Gene PITSLRE (Sea Urchin)

PITSLRE

Species: Sea Urchin
Alias: PITSLRE, SPU_016748, Spk122
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: PITSLRE

Sequence

Name Sequence Type Origin Length Description Download
PITSLRE.AA Protein None 601 None Fasta, JSON
PITSLRE.kin_dom Protein Kinase Domain None 286 None Fasta, JSON

Protein domain

Protein domains of PITSLRE.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PITSLRE.AA PITSLRE 245-530 73 5.4e-241 806.89 In-house 1-295 (295) Show / Hide 
Range on Protein: 245-530
Range on HMM: 1-295/295
Sequence Identity: 73% (216 aa)

FQCLNRIAEGTYGVVYRANEKKKNDIVALKRLKME--KEKEGFPITSLREISTLLKA-QHRNIVTVREIVVGSNMDKIYIVMDYVEHDLKSLMETMK---
|||||||.||||||||||..|....||||||||||  ||||||||||||||...|.| ||.|||.|.|||.||||||||.||.|||||||||||.||   
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

QPFTIGETKCLILQLLRGVHHLHDNWILHRDLKTSNLLLNHQGCLKIGDFGLAREYGSPIKPYTSIVVTLWYRAPELLLGTKVYSTPIDMWSVGCIFAEF
|||..||.|||..||||||.|.|||||.||||||||||..|.|.|||.||||||||||||||||..||||||||||||||.|.||||.||||||||||||
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

LTIKPIFNGRSEIDQLNRIFKELGTPSEKIWPGYNELPAVKKTT-FAHHPYNNLRNRFG--TYLTDVGFELLNRFLTYDPVRRISAEDALKHPYF
.|.||.|.|.|||||.|.||||.|||.||||||..|||..|... |.|.||||||.||.  ....|.||.|||..|||.| .||.|.||||||.|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase PITSLRE.AA CDK 245-530 47 2.4e-174 562.38 In-house 1-284 (284) Show / Hide 
Range on Protein: 245-530
Range on HMM: 1-284/284
Sequence Identity: 47% (153 aa)

FQCLNRIAEGTYGVVYRANEKKKN-----DIVALKRLKMEK-----EKEGFPITSLREISTLLKAQHRNIVTVREIVVGSNMD---------KIYIVMDY
...|..| ||||||||.|  |. .     .|||||...||.     ||||||||..||||.| .  | |||.........|||         |.|.|..|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

VEHDLKSLMETMKQPFTIGETKCLILQLLRGVHHLHDNWILHRDLKTSNLLLNHQGC-----LKIGDFGLAREYGS------PIKPYTSIVVTLWYRAPE
..||||..|.           ||...|||||.|..|.|||.|||||..|.|.|..|.     |||.||||||..|.      |...||. ||||||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLLGTKVYS--TPIDMWSVGCIFAEFLT---IKPIFNGRSEIDQLNRIFKELGTPSEKIWPGYNELPAVKKTTFAHHPYNNLRNRFGTYLTDVGFELLNR
||||.| ||  ||||||||||||||..|    ||.| |.|||||| .||. .|||.|..|||  .||                            .|||.
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DLLNK

FLTYDPVRRISAEDALKHPYF
.|.||| .|||||.||.||||
MLCYDPKKRISAEQALQHPYF
Kinase PITSLRE.AA CDC2 245-530 45 5.5e-142 439.45 In-house 1-301 (301) Show / Hide 
Range on Protein: 245-530
Range on HMM: 1-301/301
Sequence Identity: 45% (140 aa)

FQCLNRIAEGTYGVVYRANEKKKNDIVALKRLKMEKEKEG--FPITSLREISTLLKAQ-HRNIVTVREIVVGSNMDKIYIVMDYVEHDLKSLME-TMK--
.|....| ||||||||.. ... |.|||||. . | | ||  .| |..||||.| . . | |||. .....     |.|.| .|...||| .|.   .  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

QPFTIGETKCLILQLLRGVHHLHDNWILHRDLKTSNLLLNHQGCLKIGDFGLAREYGSPIKPYT--SIVVTLWYRAPELLLGTKVYSTPIDMWSVGCIFA
....    | .. |.|.|||..| . |.||||| .|.|.. .| .||.||||||  | ||..||    ||||||||||.||| | ||||.||||.|||||
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

EF---LTIKPIFNGRSEIDQLNRIFKELGTPSEKIWPGYNELP-------AVKKTTFAHHPYNNLRNR-FGTYLTDVGFELLNRFLTYDPVRRISAEDAL
|.    | ||.| | |||||| .||. ||||.|..|||  .||         |.. . .. .||. .. . . |.. |..||.. | ||| .||||..||
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQ-SCLDPEGIDLLMQMLQYDPQKRISAKEAL

KHPYF
.||||
QHPYF
Kinase PITSLRE.AA CDK10 245-530 53 8.70000000001e-141 474.01 In-house 1-285 (285) Show / Hide 
Range on Protein: 245-530
Range on HMM: 1-285/285
Sequence Identity: 53% (153 aa)

FQCLNRIAEGTYGVVYRANEKKKNDIVALKRLKMEKEKEGFPITSLREISTLLKAQHRNIVTVREIVVGSNMDKIYIVMDYVEHDLKSLMETMKQPFTIG
|  |||. |||||.|||| . . ..|||||. .|.|||.| || .||||  |.. .| ||| ..|.|||  .| |..||.| | || ||.. | ||||  
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPQPFTET

ETKCLILQLLRGVHHLHDNWILHRDLKTSNLLLNHQGCLKIGDFGLAREYGSPIKPYTSIVVTLWYRAPELLLGTKVYSTPIDMWSVGCIFAEFLTIKPI
. ||..||.|||.. ||||...||||| ||||.  .||.|. |||||| || |.|| |  .|||||||||||||..   | |||| |||| .| |  ||.
QVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELLVHKPL

FNGRSEIDQLNRIFKELGTPSEKIWPGYNELPAVKKTTFAHHPYNNLRNRFGTYLTDVGFELLNRFLTYDPVRRISAEDALKHPYF
. | ||| |.. | . ||||||.||||. .||.|.. |  . |||||...| ..| . | .|||  . |.| .|  ||..|.  ||
MPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKF-HWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase PITSLRE.AA CMGC 245-530 27 1.8e-138 458.13 In-house 1-513 (513) Show / Hide 
Range on Protein: 245-530
Range on HMM: 1-513/513
Sequence Identity: 27% (143 aa)

FQCLNRIAEGTYGVVYRANE--------------KKKNDIVALKRLK---MEK------EKEGFPITSLREISTLLKAQ-----------------HRNI
......| ||||||||..                .. | |||.|..|   .|       ||.||||..||||. | . .                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VTVREIVVGSNMD---------------KIYIVMDYVEHDLKSLMETMK--------QPFTIGE------------TKCLI------LQLLRGVH--HLH
|. ..|.. .|.|               ..|.|..|..|||. ... ..        .|..  .             |...       |.|||..  ..|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

DNW--ILHRDLKTSNLLLNHQ--------------------GCLKIGDFGLAREYGSP---------------------IKPYTSIVVTLWYRAPELLLG
 .|  |.||||| .|.|.||.                    |.|||.|||||| |...                      .|||. |||.||||||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

TKVYS---------TPIDMWSVGCIFAEFLTI--------KPIFNGRSE-----------IDQLNRIFKELGTPS---------------EKIWPGYNEL
 | |.         |||||||||||||| .|         ||.| |.||           ||||..||| ||||.               |..||....|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PAVKKTT-------------------------FAHHPYNNLR------------------------NRFGTY----------LTDVGFELLNRFLTYDPV
|  .|.                          |  .|.....                        ..|...          ... ...||.. |.||| 
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

RRISAEDALKHPYF
.||.||.||.||||
KRITAEQALQHPYF
Kinase PITSLRE.AA CDK7 245-530 40 1.8e-127 341.65 In-house 1-288 (288) Show / Hide 
Range on Protein: 245-530
Range on HMM: 1-288/288
Sequence Identity: 40% (119 aa)

FQCLNRIAEGTYGVVYRANEKKKNDIVALKRLK----MEKEKEGFPITSLREISTLLKAQHRNIVTVREIVVGSNMDKIYIVMDYVEHDLKSLMETMKQP
.. .  | ||....||.| ... . ||| |. |     .  | |   | .|||  |   || |..  . |      . |. |.|. . ||    .  .  
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFM--HKSNIQLVFDFMDWDLEVVIKDKSII

FTIGETKCLILQLLRGVHHLHDNWILHRDLKTSNLLLNHQGCLKIGDFGLAREYGSPIKPYTSIVVTLWYRAPELLLGTKVYSTPIDMWSVGCIFAEFLT
.|  . |   ...|.|. ..| |||||||||  |||.|  | |||.|||||| |||| . ||. ||| |||||||| | . | | .||||||||||| . 
LTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELML

IKPIFNGRSEIDQLNRIFKELGTPSEKIWPGYNELPAVKKTTFAHHPY---NNLRNRFGTYLTDVGFELLNRFLTYDPVRRISAEDALKHPYF
  |.. | |.|||| |||. ||||.|. ||.  ...     .|  .|      ||..| |  .|   .|. . .| .|..|... ..||.|||
RVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDY--IKFKDFPGYSRTPLRHIF-TAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase PITSLRE.AA CDK5 245-530 42 2e-121 385.61 In-house 1-287 (287) Show / Hide 
Range on Protein: 245-530
Range on HMM: 1-287/287
Sequence Identity: 42% (124 aa)

FQCLNRIAEGTYGVVYRANEKKKNDIVALKRLKMEKEKEGFPITSLREISTLLKAQHRNIVTVREIVVGSNMDKIYIVMDYVEHDLKSLMETMKQPFTIG
.. ...| |||||.||.| .|.   |||||| ... | || | | .|||. |   .|.|||    ..   .  |. .|  ..  |||  |. ..      
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEK--KLTLVFEFCDQDLKKYMDSCNGEMDMH

ETKCLILQLLRGVHHLHDNWILHRDLKTSNLLLNHQGCLKIGDFGLAREYGSPIKPYTSIVVTLWYRAPELLLGTKVYSTPIDMWSVGCIFAEFL-TIKP
  | ...|||.|.   |.. .||||||  ||| | .| || .|||||| .| |.. |.. |||||||.|  |.| |.|||.|||||.||||||   . .|
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRP

IFNGRSEIDQLNRIFKELGTPSEKIWPGYNELPAVK--KTTFAHHPYNN-LRNRFGTYLTDVGFELLNRFLTYDPVRRISAEDALKHPYF
 | | .. ||| |||| .|||.|  ||.  .||  |   . .  .| .  . .     |   | .||.. | ..|  ||||..||.||||
LFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK-LDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase PITSLRE.AA CRK7 245-530 36 1.1e-107 364.08 In-house 1-343 (343) Show / Hide 
Range on Protein: 245-530
Range on HMM: 1-343/343
Sequence Identity: 36% (126 aa)

FQCLNRIAEGTYGVVYRANEKKKNDIVALKRLKMEKE---KEGFPITSLREISTLLKAQHRNIVTVREIVVG------SNMDK--IYIVMDYVEHDLKSL
.. .. | ||||| || |  |. ...||||...|. |   |||||||. |||  |   .|.|||. .|||.       .. .|  .| | .|. |||  |
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

METM-KQPFTIGETKCLILQLLRGVHHLHDNWILHRDLKTSNLLLNHQGCLKIGDFGLAREYGSPI--KPYTSIVVTLWYRAPELLLGTKVY--------
.|    . |  .. ||.  ||| |.  .|.. .||||.| ||.|.| || .|| |||||| | |    .|||  |.|||||.||||||.. |        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------STPIDMWSVGCIFAEFLTIKPIFNGRSEIDQLNRIFKELGTPSEKIWPGYNELPAVK----KTTFAHHPY
                               . |||||.|||..| .| ||||.|. |..||  |.|  |.|    ||   .||  .    | ..     
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLR

NNLRNRFG-TYLTDVGFELLNRFLTYDPVRRISAEDALKHPYF
..   ..    ..   . ||   |..||  |..||..| |..|
EEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase PITSLRE.AA S_TKc 245-530 27 5.1e-95 322.9 SMART 1-231 (231) Show / Hide 
Range on Protein: 245-530
Range on HMM: 1-231/231
Sequence Identity: 27% (82 aa)

FQCLNRIAEGTYGVVYRANEKKKNDIVALKRLKMEKEKEGFPITSLREISTLLKAQHRNIVTVREIVVGSNMDKIYIVMDYVEH---DLKSLMETMKQP-
.. |. | .|..|.||.. .|| . |||.|..|         .. .|||. | | .| |||.  .. .    |..|.||.|...   ||..... .. . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTIGETKCLILQLLRGVHHLHDNWILHRDLKTSNLLLNHQGCLKIGDFGLAREYGSPIKPYTSIVVTLWYRAPELLLGTKVYST-PIDMWSVGCIF
    |.  ...... |..... ..|...|.||||| .|.||..  ..||.||||||..       |....|.||.|||.|     |.. ..|.||.|||.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

AEFLTIKPIFNGRSEIDQLNRIFKELGTPSEKIWPGYNELPAVKKTTFAHHPYNNLRNRFGTYLTDVGFELLNRFLTYDPVRRISAEDALK-------HP
.|.|. .| |       |....|| .|                                     .. . ..... |..|| .|..| .||.       ||
YEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

YF
.|
WF
Kinase PITSLRE.AA CDK8 249-530 34 1.2e-94 297.17 In-house 1-329 (329) Show / Hide 
Range on Protein: 249-530
Range on HMM: 1-329/329
Sequence Identity: 34% (114 aa)

NRIAEGTYGVVYRANEKKK----NDIVALKRLKMEK------EKEGFPITSLREISTLLKAQHRNIVTVREIVVGSNMDKIYIVMDYVEHDLKSLMETMK
  |. |||| || | .||.    |  .|||... ||      | .|.  .  |||  .   .| |... ...    .  ......|| ||||       .
KYIGRGTYGHVYKAKRKKQKKKPNKEYALKQFRTEKDGVEQLEGTGISMSACREIALCRELHHPNVICLQRVFLNHKDKCVWMLFDYAEHDLWHIIKFHR

QPF--TIGET-------KCLILQLLRGVHHLHDNWILHRDLKTSNLLLNHQG------CLKIGDFGLAREYGSPIKPYTS---IVVTLWYRAPELLLGTK
..    .. |       | .. |.| |.| || ||.|||||| .| ..   |      | ||.|.|.|| . .| ||      .|||.|||||||||| .
HNKAHMKDPTMVPRNMVKSIMWQILDGIHYLHSNWVLHRDLKPANIMVMGDGPEDMCGCVKIADMGFARIFHNPLKPLYDLDPVVVTFWYRAPELLLGAR

VYSTPIDMWSVGCIFAEFLTIKPIFNGRSE-----------IDQLNRIFKELGTPSEKIWPGYNELPAVKKTTF-AHH--PYNN--LRNRFGTY---LTD
 |   || |..|||||| .| .||| .. |            ||| |||. .|.|..|.||    .|  .. .  .     | |  |   .. .      
HYTKAIDIWAIGCIFAELITSEPIFHCKEEKLDIKTQNPYHHDQLDRIFHVMGFPQDKMWPDIKKMPEHQRLMKDFRRMQTYPNCSLHWYMEKHKIKRDS

VGFELLNRFLTYDPVRRISAEDALKHPYF
  ..|| . ||.||  ||..|.|. ||||
HAYHLLYKMLTMDPTKRITCEQAMEHPYF
Kinase PITSLRE.AA Pkinase 245-530 30 3.3e-93 320.75 Pfam 1-293 (293) Show / Hide 
Range on Protein: 245-530
Range on HMM: 1-293/293
Sequence Identity: 30% (93 aa)

FQCLNRIAEGTYGVVYRANEKKKNDIVALKRLKMEKEKEGFPITSLR--EISTLLKAQHRNIVTVREIVVGSNMDKIYIVMDYVEHDLKSLMETM-----
.... .| .|..|.||.. .|. ..|||.|..| ..||.....| .|  ||. ... .| |||. ....     |.||.||.|.|..|. .|. .     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYIST

--KQPF--TIGETKCLILQLLRGVHHLHDNWILHRDLKTSNLLLNHQGCL----KIGDFGLAREY-GSPIKPYTSIVVTLWYRAPELLLGTKVYSTPIDM
  . .|  .  | |. ..|.|||. ..|...|.||||| .|.|....| .    ||.|||||. .   .   .|....|.||.|||...| . |....||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSVGCIFAEFLTIKPIFNGR----SEIDQLNRIFKELGTPSEKIWPGYNELPAVKKTTFAHHPYNNLRNRFGTYLTDVGFELLNRFLTYDPVRRISAEDA
||.|||..|.|. .|.| |.    . .||. .|.. .|.| .  ||  .. .  . ...   .    . .| ..... . ..... |..|| .|..||..
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQI

LKHPYF
|.||.|
LQHPWF
Kinase PITSLRE.AA CDK4 245-530 40 4.4e-87 295.62 In-house 1-290 (290) Show / Hide 
Range on Protein: 245-530
Range on HMM: 1-290/290
Sequence Identity: 40% (120 aa)

FQCLNRIAEGTYGVVYRANEKKKNDIVALKRLKMEKEKE--GFPITSLREIS---TLLKAQHRNIVTVREIVVGSNMDK----IYIVMDYVEHDLKSLME
.||.. | || || ||||   .   .||||. .   . |  | |.  .||||    | .  | |||   ..   .  |     | .|.  .. ||. ...
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

TMKQ----PFTIGETKCLILQLLRGVHHLHDNWILHRDLKTSNLLLNHQGCLKIGDFGLAREYGSPIKPYTSIVVTLWYRAPELLLGTKVYSTPIDMWSV
 . .    | ||   | .  ||||||  || . | |||||  |.|.. .| .|. ||||||.|..  .  |..|||||||||| ||    | ||.|||||
KCPPPGMPPCTI---KHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMA-LTPVVVTLWYRAPEVLL-QSYYNTPVDMWSV

GCIFAEFLTIKPIFNGRSEIDQLNRIFKELGTPSEKIWPGYNELPAVKKTTFAHHPYNNLRNRFGTYLTDVGFELLNRFLTYDPVRRISAEDALKHPYF
||||||    .| | | || ||| .||.  |.| |. ||    ||      |.     ...  | . .   | .||.. |.|.. .|.||. .|.||||
GCIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP---WDHFPQRHPRPFKD-FCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase PITSLRE.AA Pkinase_Tyr 245-392 30 1.9e-16 56.36 Pfam 1-159 (270) Show / Hide 
Range on Protein: 245-392
Range on HMM: 1-159/270
Sequence Identity: 30% (51 aa)

FQCLNRIAEGTYGVVYRANEK----KKNDIVALKRL---KMEKE--KEGFPITSLREISTLLKA-QHRNIVTVREIVV--GS-NMDKIYIVMDYVEH-DL
 . .  . || .|.||..  |    ...  || | |    |...  .| |    .||.... .  .| |||    ...  |  |  .||||| |..| ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF----MREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDL

KSLMETM---KQPFTIGETKCLILQLLRGVHHLHDNWILHRDLKTSNLLLNHQGCLKIGDFGLAR
..   .    |||.|. .  .  .|  .|  .|... . |||| . | |...... ||.||||||
LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase PITSLRE.AA TyrKc 245-530 21 2e-12 -21.77 SMART 1-280 (280) Show / Hide 
Range on Protein: 245-530
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

FQCLNRIAEGTYGVVYRANEKKKNDIVALKRLKMEKEKEGFPITSLREISTLLKA--QHRNIVTVREIVVGS-----NMDKIYIVMDYVEH-DLKSLMET
 . .  . || .|.||..  |     || | || .. .| |    .||.. . |   .| |||    ... .       . ..||| |..| |||.    
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDF----MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

MKQPFTIGETKCLILQLLRGVHHLHDNWILHRDLKTSNLLLNHQGCLKIGDFGLAREYGSP-----IKPYTSI----VVT--LWYR--APELLLGTKVYS
 .  ..  .     .|  .|  .||.. . |||| . | |...... ||.||||.|. ..       | | .          | .|  ||| .  .....
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

TPIDMWSVGCIFAEFLT--------I----KPIFNGRSEIDQLNRIFKELG----TPSEKIWPGYNELPAVKKTTFAHHPYNNLRNRFGTYLTDVGFELL
|  | || |    | .|        .    .. .  .  ..| .|  .                                       |    .|  ... 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------F-VCCPDEMYQIM

NRFLTYDPVRRISAEDALKHPYF
 .   .||  | . ..   | .|
KQCWHEDPEDRPTFSEI--HECF