Gene GAK (Sea Urchin)
GAK
Sequence
Protein domains of GAK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GAK.AA | GAK | 34-82 | 54 | 2.6e-23 | 74.23 | In-house | 1-50 (277) | Show / Hide |
Range on Protein: 34-82 Range on HMM: 1-50/277 Sequence Identity: 54% (27 aa) LKVRRVIAE-GFAFVYVAQENSTGKEFALKRLLANDEEKSKEILQEIAIL . ||.|||| |||||||||. ||.|.||||.| .|..... | .|| .. YRVRCVIAEGGFAFVYVAQDVQTGREYALKRMLSHDMQANRAIINEICMM |
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| Kinase | GAK.AA | NAK | 34-82 | 31 | 3.9e-16 | 50.28 | In-house | 1-60 (299) | Show / Hide |
Range on Protein: 34-82 Range on HMM: 1-60/299 Sequence Identity: 31% (19 aa) LKVRRVIAE-GFAFVYVAQ---------ENSTGKEFALKRLLAN-DEEKSKEILQEIAIL ..|....|| ||..||..| ||.|...||||.. . ||.. ... .|| .. YTVEKYLAEGGFSYVYLVQDNYINHPDNPNSNGEKYALKRMICHSDEQDLNACKREIEMM |
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| Kinase | GAK.AA | NAK-Unclassified | 34-79 | 27 | 2e-06 | 18.43 | In-house | 1-61 (405) | Show / Hide |
Range on Protein: 34-79 Range on HMM: 1-61/405 Sequence Identity: 27% (17 aa) LKVRRVIAE-GFAFVYVAQ--------E------NSTGKEFALKRLLANDEEKSKEILQEI .. | .|| ||.|||... .|... .||| . ||| .. || YTIVRYLAEGGFSFVYLVKFSKYINPPDNTASVPHSNSNMYCLKRMICQDEESLNTMKREI |
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| Kinase | GAK.AA | BIKE | 34-82 | 30 | 1.8e-05 | 15.49 | In-house | 1-49 (267) | Show / Hide |
Range on Protein: 34-82 Range on HMM: 1-49/267 Sequence Identity: 30% (15 aa) LKVRRVIAE-GFAFVYVAQENSTGKEFALKRLLANDEEKSKEILQEIAIL | ..|| ||| |....... .|||| | |. . |. |. VTVEEQLAEGGFAMVFLVRDHKG-NKCALKRMYVNNEHDLNVCCREHQIM |
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| Kinase | GAK.AA | CAMK | 39-82 | 10 | 0.001935 | 6.15 | In-house | 1-85 (425) | Show / Hide |
Range on Protein: 39-82 Range on HMM: 1-85/425 Sequence Identity: 10% (9 aa) VIAE-GFAFVYVAQENSTG------------KEFALKRLLAN----------------------------DEEKSKEILQEIAIL .. . .|. |. ... .|. ...| | . . .... |....||.|. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIM |
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| Kinase | GAK.AA | Pkinase | 34-82 | 29 | 0.022746 | 9.46 | Pfam | 1-54 (293) | Show / Hide |
Range on Protein: 34-82 Range on HMM: 1-54/293 Sequence Identity: 29% (16 aa) LKVRRVIAEG-FAFVYVAQENSTGKEFALKRLLANDEEKSKEILQ----EIAIL ... |.| .| |. || ... .|||..|.|.. .|...|.. ||.|. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIM |
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| Kinase | GAK.AA | Ciliate-E2 | 34-82 | 21 | 0.169895 | 0.88 | In-house | 1-70 (365) | Show / Hide |
Range on Protein: 34-82 Range on HMM: 1-70/365 Sequence Identity: 21% (15 aa) LKVRRVIAEG-FAFVYVAQENSTGKEFALKR--------------------LLANDEEKSKEILQEIAIL |. ..| .| |. || .. ...|.||.|. . . . . ..|.||| |. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIM |
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| Kinase | GAK.AA | GAK | 170-306 | 65 | 2.6e-110 | 367.8 | In-house | 139-277 (277) | Show / Hide |
Range on Protein: 170-306 Range on HMM: 139-277/277 Sequence Identity: 65% (91 aa) ENFLIGSKKTLKLCDFGSATSKSYQPDSSWSSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINHAMDVWALGCMLYTMCYRQHPFEDSAKLRIINANY ||||||..||.|||||||||.||..||.|||..|||..|||..||||||||.||..|||.|.||.|..|.||.|||||.||||||||||.|||||||.|| ENFLIGNQKTIKLCDFGSATTKSHYPDYSWSAQKRSMVEDEMFRHTTPMYRSPEMCDLYSNWPIGHKQDIWAMGCMLYFMCYRQHPFEDGAKLRIINGNY T--IPEDDEEYMILHDLIRAMLQVDPRNRPPLEVIVAQL . ||..|..||..||||||.|||.|..|. .| .. MKPIPPQDNQYMCFHDLIRACLQVNPDERLDIAMVVEYM |
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| Kinase | GAK.AA | NAK | 170-306 | 46 | 2.6e-81 | 271.15 | In-house | 152-299 (299) | Show / Hide |
Range on Protein: 170-306 Range on HMM: 152-299/299 Sequence Identity: 46% (69 aa) ENFLIGS---KKTLKLCDFGSATSKSYQPDSSWSSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINHAMDVWALGCMLYTMCYRQHPFED------SA ||.|... ....|||||||.| ...||. .|....||...|.....||||||.||..||| |.||.. .|.||||||||.||...||||| |. ENILLSESHHDGNYKLCDFGSMTTAIIQPENRWEAQYRSMVQDWINKYTTPMYRAPEMCDLYSNCPIDEKVDIWALGCMLYKMCFYTHPFEDCYQRHDSS KLRIINANYT--IPEDDEEYMILHDLIRAMLQVDPRNRPPLEVIVAQL ||.|.|.||. ||... .. .|||||.||..||..|| . .. || KLAIQNGNYKYSIPDNSRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL |
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| Kinase | GAK.AA | NAK-Unclassified | 181-308 | 35 | 4.9e-36 | 123.19 | In-house | 272-405 (405) | Show / Hide |
Range on Protein: 181-308 Range on HMM: 272-405/405 Sequence Identity: 35% (49 aa) KLCDFGSATSKSYQPDSSWSSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINHAMDVWALGCMLYTMCYRQHPFEDSAKLR-------IIN--ANYTI |||||||.. . . .. |.|. .|||| ||.||..||| . ||. |.||||| ||.||. |||.. | |.. ..|.. KLCDFGSCCECIITIE---NRQEMQYLQDWINMHTTPQYRAPEMIDLYRCCPIDEKIDIWALGCFLYKMCFYTTPFEMCGQLHNASVTYKILHGLGKYEF PEDDEEYMILHDLIRAMLQVDPRNRPPLEVIVAQLQE | || ||. ||..||..|| . . .. . PSNHNYSNQLHNLIKIMLNEDPIQRPNIYQVLNHICQ |
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| Kinase | GAK.AA | BIKE | 170-297 | 40 | 2.5e-29 | 102.21 | In-house | 135-259 (267) | Show / Hide |
Range on Protein: 170-297 Range on HMM: 135-259/267 Sequence Identity: 40% (53 aa) ENFLIGSKK--TLKLCDFGSATSKSYQPDSSWSSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINHAMDVWALGCMLYTMCYRQHPFEDSAKLRIINA || |. ... |||||||| | .| . . .|| . || || || ||| .| |.|||||||| .|. ||. | .| | . ENILLHDHGPPHYVLCDFGSATNKFLNPQK--HGVN--YVKDEIEKYTTMCYRAPEMIDLYSGKEITTKADIWALGCMLYKLCFFCLPFGES-QLAICDG NYTIPEDDEEYMILHDLIRAMLQVDPRNRP |.|||. .| ||| || .|. || NFTIPDNSKYSREMHCLIRYMLEPDMEKRP |
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| Kinase | GAK.AA | Ciliate-E2 | 169-297 | 18 | 7.2e-19 | 61.39 | In-house | 189-353 (365) | Show / Hide |
Range on Protein: 169-297
Range on HMM: 189-353/365
Sequence Identity: 18% (36 aa)
LENFLIGSKKTLKLCDFGSAT--------------SKSYQPDS----------SWSSLKRSTLEDEFARHT------------TPMYRPPEILDLYE---
.|| |. .|..||| .. .| |. . . ||.| .|||| .
PENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD----------------QIIQQNMFNTICGTPGYMAPEILNGKKYDN
---NFPINHAMDVWALGCMLYTMCYRQHPFEDSAKLRIINA-NYTIP----------------EDDEEYMILHDLIRA----MLQVDPRNRP
. ... |.|.||..|| |.. ..|| ...| .. .| . .. |||. |||.|| .|.
QQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRI
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| Kinase | GAK.AA | CAMK | 169-300 | 18 | 2.8e-16 | 48.29 | In-house | 207-417 (425) | Show / Hide |
Range on Protein: 169-300 Range on HMM: 207-417/425 Sequence Identity: 18% (40 aa) LENFLIGSKK-----------------TLKLCDFGSATSKSYQPDSSWSSLKRSTLEDEFA-------------RHTTPMYRP-PEILD----------- .|| |. ... ..|..||| |. . .. | . . . || | . ||.| PENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNAT LYENFPINHAMDVWALGCMLYTMCYRQHPFEDS-----------------AKLRIINANYT-IPED--------DEEYMI-------------LHDLIRA . |. ... . |.|..|..||.| ||... . .|....|. .|. ..|. |||| DEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRK MLQVDPRNRPPLE |||||| .|. .| MLQVDPEKRMTIE |
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| Kinase | GAK.AA | MPSK | 238-306 | 38 | 7e-16 | 53.56 | In-house | 207-281 (281) | Show / Hide |
Range on Protein: 238-306 Range on HMM: 207-281/281 Sequence Identity: 38% (29 aa) DVWALGCMLYTMCYRQHPFE------DSAKLRIINANYTIPEDDEEYMILHDLIRAMLQVDPRNRPPLEVIVAQL |.| ||| || ||| |.. || | . | | |||. .|.|| |. ||| || .. |. DIWSLGCVLYAMCYFHSPYDMIYQRGDSVHLAVQNRNFNIPENSRYSQDMHQLISYMMRVDPMERPHIFWVLNQT |
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| Kinase | GAK.AA | TKL-ciliate1 | 207-306 | 26 | 1.4e-15 | 49.81 | In-house | 168-279 (279) | Show / Hide |
Range on Protein: 207-306 Range on HMM: 168-279/279 Sequence Identity: 26% (30 aa) LEDEFARHTTPMYRPPEILD--LYENFPINHAMDVWALGCMLYTMCYRQHPFEDSAKLRIINANYTIPEDD------------EEYMILHDLIRAMLQVD . | | ||.... ||..| .. | ||| |..|.| .| .| | ||. |. || ..| .|.|. .. . MQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPFQQ--KMSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQN PRNRPPLEVIVAQL | || . | | PNKRPNFNEIIQIL |
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| Kinase | GAK.AA | Pkinase | 169-306 | 20 | 4.3e-15 | 54.46 | Pfam | 136-293 (293) | Show / Hide |
Range on Protein: 169-306 Range on HMM: 136-293/293 Sequence Identity: 20% (36 aa) LENFLIGSKKTL----KLCDFGSATSKSYQPDSSWSSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINHAMDVWALGCMLYTMCYRQHPFEDS----- .||.|| .. .. |.||||.| .. . | . . || |..||.. .. .. .. |.|..||.|| |. .. || .. PENILIDNNGHIDACVKICDFGLAKQFD--------Y-NNS-MTTFCG---TPWYMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN -AKLRIINANYT------IPEDDEEY-----------------MILHDLIRAMLQVDPRNRPPLEVIVAQ--L .. .|. . .|...... . |.|. .|..|| || | |. . HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | GAK.AA | TKL | 170-306 | 16 | 6.2e-15 | 50.23 | In-house | 169-364 (364) | Show / Hide |
Range on Protein: 170-306 Range on HMM: 169-364/364 Sequence Identity: 16% (33 aa) ENFLIGSKKT--------------LKLCDFGSATSKSYQPDSSWSS--------LKRSTLEDEFARHTTPMYRPPEILD---LYEN----------FPIN .| |. .. | .|.|||| ....| ... .. .. .. . . || . .||.|. |.. |. . KNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYS HAMDVWALGCMLYTMCYRQHPFEDSAKLRII---------NANY------TIPE--------DDEEYM--ILHDLIRAMLQVDPRNRPPLEVIVAQL ..||.. | .|. .. |..|..| .| .. .||. ..... . .|. . ||..|| . |. .| EKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | GAK.AA | Ciliate-E2-Unclassified | 169-297 | 18 | 8.9e-15 | 47.71 | In-house | 172-341 (352) | Show / Hide |
Range on Protein: 169-297 Range on HMM: 172-341/352 Sequence Identity: 18% (32 aa) LENFLIGSKK---TLKLCDFGSATSKSYQPDSSWSSL--KRSTLEDEFARHT--TPMYR----PPEIL--DLYE--NFPINHAMDVWALGCMLYTMCYRQ .|| |. ... .|..|||.. ..... . |.. . .. . .. ||.| .||.| |. . .. |.|.||. || |.. . PENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA---YKCDIWSLGVILYEMLFGY HPFE--DSAK----------------LRIINANYTIPEDDEEY----MILH--------DLIRAMLQVDPRNRP .||. .. . |. . . | . .. .... ||.. ||...| .|. YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI |
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| Kinase | GAK.AA | S_TKc | 169-310 | 12 | 1.5e-05 | -95.68 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 169-310
Range on HMM: 1-231/231
Sequence Identity: 12% (33 aa)
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YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYM
----------------------ENFLIGSKKTLKLCDFGSATSKSYQPDSSWSSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINH-AMDVWALGCML
|| |. . ..|.||||.|. || |..||.| . .. . |.|..||.|
YQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCIL
YTMCYRQHPFEDSAKLRIINANYTIPEDDEEYMILHDLIRAMLQVDPRNRPPLEVIVA-----QLQEIA
| |.... ||. .... . |.|| .||.||..|| . . . .
YEMLCGYPPFP--QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| PTEN_C2 | GAK.AA | PTEN_C2 | 552-693 | 21 | 7.1e-25 | 91.16 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 552-693 Range on HMM: 1-141/141 Sequence Identity: 21% (33 aa) PHQRVLLIKSLRL-TPVPLYNKMRSGCPSVRPYVRTSVPDELI-RFGGHEVKGQRGFEVEDASAFIDLNIPVCGDVMVVVYHAR-ST--FGGKVQGKVTG |. . | ...... ..| |.. || .|||.. |. . . . .... . ... ... ..||.|||.. .|| . |. ... PPPKPLFLHCIIMDHGIPNF-KQGGGC--WRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEEC----- LKMFQFQFNTGFIEPGTKEISFNRYELD-FFEL---DKFAEHFHASLDVVV ||.|.|||.||| ..... |...||| .. ..| . |.. . --MFRFWFNTCFIEHNNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE |
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| DnaJ | GAK.AA | DnaJ | 1330-1391 | 25 | 0.000116 | 17.03 | SMART | 1-72 (72) | Show / Hide |
Range on Protein: 1330-1391 Range on HMM: 1-72/72 Sequence Identity: 25% (18 aa) EDRWKPVGMHQLVEHNQVKKWYRKAVLSAHPDKQVGTPN----------EELAKLIFMELSDAWSAFEEAGA .| .. | .. ...|| ||| .. |||| | | .| |. |.|.. |.. RDYYEILGVPRDADDDEIKKAYRKLAKKYHPDKNPGDPERSCWKLCWEEKEEAEEKFKEINEAYEVLSDPEK |
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