Gene KIS (Sea Urchin)

KIS

Species: Sea Urchin
Alias: KIS, Spk206, SPU_027616
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: KIS

Sequence

Name Sequence Type Origin Length Description Download
KIS.AA Protein None 710 None Fasta, JSON
KIS.kin_dom Protein Kinase Domain None 473 None Fasta, JSON

Protein domain

Protein domains of KIS.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase KIS.AA KIS 126-598 80 0.0 1421.51 In-house 1-473 (473) Show / Hide 
Range on Protein: 126-598
Range on HMM: 1-473/473
Sequence Identity: 80% (383 aa)

WTLGRVLGMGRCAKVYHMSTDQDSFQAAVKVYRKEEKYRLAFIKEMCNLNAVYGDRRVISVYGTFTHKGHPCLAMELLDFNLKEFIYRSENCRVILSSIP
|...|.||||||||||||||||||||..||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
WQVQRRLGMGRCAKVYHMSTDQDSFQSSVKVYRKEEKYRLAFIKEMCNLNAVYGDRRVISVYGTFTHKGHPCLAMELLDFNLKEFIYRSENCRVILSSIP

TTSNHSKNHSRVVSNVPCNNNNNDITSGTANHKDHKKGKGQGKEKKTAQSGRSHGRVRTADHTEGSGRCGTRMQTRRATAQRAAGLRSKGKDSDHGSTRA
||||||||||||||||.|.||||||||||||||||||||.|||||..||.||.|.|||||||||||||||||||.||||||.|.|.|.||||||||||||
TTSNHSKNHSRVVSNVRCCNNNNDITSGTANHKDHKKGKPQGKEKQFAQPGRTHARVRTADHTEGSGRCGTRMQKRRATAQQAQGHRNKGKDSDHGSTRA

PDSSTALASNSGRDSRTHSGTLKNTKKDNAEEDDGEEDDLADHQEGNQGASEEDVEEEDDDDEDASSYGLSLYLIQQLLRDIASCLEFVQRCGWVHGDLK
||||||...|.||..|.||...|||..|||||||.|.|||||||||||||||||||||||||||||.||.|...||...||||.|||||..|||||.|||
PDSSTAIVTNYGRFTRHHSPNVKNTRCDNAEEDDVEVDDLADHQEGNQGASEEDVEEEDDDDEDASHYGCSMWMIQHCARDIAECLEFVHHCGWVHADLK

PANILWSSQEGSWKIVDFGHSFQEGRQDFSQIQSLCYQSPEAKVWNSFVSSLGNQKVVHKMSAVDEGVTECTHAADIWSLGCVIVRAYTGMKLYGQDDVL
|.|||||.|...|||.|||||||||.|||..||..|||.|||||||.||...|||||||||||||...||||||.|||||||.|||.|||||||.|||||
PRNILWSAQNECWKIIDFGHSFQEGNQDFKYIQTDCYQAPEAKVWNCFVQAGGNQKVVHKMSAVDQSDTECTHAVDIWSLGCIIVRMYTGMKLYHQDDVL

PGACLQCRISCSNTACECEPLIENLFKPKMTNPKLSPIRQAAVHHLSDLVKSMLQCDIAKRPSAAEILTHPFF
|||||||||.|.|..|.|||.|...|||||.|.|..||||||||||.||.||||.||||.|..|..||.||||
PGACLQCRIRCQNWKCNCEPIIDHIFKPKMVNNKAIPIRQAAVHHLRDLIKSMLHCDIARRIPAEMILCHPFF
Kinase KIS.AA DYRK2 394-467 38 6.6e-15 44.59 In-house 98-173 (318) Show / Hide 
Range on Protein: 394-467
Range on HMM: 98-173/318
Sequence Identity: 38% (29 aa)

GLSLYLIQQLLRDIASCLEFVQRCGWVHGDLKPANILWSSQEGSW-KIVDFGHSFQEGR-QDFSQIQSLCYQSPEA
|.|| |.    . |  ||.| ..   .|.||||.|||  ..  |  |..||| |  | . ... .|||. | .||.
GFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEV
Kinase KIS.AA Ciliate-E2 126-509 10 1.3e-14 46.6 In-house 1-286 (365) Show / Hide 
Range on Protein: 126-509
Range on HMM: 1-286/365
Sequence Identity: 10% (48 aa)

WTLGRVLGMGRCAKVYHMSTDQDSFQAA-----------------------VKVYRKEE-KYRLAFIKEMCNLNAVYGDRR---------------VISV
  . ...| |  ..|| .. ...  | |                       .|...| . .. .  |..|  .|  |   .               .|  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFY---KKINEKNILEQLNHPNIIKM

YGTFT--HKGHPCLAMELLDF-NLKEFIYRS-ENCRVILSSIPTTSNHSKNHSRVVSNVPCNNNNNDITSGTANHKDHKKGKGQGKEKKTAQSGRSHGRV
| .|    . .  | ||...  .|...|. .  ..  ...                                                            
YECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE------------------------------------------------------------

RTADHTEGSGRCGTRMQTRRATAQRAAGLRSKGKDSDHGSTRAPDSSTALASNSGRDSRTHSGTLKNTKKDNAEEDDGEEDDLADHQEGNQGASEEDVEE
                                                                                                    
----------------------------------------------------------------------------------------------------

EDDDDEDASSYGLSLYLIQQLLRDIAS---------------CLEFVQRCG-WVHGDLKPANILWSSQEGSWKIVDFGH--SFQEGRQDFSQIQSLCYQS
            .... |... . |..               .||.    .  .| |.|| |||        ||.|||    ... .|. ..  ..|.  
------K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTH-KQQCKWY

PEAK-----------------VWNSFVSSLGNQKV-VHKMSAVD--EGVTECTHAADIWSLGCVI
.. |                 . |... ..| .   ....   |  .. .. ....||||||...
MF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase KIS.AA CMGC 183-466 8 1.3e-14 43.57 In-house 100-295 (513) Show / Hide 
Range on Protein: 183-466
Range on HMM: 100-295/513
Sequence Identity: 8% (31 aa)

VISVYGTFTHKG-----------------HPCLAMELLDFNLKEFIY-----------------------RSENCRVILSSIPTTSNHSKNHSRVVSNVP
... |  |.||.                 | .| .|..| .|...|.                       |.                            
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRR----------------------------

CNNNNNDITSGTANHKDHKKGKGQGKEKKTAQSGRSHGRVRTADHTEGSGRCGTRMQTRRATAQRAAGLRSKGKDSDHGSTRAPDSSTALASNSGRDSRT
                                                                                                    
----------------------------------------------------------------------------------------------------

HSGTLKNTKKDNAEEDDGEEDDLADHQEGNQGASEEDVEEEDDDDEDASSYGLSLYLIQQLL------RDIASCLE--FVQRCG--WVHGDLKPANILWS
                                                      ...|. ..      . |  .|.  .  . .   .| ||||.||| .
-----------------------------------------------------PPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILIN

SQE-------------------GSWKIVDFGHSFQEGRQ------------------------DFSQIQSLCYQSPE
..                    |  || ||| . ...                            ...... | .||
HNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPE
Kinase KIS.AA Ciliate-E2-Unclassified 126-466 9 1.5e-12 39.91 In-house 1-236 (352) Show / Hide 
Range on Protein: 126-466
Range on HMM: 1-236/352
Sequence Identity: 9% (39 aa)

WTLGRVLGMGRCAKVYHMSTDQDSFQA------------AVKVYRKEEKYRLAFIKEMCNLNAVYGDR----------------RVISVYGTFTHKGHPC
 ......| |  .|||..  ...  |.            ..| .....   .  .|||.|..  | .|                 ..  . .|. | ...
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY

LAMELL-DFNLKEFIYRSENCRVILSSIPTTSNHSKNHSRVVSNVPCNNNNNDITSGTANHKDHKKGKGQGKEKKTAQSGRSHGRVRTADHTEGSGRCGT
. ||.. . .|...|  ...                                                                                
IVMEYCEGGDLWQYIKKRKKQK------------------------------------------------------------------------------

RMQTRRATAQRAAGLRSKGKDSDHGSTRAPDSSTALASNSGRDSRTHSGTLKNTKKDNAEEDDGEEDDLADHQEGNQGASEEDVEEEDDDDEDASSYG--
                                                                                 . .             .  
---------------------------------------------------------------------------------Q-K------------GNDL

---------LSLYLIQ-----QLLRDIASCLEFVQRCG-WVHGDLKPANILWSSQEG--SWKIVDFGHS--------FQEGRQ-----------DFSQIQ
         .. . ..     .... | ..||.  . .  .| |.|| ||| ... .    || ||| |        .. ..|             ....
FHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCG

SLCYQ----SPE
...|.    .||
TPNYMPQYTAPE
Kinase KIS.AA S_TKc 126-598 11 2.3e-12 4.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 126-598
Range on HMM: 1-231/231
Sequence Identity: 11% (57 aa)

WTLGRVLGMGRCAKVYHMSTDQDSFQAAVKVYRKEEKYRLAFIKEMCNLNAVYGDRRVISVYGTFTHKGHPCLAMELLDFNLKEFIYRSENCRVILSSIP
....|..| |  .|||      .  . |.|. .                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

TTSNHSKNHSRVVSNVPCNNNNNDITSGTANHKDHKKGKGQGKEKKTAQSGRSHGRVRTADHTEGSGRCGTRMQTRRATAQRAAGLRSKGKDSDHGSTRA
                                                                                                    
----------------------------------------------------------------------------------------------------

PDSSTALASNSGRDSRTHSGTLKNTKKDNAEEDDGEEDDLADHQEGNQGASEEDVEE--EDDDDEDASSYG------LSLYLIQQLLRDIASCLEFVQRC
            .. |     ||. . .|     .  .|      ..     | ..    |  |   .  .      ..   .. ... |.. ||.  . 
------------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH

GWVHGDLKPANILWSSQEGSWKIVDFGHSFQEGRQDFSQIQSLCYQSPEAKVWNSFVSSLGNQKVVHKMSAVDEGVTECTH-AADIWSLGCVIVRAYTGM
| .| ||||.||| ..     || ||| . |      ... .. | .||                              .. ..|.||.||..   ..| 
GIIHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL--------------------------GYGKCKCDWWSCGCILYEMLCGY

KLYGQDDVLPGACLQCRISCSNTACECEPLIENLFKPKMTNPKLSPIRQAAVHHLSDLVKSMLQCDIAKRPSAAEILT-------HPFF
 ..        . .  .|                                  . . |... .|| | .|||.| |.|.       ||.|
PPFP-----QMQMMFKKIG--------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase KIS.AA DYRK 394-466 35 3.6e-12 42.04 In-house 98-174 (320) Show / Hide 
Range on Protein: 394-466
Range on HMM: 98-174/320
Sequence Identity: 35% (27 aa)

GL-SLYLIQQLLRDIASCLEFVQRC-GWVHGDLKPANILWSS--QEGSWKIVDFGHSFQEGRQDFSQIQSLCYQSPE
|. || |... .. |  || | ...   .|.|||| ||.  .  .    |..||| | .|... ...|||  | .||
GFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPE
Kinase KIS.AA IRE 569-598 40 9.6e-11 33.04 In-house 258-292 (292) Show / Hide 
Range on Protein: 569-598
Range on HMM: 258-292/292
Sequence Identity: 40% (14 aa)

HHLS-----DLVKSMLQCDIAKRPSAAEILTHPFF
.|..     ||...|.. |  |||.. |.| ||||
NHWHIVIACDLIHQMIHHDPQKRPTIKECLNHPFF
Kinase KIS.AA CMGC 573-598 53 2.5e-10 29.21 In-house 488-513 (513) Show / Hide 
Range on Protein: 573-598
Range on HMM: 488-513/513
Sequence Identity: 53% (14 aa)

DLVKSMLQCDIAKRPSAAEILTHPFF
||.| |||.| .||..|...| ||.|
DLLKKMLQYDPDKRITAEQALQHPYF
Kinase KIS.AA Ciliate-E2 573-598 45 7.8e-10 29.93 In-house 335-365 (365) Show / Hide 
Range on Protein: 573-598
Range on HMM: 335-365/365
Sequence Identity: 45% (14 aa)

DLVKS----MLQCDIAKRPS-AAEILTHPFF
|| |     |||.|  ||.. . .|| ||.|
DLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase KIS.AA DyrkP 573-598 50 4.8e-09 25.22 In-house 298-323 (323) Show / Hide 
Range on Protein: 573-598
Range on HMM: 298-323/323
Sequence Identity: 50% (13 aa)

DLVKSMLQCDIAKRPSAAEILTHPFF
| |...|| |  .||.| | | ||.|
DFVRQCLQIDFTRRPTAKEALQHPWF
Kinase KIS.AA Pkinase 126-446 11 9.3e-08 28.51 Pfam 1-159 (293) Show / Hide 
Range on Protein: 126-446
Range on HMM: 1-159/293
Sequence Identity: 11% (38 aa)

WTLGRVLGMGRCAKVYHMSTDQDSFQAAVKVYRKEEKYRLAFIK-----EMCNLNAVYGDRRVISVYGTFTHKGHPCLAMELLDF-----NLKEFIYRSE
...||..| |  ..||.     .. . |||. .|...     .      | . .. . .   ..  |..|. |.|... ||...       |...| .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

NCRVILSSIPTTSNHSKNHSRVVSNVPCNNNNNDITSGTANHKDHKKGKGQGKEKKTAQSGRSHGRVRTADHTEGSGRCGTRMQTRRATAQRAAGLRSKG
                                                                                                    
----------------------------------------------------------------------------------------------------

KDSDHGSTRAPDSSTALASNSGRDSRTHSGTLKNTKKDNAEEDDGEEDDLADHQEGNQGASEEDVEEEDDDDEDASSYGL--SLYLIQQLLRDIASCLEF
                                                                           .. ..  |   ..  .. |.. ||.
--------------------------------------------------------------------------WRHGCFYFSEWECKFYMYQILRGLEY

VQRCGWVHGDLKPANILWSSQEGSW----KIVDFGHS
  ..| .| ||||.||| . ..|      || ||| .
CHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLA
Kinase KIS.AA DYRK 568-598 38 1.9e-07 24.23 In-house 290-320 (320) Show / Hide 
Range on Protein: 568-598
Range on HMM: 290-320/320
Sequence Identity: 38% (12 aa)

VHHLSDLVKSMLQCDIAKRPSAAEILTHPFF
.| . |..| .|| | .||..... | ||.|
DHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase KIS.AA WEE 398-446 31 2.1e-07 20.96 In-house 111-179 (297) Show / Hide 
Range on Protein: 398-446
Range on HMM: 111-179/297
Sequence Identity: 31% (22 aa)

YLIQQLLRDIASCLEFV-QRCGWVHGDLKPANILWSSQE-------------------GSWKIVDFGHS
..| |.|.||.  | .. ..|| || |.||.||. |..                    .  || ||||.
WMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHV
Kinase KIS.AA Ciliate-E2-Unclassified 573-598 33 3.8e-07 20.87 In-house 323-352 (352) Show / Hide 
Range on Protein: 573-598
Range on HMM: 323-352/352
Sequence Identity: 33% (10 aa)

DLVK----SMLQCDIAKRPSAAEILTHPFF
|...    .||. .. ||... .|| ||.|
DFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase KIS.AA Pkinase 573-598 50 5.4e-07 25.8 Pfam 268-293 (293) Show / Hide 
Range on Protein: 573-598
Range on HMM: 268-293/293
Sequence Identity: 50% (13 aa)

DLVKSMLQCDIAKRPSAAEILTHPFF
|..|..|. | .|||.|..|| ||.|
DFIKWCLCKDPKKRPTAEQILQHPWF
Kinase KIS.AA TyrKc 126-598 9 1e-06 -116.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 126-598
Range on HMM: 1-280/280
Sequence Identity: 9% (50 aa)

WTLGRVLGMGRCAKVYHMSTDQDSFQAAVKVYRKEEKYRLAFIKEMCNLNAVY-GDRRVISVYGTFTHK-------GHPCLAMELLDF-NLKEFI-YRSE
 |||..|| |   .||.   .    | |||. ...   | .|..|.  .  ..     ..  ||  |..       . ... ||. .  .||... .. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

NCRVILSSIPTTSNHSKNHSRVVSNVPCNNNNNDITSGTANHKDHKKGKGQGKEKKTAQSGRSHGRVRTADHTEGSGRCGTRMQTRRATAQRAAGLRSKG
.                                                                                                   
K---------------------------------------------------------------------------------------------------

KDSDHGSTRAPDSSTALASNSGRDSRTHSGTLKNTKKDNAEEDDGEEDDLADHQEGNQGASEEDVEEEDDDDEDASSYGLSLYLIQQLLRDIASCLEFVQ
                                                                               |..    .   .||.  |.  
-------------------------------------------------------------------------------LCMKDLLSFCWQIACGMEYLH

RCGWVHGDLKPANILWSSQEGSWKIVDFGHSFQEGRQ--------DFSQ----------------------------------------IQSLCYQSPEA
. . .| ||   |.| ...    || ||| |   .            ..                                        | ... | .. 
SKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPG

-----KVWNSFVSSLGNQKVVHKMSA----VDEGVTECTHAADIWSLGCVIVRAYTGMKLYGQDDVLPGACLQCRISCSNTACECEPLIENLFKPKMTNP
     . .   .  . . .   ..                                                                            
MIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------------------------------------------------------

KLSPIRQAAVHHLSDLVKSMLQC---DIAKRPSAAEILTHPFF
         |.  ... . |.||   | ..||. .||  | .|
-------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase KIS.AA STE 570-598 38 2e-06 18.66 In-house 329-359 (359) Show / Hide 
Range on Protein: 570-598
Range on HMM: 329-359/359
Sequence Identity: 38% (12 aa)

HLSDLVKSMLQCDIAKRPSAAEILT--HPFF
.. | ..  || |  |||.| . |   |||.
EFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase KIS.AA WEE 571-598 35 2e-06 17.36 In-house 270-297 (297) Show / Hide 
Range on Protein: 571-598
Range on HMM: 270-297/297
Sequence Identity: 35% (10 aa)

LSDLVKSMLQCDIAKRPSAAEILTHPFF
| .|.|.|.. |  .||.....| ||  
LKQLIKWMMHPDPEQRPTCQQLLQHPVL
Kinase KIS.AA STE 420-448 44 4e-06 17.95 In-house 174-196 (359) Show / Hide 
Range on Protein: 420-448
Range on HMM: 174-196/359
Sequence Identity: 44% (13 aa)

VHGDLKPANILWSSQEGSWKIVDFGHSFQ
.| |.||||||        |..|||.. |
IHRDIKPANILL------VKLCDFGVCGQ
Kinase KIS.AA DyrkP 400-466 35 2e-05 13.1 In-house 108-175 (323) Show / Hide 
Range on Protein: 400-466
Range on HMM: 108-175/323
Sequence Identity: 35% (24 aa)

IQQLLRDIASCLEFVQRCGWVHGDLKPANILWSSQE-GSWKIVDFGHSFQEGRQDFSQIQSLCYQSPE
.|..   |   |...     .| |||| |||  |.  .  ||.||| |        | .||  |  ||
LQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPE
Kinase KIS.AA IRE 400-444 34 0.000111 11.68 In-house 118-169 (292) Show / Hide 
Range on Protein: 400-444
Range on HMM: 118-169/292
Sequence Identity: 34% (18 aa)

IQQLLRDIASCLEFVQRCGWVHGDLKPANILWSS----QEG---SWKIVDFG
. ||...... |..    . || |||| ||| .     |.|   . .| |||
MWQLIKQCMNGLQHLHSQNIVHRDLKPHNILIHMNRPNQHGENNRFMISDFG
Kinase KIS.AA DYRK 182-211 40 0.000297 12.12 In-house 62-91 (320) Show / Hide 
Range on Protein: 182-211
Range on HMM: 62-91/320
Sequence Identity: 40% (12 aa)

RVISVYGTFTHKGHPCLAMELLDFNLKEFI
...  |  |.|..| |.  |||. ||.||.
HCVHMYDYFYHRNHLCIVFELLSMNLYEFL
Kinase KIS.AA WEE 495-519 40 0.000339 10.06 In-house 210-236 (297) Show / Hide 
Range on Protein: 495-519
Range on HMM: 210-236/297
Sequence Identity: 40% (11 aa)

ECTHA--ADIWSLGCVIVRAYTGMKLY
..||.  ||| |||..|. . ..| |.
HYTHLYKADIFSLGITIYELACNMDLP
Kinase KIS.AA DyrkP 501-524 41 0.001683 6.63 In-house 187-210 (323) Show / Hide 
Range on Protein: 501-524
Range on HMM: 187-210/323
Sequence Identity: 41% (10 aa)

DIWSLGCVIVRAYTGMKLYGQDDV
|.|||||..   .||  |.  | .
DMWSLGCILAELWTGNVLFQNDNI
Kinase KIS.AA DYRK2 190-211 45 0.003298 5.91 In-house 70-91 (318) Show / Hide 
Range on Protein: 190-211
Range on HMM: 70-91/318
Sequence Identity: 45% (10 aa)

FTHKGHPCLAMELLDFNLKEFI
|.  .| |.. |||. ||.|.|
FYFRNHHCITFELLSMNLYEYI
Kinase KIS.AA STE 126-365 6 0.003693 7.15 In-house 1-112 (359) Show / Hide 
Range on Protein: 126-365
Range on HMM: 1-112/359
Sequence Identity: 6% (17 aa)

WTLGRVLGMGRCAKVYHM---------STDQD------SFQAAVKVYRKEE------------------KYRLAFIKEMCNLNAVYG-DRRVISVYGTFT
|.. ...| | . .||           .|..        .  |.|. ..|.                  . .  ..||.  ..        ..  ||.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HKGHPCLAMELLDFNLKEFIYRSENCRVILSSIPTTSNHSKNHSRVVSNVPCNNNNNDITSGTANHKDHKKGKGQGKEKKTAQSGRSHGRVRTADHTEGS
..||.                                                                                               
KEGHN-----------------------------------------------------------------------------------------------

GRCGTRMQTRRATAQRAAGLRSKGKDSDHGSTRAPDSSTALASNSGRDSRTHSGTLKNTKKDNAEEDDGEEDDL
                                                                   ....|.|
-------------------------------------------------------------------HKNDDEL
Kinase KIS.AA DYRK2 501-515 53 0.007145 4.8 In-house 184-198 (318) Show / Hide 
Range on Protein: 501-515
Range on HMM: 184-198/318
Sequence Identity: 53% (8 aa)

DIWSLGCVIVRAYTG
|.||.||...  |||
DMWSFGCIMAELYTG
Kinase KIS.AA STE 490-510 40 0.007259 6.1 In-house 238-259 (359) Show / Hide 
Range on Protein: 490-510
Range on HMM: 238-259/359
Sequence Identity: 40% (9 aa)

DEG-VTECTHAADIWSLGCVIV
..| . ...  .|||||||.|.
GQGRDKGYDTKCDIWSLGCTII
Kinase KIS.AA DYRK2 584-598 26 0.017304 3.53 In-house 304-318 (318) Show / Hide 
Range on Protein: 584-598
Range on HMM: 304-318/318
Sequence Identity: 26% (4 aa)

AKRPSAAEILTHPFF
..| .....| ||..
SERMTPSQALKHPWI
Kinase KIS.AA CMGC 494-509 37 0.028982 2.2 In-house 310-325 (513) Show / Hide 
Range on Protein: 494-509
Range on HMM: 310-325/513
Sequence Identity: 37% (6 aa)

TECTHAADIWSLGCVI
.. | . |.||.||..
MHYTTPIDMWSVGCIF
Kinase KIS.AA Ciliate-E2-Unclassified 498-509 50 0.034462 3.42 In-house 249-260 (352) Show / Hide 
Range on Protein: 498-509
Range on HMM: 249-260/352
Sequence Identity: 50% (6 aa)

HAADIWSLGCVI
...||||||...
YKCDIWSLGVIL
Kinase KIS.AA DyrkP 173-210 39 0.09105 0.82 In-house 53-90 (323) Show / Hide 
Range on Protein: 173-210
Range on HMM: 53-90/323
Sequence Identity: 39% (15 aa)

NLNAVYGDRRVISVYGTFTHKGHPCLAMELLDFNLKEF
| |    .. |. .|  | || |  .  |||. || ||
NYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEF
Kinase KIS.AA DYRK 501-510 60 0.120925 2.26 In-house 186-195 (320) Show / Hide 
Range on Protein: 501-510
Range on HMM: 186-195/320
Sequence Identity: 60% (6 aa)

DIWSLGCVIV
|.|||||...
DMWSLGCILA
Kinase KIS.AA Pkinase 497-515 31 0.158379 6.48 Pfam 190-208 (293) Show / Hide 
Range on Protein: 497-515
Range on HMM: 190-208/293
Sequence Identity: 31% (6 aa)

THAADIWSLGCVIVRAYTG
....|.||.||..   ..|
GPKVDMWSCGCILYEMLCG
RRM_1 KIS.AA RRM_1 640-695 31 3.8e-08 31.03 Pfam 13-73 (73) Show / Hide 
Range on Protein: 640-695
Range on HMM: 13-73/73
Sequence Identity: 31% (19 aa)

QDIKRECLKFGPIKSLLIPK-----AGPGKGTAFIEFEDSANTKSALNALIGQKLFNQPVL
.|...   |||||.|  |..      |  .| ||.||||.   ..|. |. |... . .. 
EDLRDLFSKFGPIESIRIMRDNTRETGRSRGFAFVEFEDHEDAEKAIQAMNGKEFNGREIR
RRM KIS.AA RRM 616-697 15 1e-06 29.35 SMART 1-121 (121) Show / Hide 
Range on Protein: 616-697
Range on HMM: 1-121/121
Sequence Identity: 15% (20 aa)

TLRLSNLVSSNVDLTNQKVFHSLYQDIKREC--------------LKFGPIKSLLIPKA------------------------GPGKGTAFIEFEDSANT
|.  .||          . .    .|... .               .||||..  |..                         |  .| ||.|||| .  
TIFVGNLN---------DPWDVTEEDLREFFKDMHSVHIHQCNCCSQFGPIVDCRIMRDKDNIHYYRCSRFCQMHQLGKNSNTGRSRGFAFVEFEDEEDA

KSA--LNALI---GQKL--FNQP---VLIS
. |  ....    |...   ..|   . ..
EKAMVIEMMNASKGHEFRDDGRPTGHIRVK