Gene CDKL2 (Sea Urchin)

CDKL2

Species: Sea Urchin
Alias: SPU_000563, Spk123, CDKL2
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: CDKL

Sequence

Name Sequence Type Origin Length Description Download
CDKL2.AA Protein None 647 None Fasta, JSON
CDKL2.kin_dom Protein Kinase Domain None 284 None Fasta, JSON

Protein domain

Protein domains of CDKL2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDKL2.AA CDKL 55-338 69 2.1e-225 755.11 In-house 1-286 (286) Show / Hide 
Range on Protein: 55-338
Range on HMM: 1-286/286
Sequence Identity: 69% (199 aa)

YESFGLVGEGSYGQVLKCRHKETNQVVAIKKFLEGEDDKMVKKIAMREVRMLKQLRHENLVNLIEVFRRKKRLYLVFEFMDHTVLDELEKYPMGLDESLV
||..|.|||||||.|.|||.|||.|.||||||.|.|||.|||||||||..|||||.|||.||||||||||..|.||||..|||||.|||.||.|.||..|
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

RKYMWQILKGIEFCHINNIIHRDIKPENILVS-KSKVVKLCDFGFARTIAGPGEIYTDYVATRWYRAPELLVGDTKYGKAIDLWAVGCLQAEMLTGEPLF
|||||||||.|.|||..|.|||||||||||.. |...||||||||||..|.||||||||||||||||||||||||.|||..|.||.||..|||..|.||.
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLW

PGDSDIDQLYHIIRCFGTLIQRHKEIFLKNPLFVGMRLPEVKNVEPLEKRFPTLS-GLSISMMKSCLHLDPDQRPTCTQFLKHEFF
||.|||||||||..|.|.||.||.|||.|||.|.||..||....||||||.|..| ......||.|||.|||.|.||.|...|..|
PGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase CDKL2.AA CMGC 55-338 24 6.9e-132 436.07 In-house 1-513 (513) Show / Hide 
Range on Protein: 55-338
Range on HMM: 1-513/513
Sequence Identity: 24% (127 aa)

YESFGLVGEGSYGQVLKCRH--------------KETNQVVAIKKFLEGEDDKMVKK----------IAMREVRMLKQLR-----------------HEN
||  . .|||.||.| |||.              .|||..|||||. . . ..  .|          .| ||...||.|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNLIEVFRRKK-----------------RLYLVFEFMDHTVLDELEKYP--------MGLDESL------------VRKYM------WQILKGIE--FC
.|.|...|..|.                  ||||||.|||. .. .....        |.|.|              ....|      .|||.|..  .|
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HINN--IIHRDIKPENILVSKS--------------------KVVKLCDFGFARTIAGP---------------------GEIYTDYVATRWYRAPELLV
| ..  |||||.||||||...                      ..|.||||.|| .  .                     .. ||.||.||||||||.|.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GD---------TKYGKAIDLWAVGCLQAEMLTG--------EPLFPGDSD-----------IDQLYHIIRCFGTLI---------------QR-------
|.         ..|...|| |.|||  |||.||        .|||||.|.           ||||..|.. .||                 ..       
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

------------------HKEIFLKNPLFVGMRLPEVK--NVEPLEKRFPT--------------------------------LSGLSISMMKSCLHLDP
                  |. .| .|... . |.|...  . ..|....|.                                .. . |  .| .|..||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

DQRPTCTQFLKHEFF
|.|.|. | |.|..|
DKRITAEQALQHPYF
Kinase CDKL2.AA CDK 55-271 40 1.2e-105 339.06 In-house 1-243 (284) Show / Hide 
Range on Protein: 55-271
Range on HMM: 1-243/284
Sequence Identity: 40% (104 aa)

YESFGLVGEGSYGQVLKCRHKETN-----QVVAIKKF-LEGE----DDKMVKKIAMREVRMLKQLRHENLVNLIEVFRRK-----------KRLYLVFEF
||    .|||.||.| |.|.|.|.     |.||.||. .| |    ..  .   | ||. .||.| |.| |.|..|.  |           ..||.|||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MDHT---VLDELEKYPMGLDESLVRKYMWQILKGIEFCHINNIIHRDIKPENILVSKSKV-----VKLCDFGFARTIAG------PGEIYTDYVATRWYR
|||    ..|             .. ||||.|.|...|| |.|.|||.|| |||...  .     .|. |||.||          |   ||  | |.|||
MDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYR

APELLVGDTKYG--KAIDLWAVGCLQAEMLT---GEPLFPGDSDIDQLYHIIRCFGT
||||| |...|.   .||.|.|||  |||.|   ..|||||||.|||| .|.| .||
APELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGT
Kinase CDKL2.AA S_TKc 55-338 31 1.6e-101 344.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 55-338
Range on HMM: 1-231/231
Sequence Identity: 31% (94 aa)

YESFGLVGEGSYGQVLKCRHKETNQVVAIKKFLEGEDDKMVKKIAMREVRMLKQLRHENLVNLIEVFRRKKRLYLVFEFMDH---TVLDELEKYPMG---
||   ..|.|..|.| |||||.|...||||.           . ..||...||. .|.|.|.|..||.  ..||.|.|..|.   ...| ..|.. .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LDESLVRKYMWQILKGIEFCHINNIIHRDIKPENILVSKSKVVKLCDFGFARTIAGPGEIYTDYVATRWYRAPELLVGDTKYGK-AIDLWAVGCLQAE
  ..|  .|.||.||....|.|| ..|||||.||||||...  ..|.||||.|| .       | .. |.||.|||.|    .||| ..| |..||. .|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

MLTGEPLFPGDSDIDQLYHIIRCFGTLIQRHKEIFLKNPLFVGMRLPEVKNVEPLEKRFPTLSGLSISMMKSCLHLDPDQRPTCTQFLK-------HEFF
||.|.|.||   ........|.                                        |   ..... ||. ||..|||. . |.       |..|
MLCGYPPFP---QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDKL2.AA Pkinase 55-338 32 5e-100 343.42 Pfam 1-293 (293) Show / Hide 
Range on Protein: 55-338
Range on HMM: 1-293/293
Sequence Identity: 32% (97 aa)

YESFGLVGEGSYGQVLKCRHKETNQVVAIKKFLEGEDDKMVKKIAMR--EVRMLKQLRHENLVNLIEVFRRKKRLYLVFEFMDHT----VLDELEK--YP
|.  . .|.||.|.| ||.|| |...||.|..   .... ..... |  |....| |.|.| | |...|..|...|.|.|.....     | .. .  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

MGL--DESLVRKYMWQILKGIEFCHINNIIHRDIKPENILVSKSKVV----KLCDFGFARTI-AGPGEIYTDYVATRWYRAPELLVGDTKYGKAIDLWAV
 ..  .|  ...||.|||.|.|.|| ..|||||.||||||...  ..    |.||||.|. .   ... .|... |.||.|||.. |...||...| |..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCLQAEMLTGEPLFPGD----SDIDQLYHIIRCFGTLIQRHKEIFLKNPLFVGMRLPEVKNVEPLEKRFPTLSGLSISMMKSCLHLDPDQRPTCTQFLKH
||. .|||.|.|.|||.    . .||.. | |  |. . .. .    ...|   |  . .  . .... . .|   .. .|.||..|| .|||..| |.|
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQH

EFF
..|
PWF
Kinase CDKL2.AA CDC2 55-271 44 1.4e-95 294.25 In-house 1-227 (301) Show / Hide 
Range on Protein: 55-271
Range on HMM: 1-227/301
Sequence Identity: 44% (102 aa)

YESFGLVGEGSYGQVLKCRHKETNQVVAIKKF-LEGEDDK-MVKKIAMREVRMLKQLR-HENLVNLIEVFRRKKRLYLVFEFMDHTVLDELE-KYPM--G
|..   .|||.|| | ||....|||.||.||. || ||.   |   |.||   || |. |.|.| | .|.   ..||.|||..|.     .. . |    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LDESLVRKYMWQILKGIEFCHINNIIHRDIKPENILVSKSKVVKLCDFGFARTIAGPGEIYT--DYVATRWYRAPELLVGDTKYGKAIDLWAVGCLQAEM
....||..||.|||.|..||| . |.|||.|| |||..|. ..|. ||| ||..  |   ||    | |.||||||.| |. .|  ..|.|..||. |||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---LTGEPLFPGDSDIDQLYHIIRCFGT
    | .|||.||| ||||. | | .||
FMDVTKKPLFHGDSEIDQLFKIFRILGT
Kinase CDKL2.AA CDK7 55-271 41 1.6e-95 254.83 In-house 1-221 (288) Show / Hide 
Range on Protein: 55-271
Range on HMM: 1-221/288
Sequence Identity: 41% (92 aa)

YESFGLVGEGSYGQVLKCRHKETNQVVAIKKFL----EGEDDKMVKKIAMREVRMLKQLRHENLVNLIEVFRRKKRLYLVFEFMDHTVLDELEKYPMGLD
||   ..||| .. | | . ..|.|.|||||        | .  .   |.||. .|. ..|.| ..|| .|  |  ..|||.|||       .     | 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

ESLVRKYMWQILKGIEFCHINNIIHRDIKPENILVSKSKVVKLCDFGFARTIAGPGEIYTDYVATRWYRAPELLVGDTKYGKAIDLWAVGCLQAEMLTGE
 . .  || ..|.|.|.|| | | |||.|| | |...  ..|. ||| || .  | .|||  | |||||||||| |   || ..|.|.|||  || .   
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PLFPGDSDIDQLYHIIRCFGT
| .|||||||||  | .  ||
PYLPGDSDIDQLTRIFQTLGT
Kinase CDKL2.AA RCK 55-338 35 1.2e-88 281.41 In-house 1-298 (298) Show / Hide 
Range on Protein: 55-338
Range on HMM: 1-298/298
Sequence Identity: 35% (107 aa)

YESFGLVGEGSYGQVLKCRHKETNQVVAIKKFLEGEDDKMVKKIAMREVRMLKQLR-HENLVNLIEVFRRKK--RLYLVFEFMDHTVLDELEK---YPMG
|     .|.|.|| |.| . |||...|||||    .  .    .  ||.. |. |  |.|...|.||.| ..  .||.|||.||  .   ..        
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK-QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKY

LDESL--VRKYMWQILKGIEFCHINNIIHRDIKPENILVSK---------SKVVKLCDFGFARTIAGPGEI-YTDYVATRWYRAPELLVGDTKYGKAIDL
| |.   ....| |||.|....| ... |||.|||||....         . ..|..||| .| |    .  ||||| ||||||||.|  .|.| . .|.
LPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIR--SKPPYTDYVSTRWYRAPECLLRCTYYNSPMDI

WAVGCLQAEMLTGEPLFPGDSDIDQLYHIIRCFGTLIQRHKEIFLKNPLFVGMRLPEVKNVEPLEKRFPTLSGLSISMMKSCLHLDPDQRPTCTQFLKHE
|||||  .|  .  ||||| | |||.. |.   || ...  . . |    .. ..| .|   ||.. .| .|   |. |. .|  ||. |.|  | |.| 
WAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCK-GMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHP

FF
.|
YF
Kinase CDKL2.AA CDK5 55-338 36 2.6e-83 263.02 In-house 1-287 (287) Show / Hide 
Range on Protein: 55-338
Range on HMM: 1-287/287
Sequence Identity: 36% (104 aa)

YESFGLVGEGSYGQVLKCRHKETNQVVAIKKFLEGEDDKMVKKIAMREVRMLKQLRHENLVNLIEVFRRKKRLYLVFEFMDHTVLDELEKYPMGLDESLV
||    .||| || | | | |||  .||.|.    ..|  |   |.||. .|| |.|.| | |. |    |.| |||||.|      ...   ..|  ..
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

RKYMWQILKGIEFCHINNIIHRDIKPENILVSKSKVVKLCDFGFARTIAGPGEIYTDYVATRWYRAPELLVGDTKYGKAIDLWAVGCLQAEML-TGEPLF
. .|.| |||..||| ... ||| || | |..|    || ||| ||    |   |.  | | |||.|  | |  .|   ||.| .||  |||  .| |||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGDSDIDQLYHIIRCFGTLIQRHKEIFLKNPLFV--GMRLPEVKNVEPLEKRFPTLSGLSISMMKSCLHLDPDQRPTCTQFLKHEFF
|| .. |||  | .  ||    .     | | .      .|     .....  | |..    ...  | ..|.|| .  . |.| .|
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDKL2.AA MAPK 55-338 31 9.7e-78 264.58 In-house 1-328 (328) Show / Hide 
Range on Protein: 55-338
Range on HMM: 1-328/328
Sequence Identity: 31% (103 aa)

YESFGLVGEGSYGQVLKCRHKE------TNQVVAIKKFLEGEDDKMVKKIAMREVRMLKQL-RHENLVNLIEVFRRK-----------KRLYLVFEFMDH
|.    .|.|.||.| ....|.      ... |||||.    ....  | . ||...|. . .||| ..|...|. .           . .|.|.|.|..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

TVLDELEKYPMGLDESLVRKYMWQILKG--IEFCHINNIIHRDIKPENILVSKSKVVKLCDFGFARTIAG-PGEIY-------------TDYVATRWYRA
     ..  .  |..  ..  |.|||.|  . . |  |.||||.||.|||| .   .|.|||| ||.|.    ...             |.|||||||||
DLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PELLVGD--TKYGKAIDLWAVGCLQAEMLT-GEPLFPGDSDIDQLYHIIRCFGTLIQRHKEIFLK-NPLF--VGMRL--PEVKNVEPLEKRFPT----LS
||.. .   ..| ||.| |.|||  ||||| . |||||.. |||. .|.   ||   ..   ... ..    .  .|  .  ..  |.|| ||      .
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTP-SEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNAN

GLSISMMKSCLHLDPDQRPTCTQFLKHEFF
 . | ...  |..|||.| |  . | |..|
PQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDKL2.AA MAK 55-338 31 1.8e-75 239.6 In-house 1-352 (352) Show / Hide 
Range on Protein: 55-338
Range on HMM: 1-352/352
Sequence Identity: 31% (114 aa)

YESFGLVGEGSYGQVLKCRH------------------------------KETNQVVAIKKFLEGEDDKMVKK-------IAMREVRMLKQLR-HENLVN
|     .| |.||.|.. .                               ..|  .||||        .| ||       . .|||  || |  | |.| 
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIK--------RMKKKFYSWEECMNLREVKSLKKLNAHPNIVK

LIEVFR--RKKRLYLVFEFMDHTVLDELEKYPM-GLDESLVRKYMWQILKGIEFCHINNIIHRDIKPENILVSKS-----------------KVVKLCDF
| ||.|      ||.|||.|     . .       . |. .|  |.||| |. | | ..  |||.|||||... .                  ..|. ||
LKEVIRDSENDHLYFVFEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADF

GFARTIAGPGEIYTDYVATRWYRAPELLVGDTKYGKAIDLWAVGCLQAEMLTGEPLFPGDSDIDQLYHIIRCFGTLIQRH------------------KE
| || |      ||||| |||||||| |   |.|.. ||.|||||  ||. |  ||||| | |||.. |.   || . .                     
GLAREIRSK-PPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDG

IFLKNPLFVGMRLPEVKN--VEPLEKRFPTLSG-LSISMMKSCLHLDPDQRPTCTQFLKHEFF
. | . .  ..|.|..    . ||..  |. |   .| .|| .|  ||. |||  | .|. .|
YQLAHMM--NFRFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase CDKL2.AA ERK7 55-338 35 3.6e-71 242.59 In-house 1-292 (292) Show / Hide 
Range on Protein: 55-338
Range on HMM: 1-292/292
Sequence Identity: 35% (105 aa)

YESFGLVGEGSYGQVLKCRHKETNQVVAIKKFLEGEDDKMVKKIAMREVRMLKQLR-HENLVNLIEVFRRK--KRLYLVFEFMDHTVLDELEKYPMGLDE
||    .| | || | |   | | ||||.||      ..       ||. .|.... |.|.. ||.|.| .  . .|||||||. | |    .    | .
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFME-TDLHAVIRKGNILKD

SLVRKYMWQILKGIEFCHINNIIHRDIKPENILVSKSKVVKLCDFGFARTIAGPGE------IYTDYVATRWYRAPELLVGDTKYGKAIDLWAVGCLQAE
  ..  |.|.|. | . |  |.||||.|| |||.    .||.|||| ||.||   |      . |.||||||||||| |.| ..| |..|.| .||  .|
IHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGE

MLTGEPLFPGDSDIDQLYHIIRCFGTLIQRHKEIFLKNPLFVGMRLPEVKNVEPLEKRFPTLSGLSISMMKSCLHLDPDQRPTCTQFLKHEFF
||.| |.||| | ..|.  |..  .   |   |    .   . .   .... ..|.. .|  .   |...|  | . |..| | .| |.| . 
MLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase CDKL2.AA Pkinase_Tyr 62-202 36 1.8e-22 76.74 Pfam 8-161 (270) Show / Hide 
Range on Protein: 62-202
Range on HMM: 8-161/270
Sequence Identity: 36% (56 aa)

GEGSYGQVLKCRHK----ETNQVVAIKKFLEGEDDKM--VKKIAMREVRMLKQL-RHENLVNLIEVFR-RKKR--LYLVFEFMDH-TVLDELEKY---PM
|||..|.| |.. |    .|.. ||.|.  || ...    ..    |....||| .|.|.|.|. |   ...   .|.|.|.| |   || | |    . 
GEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQ

GLDESLVRKYMWQILKGIEFCHINNIIHRDIKPENILVSKSKVVKLCDFGFARTI
 |. .   .. ||| || |. . .|.||||.   |.||....||| |||| ||.|
PLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase CDKL2.AA TyrKc 55-338 25 3.1e-17 55.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 55-338
Range on HMM: 1-280/280
Sequence Identity: 25% (80 aa)

YESFGLVGEGSYGQVLKCRHKETNQVVAIKKFLEGEDDKMVKKIAMREVRMLKQL--RHENLVNLIEVFRRK-------KRLYLVFEFMDHTVLDE-LEK
 .     ||| .|.| |.. |   . ||.|.  |.      ..  ||| |....|  .|.|.|.|. | . .       . |..|.|.|.|  |.. | |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

YPMGLDESLVRKYMWQILKGIEFCHINNIIHRDIKPENILVSKSKVVKLCDFGFARTIAGP------GEIYT------DY--VATRWYRAPELLVGDTKY
.   |  .   ...||| .| |. | .|.||||.   |.||.. ..|| .||| .| |         .. |.          .  ||. ||| .  . |.
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKF

GKAIDLWAVGCLQAEMLT-GEPLFPGD----SDIDQLYHIIRCFGTLIQRHK----EIFLKNPLFVGMRLPEVKNVEPLEKRFPTLSGLSISMMKSCLHL
  . | |. | .  |..| |..  ||.     . ..... ..  . . | .                               |.. .    ..||.| | 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------FVCCPDEMYQIMKQCWHE

DPDQRPTCTQFLKHEFF
||..||| ..   ||.|
DPEDRPTFSEI--HECF
Kinase CDKL2.AA CDK7 299-338 35 3.2e-07 14.81 In-house 249-288 (288) Show / Hide 
Range on Protein: 299-338
Range on HMM: 249-288/288
Sequence Identity: 35% (14 aa)

PLEKRFPTLSGLSISMMKSCLHLDPDQRPTCTQFLKHEFF
||...|   |   . .|.  . ..| .| |||| ||...|
PLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDKL2.AA CDK 315-338 33 3.6e-07 18.83 In-house 261-284 (284) Show / Hide 
Range on Protein: 315-338
Range on HMM: 261-284/284
Sequence Identity: 33% (8 aa)

MKSCLHLDPDQRPTCTQFLKHEFF
. ..| .||..| ...| |.|..|
LNKMLCYDPKKRISAEQALQHPYF
Kinase CDKL2.AA CDC2 312-338 29 0.002795 5.35 In-house 275-301 (301) Show / Hide 
Range on Protein: 312-338
Range on HMM: 275-301/301
Sequence Identity: 29% (8 aa)

ISMMKSCLHLDPDQRPTCTQFLKHEFF
|.  .. |..|| .| .  . |.| .|
IDLLMQMLQYDPQKRISAKEALQHPYF
Kinase CDKL2.AA Pkinase_Tyr 313-328 56 0.104916 6.4 Pfam 247-262 (270) Show / Hide 
Range on Protein: 313-328
Range on HMM: 247-262/270
Sequence Identity: 56% (9 aa)

SMMKSCLHLDPDQRPT
..||.| | ||..|||
DLMKQCWHYDPEDRPT