Gene TOPK (Sea Urchin)

TOPK

Species: Sea Urchin
Alias: TOPK, Spk195, SPU_007078
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: TOPK

Sequence

Name Sequence Type Origin Length Description Download
TOPK.AA Protein None 422 None Fasta, JSON
TOPK.kin_dom Protein Kinase Domain None 262 None Fasta, JSON

Protein domain

Protein domains of TOPK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TOPK.AA TOPK 51-70 60 1.3e-11 37.21 In-house 1-20 (292) Show / Hide 
Range on Protein: 51-70
Range on HMM: 1-20/292
Sequence Identity: 60% (12 aa)

SPFMKKLGWGTGVSVYLLER
||.|.|||.|||..||...|
SPMMQKLGHGTGIRVYRMDR
Kinase TOPK.AA TOPK 149-417 60 3.4e-208 697.95 In-house 21-292 (292) Show / Hide 
Range on Protein: 149-417
Range on HMM: 21-292/292
Sequence Identity: 60% (166 aa)

SPRPDGSGRSPWAVKKIRSKYKKGRGDVDVEGRLKKEAVILKKMSHANIVEFRALSKSADGSLCLSMENG-QQSLMGMIDQRKEAGKGPFPAAQIYQVAL
|||  |  .|||||||||.........|..||||..||.|||||.|.|||.|||.....||||||.||.. |||||.||..|....|||||||.||..|.
SPR-RGEIHSPWAVKKIRQNCRDHYRTVYQEGRLMHEAKILKKMHHPNIVGFRAFTENDDGSLCLAMEMCGQQSLMDMIEERHDEDKGPFPAAHIYKMAM

SLASALNYLHNDLKYIHGDLKSGNVLVKGDFETVKLCDFGVALKLTDDLNG--LENPTDDYVGSQPWN-AMEVHMAGDITHKTDMFSYGLVIWEMMSLEA
..|.||.||||...|.||||||.||||||||||.|||||||.|.|....|.  |.||.|.|||.|||. .|.|||.|.||||.||||.||||||||.|..
HMAQALDYLHNEKHYMHGDLKSFNVLVKGDFETCKLCDFGVSLPLDENMNVNFLKNPEDCYVGTQPWCPKMVVHMNGVITHKADMFSFGLVIWEMMTLCI

PHLDLLFSGDDSEYDDDETSFDESEFEAALGTRPPLPKENLGPAYQFLIELFCACTIEDPTQRPSAKMTLAAL
||..|.|..||..||.|||.||..|..||||||.|...|||...|||..||||.||.|||..||||.....||
PHINLPFDDDDEDYDFDETDFDDEEYYAALGTRMPINMENLDDTYQFQCELFCFCTNEDPNDRPSAMHIHEAL
Kinase TOPK.AA TKL 161-417 20 4.2e-30 105.59 In-house 30-364 (364) Show / Hide 
Range on Protein: 161-417
Range on HMM: 30-364/364
Sequence Identity: 20% (72 aa)

AVKKIRSKYKKGRGDVDVE---------------------GRLKKEAVILKKMSHANIVEFRALSKSADG------------SLCLSMENG-QQS-LMGM
||||..|.. . . . . |                      ....|...... .| ||| | . ... ..             ||. ||     | |  .
AVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYL

IDQRKEAGKGPFPAAQIYQVALSLASALNYLHNDLK-------YIHGDLKSGNVLVKGDFE-------------TVKLCDFGVALKLTDDLNGLENP---
.              |. . ||. |...||||..          || |||| |.||. ...             ..|.|||| .  .. . |   .    
H------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTM

------------TDDYVGSQPWNAMEVHM----------------AGDITHKTDMFSYGLVIWEMMSLEAPHLDLLFSGDDSEYDDDETSFD---ESEFE
            |   .|.  | | || .                 .. . |.|..|.|.|.||... .            ..|. ..  |    | .|.
MESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---------PYYDYPYMPMIFQDPFEEMFM

AAL--GTRPPLPKENL--------GPAYQFLIELFCACTIEDPTQRPSAKMTLAAL
 .   | |||.| . .         .. . ...|   |  .||..|||..  |  |
MVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase TOPK.AA Pkinase 170-417 18 1.8e-26 94.71 Pfam 30-293 (293) Show / Hide 
Range on Protein: 170-417
Range on HMM: 30-293/293
Sequence Identity: 18% (53 aa)

KKGRGDVDVEGRLKK-----EAVILKKMSHANIVEFRALSKSADGSLCLSMENGQQ-----SLM----GMIDQRKEAGKGPF--PAAQIYQVALSLASAL
|. . . . .. ..      |. |.|...| |||...    . ...... ||  .      .|.    .         .|.|  .  ..  ... ....|
KIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST-------WRHGCFYFSEWECKFYMYQILRGL

