Gene CDKL5 (Sea Urchin)

CDKL5

Species: Sea Urchin
Alias: CDKL5, Spk124, SPU_016561
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: CDKL

Sequence

Name Sequence Type Origin Length Description Download
CDKL5.AA Protein None 269 None Fasta, JSON
CDKL5.kin_dom Protein Kinase Domain None 168 None Fasta, JSON

Protein domain

Protein domains of CDKL5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDKL5.AA CDKL 4-239 56 4.4e-166 558.06 In-house 1-237 (286) Show / Hide 
Range on Protein: 4-239
Range on HMM: 1-237/286
Sequence Identity: 56% (135 aa)

YEVLGIVGEGAYGVVMKCRHKESKEVMAIKKFKDSEANEDVRRTILRELKLLRQLKQENIVEVREAFRRRGKLYLVFEYVEKNMLELLEENPKGVPPEKV
|| || ||||.||||||||.||. .. ||||||.|| .. |.....||.|.|.|||.||||. .|.|||..||.|||||.....|..|||.|.||....|
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

RSYIYQLIKAIHWCHRNDVIHRDIKPENLLIS-AKDTLKLCDFGFARNLDGNSSANYTDYVATRWYRSPELLLG-SAYGKAVDVWAIGCILGELSDGNAI
|.|..|..|||..|| ...|||||||||.||. .....||||||||| .  .....|||||||||||.||||.|   |||.||.|||||...|..||...
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPL

FPGESEIDQLYMIQKILGPLPHYQMAIFDNSPRFSGLK
.||.|.|||||.||| ||||   .. ||  .|.|.|.|
WPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMK
Kinase CDKL5.AA CMGC 4-222 25 4.5e-108 356.35 In-house 1-374 (513) Show / Hide 
Range on Protein: 4-222
Range on HMM: 1-374/513
Sequence Identity: 25% (96 aa)

YEVLGIVGEGAYGVVMKCRH--------------KESKEVMAIKKFKDSEANEDVRR----------TILRELKLLRQLK----------------QEN-
||... .|||.|||| |||.              .|..|. ||||.|  . .|.  .          ..|||.|.|..|.                ..| 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVEVREAFRRRG-----------------KLYLVFEYVEKNMLELLEENPK--------GVPPEK------------VRSYI------YQLIKAIH--WC
||  .. |....                 .|||||||.... ......|..        . .. .            .....      ||......   |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HRND--VIHRDIKPENLLISAK--------------------DTLKLCDFGFARNLDGNS--------------------SANYTDYVATRWYRSPELLL
|...  .||||.||||.||. .                    ..||.||||.|| .. .|                    .  ||.||.|||||.||.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GSA----------YGKAVDVWAIGCILGELSDG--------NAIFPGESE-----------IDQLYMIQKILGPLP
|.           |....|.|..|||..|.  |          .|||.||           ||||..| |.||. .
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT
Kinase CDKL5.AA CDK 4-219 35 1.6e-91 293.04 In-house 1-242 (284) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-242/284
Sequence Identity: 35% (89 aa)

YEVLGIVGEGAYGVVMKCRHKESK-----EVMAIKKFK-DSE----ANEDVRRTILRELKLLRQLKQENIVEVREAFRRR-----------GKLYLVFEY
|| |  .|||.|||| |.|.|...     .. |.||.. ..|    . | .  | .|| .||..|  .||| ... .               |||.||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

VEKNMLELLEENPKGVPPEKVRSYIYQLIKAIHWCHRNDVIHRDIKPENLLISAKDT-----LKLCDFGFARNLDGN-----SSANYTDYVATRWYRSPE
..    ....          ...|..||....| ||.| ..|||.|| |.||. . .     ||. |||.||    .      .  ||  | |.|||.||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLLGSA-YG--KAVDVWAIGCILGELSD---GNAIFPGESEIDQLYMIQKILG
|||||  |.   ..|.|..|||..|.     . ..|||.|||||| .| .|.|
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICG
Kinase CDKL5.AA CDC2 4-219 39 4.8e-87 267.51 In-house 1-226 (301) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-226/301
Sequence Identity: 39% (91 aa)

YEVLGIVGEGAYGVVMKCRHKESKEVMAIKKFKDSEANED--VRRTILRELKLLRQLK-QENIVEVREAFRRRGKLYLVFEYVEKNMLELLE-ENP--KG
|. .  .||| |||| ||........ |.||..    .|.  |  |..||. .|  ||  .|||  .. .    |||.||||.. .  .... ..|  | 
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

VPPEKVRSYIYQLIKAIHWCHRNDVIHRDIKPENLLISAKDTLKLCDFGFARNLDGNSSANYT--DYVATRWYRSPELLLGS-AYGKAVDVWAIGCILGE
.||..|.||.||.....| ||.. ..|||.|| |.||..| ..|. ||| ||.   . . .||    | |.|||.||.|||.  |  .||.|.||||. |
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIP-IRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAE

L---SDGNAIFPGESEIDQLYMIQKILG
.       ..|.|.||||||. | .|||
MFMDVTKKPLFHGDSEIDQLFKIFRILG
Kinase CDKL5.AA RCK 4-219 37 3.1e-84 267.12 In-house 1-231 (298) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-231/298
Sequence Identity: 37% (88 aa)

YEVLGIVGEGAYGVVMKCRHKESKEVMAIKKFKDSEAN-EDVRRTILRELKLLRQLK-QENIVEVREAFRRRG--KLYLVFEYVEKNMLELLEE---NPK
| ..  .|.|.||.||| . ||..|. |||| |   .. |.. .  |||.| || |.  .||....| .| .    ||.||||...|  .....     |
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMN--LREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRK

GVPPEK--VRSYIYQLIKAIHWCHRNDVIHRDIKPENLLISA---------KDTLKLCDFGFARNLDGNSSANYTDYVATRWYRSPELLLGS-AYGKAVD
 .| ..  .....||...... .|..   |||.||||....           |..|..||| .|     |  .||||| |||||.||.|| .  | . .|
YLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREI--RSKPPYTDYVSTRWYRAPECLLRCTYYNSPMD

VWAIGCILGELSDGNAIFPGESEIDQLYMIQKILG
.||.|||  ||   .. ||| |||||.. | |..|
IWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMG
Kinase CDKL5.AA Pkinase 4-239 30 4.1e-81 280.58 Pfam 1-251 (293) Show / Hide 
Range on Protein: 4-239
Range on HMM: 1-251/293
Sequence Identity: 30% (77 aa)

YEVLGIVGEGAYGVVMKCRHKESKEVMAIKKFKDSEANEDVRRTILR--ELKLLRQLKQENIVEVREAFRRRGKLYLVFEYVEK-----NMLELLE-ENP
|......|.|..|.| ||.|| . .. |.|..| .........| .|  |..... |. .|||. ...|......|.|.||.|.        .... .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KGV--PPEKVRSYIYQLIKAIHWCHRNDVIHRDIKPENLLISAKDTL----KLCDFGFARNLDGNSSANYTDYVATRWYRSPELLL-GSAYGKAVDVWAI
...  ... ...|.||.....  ||.. .||||.||||.||. ....    |.||||.|. .|  ..  .|... |.||..||... |. ||..||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCILGELSDGNAIFPGE----SEIDQLYMIQKILGPLPHYQMAIFDNSPRFSGLK
|||| |.  |. .|||.    . .||..||..|.|| .|..    .. ..|. ..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FR
Kinase CDKL5.AA CDK7 4-219 36 7.4e-80 212.24 In-house 1-220 (288) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-220/288
Sequence Identity: 36% (81 aa)

YEVLGIVGEGAYGVVMKCRHKESKEVMAIKKFK----DSEANEDVRRTILRELKLLRQLKQENIVEVREAFRRRGKLYLVFEYVEKNMLELLEENPKGVP
|| .  .||| ...| | . ... .. |||| |     |||   . || .|| |.|. .. .|... . .|  .  ..|||.. .  . .  . .     
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

PEKVRSYIYQLIKAIHWCHRNDVIHRDIKPENLLISAKDTLKLCDFGFARNLDGNSSANYTDYVATRWYRSPELLLGS-AYGKAVDVWAIGCILGELSDG
|  . .|  .. . . .|||| . |||.|| |||..    ||. ||| ||   |    .||  | |||||.|||| |   || .||.|..|||. ||   
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFY-GSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLR

NAIFPGESEIDQLYMIQKILG
. ..||.|.||||  | ..||
VPYLPGDSDIDQLTRIFQTLG
Kinase CDKL5.AA S_TKc 4-269 29 8.1e-75 255.78 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-269
Range on HMM: 1-231/231
Sequence Identity: 29% (84 aa)

YEVLGIVGEGAYGVVMKCRHKESKEVMAIKKFKDSEANEDVRRTILRELKLLRQLKQENIVEVREAFRRRGKLYLVFEYVEK---NMLELLEENPKG---
||.| ..|.||.|.|.|||||......|||. |         ..|.||...|.. . .|||   ..|.  ..||.|.||..    ............   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VPPEKVRSYIYQLIKAIHWCHRNDVIHRDIKPENLLISAKDTLKLCDFGFARNLDGNSSANYTDYVATRWYRSPELLLGSAYGK-AVDVWAIGCILGE
   |.  .|.|.||...|.  ||.. .||||.||||.|..   ..|.||||.|| |        | .. |.||..||.|    ||| ..|.|..|||| |
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LSDGNAIFPGESEIDQLYMIQKILGPLPHYQMAIFDNSPRFSGLKVTILSIQFKRSIFRIFS-------CLLAVLK-----NNHIHM
.  |   ||      |..|. |..|                        | ..|  | ...            .|.     ..|  .
MLCGYPPFP------QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDKL5.AA MAPK 4-219 32 1.2e-68 234.36 In-house 1-252 (328) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-252/328
Sequence Identity: 32% (81 aa)

YEVLGIVGEGAYGVVMKCRHKE------SKEVMAIKKFKDSEANEDVRRTILRELKLLRQL-KQENIVEVREAFRR------RG-----KLYLVFEYVEK
|. |  .|.|||||| ....|.      ...  ||||. .   |.   . ..||.|||| . . |||. ... |.       .       .|.|.|. | 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NMLELLEENPKGVPPEKVRSYIYQLIKA--IHWCHRNDVIHRDIKPENLLISAKDTLKLCDFGFARNLDGNSSANY-------------TDYVATRWYRS
..  ... ..     . ... .||....  .   |  .|||||.||.|.|.   ..||.|||| || .| ... ..             |.||||||||.
DLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PELLLG---SAYGKAVDVWAIGCILGELSD-GNAIFPGESEIDQLYMIQKILG
||..|.     | ||||.|..|||..|.   .  .|||.. |||. .| ..||
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLG
Kinase CDKL5.AA CDK5 4-219 39 1.4e-68 215.67 In-house 1-217 (287) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-217/287
Sequence Identity: 39% (87 aa)

YEVLGIVGEGAYGVVMKCRHKESKEVMAIKKFKDSEANEDVRRTILRELKLLRQLKQENIVEVREAFRRRGKLYLVFEYVEKNMLELLEENPKGVPPEKV
|| .  .||| ||.| | | ||..|..|.|. .  .  | |  | .||  ||. || .|||          || ||||.. . .   ...   .. .. .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

RSYIYQLIKAIHWCHRNDVIHRDIKPENLLISAKDTLKLCDFGFARNLDGNSSANYTDYVATRWYRSPELLLGS-AYGKAVDVWAIGCILGELS-DGNAI
.|..||| | .  || . | ||| || ||||. . .||| ||| ||   |    .|.  | | ||| |  |.||  |   .|.| .|||. |..  |   
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAF-GIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPL

FPGESEIDQLYMIQKILG
||| .. |||  | ||.|
FPGNDVEDQLKRIFKIMG
Kinase CDKL5.AA CCRK 4-219 40 2.9e-62 213.18 In-house 1-218 (285) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-218/285
Sequence Identity: 40% (88 aa)

YEVLGIVGEGAYGVVMKCRHKESKEVMAIKKFKDSEANEDVRRTILRELKLLRQLKQEN-IVEVREAFRRRGKLYLVFEYVEKNMLELLEENPKGVPPEK
| .|. .|||| |.| | .| |  |..|.||      .. .  . |||.| |  . ..  .|.... |   .   ||||..   . | . .  . . . .
YCILDRIGEGAHGIVFKAKHVETGEIVALKKVALRRLDDGIPNQALREIKALQEIEDNQYVVQLKDVFPHGTGFVLVFEFMLSDLAEVVRHAQRPLAEAQ

VRSYIYQLIKAIHWCHRNDVIHRDIKPENLLISAKDTLKLCDFGFARNLDGNSSANYTDYVATRWYRSPELLLGS-AYGKAVDVWAIGCILGELSDGNAI
|.||.  |.| . .|| |...|||.|| |||||.   ||. ||| ||      .  ||  ||||||| |||| |   | . ||.||.|||.|||  .  |
VKSYMQMLLKGVAHCHENNIMHRDLKPANLLISESGHLKIADFGLARVFSNDEGRQYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNNSPI

FPGESEIDQLYMIQKILG
|||| .|.|| .. .|||
FPGENDIEQLCCVLRILG
Kinase CDKL5.AA ERK7 4-219 39 3.4e-61 207.96 In-house 1-224 (292) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-224/292
Sequence Identity: 39% (89 aa)

YEVLGIVGEGAYGVVMKCRHKESKEVMAIKKFKDSEANE-DVRRTILRELKLLRQLK-QENIVEVREAFRRRGK--LYLVFEYVEKNMLELLE--ENPKG
||..  .| ||||.| |   | .|.|.|.||  |   |. |  ||  ||  .|....  .||. . . .|      .|||||. |  .       .  | 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRT-FREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKD

VPPEKVRSYIYQLIKAIHWCHRNDVIHRDIKPENLLISAKDTLKLCDFGFAR---NLD--GNSSANYTDYVATRWYRSPELLLGS-AYGKAVDVWAIGCI
.    ... .|||..|| . |  .|||||.|| |.|. .. ..|.|||| ||   ...  ...    |.||||||||.|| ||||  | |.|| | ||||
I---HKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCI

LGELSDGNAIFPGESEIDQLYMIQKILG
|||.  | ..||| | ..|.  | ....
LGEMLRGKPMFPGTSTMNQIEKILETIP
Kinase CDKL5.AA Pkinase_Tyr 4-187 24 1.1e-15 53.8 Pfam 1-199 (270) Show / Hide 
Range on Protein: 4-187
Range on HMM: 1-199/270
Sequence Identity: 24% (50 aa)

YEVLGIVGEGAYGVVMKCRHK----ESKEVMAIKKFKDSEANEDV--RRTILRELKLLRQL-KQENIVEVREAFR-RRGK--LYLVFEYVEK-NMLELLE
 . .   ||||.|.|.|.. |    . |   |.|. |.  | ..   |.  .||.|...|| . .|||    .   ...   .|.|.||... ..|. | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

EN---PKGVPPEKVRSYIYQLIKAIHWCHRNDVIHRDIKPENLLISAKDTLKLCDFGFARNLDGNSSANYTDYVAT------RWYRSPELLLGSAYGKAV
..   .. ....   .. .|  |.  . ...  ||||.   | |.. . . | |||| || .   .  .|  ....      .|. .|| .  . .  . 
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYY-YRKRGGGKLPIKWM-APECINYGKFTTKS

DVWA
|||.
DVWS
Kinase CDKL5.AA TyrKc 4-242 19 4.7e-14 4.52 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-242
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

YEVLGIVGEGAYGVVMKCRHKESKEVMAIKKFKDSEANEDVRRTILRELKLLRQL--KQENIVEVREAFRRR-------GKLYLVFEYVEK-NMLELLEE
 . . . ||||.|.|.|.. |   .  |.|. |..      |. ..||......|  . .|||    . .         . |..|.||... . .. | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

NPKGVPPEKVRSYIYQLIKAIHWCHRNDVIHRDIKPENLLISAKDTLKLCDFGFARNLDGN-----SSANYT------DY--VATRWYRSPELLLGSAYG
. . .....  |. .|  .     |.. .||||.   | |.... | | .||| .|...       |.  |.          .  ||. .|| .  . . 
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECINYGKFT

KAVDVWAIGCILGEL-SDGNAIFPGESE--IDQLYMIQKILGP----LPHY---------QMAIFD------NS-----PRFSGLKVTI
 . |||. |  . |. ..|    ||. .  ..   .|...        |..           ....      .      |.|| ..  .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF