Gene ERK1 (Sea Urchin)

ERK1

Species: Sea Urchin
Alias: ERK1, Spk343, SPU_019715, SpERK
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
ERK1.AA Protein None 336 None Fasta, JSON
ERK1.kin_dom Protein Kinase Domain None 289 None Fasta, JSON

Protein domain

Protein domains of ERK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ERK1.AA ERK1 7-295 87 2.1e-242 811.59 In-house 1-289 (289) Show / Hide 
Range on Protein: 7-295
Range on HMM: 1-289/289
Sequence Identity: 87% (253 aa)

YTELEAIAQGALALCSSAVDTRHGGKVAIKKISPFEHQTYCQRTLREIKILTRFNHENIINIQDIIKADTIEAMRDVYIVQSLMETDLYKLLKTQPLSND
||.|..|..||.....||.||.|. .||||||||||||||||||||||||||||.|||||||||||.|||||.||||||||.|||||||||||||.||||
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKTQHLSND

HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPGHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN
||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||
HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN

RPIFPGKHYLDQLNHILGVLGSPSQDDLKCIINEKARAYLQGLPFKSKIPLKSLFPKADNKALDFLERMLSFNPDKRITVEEALAHPYL
||||||||||||||||||||||||||||.||||||||.|||.||.|.|.|...||||||.||||.|..||.|||.||||||||||||||
RPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase ERK1.AA MAPK 7-295 54 3.7e-195 654.64 In-house 1-328 (328) Show / Hide 
Range on Protein: 7-295
Range on HMM: 1-328/328
Sequence Identity: 54% (180 aa)

YTELEAIAQGALALCSSAVDTR------HGGKVAIKKIS-PFEHQTYCQRTLREIKILTRF-NHENIINIQDIIKA------DTIEAMRDVYIVQSLMET
|. |. | |||  .  ||.|.|       | |||||||| ||...|.|.||.||||.| .| .|||||...||...      ...| ..|.|||. ||||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLYKLLKTQP-LSNDHICYFLYQILRG--LKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPG-HDHTG----------FLTEYVATRWYRAP
||....|.|. ||.|||.||.||||||  |||||||||.||||||||.|.|. ||||||||||||..||  |.|..          ..||||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EIMLN--SKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGVLGSPSQDDLKCII-NEKARAYLQGL---PFKSKIPLKSLFPK----ADNK
|||||  ...|||..|.||||||.||||. ..|.||||.|.||.|.|. |||.||.....||  .|.|| |.|.|   | . |.|....||.    |. .
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

ALDFLERMLSFNPDKRITVEEALAHPYL
|.|.||.|| |.|||||||||||.|||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase ERK1.AA ERK 7-295 53 9.69999999999e-170 570.19 In-house 1-307 (307) Show / Hide 
Range on Protein: 7-295
Range on HMM: 1-307/307
Sequence Identity: 53% (164 aa)

YTELEAIAQGALALCSSAVDTR-----HGGKVAIKKI-SPFEHQTYCQRTLREIKILTRFN-HENIINIQDIIKADTIEAMRDVYIVQSLMETDLYKLLK
|  .. | .||  .  ||.|.       | |||||||  .|.|  || |||||||.|  |. |||||...||.. . .| . |.|.|. |||||| .  .
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

TQ-PLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPGHDHT-----GFLTEYVATRWYRAPEIMLNSKGYTKSIDI
.| .|| ||. ||.||||.||||||||||.||||||||.|.|  ||||||||||||. |....       .|.||||||||||||||||. . |||..||
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSP-SQDDLKCIINEKARAYLQGLPF--KSKIPLKSLFPKAD--NKALDFLERMLSFNPDKRITVEE
||.|||.||||  .|.|||| |..|.|.|. ..|.| |..||..| .|.|. |.  ||.  . ..|....||.|.   .|.| ||.|| |.|||||||||
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

ALAHPYL
.|.|||.
CLEHPYF
Kinase ERK1.AA CMGC 7-295 28 2.3e-140 464.41 In-house 1-513 (513) Show / Hide 
Range on Protein: 7-295
Range on HMM: 1-513/513
Sequence Identity: 28% (145 aa)

YTELEAIAQGALALCSSAVDTRHGGK--------------VAIKKIS-PFEHQTYCQ----------RTLREIKILTRFN-----------------HEN
|. .. | .|. .   ...|.| ..|              ||||||. || ... ..          |.||||||| ..|                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IINIQDIIKAD---TIEA---------MRDVYIVQSLMETDLYKLLKTQP----------LSNDH------------ICYFL------YQILRGLK--YI
|....||.. .   . |.         ....|.|  .|..|||...| ..          ||  |            |.||.      ||||||||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAN--VLHRDLKPSNLLLNTTCDL--------------------KICDFGLARIADPGHDH------------------TGFLTEYVATRWYRAPEIML
||..  ..||||||.|.|.| .|.|                    |||||||||. .| .||                  . ..|.||.|||||||||.|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

NS---------KGYTKSIDIWSVGCILAEMLSN--------RPIFP-----------GKHYLDQLNHILGVLGSP----------------SQDDLKCII
..         ..||..||.||||||.|||. .        .|.||           ||...|||..|  |||.|                .... ..| 
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------NEKARAYLQG---LPFKSKIPLKSLFPK-----------------------------------ADNKALDFLERMLSFNP
                    .|.|| |.|    .| . ..|.|.|||.                                   .| .|.|.|..|| ..|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

DKRITVEEALAHPYL
|||||.|.||.|||.
DKRITAEQALQHPYF
Kinase ERK1.AA p38 7-295 46 7.50000000001e-133 447.65 In-house 1-289 (289) Show / Hide 
Range on Protein: 7-295
Range on HMM: 1-289/289
Sequence Identity: 46% (138 aa)

YTELEAIAQGALALCSSAVDTRHGGK---VAIKKIS-PFEHQTYCQRTLREIKILTRFNHENIINIQDIIKA--DTIEAMRDVYIVQSLMETDLYKLLKT
| .|. . .||    ..|.|.| |.|   |||||.. ||.   .  || ||.. |   .|||.| . |.     . .. ..|||.|  .|..||....|.
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

QPLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPGHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCIL
| || ||| . .|||||||||||||.. ||||||||. .|  |.|.| |||||| .|        .|.|||||||||||||||   ||. .||||||||.
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDE------MTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIM

AEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLKCIINEKARAYLQGLPFKSKIPLKSLFPKADNKALDFLERMLSFNPDKRITVEEALAHPYL
||... |. |||. ..|||. |. |.|.|..  .. | .|.||.|.|..|   .  ....|..|. .|.| ||.||   ||||||.|||..|||.
AELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase ERK1.AA ERK5 7-295 50 1.3e-125 423.57 In-house 1-295 (295) Show / Hide 
Range on Protein: 7-295
Range on HMM: 1-295/295
Sequence Identity: 50% (148 aa)

YTELEAIAQGALALCSSAVDTRHGGKVAIKKI-SPFEHQTYCQRTLREIKILTRFNHENIINIQDIIKADT-IEAMRDVYIVQSLMETDLYKLLK-TQPL
|  .| | .||    .||.  . | .||||||   |.  |  .||.||.|||  | |.||| |.||..    .  |.|||.|  ||| || ...   ||.
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADP--GHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILA
. .|| ||||||||||||.|||.|.|||||||||| |  |.||| |||.||        .|  |.|||||||||||||.|. |. ||. ||.||||||. 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLKCIINEKARAYLQG-LPFKSKIPLKSLFPKADNKALDFLERMLSFNPDKRITVEEALAHPYL
||.. | .|||| |..||. |. ||| |.   .. .  .. ..|.|  .| .   ... ..|||| .||| | ||| | | .|||| .|| ||.|
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase ERK1.AA ERK7 7-295 45 1.3e-113 383.71 In-house 1-292 (292) Show / Hide 
Range on Protein: 7-295
Range on HMM: 1-292/292
Sequence Identity: 45% (133 aa)

YTELEAIAQGALALCSSAVDTRHGGKVAIKKI-SPFEHQTYCQRTLREIKILTRFN-HENIINIQDIIKADTIEAMRDVYIVQSLMETDLYKLLK-TQPL
|  .. . .||  .   |.| | .  ||.|||   |  ||  ||| ||| .|  |. |.||| . ..|.|   .  ||.|.|   |||||    .  . |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRA---DNDRDIYLVFEFMETDLHAVIRKGNIL

SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-IADPG--HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCIL
 . |  | .||.|| .||.||.||.||||||||.||.. | .|.||||||| ||.    ..... |||||||||||||||.| |. ||| .| ||.||||
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCIL

AEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLKCIINEKARAYLQGLPFKSKIPLKSLFPKADNKALDFLERMLSFNPDKRITVEEALAHPYL
.||| ..|.|||   ..|.. || ... |.| |.. |  . |   |. .. . . .|. ..|.. . |.| | |.| |||.||.|.|.||.||| 
GEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase ERK1.AA ERK3 7-295 43 1.1e-107 347.61 In-house 1-300 (300) Show / Hide 
Range on Protein: 7-295
Range on HMM: 1-300/300
Sequence Identity: 43% (131 aa)

YTELEAIAQGALALCSSAVDTRHGGKVAIKKISPFEHQTYCQRTLREIKILTRFNHENIINIQDIIKADTIEAMRD-----------VYIVQSLMETDLY
.  |     |   |  |||| .   |||||||.    .  |   ||||||. | .|.||. . ...     .   |           |.||| .||||| 
FCDLRPLGCGSNGLVFSAVDSECCKKVAIKKIVLTDKKS-CKHALREIKIIRRLDHDNIVKVYEVLFPKGSDNQDDEDIGILFELRTVCIVQEYMETDLA

KLLKTQPLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT-CDLKICDFGLARIADPGHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIW
 ..  |.||..|.  | || ||||||||||||||||||| |.. ||    ||| |||.||| ||   | |.|.| . |.||| |. .|    ||| ||.|
CVMEQQRLSEEHARLFMYQLLRGLKYIHSANVLHRDLKPANIFINTEDLVLKIGDFGMARIVDPHYSHKGYLSEGLVTKWYRSPRLLLQPNNYTKAIDMW

SVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLKCIINEKARAYLQGLPFKSKIPLKSLFPKADNKALDFLERMLSFNPDKRITVEEALAHPY
. ||||||||  .. |.| | | |.  ||         |.  .       |..      . ||| | .  |  ||||||.|| |.|  |.| |.|| |||
AAGCILAEMLTGKMLFAGAHELEQMMLILDSIPVVHEEDKNELLCVMPSKYIKNYMWYPHHPLKQLLCNIDCHALDFLEQMLTFDPMDRLTAEMALQHPY

L
.
M
Kinase ERK1.AA nmo 8-295 44 1.7e-101 312.91 In-house 2-292 (292) Show / Hide 
Range on Protein: 8-295
Range on HMM: 2-292/292
Sequence Identity: 44% (131 aa)

TELEAIAQGALALCSSAVDTRHGGKVAIKKISP-FEHQTYCQRTLREIKILTRFNHENIINIQDIIKADTIEAMRDVYIVQSLMETDLYKLLKT-QPLSN
     |  ||. .  |  | | | .||.||.   |     |.|  ||.|.|  |.|.|..   ||...  .. ....|.|  ||  || |..   |.|| 
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS

DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPGHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
||.  |||||||||||.||||.||||.|| |||.|  | ||||||||||. ..  |.   .|. | | .||||||.. .. ||  .|||||||| ||.| 
DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQ--DQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLG

NRPIFPGKHYLDQLNHILGVLGSPSQDDLKCIINEKARAYLQGLPFK--SKIPLKSLFP--KADNKALDFLERMLSFNPDKRITVEEALAHPYL
 | .|  .  ..||. |  .|| ||..|.|    | |.| .   | |  .   |  |    .|   | . | ||| |.||||| ...|||||||
RRILFQAQSPIQQLQMITDLLGTPSMEDMKYAC-EGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase ERK1.AA S_TKc 7-295 28 3.4e-93 316.85 SMART 1-231 (231) Show / Hide 
Range on Protein: 7-295
Range on HMM: 1-231/231
Sequence Identity: 28% (89 aa)

YTELEAIAQGALALCSSAVDTRHGGKVAIKKISPFEHQTYCQRTLREIKILTRFNHENIINIQDIIKADTIEAMRDVYIVQSLMET---DLYKLLKTQP-
|. |. | .|| . .  ..... | .||||.|.        ....|||.|| . .|.||... |..         ..|.|  ....   ||....| .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGR

------LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPGHDHTGFLTEYVATRWYRAPEIMLNSKGYTK-SIDIWS
      ..  |.....|||...|.|.|| ...||||||.|.||..   .|||||||||.           | .. |.||.|||..    ||.| ..|.||
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGKCKCDWWS

VGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLKCIINEKARAYLQGLPFKSKIPLKSLFPKADNKALDFLERMLSFNPDKRITVEEALA----
.||||.|||. .| ||      |.. .. ..|                                     .  |.||....| ..|.||.|. |||.    
CGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---HPYL
   ||..
IKCHPWF
Kinase ERK1.AA Pkinase 7-295 29 1.2e-85 295.65 Pfam 1-293 (293) Show / Hide 
Range on Protein: 7-295
Range on HMM: 1-293/293
Sequence Identity: 29% (92 aa)

YTELEAIAQGALALCSSAVDTRHGGKVAIKKISPFEHQTYCQRTLR---EIKILTRFNHENIINIQDIIKADTIEAMRDVYIVQSLMET-----DLYKLL
|. .. | .|. . .  ...   | .||.|.|.  .    ...|.|   ||.|. |.||.||. . |.         ...|.|. ..|      ||. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

K---TQPL--SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDL----KICDFGLARIADPGHDHTGFLTEYVATRWYRAPEIMLNSKGYTK
.     ..  | .... ..|||||||.|.|| ...||||||.|.|.. ....    ||||||||. .|  . . . .| .. |.||.|||. . ...|..
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

SIDIWSVGCILAEMLSNRPIFPGK----HYLDQLNHILGVLGSPSQDDLKCIINEKARAYLQGLPFKSKIPLKSLFPKADNKALDFLERMLSFNPDKRIT
..|.||.||||.|||. ||.|||.    . .||.  |  ..| |   |    ...  .  ..  . .  . .. . ....  ..||....| ..| ||.|
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPT

VEEALAHPYL
 |..| ||..
AEQILQHPWF
Kinase ERK1.AA MAPK-Unclassified 7-157 47 4.9e-64 219.06 In-house 1-161 (575) Show / Hide 
Range on Protein: 7-157
Range on HMM: 1-161/575
Sequence Identity: 47% (76 aa)

YTELEAIAQGALALCSSAVDTRH-GGKVAIKKIS-PFEHQTYCQRTLREIKILTRFNHENIINIQDIIKADTIEA--MRDVYIVQSLMET---DLYKLLK
|.  . | .||      |.|..  . .|||||.   |. .| | |.|||| ||   ||.|||.||||. ..  .     |.|||  .|.|   ||....|
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

-TQ-PLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-IAD
  | ...  || ||.|||||||||.|||...||||||||||.|  | ..|||||..| | |
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIED
Kinase ERK1.AA MAPK-Unclassified 162-295 34 1.7e-55 190.66 In-house 401-575 (575) Show / Hide 
Range on Protein: 162-295
Range on HMM: 401-575/575
Sequence Identity: 34% (61 aa)

HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN-----------RPIFPGKH--------------------YLDQLNHILGVLGSPS
| . .|.||.||||||||||| .. |.. .||||.|||.|||...           ||.|||.                     . ||.. |. .||.| 
HCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPP

QDDLKCIINEKARAYLQGLPFKSKIPLKSLFPKADN----------KALDFLERMLSFNPDKRITVEEALAHPYL
. |.  | . .|| |.|..  |  .. ..|.. .             ..||.  || ||| |||| ..|| ||| 
EEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase ERK1.AA TyrKc 7-295 19 6.4e-13 -13.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 7-295
Range on HMM: 1-280/280
Sequence Identity: 19% (62 aa)

YTELEAIAQGALALCSSAVDTRHGGKVAIKKISPFEHQTYCQRTLREIKILTRF--NHENIINIQDIIKADTIEAM------RDVYIVQSLMET-DLYKL
 | .. .  ||      .. .    .||.|.. .       .  .||..|....  .|.||..    . .  ..          ..||  .|.  || . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVR----LYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LKTQP--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPG------HDHTGF----LTEY-VATRWYRAPEIMLNS
|.     |.... ..| .|| .|  |.|| |. ||||   | |..     ||.||||.|  . .      .|         . . .  ||. ||| .  .
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECINYG

KGYTKSIDIWSVGCILAEMLSNRPIFPGK-----HYLDQLNHILGVLGSPSQDDL----KCIINEKARAYLQGLPFKSKIPLKSLFPKADNKALDFLERM
|  ||| |.|| |  . |....    .          ... . .   . . | .                               |. .  .  .  .. 
KFTTKS-DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------FVCCPDEMYQIMKQC

LSFNPDKRITVEEALAHPYL
  ..|..| | .|   | ..
WHEDPEDRPTFSEI--HECF
Kinase ERK1.AA Pkinase_Tyr 51-154 32 2.4e-10 35.69 Pfam 51-159 (270) Show / Hide 
Range on Protein: 51-154
Range on HMM: 51-159/270
Sequence Identity: 32% (37 aa)

LREIKILTRF-NHENIINIQDIIKADTIEAMRD--VYIVQSLMET-DLYKLLKTQ-----PLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNT
.||.||.. . .|.||..   ..     .  .   .|||  .|.  ||.. |...     ||.  ... . .|| .|. | .| |  ||||   | |.. 
MREAKIMKQLGHHPNIVRLYGVCT----DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE

TCDLKICDFGLAR
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NNVVKICDFGLAR