDIKPDNFLMG-LGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYF

VIGQLPWRKIKDK------EQVGLLKEKYDHRLLLKHMPMEFKQILEQFQSLEYADKPDYKCI
  | |||  .|        |..   | .     | | .| ||.| ..  ..|.. |||||  .
NRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase TTBK.AA CK1-A 16-271 34 1.3e-46 161.15 In-house 1-261 (261) Show / Hide 
Range on Protein: 16-271
Range on HMM: 1-261/261
Sequence Identity: 34% (91 aa)

WKVTKKIGGGGFGEIYEALDQVIDECVAIKLESALQPKQVLKMEVAVLKKLQGRDHICKFIGCGRNDQFNYVVMTVQGQNLAELRRAQPRGTFSVSTMLR
... .||| | ||.|| ..     | ||||.||.      |  |  | . |||   | .    |.. ..| .|| . |  | .|     |  |.. |.| 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKR-RFTMKTVLM

LGVQILESIESIHEVGFLHRDIKPSNFAIGKAAANTRKVYMLDFGLARQYTNSQGQVRTP-RPVAGFRGTVRYASVNAHRNREMGRHDDLWSLFYMLVEF
|  |..  || .|| .|.|||||| || .|       |....|||||..|  |. .   | |      ||.||||.|||   |  | ||. |. |... |
LADQMIMRIEYVHEKNFIHRDIKPDNFLMG-IGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYF

VIGQLPWRKIKDK------EQVGLLKEKYDHRLLLKHMPMEFKQILEQFQSLEYADKPDYKCI
  |.|||  .| .      |..   |       | | .| ||  ...  ..| . ..|||  .
NRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase TTBK.AA CK1-Unclassified 16-165 37 3.3e-46 134.38 In-house 1-158 (244) Show / Hide 
Range on Protein: 16-165
Range on HMM: 1-158/244
Sequence Identity: 37% (60 aa)

WKVTKKIGGGGFGEIYEALDQVIDECVAIKLESALQPKQVLKMEVAVLKKLQGRD-------HICKFIGCGRNDQ--FNYVVMTVQGQNLAELRRAQPRG
 .|..||| | |||||.. .   .| ||||||.. .    |. |. ... ||..        .| | . ||...|  .|..||.  |..| .|     | 
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNR-

TFSVSTMLRLGVQILESIESIHEVGFLHRDIKPSNFAIGKAAANTRKVYMLDFGLARQY
 ||. | | .. |... || .|. .|.|||||| || .||   |  .||. ||||.  |
KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRY
Kinase TTBK.AA CK1-Unique 16-222 28 3.9e-39 133.3 In-house 1-233 (337) Show / Hide 
Range on Protein: 16-222
Range on HMM: 1-233/337
Sequence Identity: 28% (66 aa)

WKVTKKIGGGGFGEIYEALDQVIDE---------CVAIKLESALQPKQVLKMEVAVLKKLQGRD-------HICKFIGCGRNDQFNYVVMTVQGQNLAEL
|.|.|.||.||.|  .. ...| ..         |      .. .. | |. | .|.| .   .       | |. .  .  ..  . |||  | .. |.
WCVIKHIGYGGYGCVHR-VIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEEC

RRAQPRGTFSVS------TMLRLGVQILESIESIHEVGFLHRDIKPSNFAIGKAA-ANTRKVYMLDFGLARQ--YTNSQGQVRTPRPVAGFRGTVRYASV
...  .  |  .      . ...| |.|. ||  |..||.||..|| |.  . .  .  .  ||||.|  |        .|.| ||| . |||. .|.. 
CMMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPC

NAHRNREMGRHDDLWSLFYMLVEFVIGQ--LPWR
  |. || || ||. |.||||.  | .   | |.
SCHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK
Kinase TTBK.AA Dual 16-275 28 5.7e-39 128.61 In-house 1-282 (282) Show / Hide 
Range on Protein: 16-275
Range on HMM: 1-282/282
Sequence Identity: 28% (80 aa)

WKVTKKIGGGGFGEIYEALDQVI----DECVAIKLESALQPKQVL--KMEVAVLKKLQG---------RDHICKFIGCGR--NDQFNYVVMTVQGQNLAE
||| . .| |||...|   ..      ..|...|.||    |  |  | |. | .|  .           .   |.  |    |  .|.||   |  | |
WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE

LRRAQPRGTFSVSTMLRLGVQILESIESIHEVGFLHRDIKPSNFAIGKAAANTRKVYMLDFGLARQYTN-SQGQVRTPRPVAGFRGTVRYASVNAHRNRE
 ||    | .|...    . | |..|   | .|.|||.|||.||..|  .  | .|||.||...| |   . ...||.|    . |. |||.      ..
IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDET-TVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQKD

MGRHDDLWSLFYMLVEFV-IGQ-LPWRKIKDKEQVGLLKEKY---DHRLLLKHMPMEFKQILEQFQSLEYADKPDYKCIHSLL
 || ||| .  ||.      .  ..|||  |   .   |.     .      | | ..| ..    ...|   |||  .   |
QGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQYSHIPRRLKPLVSYVNGYQYDSTPDYDYFRNCL
Kinase TTBK.AA Pkinase 16-222 25 1.5e-23 84.31 Pfam 1-213 (293) Show / Hide 
Range on Protein: 16-222
Range on HMM: 1-213/293
Sequence Identity: 25% (56 aa)

WKVTKKIGGGGFGEIYEALDQVIDECVAIKLESALQPKQVLKM------EVAVLKKLQGRDHICKFIGCGRNDQFNYVVM-TVQGQ----NLAELRRAQP
... .||| |.||. |.. ..   . ||.|  .    |   ..      |....|.| . ..|...... ....  |.||  ..|      |... ... 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

RGTF--SVSTMLRLGVQILESIESIHEVGFLHRDIKPSNFAIGKAAANTRKVYMLDFGLARQYTNSQGQVRTPRPVAGFRGTVRYASVNAHR-NREMGRH
.|.|  |  .  .   |||. .| .|. |..|||.||.|. | .   .  .|   |||||.|.          .   .| || .|..   .| ... |. 
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

DDLWSLFYMLVEFVIGQLPWR
 | ||.  .| |.. |..|..
VDMWSCGCILYEMLCGRPPFP
Kinase TTBK.AA S_TKc 16-297 21 1.5e-17 65.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-297
Range on HMM: 1-231/231
Sequence Identity: 21% (63 aa)

WKVTKKIGGGGFGEIYEALDQVIDECVAIKLESALQPKQVLKMEVAVLKKLQGRDHICKFIGCGRNDQFNYVVMTVQGQ---NLAELRRAQPRGT----F
... .||| |.||. | . .   .. ||||  .     . .. |...|||  . ..|.|.... .. .. |.||   ..   .| .. . ..|.     |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SVSTMLRLGVQILESIESIHEVGFLHRDIKPSNFAIGKAAANTRKVYMLDFGLARQYTNSQGQVRTPRPVAGFRGTVRYASVNAHRNREMGR-HDDLWSL
.  .  ..  ||.. .| .|. |..|||.||.|  . .       .   |||||||.               | ||  | .         |.   | ||.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

FYMLVEFVIGQLPWRKIKDKEQVGLLKEKYDHRLLLKHMPMEFKQILEQFQSLEYADKPDYKCIHSLLERCMN-----RKNIKENDAYDWE---RPPV
  .| |.. |. |..                      .| | ||.|.            .  ... ....|..     |  . |  ...|.    | .
GCILYEMLCGYPPFP----------------------QMQMMFKKIG------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TTBK.AA CK1-Unclassified 183-238 51 8.4e-13 34.13 In-house 178-229 (244) Show / Hide 
Range on Protein: 183-238
Range on HMM: 178-229/244
Sequence Identity: 51% (29 aa)

GTVRYASVNAHRNREMGRHDDLWSLFYMLVEFVIGQLPWRKIKDKEQVGLLKEKYD
|| ||||.|||.  | .| ||| || | |. |  |.|||  || ...    ||||.
GTARYASINAHLGIEQSRRDDLESLGYVLIYFLKGSLPWQNIKANNK----KEKYE
Kinase TTBK.AA TyrKc 16-275 19 2.2e-08 -87.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-275
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

WKVTKKIGGGGFGEIYEALDQVIDECVAIKLESALQPKQVLKMEVAVLKKL-QGRDHICKFIGCGRND-------QFNYVVM-TVQGQNLAELRRAQPRG
 .  ||.| | |||.|..      . ||.|   .   .. .  |  ...||    ..| ...|. . .       .  ..||  . . .| .  |.  . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

TFSVSTMLRLGVQILESIESIHEVGFLHRDIKPSNFAIGKAAANTRKVYMLDFGLARQYTNS--QGQVRTPRPVA----GFR--GTVRYASVNAHRNREM
 ......|   .|| .  | .|. .. |||.   |  .|.       |   ||||.|  ..   || ...   ..    | .    .|  .  . . .. 
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

GRHDDLWS---LFYMLVEFVIGQLPWRK-----IKDKEQVGLLKEKYDHRLLLK-------HMPMEFKQILEQFQSLEYADKPDYKCIHSLL
    | ||   . . .  .  || |.       ....| . ..|. |  .           ..| |  || .|    . .| |  . ||...
TTKSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF