Gene Spk377 (Sea Urchin)
Spk377
Sequence
Protein domains of Spk377.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Spk377.AA | urchA | 479-673 | 56 | 1.2e-152 | 495.63 | In-house | 1-208 (208) | Show / Hide |
Range on Protein: 479-673 Range on HMM: 1-208/208 Sequence Identity: 56% (117 aa) LGRGVAGTVYLFRHAVSKIPVAAKLVEYPG---------ECFRNEVRIHQAISGLPWFPTFYGSFDIDGDQSVLAMEFVGSESEDRSYTITDCLEKSMLK |||||.|||.|.||.....|||.|..|.|. |||.||..|||.....||||||||...|..|. ..||||.|.|....|||||.||.|.|.. LGRGVYGTVHLYRHRQTDHPVALKVIELPKEYKKMRRKIECFQNEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDKAMEM TGPDLTRDEWFYVLNGVAEGLKALHSKGFLCNDLKEDNVLVVE-ESGLWRAKIIDLGWASAIATPF---VMPLDEEQIDFYRSGRGCCHIAPECVLDARP ..|.||||.|..|....|||||..|.||||||||||||.||.. |.|.|||||||.|||. ...|| .|..|..|..|||....||||||||.|||.| RQPALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFGRWRAKIIDFGWACPCQMPFPACRMHFDQRQKQFYRYCHRCCHIAPECALDAQP CSTSSDVY |||||||| CSTSSDVY |
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| Kinase | Spk377.AA | urch | 479-676 | 43 | 9.79999999999e-113 | 380.83 | In-house | 1-217 (217) | Show / Hide |
Range on Protein: 479-676 Range on HMM: 1-217/217 Sequence Identity: 43% (94 aa) LGRGVAGTVYLFRHAVSKIPVAAKLVEYPG-----------------ECFRNEVRIHQAISGLPWFPTFYGSFDIDGDQSVLAMEFVGSESEDRSYTITD .|||..|.|.|.||. .|.||| | ...| |.|..|...||..|| |.||.||| .||| |. .|.|||.|......||.... IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDID-DDLCLVMEFIGDKKTGKSYPLHW CLEKS-MLKTGPDLTRDEWFYVLNGVAEGLKALHSKGFLCNDLKEDNVLVVE-ESGLWRAKIIDLGWASAIATPF-VMPLDEEQIDFYRSGRGCCHIAPE |..|| |....|.|....|. ... ...|..|.|..|||.|||||||||... ..| |.|.|||.||.. ...|| .|....|....|..|.|.|||||| CIHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPE CVLDARPCSTSSDVYSLG ||||..|||..|||||.| CVLDGQPCSIASDVYSVG |
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| Kinase | Spk377.AA | urch-unclassified | 514-676 | 30 | 2e-36 | 127.15 | In-house | 52-215 (215) | Show / Hide |
Range on Protein: 514-676 Range on HMM: 52-215/215 Sequence Identity: 30% (51 aa) EVRIHQAISGLPWFPTFYGSFDIDGDQSVLAMEFVGSESEDRSYTITDCLEKSMLKTGPDLTRDEWFYVLNGVAEGLKALHSKGFLCNDLKEDNVLVVEE |...|.. .. | || || .. .. . ..||| | . . |. . . | | | . .|. .. . .|..|.|... | |||| .|.|. EAMVHRLFADHPYFPRCYGMVKHEDCPC-IVMEFLGDKQTYTVYPLCQWIHERH-KSNPALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWC SG--LWRAKIIDLGWASAIATP---FVMPLDEEQIDFYRSGRGCCHIAPECVLDARPCSTSSDVYSLG . |.|.|||.| .| .. | . .. |.. |..| |.||| ||. | | ||.|||| DHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMRE--YMMGKIYHHMAPEIVLYGQPTSVYSDIYSLG |
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| Kinase | Spk377.AA | urchC | 511-679 | 30 | 6e-21 | 64.39 | In-house | 54-223 (223) | Show / Hide |
Range on Protein: 511-679
Range on HMM: 54-223/223
Sequence Identity: 30% (52 aa)
FRNEVRIHQAISGLPWFPTFYGSFDIDGDQSVLAMEFVGSESEDRSYTITDCLE-KSMLKTGPDLTRDEWFYVLNGVAEGLKALHSKGFLCNDLKEDNVL
.. | |. | .|. |.|| .|| ||.. . ||.|. ..| | .. . |.. . . .| ..|. | | || | ||||
CEKEARVGQMMSTCPYFPRMYGTVMIDENMCIVT-EFIGDKQQGKVYMLHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVL
VVEESGLWRAKIIDLGWASAIATPFVMPLDEEQIDFYRSGRGCCHIAPECVLD--ARPCSTSSDVYSLGRLL
| . |||.| | .| | . . . . | ||||| ||| | .||.|| | .|
LEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFIHIAPE-VLDIDGCQVSVASDIYSVGVIL
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| Kinase | Spk377.AA | urchB | 586-676 | 39 | 1.1e-13 | 45.7 | In-house | 121-212 (212) | Show / Hide |
Range on Protein: 586-676 Range on HMM: 121-212/212 Sequence Identity: 39% (36 aa) VAEGLKALHSKGFLCNDLKEDNVLVVEESGLWRAKIIDLGWASAIATPFVM-PLDEEQIDFYRSGRGCCHIAPECVLDARPCSTSSDVYSLG . |. .| | | |||| |||| . | ||| | .| | | | . .| | | |||| .|. . | ||||.| | IVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVSTITAPLKMVEVPKELKMAYVHGEEADYIAPEVILHGQSTSISSDVFSVG |
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| S_TKc | Spk377.AA | S_TKc | 473-717 | 18 | 3.4e-11 | -12.77 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 473-717 Range on HMM: 1-231/231 Sequence Identity: 18% (52 aa) SRCSIELGRGVAGTVYLFRHAVSKIPVAAKLVEYPGECFRNEVRIHQAISGLPWFPTFYGSFDIDGDQSVLAMEFVGS--ESEDRSYTITDCLEKSMLKT . ..|.| |.||. || .. || | . | .|.|..|.. . |. ..|..|. | . ||... . | . . | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGD----------LFDYIKKR GPD-----LTRDEWFYVLNGVAEGLKALHSKGFLCNDLKEDNVLVVEESGLWRAKIIDLGWASAIATPFVMPLDEEQIDFYRSGRGCCH----IAPECVL |. .. . ... ....|. .||.|.. ||| .|.|. | . ||.| | | . . .| .||| . GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------------TTFCGTPWYMAPEVL- DARPCST-SSDVYSLG--------------RLLAMVGRAMRYDDFECFGTQIYLADEDQRPTVQEIID--------QLY . .. ..|..|.| . .| . . ... | .. | ..|||. |. . ---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | Spk377.AA | urchB | 517-549 | 54 | 2e-06 | 19.11 | In-house | 62-93 (212) | Show / Hide |
Range on Protein: 517-549 Range on HMM: 62-93/212 Sequence Identity: 54% (18 aa) IHQAISGLPWFPTFYGSFDIDGDQSVLAMEFVG ||| .|. |.|| |.| ||| | .| |||| IHQLMSDSPYFPKFWGTLDIDNDL-CQAQEFVG |
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| Kinase | Spk377.AA | TKL | 585-676 | 21 | 3e-06 | 18.35 | In-house | 140-276 (364) | Show / Hide |
Range on Protein: 585-676 Range on HMM: 140-276/364 Sequence Identity: 21% (29 aa) GVAEGLKALHS--------KGFLCNDLKEDNVLVVEES-----------GLWRAKIIDLGWASAIATPFVMPLDEEQID------FYR--SGRGC---CH ..| |. ||| .. . ||| .|.|| | |..|| |.| . . . . | . . .| ... | .. DIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRW IAPECVLDA---------------RPCSTSSDVYSLG |||. .. .. |...|||| | MAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG |
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| Kinase | Spk377.AA | LISK-DD1 | 585-627 | 40 | 6e-06 | 17.74 | In-house | 131-174 (290) | Show / Hide |
Range on Protein: 585-627 Range on HMM: 131-174/290 Sequence Identity: 40% (18 aa) GVAEGLKALHSKGFLCNDLKEDNVLVVEE-SGLWRAKIIDLGWA ..|.. ||||. . ||| | || | ...||.|..|.| | DIACAMAYLHSKNIIHRDLKSKNILVDENGDSQWRIKVCDFGFA |
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| Kinase | Spk377.AA | Dicty5 | 585-625 | 39 | 7e-06 | 16.19 | In-house | 112-149 (260) | Show / Hide |
Range on Protein: 585-625 Range on HMM: 112-149/260 Sequence Identity: 39% (16 aa) GVAEGLKALHSKGFLCNDLKEDNVLVVEESGLWRAKIIDLG ..| ... |||.. ||| |.|. |. | .|||| | DIAQSMRHLHSMNIIHRDLKSMNFLITEN---WKIKIIDFG |
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| Kinase | Spk377.AA | C8 | 588-679 | 21 | 1e-05 | 15.99 | In-house | 134-226 (226) | Show / Hide |
Range on Protein: 588-679 Range on HMM: 134-226/226 Sequence Identity: 21% (21 aa) EGLKALHSKGFLCNDLKEDNVLVVEESGLW-RAKIIDLGWASAIATPFVMPLDEEQIDFYRSGRGCCHIAPECVLD----ARPCSTSSDVYSLGRLL .|. .|.| .. |.| .| || .. |. |.| ||.. .. . .||| . . . ||..|.| .| DGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNT----CGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | Spk377.AA | Ciliate-C7 | 586-609 | 54 | 1.5e-05 | 14.3 | In-house | 111-134 (164) | Show / Hide |
Range on Protein: 586-609 Range on HMM: 111-134/164 Sequence Identity: 54% (13 aa) VAEGLKALHSKGFLCNDLKEDNVL .|.|| |||... |||| || | IAQGLYYIHSKNCVVNDLKMDNIL |
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| TyrKc | Spk377.AA | TyrKc | 473-716 | 19 | 0.000681 | -159.68 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 473-716 Range on HMM: 1-280/280 Sequence Identity: 19% (60 aa) SRCSIELGRGVAGTVYLFRHAVSKIPVAAKLVE--YPGECFRNEVRIHQAISGL-PWFP---TFYGSFDIDG------DQSVLAMEFVGSESEDRSYTIT . .||.| |.||. . |.|| | . | |..| || . | . | .|| .| .. . ||.. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARI---MCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG--------- DCLEKSMLKTGPDLTRDEWFYVLNGVAEGLKALHSKGFLCNDLKEDNVLVVEESGLWRAKIIDLGWASAIATP-FVMPLDEEQIDFYRSGRGCCH----- .| . |..|.|. .. . .|.| ||||.. || |.|| |. ..|| | | . .| |.. ....... -DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLPI --IAPECVLDARPCSTSSDV----------YSLGRLLA-------MVGRAMRYDDFECFGTQIYLA-----------------------DEDQRPTVQEI |||| . . ..| ||| ...| | . .. . . . . | ..||| .|| RWMAPECINYGK-FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI IDQL .... HECF |
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| Kinase | Spk377.AA | TKL | 704-716 | 46 | 0.029376 | 3.95 | In-house | 352-364 (364) | Show / Hide |
Range on Protein: 704-716 Range on HMM: 352-364/364 Sequence Identity: 46% (6 aa) DQRPTVQEIIDQL ..||. |||...| EKRPSFQEILKRL |
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| Kinase | Spk377.AA | urchB | 478-502 | 48 | 0.05021 | 3.46 | In-house | 6-30 (212) | Show / Hide |
Range on Protein: 478-502 Range on HMM: 6-30/212 Sequence Identity: 48% (12 aa) ELGRGVAGTVYLFRHAVSKIPVAAK | ||| | | . || |.| | | EIGRGTYGRVVIARHRQTKVPLAIK |
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| Kinase | Spk377.AA | urch-unclassified | 479-500 | 36 | 0.137135 | 1.82 | In-house | 1-22 (215) | Show / Hide |
Range on Protein: 479-500 Range on HMM: 1-22/215 Sequence Identity: 36% (8 aa) LGRGVAGTVYLFRHAVSKIPVA .| | | |.. || .||. IGKGTFGKVFMMRHQREAVPVK |
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| Kinase | Spk377.AA | Pkinase | 586-625 | 34 | 0.166849 | 6.4 | Pfam | 117-157 (293) | Show / Hide |
Range on Protein: 586-625 Range on HMM: 117-157/293 Sequence Identity: 34% (14 aa) VAEGLKALHSKGFLCNDLKEDNVLVVEESGL-WRAKIIDLG ...||. .||.|.. ||| .|.|.... . . ||.| | ILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFG |
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| Pkinase | Spk377.AA | Pkinase | 473-509 | 27 | 0.258114 | 5.73 | Pfam | 1-37 (293) | Show / Hide |
Range on Protein: 473-509 Range on HMM: 1-37/293 Sequence Identity: 27% (10 aa) SRCSIELGRGVAGTVYLFRHAVSKIPVAAKLVEYPGE .. .|.| |.||. .| . . || | .....| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHE |
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| Kinase | Spk377.AA | Pkinase | 655-676 | 27 | 1.651286 | 2.88 | Pfam | 178-199 (293) | Show / Hide |
Range on Protein: 655-676 Range on HMM: 178-199/293 Sequence Identity: 27% (6 aa) IAPECVLDARPCSTSSDVYSLG .||| ...... ....|..|.| MAPEVIRGGQYYGPKVDMWSCG |
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