Gene IKKa (Sea Urchin)

IKKa

Species: Sea Urchin
Alias: SpIKK2, Spk162, IKKa, SPU_008255
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: IKK

Sequence

Name Sequence Type Origin Length Description Download
IKKa.AA Protein None 324 None Fasta, JSON
IKKa.kin_dom Protein Kinase Domain None 262 None Fasta, JSON

Protein domain

Protein domains of IKKa.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IKKa.AA IKK 9-275 22 2.6e-123 415.99 In-house 1-297 (297) Show / Hide 
Range on Protein: 9-275
Range on HMM: 1-297/297
Sequence Identity: 22% (68 aa)

WQFKKLLGSGSFGEVLLYQLG-VGRKVGRFEAESVDWSRCMWSRFGVGEESVRPCCG---VWLASLWCLVGVVVVSGWRRCGVGLVSMSSQFGVDANVGL
|.....||.|.||.|...... .||||.........|.||.|......|...|....   ||....|||........|..|......|....|.|....|
WEMCDRLGQGAFGNVYHWRHKKTGRKVAVKHCNHMSWMRCRWVWCREFEWMKRLNHQRQFVWFPNIWCLCDIEEDMQWQICKQPVIVMEYCTGGDLYKYL

ASMWCHFGLVCGVDEESVCPRCGVGLVLMWSQFGVDVVSVRRQCGETSEYIALKRCKSILQLENLKRWRDEVEFMRNLEHPNIVQGRPVPPELEAKP-NE
.|.|...||..|.....||..|..|.....||.|...................|....|........|.|...||....................|| ..
NSPWNCCGLKEGHEFLQVCRDCCAGMHHLHSQNGIVHRDIKPGNIMCQKGEDGKTIYKITDFGYAREWDDDEMFMSFYGTEEYLHPDMYERAVLRKPHQK

PPCLAMEFCSRGDLRKKLS--ELPNMCGLPEAEILLLSKHIAS-----------------------AMEYLHKSDIIHRDIKPENIMVQDWKGQCHG
|.|......|.|.......  |||.|............|||..                       ...|.|...|||....|..||...|. .  .
PYCATVDYWSFGVTFYHCATGELPFMPHWQPRRWHEKMKHITTEKPSGVCIGVQEEMNGPVEWSSHLPQYCHLCQIIHEQMEPWCIMMLEWHQDQCW
Kinase IKKa.AA Pkinase 163-266 29 3.1e-19 69.09 Pfam 31-141 (293) Show / Hide 
Range on Protein: 163-266
Range on HMM: 31-141/293
Sequence Identity: 29% (35 aa)

ILQLENLKRWRD-------EVEFMRNLEHPNIVQGRPVPPELEAKPNEPPCLAMEFCSRG----DLRKKLS--ELPNMCGLPEAEILLLSKHIASAMEYL
|. ... | | |       |.. |..| |||||. . .  .     .  ... ||.|  |    ||   .|  .  ..  ..| |.    . |....||.
IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYC

HKSDIIHRDIKPENIMV
|.  |||||.|||||..
HSMGIIHRDLKPENILI
Kinase IKKa.AA Ciliate-E2 207-266 33 5.6e-19 61.76 In-house 111-194 (365) Show / Hide 
Range on Protein: 207-266
Range on HMM: 111-194/365
Sequence Identity: 33% (28 aa)

LAMEFCSRGDLRKKLSELPNMC--------GLPEAEILLLSKHIAS---------------AMEYLHKSD-IIHRDIKPENIMV
| ||.|. |||.. . . .  .         . | ||. ..|.|..               |.||||.   |||||||||||..
LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF
Kinase IKKa.AA ULK 209-268 38 7.6e-18 58.95 In-house 99-165 (329) Show / Hide 
Range on Protein: 209-268
Range on HMM: 99-165/329
Sequence Identity: 38% (26 aa)

MEFCSRGDLRKKLS---ELP----NMCGLPEAEILLLSKHIASAMEYLHKSDIIHRDIKPENIMVQD
||.|  |||.. ..   .||    .   |.| |..   |.|.... .|||  ||||||||.||.. .
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHN
Kinase IKKa.AA ULK 206-268 37 9e-18 59.68 In-house 93-161 (324) Show / Hide 
Range on Protein: 206-268
Range on HMM: 93-161/324
Sequence Identity: 37% (26 aa)

CLAMEFCSRGDLRKKLS---ELP---NMCGLPEAEILLLSKHIASAMEYLHKSDIIHRDIKPENIMVQD
.. ||.|  |||.. .    .||   .   |.| |..   |.|.... .|||  ||||||||.||.. .
YIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHN
Kinase IKKa.AA Ciliate-E2-Unclassified 205-268 27 1.5e-17 57.51 In-house 96-179 (352) Show / Hide 
Range on Protein: 205-268
Range on HMM: 96-179/352
Sequence Identity: 27% (23 aa)

PCLAMEFCSRGDLRKKLSELPN--------------MCGLPEAEIL-----LLSKHIASAMEYLHKSD-IIHRDIKPENIMVQD
... ||.|  |||.. ... ..               . ..| ...      . ..| .. ||||..  |||||||||||....
IYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDN
Kinase IKKa.AA CAMK 206-268 30 5.4e-17 50.61 In-house 133-214 (425) Show / Hide 
Range on Protein: 206-268
Range on HMM: 133-214/425
Sequence Identity: 30% (25 aa)

CLAM---EFCSRG----DLRKKLSELPN------------MCGLPEAEILLLSKHIASAMEYLHKSDIIHRDIKPENIMVQD
.. |   |.|| |    ||  .. | ..               ..|.|   . . |.||..|.|. .|.|||.|||||...|
YMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDD
Kinase IKKa.AA CAMKL 206-266 39 7.7e-17 50.13 In-house 97-160 (297) Show / Hide 
Range on Protein: 206-266
Range on HMM: 97-160/297
Sequence Identity: 39% (25 aa)

CLAMEFCSRGD--LRKKLSELPNMC-GLPEAEILLLSKHIASAMEYLHKSDIIHRDIKPENIMV
.| || || |.  |  .. . ..    .|| |   . . | ||..|.|. .|.|||||||||..
YLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILL
Kinase IKKa.AA CAMK-Unique 209-267 28 1e-16 51.5 In-house 114-191 (363) Show / Hide 
Range on Protein: 209-267
Range on HMM: 114-191/363
Sequence Identity: 28% (22 aa)

MEFCSRGDLRKKLSELPN-----------------MCGLPE--AEILLLSKHIASAMEYLHKSDIIHRDIKPENIMVQ
||.|  ||| ... ..                    . . |  .......  ..|| .|.|. ||.|||.|.|||||.
MEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVC
Kinase IKKa.AA TKL 203-266 29 1.6e-16 56.01 In-house 105-173 (364) Show / Hide 
Range on Protein: 203-266
Range on HMM: 105-173/364
Sequence Identity: 29% (23 aa)

EP------PCLAMEFCSRGDLRKKLSELPNMCGLPEAEILLLSKHIASAMEYLHKSD--------IIHRDIKPENIMV
.|      .|. ||.|..|.|.  |             .. ... ||..|.||| ..        |||||.|..||.|
HPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILV
Kinase IKKa.AA STE 206-270 28 1.3e-13 44.55 In-house 113-187 (359) Show / Hide 
Range on Protein: 206-270
Range on HMM: 113-187/359
Sequence Identity: 28% (22 aa)

CLAMEFCSRGDLRKKLSELPNMCG-----------LPEAEILLLSKHIASA-MEYLHKSDIIHRDIKPENIMVQDWK
...||... | |.. . .   . .           .|| .|    . |  . ..|||.  |||||||| ||..   |
WICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--VK
Kinase IKKa.AA Pkinase_Tyr 200-259 31 2.8e-10 35.46 Pfam 75-137 (270) Show / Hide 
Range on Protein: 200-259
Range on HMM: 75-137/270
Sequence Identity: 31% (20 aa)

KPNEP--PCLAMEFCSRGDLRKKLSEL-PNMCGLPEAEILLLSKHIASAMEYLHKSDIIHRDI
.  ||  ... ||..  |||.. | .  ..   |.  ..|  .  ||..||||.   .||||.
DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase IKKa.AA S_TKc 142-316 16 2e-09 -38.74 SMART 1-231 (231) Show / Hide 
Range on Protein: 142-316
Range on HMM: 1-231/231
Sequence Identity: 16% (43 aa)

VSVRRQCGE-------------TSEYIALKRCKSILQLENLKRWRDEVEFMRNLEHPNIVQGRPVPPELEAKPNEPPCLAMEFCSR--GDLRKKLSELPN
  . |. |.             | .. |.|. |        .. | |.. ...  |||||.   |  .      .  .. ||.|.   |||.. . . . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGR

M---CGLPEAEILLLSKHIASAMEYLHKSDIIHRDIKPENIMVQDWKGQC---------------------------HGT--------------------
    ...|| ..  . . |..|.||.|.  |||||.|||||.. .   .                            .|.                    
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYP

--TQTVDLVIHSPVTYPLDHDTSNDTCIYKLANWERE------ILK---------FM
    .......  .      .   |  | |. ... |      .|.         ..
PFP-QMQMMFKKIG-----SPEAKD-FIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase IKKa.AA TyrKc 9-316 11 1.3e-07 -99.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-316
Range on HMM: 1-280/280
Sequence Identity: 11% (48 aa)

WQFKKLLGSGSFGEVLLYQLGVGRKVGRFEAESVDWSRCMWSRFGVGEESVRPCCGVWLASLWCLVGVVVVSGWRRCGVGLVSMSSQFGVDANVGLASMW
 ...| ||.| |||| . ..                                                                                
ITLGKKLGEGAFGEVYKGTWK-------------------------------------------------------------------------------

CHFGLVCGVDEESVCPRCGVGLVLMWSQFGVDVVSVRRQCGETSEYIALKRCKSILQLENLKRWRDEVEFMRNL--EHPNIVQGRPVPPELEAKPN----
                                            .  | | .|.      ..  ..| . |..|  .|||||.   |     .       
--------------------------------------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGV-----CTQQGRNF

---EPPCLAMEFCSRGDLRKKLSELPNMCGLPEAEILLLSKHIASAMEYLHKSDIIHRDIKPENIMVQDWK-------GQCHGTTQT-------VDLVI-
   ||... ||... |||.. | .  .   |. .. |  .  ||. |||||.  .||||.   |..| . .       | .   .            .  
MYIEPLMIVMEYMPHGDLKDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKK

---HSP--------------------------------------VTYPLD------------HDTSNDTCIYKLAN--------------------WER-
   ..                                        . . .            ..  .     . .|                    |.. 
EHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHED

--------EILKFM
        || ...
PEDRPTFSEIHECF
Kinase IKKa.AA CAMKL 9-34 42 0.000727 8.05 In-house 1-28 (297) Show / Hide 
Range on Protein: 9-34
Range on HMM: 1-28/297
Sequence Identity: 42% (12 aa)

WQFKKLLGSGSFGEVLLYQL-GV-GRKV
... | || ||||.| | .     |.||
YRIGKTLGKGSFGKVKLATHIRTTGEKV
Kinase IKKa.AA ULK 9-23 46 0.001689 8.18 In-house 1-15 (329) Show / Hide 
Range on Protein: 9-23
Range on HMM: 1-15/329
Sequence Identity: 46% (7 aa)

WQFKKLLGSGSFGEV
.. .. ||.|||| |
YCLNHCLGKGSFGKV
Kinase IKKa.AA ULK 9-23 43 0.001757 8.29 In-house 1-16 (324) Show / Hide 
Range on Protein: 9-23
Range on HMM: 1-16/324
Sequence Identity: 43% (7 aa)

WQFKKLLGSGSFG-EV
.. .. ||.||||  |
YCLNHCLGKGSFGVKV
Kinase IKKa.AA STE 149-189 23 0.005261 6.6 In-house 36-94 (359) Show / Hide 
Range on Protein: 149-189
Range on HMM: 36-94/359
Sequence Identity: 23% (14 aa)

GETSEYIALKRCK----------------SILQLENLKRWRDEVEFMRNLE--HPNIVQ
||| |..| |. .                .. . |....   |...|...   |||||.
GETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVK
Kinase IKKa.AA CAMK 14-25 66 0.015449 3.19 In-house 1-12 (425) Show / Hide 
Range on Protein: 14-25
Range on HMM: 1-12/425
Sequence Identity: 66% (8 aa)

LLGSGSFGEVLL
 ||.||||.| |
TLGRGSFGKVKL
Kinase IKKa.AA Pkinase 9-25 41 0.02023 9.64 Pfam 1-17 (293) Show / Hide 
Range on Protein: 9-25
Range on HMM: 1-17/293
Sequence Identity: 41% (7 aa)

WQFKKLLGSGSFGEVLL
..... .||||||.| .
YHIGRKIGSGSFGCVYK
Kinase IKKa.AA STE 9-23 40 0.022245 4.36 In-house 1-15 (359) Show / Hide 
Range on Protein: 9-23
Range on HMM: 1-15/359
Sequence Identity: 40% (6 aa)

WQFKKLLGSGSFGEV
|.. . .|.|.||.|
WEGIEKIGKGAFGTV
Kinase IKKa.AA Pkinase_Tyr 156-189 32 0.022266 8.68 Pfam 32-68 (270) Show / Hide 
Range on Protein: 156-189
Range on HMM: 32-68/270
Sequence Identity: 32% (12 aa)

ALKRCKSILQLEN--LKRWRDEVEFMRNL-EHPNIVQ
| | .|     |.  ..    |.. |..|  |||||.
AVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVR
Kinase IKKa.AA CAMK-Unique 9-24 31 0.022923 3.39 In-house 1-16 (363) Show / Hide 
Range on Protein: 9-24
Range on HMM: 1-16/363
Sequence Identity: 31% (5 aa)

WQFKKLLGSGSFGEVL
. . ...|.|.||.|.
YKMHRIIGHGNFGHVY
Kinase IKKa.AA TKL 15-23 77 0.031289 3.85 In-house 1-9 (364) Show / Hide 
Range on Protein: 15-23
Range on HMM: 1-9/364
Sequence Identity: 77% (7 aa)

LGSGSFGEV
.|||.||||
IGSGGFGEV
Kinase IKKa.AA CAMKL 175-189 38 0.031783 2.73 In-house 62-79 (297) Show / Hide 
Range on Protein: 175-189
Range on HMM: 62-79/297
Sequence Identity: 38% (7 aa)

EVEFMRNLE---HPNIVQ
|.. |. |    ||||..
EIQIMKMLNIGKHPNIIK
Kinase IKKa.AA CAMK 173-189 37 0.086834 0.73 In-house 79-102 (425) Show / Hide 
Range on Protein: 173-189
Range on HMM: 79-102/425
Sequence Identity: 37% (9 aa)

RDEVEFMRN-------LEHPNIVQ
| |.| |..       | ||||..
RREIEIMKKLQGIGNKLDHPNIIK
Kinase IKKa.AA Pkinase_Tyr 9-23 60 0.245428 5.15 Pfam 1-15 (270) Show / Hide 
Range on Protein: 9-23
Range on HMM: 1-15/270
Sequence Identity: 60% (9 aa)

WQFKKLLGSGSFGEV
 .| | ||.|.||||
ITFGKKLGEGAFGEV