NYLHNDLKYIHGDLKSGNVLVKGDFET---VKLCDFGVALKLTDDLNGLENPTDDYVGSQPWNAMEVHM-AGDITHKTDMFSYGLVIWEMMSLEAPHLDL
.|.|.  . || |||. |.|.. . ..   ||.||||.| ..    .     .....|. .. | ||.. . ....| ||.|.|....||.. .     .
EYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR-----P

LFSGD---DSEYDDDETSFDESEFEAALGTRPPLPKENLGPAY-----------------QFLIELFCACTIEDPTQRPSAKMTLAA--L
.|.|.   |. .|...       ..  .|.... . ... . .                 . .... . |   ||..||.|.  |    .
PFPGHCWHDN-HDQMQM------ICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase TOPK.AA STE 161-349 24 2e-26 90.36 In-house 43-271 (359) Show / Hide 
Range on Protein: 161-349
Range on HMM: 43-271/359
Sequence Identity: 24% (58 aa)

AVKKIRSKYKK-----------GRGDVDVEGRLKKEAVILKKMS--HANIVEFRALSKSA------DGSLCLSMENGQ-QSLMGMIDQRKEAGK------
|.|... . ..              . . . ...||  |.||..  | |||..             |..|.. ||     ||  .|..... ||      
AIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNR

---GPFPAAQIYQVALSLASALNYLHNDLKYIHGDLKSGNVLVKGDFETVKLCDFGVALKLTDDLNGLEN-------------PTDDYVGSQPWNAMEVH
   ..||  ||  .. ..  .| |.. ....|| |.|..|.|.      ||||||||. .|||.. .. .              ..  ||.. | | || 
QHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVCGQLTDSMANI-QSNNIIDCIETMQQKRNTFVGTP-WMAPEVI

MA------GDITHKTDMFSYGLVIWEMMSLEAPHLDL
.       .. . | |. | |..|.||   . |. |.
QQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDM
Kinase TOPK.AA MLK 182-345 25 2.1e-19 64.09 In-house 52-235 (291) Show / Hide 
Range on Protein: 182-345
Range on HMM: 52-235/291
Sequence Identity: 25% (49 aa)

LKKEAVILKKMSHAN----IVEFRALSKSADGSLCLSMENGQQ-SLMGMIDQRKEAGK---------GPFPAAQIYQVALSLASALNYLHNDLK--YIHG
...|. .|...|| |    |..|.. ...    .|. ||  .  ||   .  ..  .          .  . ... . ||  |....|||....  .|| 
FEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHR

DLKSGNVLVKG-----DFETVKLCDFGVALKLTDD-LNGLENPTDDYVGSQPWNAMEV---HMAGDITHKTDMFSYGLVIWEMMSLEAP
|||| |.|.       . .|.| ||||.. ....   |   |.     |.  | | ||     ..  . | |..|.|.|.|||.. | |
DLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNA-----GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
S_TKc TOPK.AA S_TKc 117-422 20 7e-19 69.96 SMART 1-231 (231) Show / Hide 
Range on Protein: 117-422
Range on HMM: 1-231/231
Sequence Identity: 20% (63 aa)

FLNLGKTGSGEPSYWPNQCSLASVGTSESEVLSPRPDGSGRSPWAVKKIRSKYKKGRGDVDVEGRLKKEAVILKKMSHANIVEFRALSKSADGSLCLSME
.  | | |.|  .    .. ..                      |.|.|.              ....|  ||||  | ||| .     .  ..|.. ||
YEILRKIGKGAFG----KVYKCRHKK-------------TGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVME

NGQQ---SLMGMIDQRKEAGKG-PFPAAQIYQVALSLASALNYLHNDLKYIHGDLKSGNVLVKGDFETVKLCDFGVALKLTDDLNGLENPTDDYVGSQPW
   .   .|. .|..|.  |.. |||  ..  ..  ...||.|.|.  . || |||  |.|.     ..|.||||.| .|           . ..|.  .
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE---HIKICDFGLARQL-----------TTFCGTPWY

NAMEVHMAGDITH-KTDMFSYGLVIWEMMSLEAPHLDLLFSGDDSEYDDDETSFDESEFEAALGTRPPLPKENLGPAYQFLIELFCACTIEDPTQRPSAK
 | ||      .. | |. | | ...||.. . |              .... |.                       ...  . . |   ||..||.| 
MAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------------QMQMMFKKIG------------------SPEAKD-FIRKCLQKDPEKRPTA-

MTLA----ALEDVML
  |.    .  .  .
EALQDEWDIKCHPWF
Kinase TOPK.AA TK 168-417 13 1.6e-14 44.38 In-house 58-486 (486) Show / Hide 
Range on Protein: 168-417
Range on HMM: 58-486/486
Sequence Identity: 13% (60 aa)

KYKKGRGDVDVEGRLK-------------KEAVILKKMS-----HANIVEFRA-LSKSAD----------GSLCLSMENGQQ-----SLMGMIDQRKEAG
| .|   . . | ..              .|| ..|.|.     | ||| . .  ....           . ... ||  .      ||     .... .
KMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKF

KG---------------------------------------------------PFPAAQIYQ-------------------VALSLASALNYLHNDL---
.                                                    |.. .. .|                    .. .|... |||      
QHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEF

--KYIHGDLKSGNVLVKGDFE----------TVKLCDFGVALKLTDD-LNGLENPTDDYVGSQP------------------------------WNAMEV
  ...|.||   |.||  .            ..|..||| . . .   |    .. |||. ...                              | | |.
IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGS-GVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPEC

HM---------AGDITHKTDMFSYGLVIWEMMSLE-APHL----------DLLFSGDDSEYDDDETSFDESEFEAAL-----------GTRPPLPKENLG
 .          |  |.|.|..|.| ..||....  .|            |            . .  .  |.  .            | | ..|.  . 
LNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKD------------G-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHC

PAY------------QFLIELFCACTIEDPTQRPSAKMTLAAL
| .            ... .| . |  .|| .||. .  . .|
PDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TOPK.AA SLK 241-349 35 8.4e-14 42.82 In-house 98-205 (259) Show / Hide 
Range on Protein: 241-349
Range on HMM: 98-205/259
Sequence Identity: 35% (41 aa)

QIYQVALSLASALNYLHNDLKYIHGDLKSGNVLVKGDFETVKLCDFGVALKLTDDLNGLENPTDDYVGSQPWNAMEVHMAGDIT-----HKTDMFSYGLV
||  |.  .  |||.||.. | || ||| ||.|.  | . |.| ||||. |.. ...      | ..|   | | || |   .      .|.|..|.|. 
QIQYVCKHMCEALNWLHSN-KVIHRDLKAGNILMTMDGD-VRLADFGVSAKNKHTMQK----RDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGIT

IWEMMSLEAPHLDL
. ||  .| || ..
LIEMAQMEPPHHEM
Kinase TOPK.AA ZAK 250-349 35 4.4e-13 43.09 In-house 111-207 (257) Show / Hide 
Range on Protein: 250-349
Range on HMM: 111-207/257
Sequence Identity: 35% (37 aa)

ASALNYLHND--LKYIHGDLKSGNVLVKGDFETVKLCDFGVALKLTDDLNGLENPTDDYVGSQPWNAMEVH-MAGDITHKTDMFSYGLVIWEMMSLEAPH
|. . ||| |   | || |||| || .  .   .| ||||    ...           .||  || | |.      .|  .| .||| | |||.. | | 
AKGMHYLHMDAPDKIIHRDLKSRNVVIDKNG-VCKICDFGTSRDFHHHCTHMS-----WVGTFPWMAPEMILQSEPVTETCDVWSYGVVLWEMLTREVPY

LDL
 |.
KDY
Kinase TOPK.AA TKL-Unique 182-341 25 9.2e-13 41.5 In-house 42-223 (290) Show / Hide 
Range on Protein: 182-341
Range on HMM: 42-223/290
Sequence Identity: 25% (46 aa)

LKKEAVILKKMS-HANIVEFRALSK---SADGSLCLSMENGQQ-SLMGMIDQ-----RKEAGKGPFPAAQIYQVALSLASALNYLHNDLK-YIHGDLKSG
...|  ..||   |.||| . . ..    . . .|. ||  .  ||.  ..|        . . ... .|... |.  |....|||.  .  ||.|||| 
FENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSS

NVLVKGDF----ETVKLCDFGVALKLT-DDLNGLENPT----DDYVGSQPWNAMEVHMA--GDITHKTDMFSYGLVIWEMMS
|.||  .       .|.|||| .  .. .. . . ...    .. .||  | | || .    ... | | .|.| | ||. .
NFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIAT
TyrKc TOPK.AA TyrKc 118-417 20 1.8e-11 -37.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 118-417
Range on HMM: 1-280/280
Sequence Identity: 20% (69 aa)

LNLGKT-GSGE-----PSYWPNQCSLASVGTSESEVLSPRPDGSGRSPWAVKKIRSKYKKGRGDVDVEGRLKKEAVILKKM--SHANIVEFRALSKSA--
. |||. |.|.        |                           . |||....           .  . .|| |..|   .| ||| . .   .   
ITLGKKLGEGAFGEVYKGTWK-------------------------IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGR

----DGSLCLSMENGQQ-SLMGMIDQRKEAGKGPFPAAQIYQVALSLASALNYLHNDLKYIHGDLKSGNVLVKGDFETVKLCDFGVALKLTDD-LNGLEN
    .. |.. ||     .|   .  ...     .. ..  . ..  |.  .||| . ..|| ||   |.||. .. ||| .||| . ...||  .|   
NFMYIEPLMIVMEYMPHGDLKDYLRKHRPK----LCMKDLLSFCWQIACGMEYLH-SKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQG--E

PTDDYV-----GSQP-----WNAMEVHMAGDITHKTDMFSYGLVIWEMMSLEAPHLDLLFSGDDSEYDDDE--TSFDESEFEAALGTRPPLPKENLGP--
 .| |.     |.       | | |. . |  |.|.| .|.| ..||....          |.   ... .   | .|       | |.| |.... |  
SKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTY----------GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMS

---AYQFLIELFCACTIEDPTQRPSAKMTLAAL
   . . . ..   |  ||| .||. .     .
FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase TOPK.AA CAMK-Unique 234-289 26 3.8e-11 32.82 In-house 149-220 (363) Show / Hide 
Range on Protein: 234-289
Range on HMM: 149-220/363
Sequence Identity: 26% (19 aa)

KGPFPA--AQIYQVALSLASALNYLHNDLKYIHGDLKSGNVLVKGD---------------FETVKLCDFGVA
.|.| .  ... .. ..|.||..|.|. .. .|.|||  |..|.                 .  .|||||| .
QGHFSERCWDTCFIMQCLLSAVAYMHS-QDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLC
Kinase TOPK.AA Pkinase_Tyr 233-342 28 9.9e-10 33.58 Pfam 104-210 (270) Show / Hide 
Range on Protein: 233-342
Range on HMM: 104-210/270
Sequence Identity: 28% (33 aa)

GKGPFPAAQIYQVALSLASALNYLHNDLKYIHGDLKSGNVLVKGDFETVKLCDFGVALKLTDDLNGLENPTDDY-V------GSQPWNAMEVHMAGDITH
.|.|..  .. | ..  |....||. . ..|| ||   |.||. .. .|| |||| |  .         ..| | .         .| | |. . |  |.
DKQPLTMKDLLQMCWQIAKGMEYLE-SKNCIHRDLAARNCLVTENN-VVKICDFGLARDI--------YNDDYYYRKRGGGKLPIKWMAPECINYGKFTT

KTDMFSYGLVIWEMMSL
|.|  |.| ..||....
KSDVWSFGVLMWEIFTY
Kinase TOPK.AA LRRK 324-419 25 5.2e-08 24.42 In-house 260-351 (351) Show / Hide 
Range on Protein: 324-419
Range on HMM: 260-351/351
Sequence Identity: 25% (26 aa)

THKTDMFSYGLVIWEMMSLEAPHLDLLFSGDDSEYD-DDETSFDESEFEA--ALGTRPPLPKE-NLG----PAYQFLIELFCACTIEDPTQRPSAKMTLA
| |.|..|.|...|| .... .  |        |.|  |  .. ....|     | ||..| . ...    . || ||..   |  .||..||..   . 
TEKVDCYSFGMILWELLTRQHHPFD--------EHDFFDHMQW-MEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQH---CWQHDPKKRPHFSQIVK

ALED
 |..
RLSQ
Kinase TOPK.AA LRRK 242-287 31 4e-06 17.73 In-house 166-223 (351) Show / Hide 
Range on Protein: 242-287
Range on HMM: 166-223/351
Sequence Identity: 31% (18 aa)

IYQVALSLASALNYLHNDL-KYIHGDLKSGNVLVKGD-----------FETVKLCDFG
....||  |....|||.   . || |||| |.|...            . ..|..|||
KLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFG
Kinase TOPK.AA CAMK-Unique 160-200 20 0.000602 8.69 In-house 27-81 (363) Show / Hide 
Range on Protein: 160-200
Range on HMM: 27-81/363
Sequence Identity: 20% (11 aa)

WAVKKIRSKYKK-GRGDV-------------DVEGRLKKEAVILKKMSHANIVEF
||.|... .. .  ....               .  ||.|..|.|. .| ||...
WACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKL
Kinase TOPK.AA ZAK 182-200 52 0.033862 3.82 In-house 38-56 (257) Show / Hide 
Range on Protein: 182-200
Range on HMM: 38-56/257
Sequence Identity: 52% (10 aa)

LKKEAVILKKMSHANIVEF
. ||| || |..| ||. |
IEKEAEILSKIRHRNIIQF