Gene AAK1 (Sea Urchin)

AAK1

Species: Sea Urchin
Alias: Spk168, AAK1, SPU_024035
External Links: Sea Urchin Project Link ,
Annotation:

Classification

Group: Other
Family: NAK
Subfamily: BIKE

Sequence

Name Sequence Type Origin Length Description Download
AAK1.AA Protein None 1292 None Fasta, JSON
AAK1.kin_dom Protein Kinase Domain None 312 None Fasta, JSON

Protein domain

Protein domains of AAK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AAK1.AA BIKE 6-183 78 7.6e-149 500.79 In-house 86-267 (267) Show / Hide 
Range on Protein: 6-183
Range on HMM: 86-267/267
Sequence Identity: 78% (142 aa)

HVVQQMNERLSVG--FTEQEVLRIFCNVCEAVSRLHHCQTPIIHRDLKVENILLHRSG--NYMLCDFGSATGRVLDPKVHSINDIKDEIEKYTTVSYRSP
.||..||.||..|  |||||||.|||.||||||||||||||||||||||||||||..|  .|.||||||||...|.|..|..|..|||||||||..||.|
QVVNMMNQRLQQGQYFTEQEVLQIFCDVCEAVSRLHHCQTPIIHRDLKVENILLHDHGPPHYVLCDFGSATNKFLNPQKHGVNYVKDEIEKYTTMCYRAP

EMIDLYSEKTITTKADIWALGCMLYKLCFFTLPFGESSLAIQSGNFTIPDNTKYSREMHALIRYMLEVDAEKRPDIFQVSHV
|||||||.|.||||||||||||||||||||.||||||.|||..||||||||.|||||||.|||||||.|.||||||.|||||
EMIDLYSGKEITTKADIWALGCMLYKLCFFCLPFGESQLAICDGNFTIPDNSKYSREMHCLIRYMLEPDMEKRPDIYQVSHV
Kinase AAK1.AA NAK 4-184 52 8.3e-123 411.81 In-house 98-299 (299) Show / Hide 
Range on Protein: 4-184
Range on HMM: 98-299/299
Sequence Identity: 52% (106 aa)

DGHVVQQMNERLS-VG--FTEQEVLRIFCNVCEAVSRLHHCQT--PIIHRDLKVENILL---HRSGNYMLCDFGSATGRVLDPKV-HSIND---IKDEIE
.|.... ||.||.  |  |||.|.|.|||.|||.|...|.||.  ||||||.|.|||||   |..|||.||||||.|.....|.  .....   ..|.|.
HGSLWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGNYKLCDFGSMTTAIIQPENRWEAQYRSMVQDWIN

KYTTVSYRSPEMIDLYSEKTITTKADIWALGCMLYKLCFFTLPFG-------ESSLAIQSGNFT--IPDNTKYSREMHALIRYMLEVDAEKRPDIFQVSH
||||..||.|||.||||...|..|.|||||||||||.||.|.||.       .|.||||.||..  ||||..||..|| ||||||..|.|.||.|.||..
KYTTPMYRAPEMCDLYSNCPIDEKVDIWALGCMLYKMCFYTHPFEDCYQRHDSSKLAIQNGNYKYSIPDNSRYSQQMHDLIRYMLTPDPEQRPNIYQVLN

VA
..
QL
Kinase AAK1.AA NAK-Unclassified 4-180 26 7.4e-65 221.79 In-house 102-399 (405) Show / Hide 
Range on Protein: 4-180
Range on HMM: 102-399/405
Sequence Identity: 26% (80 aa)

DGHVVQQMN------ERL--SVGFTEQEVLRIFCNVCEAVSRLHHCQT--------------------------------------------PIIHRDLK
.|...  ||       ||  .  |.|||.|.|.  ||.... .|  |                                             |.||||.|
RGSLQDFMNNQRTIYQRLTEQTRFHEQECLQIMSDVCQGIQCMHQHQPRQDNATSRVNVDAVSMTYSDETAMLLEDTPLEMDMLSSNSAGSIPLIHRDIK

VENILLH----------------------------------------------------------RSGNYMLCDFGSATGRVLDPK-VHSINDIKDEIEK
.||.|.                                                            .|.| ||||||...    ..  . .. . |.|..
IENVLFCNLRRPSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSEDSEHNGIYKLCDFGSCCECIITIENRQEMQYLQDWINM

YTTVSYRSPEMIDLYSEKTITTKADIWALGCMLYKLCFFTLPFG-ESSLA-------IQS--GNFTIPDNTKYSREMHALIRYMLEVDAEKRPDIFQV
.||  ||.|||||||.   |  | ||||||| |||.||.| ||  . .|.       | .  |....|.|..||   | ||. || .|   || |.||
HTTPQYRAPEMIDLYRCCPIDEKIDIWALGCFLYKMCFYTTPFEMCGQLHNASVTYKILHGLGKYEFPSNHNYSNQLHNLIKIMLNEDPIQRPNIYQV
Kinase AAK1.AA GAK 24-184 43 9e-49 160.16 In-house 110-277 (277) Show / Hide 
Range on Protein: 24-184
Range on HMM: 110-277/277
Sequence Identity: 43% (74 aa)

VLRIFCNVCEAVSRLHHCQTPIIHRDLKVENILLHRSGNYMLCDFGSATGRVLDPKV-HSIND---IKDEIEKYTTVSYRSPEMIDLYSEKTITTKADIW
|||||   | ||  .|    ||||||.|.|| |.   .   ||||||||  .. |    | .    . ||. ..||  ||||||.||||   |  | |||
VLRIFYQMCRAVQHMHSQKPPIIHRDIKIENFLIGNQKTIKLCDFGSATTKSHYPDYSWSAQKRSMVEDEMFRHTTPMYRSPEMCDLYSNWPIGHKQDIW

ALGCMLYKLCFFTLPF-GESSLAIQSGNFT--IPD-NTKYSREMHALIRYMLEVDAEKRPDIFQVSHVA
|.||||| .|.   ||   . |.|  || .  ||   ..|.   | ||| .| |. . |.|| .| .  
AMGCMLYFMCYRQHPFEDGAKLRIINGNYMKPIPPQDNQYMC-FHDLIRACLQVNPDERLDIAMVVEYM
Kinase AAK1.AA TKL-ciliate1 21-184 24 1.8e-32 108.46 In-house 102-279 (279) Show / Hide 
Range on Protein: 21-184
Range on HMM: 102-279/279
Sequence Identity: 24% (43 aa)

EQEVLRIFCNVCEAVSRLHHCQTPIIHRDLKVENILLHRSGNYMLCDFGSATG-RVLDPKVHSINDIKDEIEKYTTVSYRSPEMID--LYSEKTITTKAD
.|  .|.   .   .. ||  | |.||||||..|||.    .|  |.|.. .   .   .. |. |.. |... ||  .. || .|  ... . |..|.|
WQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKID

IWALGCMLYKLCFFTLPFGESSLAIQSGNFTIPDNT------------KYSREMHALIRYMLEVDAEKRPDIFQVSHVA
|.|.|  .| |||   || .. .   ..   ...              ... ..| |.  ... .  |||.  ..  . 
IYAYGIVMYILCFRKTPF-QQKMSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQNPNKRPNFNEIIQIL
Kinase AAK1.AA Ciliate-E2 19-185 22 1.2e-27 92.01 In-house 142-365 (365) Show / Hide 
Range on Protein: 19-185
Range on HMM: 142-365/365
Sequence Identity: 22% (54 aa)

FTEQEVLRIFCNVCE---------------AVSRLHHCQTPIIHRDLKVENILLHRSGNYMLCDFGSAT------GRVLDPKVHSINDIKDEIEKYTTVS
|||.|...|.  ...               |.  ||     |||||.| ||||.       ..||| ..       . .. |... . .    ....| .
FTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPG

-------------------YRSPEMIDLYS------EKTITTKADIWALGCMLYKLCFFTLPFGESSLAIQSGNFTIP----------------DNTKYS
                   | .||..   .      .|  ..|.|||.||..|| ..|  .||      |. ... .|                .. | |
YMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWS

REMHALIRY----MLEVDAEKRPD-IFQV-SHVAF
 |.  ||.     ||..| |||.. . |.  |  |
QECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase AAK1.AA MPSK 20-183 36 2.1e-27 95.38 In-house 108-281 (281) Show / Hide 
Range on Protein: 20-183
Range on HMM: 108-281/281
Sequence Identity: 36% (63 aa)

TEQEVLRIFCNVCEAVSRLH-HCQTPIIHRDLKVENILLHRSGNYMLCDFGSATGRVLDPKVHS-INDIKDEIEKYTTVSYRSPEMIDLYSEKTITTKAD
||  ...||  ||| .  .|     |  |||.|  ||.|  ..   . |.|| .   .  |  .      |. .   ...|| ||     |  .|  . |
TEDQIWWIFLGVCEGLKAIHEAMPKPYAHRDMKPTNICLGDDFQPVIMDLGSMNEACIQVKGQRQACALQDWAAERCSMVYRAPELFHVQSHCVIDERTD

IWALGCMLYKLCFFTLPF------GES-SLAIQSGNFTIPDNTKYSREMHALIRYMLEVDAEKRPDIFQV-SHV
|| ||| ||  |.|  |.      | |  ||.|..|| ||.|  ||  || || ||. ||.  || || | . .
IWSLGCVLYAMCYFHSPYDMIYQRGDSVHLAVQNRNFNIPENSRYSQDMHQLISYMMRVDPMERPHIFWVLNQT
Kinase AAK1.AA Ciliate-E2-Unclassified 19-185 23 3.6e-27 91.31 In-house 135-352 (352) Show / Hide 
Range on Protein: 19-185
Range on HMM: 135-352/352
Sequence Identity: 23% (52 aa)

FTEQEVL-----RIFCNVCEAVSRLHHCQTPIIHRDLKVENILLHRSG---NYMLCDFGSATGRVLDPKVHSIND-------IKDEIEKYT-TVSYR---
||||...     ..|  .... . ||| .  |||||.| ||||.. .|   .  ..|||..     ...    |        .....   . | .|    
FTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQY

-SPEMI--DLYSEKTITTKADIWALGCMLYKLCFFTLPFG---------------------ESSLAIQSGNFTIPD--N----TKYSREMHALIR----Y
 .||..    |....   |.|||.||. || ..| ..||.                     .    |. .|. .|   .     . | |   .|.     
TAPEVLQGQNYDHSKA-YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQK

MLEVDAEKRPDIFQV-SHVAF
||... .||... |.  |  |
MLKKNPNKRITFEQILNHPWF
Kinase AAK1.AA CAMK 19-180 22 4.5e-25 77.11 In-house 176-419 (425) Show / Hide 
Range on Protein: 19-180
Range on HMM: 176-419/425
Sequence Identity: 22% (57 aa)

FTEQEVLRIFCNVCEAVSRLHHCQTPIIHRDLKVENILL-HRS----------------GNYMLCDFGSATGRVLDPKVHSINDIKDEIEK---------
|||.|. |.|  .|.||  .| .   |.||||| ||||| ...                .|  ..||| |.    . . . ..|.|..            
FTEREARRYFRQICSAVHYCHSHN--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-MHNQWTTPTE

-------YTTVSYRS-PEMIDLYS-----------EKTITTKADIWALGCMLYKLCFFTLPFGESSL------------------AIQSGNFT-IPD---
         | .| . ||..   .           .. .. |.|.|..|..|| .   ..|| ...                    |..|... .|.   
GQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFS

-------------------NTKYSREMHALIRYMLEVDAEKRPDIFQV
                   . . | |   ||| ||.|| |||. | |.
PISCNYGPEWWDDISDEFHH-FVSQECKDLIRKMLQVDPEKRMTIEQC
Kinase AAK1.AA Pkinase 6-180 22 1.3e-23 84.6 Pfam 87-287 (293) Show / Hide 
Range on Protein: 6-180
Range on HMM: 87-287/293
Sequence Identity: 22% (49 aa)

HVVQQMNERLS----VGF--TEQEVLRIFCNVCEAVSRLHHCQTPIIHRDLKVENILLHRSGNY----MLCDFGSATGRVLDPKVHSINDIKDEIEKYTT
. |.   ...|     .|  .|.|. ...  .....  .| .   ||||||| ||||... |.      .||||.|  ...|             . .||
Y-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLA--KQFD---------Y-NNS-MTT

V----SYRSPEMIDLYSEKTITTKADIWALGCMLYKLCFFTLPFGES-----------SLAIQSGNFTIPDNTKYS-------------------REMHA
.     |..|| |   . . ...|.|.|..||.|| ...  .|| ..              | .. .  .  ...|                   .|.  
FCGTPWYMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKD

LIRYMLEVDAEKRPDIFQV
.|...|..| .||| . |.
FIKWCLCKDPKKRPTAEQI
Kinase AAK1.AA ULK 109-174 26 1.1e-12 41.41 In-house 225-312 (324) Show / Hide 
Range on Protein: 109-174
Range on HMM: 225-312/324
Sequence Identity: 26% (23 aa)

EKTIT-TKADIWALGCMLYKLCFFTLPFGES--SLA----------------IQSGNFTIP---DNTKYSREMHALIRYMLEVDAEKR
.|  .  |.||| |||..| . .   || ..  ..                 |.  .. .|   .. | | |.. ||| ||..| ..|
QKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDR
S_TKc AAK1.AA S_TKc 1-185 18 9.4e-12 -4.59 SMART 17-231 (231) Show / Hide 
Range on Protein: 1-185
Range on HMM: 17-231/231
Sequence Identity: 18% (47 aa)

MVTDGH----------------------------------------------VVQ---QMNERLSVG--------FTEQEVLRIFCNVCEAVSRLHHCQT
 ... .                                              . .    . ...           |.| .. .... .|.|.  .|    
KCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH--

PIIHRDLKVENILLHRSGNYMLCDFGSATGRVLDPKVHSINDIKDEIEKYTTVSYRSPEMIDLYSEKTITT-KADIWALGCMLYKLCFFTLPFGESSLAI
 ||||||| ||||| .  . ..||||.|.                      |  |..||..        .. |.|.|..||.|| ..    ||    .. 
GIIHRDLKPENILLDE--HIKICDFGLARQL---------------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQM

QSGNFTIPDNTKYSREMHALIRYMLEVDAEKRPDIFQVS--------HVAF
   .         |.|.  .|| .|..| |||| . ..         |  |
MFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AAK1.AA ULK 19-71 32 3.9e-09 28.62 In-house 123-185 (324) Show / Hide 
Range on Protein: 19-71
Range on HMM: 123-185/324
Sequence Identity: 32% (21 aa)

FTEQEVLRIFCNVCEAVSRLHHCQTPIIHRDLKVENILLHRSGNYM------------LCDFGSA
..|||.. .|   |..   ||  .  |||||.| .|||.|    .             ..||| |
LSEQEAIQFFKQICNGFKELH--KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA