Gene Npr1 (Sea Urchin)

Npr1

Species: Sea Urchin
Alias: Npr1, SPU_015674, Spk346
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
Npr1.AA Protein None 621 None Fasta, JSON
Npr1.kin_dom Protein Kinase Domain None 241 None Fasta, JSON

Protein domain

Protein domains of Npr1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Npr1.AA RGC 116-365 41 5.9e-135 454.64 In-house 1-300 (300) Show / Hide 
Range on Protein: 116-365
Range on HMM: 1-300/300
Sequence Identity: 41% (125 aa)

KGNVIAIKRVNRQ----RVELNRNVLMEIKHVRDLQHDHVIKFIGACIDAP------NISIMTEYCPKGSLQDILENDSIELDELFKYSLMYDIVKGMLY
.|....||..|..    .....|....|.|. |.||||...||||.||| |      |..|..|||..||||||||||.|..|. ||||...|||||| |
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHNSVIQTHGNLKSSNCVVDSRFVLKITDFGL-----TSFREP--------DHAFEPDEEDSYKYYQRRLWTAPELLR-LPEIPSGG--------TQKGD
||.| |  ||||||.|||||||.|.|||||||     ..|..         | ... ...|. .||.. ||||||.||  .. .. |        |||||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VYSFGIILQEIMYREG-----VFYIK--DVDLMPEEIVKKVAN----GYKPAFRPTIDRV------TCSQEMMTLITNCWKEDSTIRPD-YSQLRGTMRK
|||||||..||. |.|     .|...  ...| |.||. .|..    |  . |||.|..       .| ... .|. .|| ||   |||  .|.| ....
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase Npr1.AA RGC 116-365 41 5.9e-135 454.64 In-house 1-300 (300) Show / Hide 
Range on Protein: 116-365
Range on HMM: 1-300/300
Sequence Identity: 41% (125 aa)

KGNVIAIKRVNRQ----RVELNRNVLMEIKHVRDLQHDHVIKFIGACIDAP------NISIMTEYCPKGSLQDILENDSIELDELFKYSLMYDIVKGMLY
.|....||..|..    .....|....|.|. |.||||...||||.||| |      |..|..|||..||||||||||.|..|. ||||...|||||| |
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHNSVIQTHGNLKSSNCVVDSRFVLKITDFGL-----TSFREP--------DHAFEPDEEDSYKYYQRRLWTAPELLR-LPEIPSGG--------TQKGD
||.| |  ||||||.|||||||.|.|||||||     ..|..         | ... ...|. .||.. ||||||.||  .. .. |        |||||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VYSFGIILQEIMYREG-----VFYIK--DVDLMPEEIVKKVAN----GYKPAFRPTIDRV------TCSQEMMTLITNCWKEDSTIRPD-YSQLRGTMRK
|||||||..||. |.|     .|...  ...| |.||. .|..    |  . |||.|..       .| ... .|. .|| ||   |||  .|.| ....
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase Npr1.AA TKL 113-363 20 3.8e-46 159.63 In-house 12-364 (364) Show / Hide 
Range on Protein: 113-363
Range on HMM: 12-364/364
Sequence Identity: 20% (72 aa)

GFYKG----------NVIAIKRVNRQRVE---------------------------LNRNVLMEIKHVRDLQHDHVIKFIGACIDAPN------------
| ..|          ...|.|. ... .                            ..     ||.. . |.|.....|.|.|.. |.            
GKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWG

-ISIMTEYCPKGSLQDILENDSIELDELFKYSLMYDIVKGMLYLHNSVI-------QTHGNLKSSNCVVDSRFV--------------LKITDFGLTSFR
 . | .||||.||| ..|           . ....|| .|| |||..           | .|||.|. ||. .               .||.||||  | 
QLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFM

EPDHAFEPDEEDSY----------KYYQRR---LWTAPELLRLPEIPS------------GGTQKGDVYSFGIILQEIMYREGVFY-IKDVDLMPE----
...   .  . .            . . ..    | |||.||  .  .              ..| |||||||.| ||. |. ..| ..  . ..     
SQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFE

EIVKKVANGYKPAFRPT--------IDRVTCSQEMMTLITNCWKEDSTIRPDYSQLRGTM
|. ..|..  ..  .|.         .  .| ..|  |.. ||..| . ||  ...  ..
EMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Npr1.AA TKL-Unique 113-294 30 2.4e-32 111.43 In-house 16-221 (290) Show / Hide 
Range on Protein: 113-294
Range on HMM: 16-221/290
Sequence Identity: 30% (66 aa)

GFYKGNVIAIKRVNR---QRVELNRNVLMEIKHVRDLQ-HDHVIKFIGACI----DAPNISIMTEYCPKGSLQDILE---------NDSIELDELFKYSL
| ..|  .|||. .    .. |. ..  .|..    |. |. . ...|.|.    ..|| .| .|||| ||| | |          |....|. . ....
GKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKM

MYDIVKGMLYLHNSV--IQTHGNLKSSNCVVDSR-----FVLKITDFGLTSFRE--PDHAFE-------PDEEDSYKYYQRRLWTAPELLRLPEIPSGGT
  ||..|| |||..   | .|..|||||  ||..     .  || ||||  |.    .  .        .....|.      .| |||.|| ..  .  .
AIDIAQGMYYLHHCEPPI-IHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSF------RWMAPEVLRMNF--CQYS

QKGDVYSFGIILQEI
.| |||||||.| ||
EKSDVYSFGIVLWEI
Kinase Npr1.AA TK 131-363 16 1.3e-30 99.19 In-house 75-486 (486) Show / Hide 
Range on Protein: 131-363
Range on HMM: 75-486/486
Sequence Identity: 16% (70 aa)

ELNRNV---------LMEIKHVRD--LQHDHVIKFIGACIDA------------PNISIMTEYCPKGS----LQDILENDSIE-----------------
|...           ..|.|  .   ..|.......|.| .             . . |..||.|.|.    |.| | . . .                 
EMHD-RDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPP

----------------------------------------------------------LDELFKYSLMYDIVKGMLYLHNSVIQ-----THGNLKSSNCV
                                                          |.   .   ...| .|| |||   ..      |..|   || 
SKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCL

VDSRFV-----------LKITDFGLT------SFREPDHA-----------------FEPDEED-SYKYYQR----RL---WTAPELLRLPEIPSG----
|... |            ||.||||.        |. ..                  ||  . | ...||      .|   |.||| |.  .  .     
VGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFE--D-DPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYG

-GTQKGDVYSFGIILQEIMYRE-GVFY--IKDVDLMP----EEIVKKVANGYKP--------AFRPTIDR-VTCS--------------QEMMTLITNCW
  | | ||.|||. . ||. .  . .|  . . | .     .|..... .| ..          |    . . |.              .|.. |.. ||
KFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCW

KEDSTIRPDYSQLRGTM
..|   ||. |||.  .
HYDPEDRPTFSQLHEQL
Kinase Npr1.AA Dicty4 146-237 36 9.4e-27 86.39 In-house 55-160 (277) Show / Hide 
Range on Protein: 146-237
Range on HMM: 55-160/277
Sequence Identity: 36% (39 aa)

LQHDHVIKFIGACI----DAPNISIMTEYCPKGSLQDILEN------DSIELD-ELFKY--SLMYDIVKGMLYLHN--SVIQTHGNLKSSNCVVDSRFVL
..| ....| |||.      . ..| |||.|||.|  .| .      .||.|| .|.|    .. |...|| .||.  .||  |  |||.|  ||  .. 
IRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVI-IHRDLKSHNLLVDKNWRV

KITDFGL
|..||||
KVCDFGL
Kinase Npr1.AA DRK 139-237 43 2.4e-24 79.4 In-house 47-146 (258) Show / Hide 
Range on Protein: 139-237
Range on HMM: 47-146/258
Sequence Identity: 43% (43 aa)

EIKHVRDLQHDHVIKFIGACIDAPNISIMTEYCPKGSLQDILENDSIELDELFKYSLMYDIVKGMLYLHNSV-IQTHGNLKSSNCVVDSRFVLKITDFGL
||     | |  .. |.|.|   | | | .|| |.|||  || ..|||.|     ..| |. ||| |||..  |  |  ||| |  ||  .  |. ||||
EINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGL
Kinase Npr1.AA TKL-ciliate2 134-364 28 8.3e-24 75.86 In-house 41-273 (273) Show / Hide 
Range on Protein: 134-364
Range on HMM: 41-273/273
Sequence Identity: 28% (72 aa)

RNVLMEIKHVRDLQHDHVIKFIGACIDAPNISIMTEYCPKGSLQDILENDSIELDELFKYSLMYDIVKGMLYLHNSVIQT-HGNLK--------------
|. . | . .  | |  .. |.||| . || .|. ||| .|||  .| |... |    .  .  || .|. ||| |     |  ||              
RDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWEDRRRIALDIARGVHYLHSSNPPIIHRDLKRQIKHKEKNLINII

------SSNCVVDSRFVLKITDFGLTSFREPDHAFEPDEEDSYKYYQRRLWTAPELLRLPEIPSGGTQKGDVYSFGIILQEIMYREGVFYIKDVDLMPEE
      | | .||  |  |.|||| |  . |.  .       |.      | ||| ..        | | ||.|..||| ||  ||  .  |  | . |.
TLIKINSLNVLVDDNFRCKLTDFGWTRVK-PQDNYMTNKIGTYQ------WMAPEVIKAFYY----TEKADVFSYSIILWEIASREPPYRNKKGDVVAEK

IVKKVANGYKPAFRPTIDRVTCSQEMMTLITNCWKEDSTIRPDYSQLRGTMR
....         |||| .  |  ..  |.  || ..  .|| . ..   . 
VMCN-------NLRPTIPK-NCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
Kinase Npr1.AA MLK 113-237 26 1.4e-22 75.22 In-house 18-179 (291) Show / Hide 
Range on Protein: 113-237
Range on HMM: 18-179/291
Sequence Identity: 26% (43 aa)

GFYKGNV-----IAIKRVN---RQRVEL----NRNVLMEIKHVRDLQHDH----VIKFIGACIDAPN-ISIMTEYCPKGSLQDILEN-DS----------
| ....      .|.|||.   .  .       ... ||..|.| |.|      .|.| |.|.. |.   | .|||..||| ..| . .|          
GRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQK

--IELDELFKYSLMYDIVKGMLYLHNSVIQ--THGNLKSSNCVVDS------RFVLKITDFGL
  .  |  .. . .... .|| |||.   .   |  |||.| ..|         .|||.|||.
NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGT
Kinase Npr1.AA Pkinase_Tyr 121-363 26 2.2e-22 76.4 Pfam 32-270 (270) Show / Hide 
Range on Protein: 121-363
Range on HMM: 32-270/270
Sequence Identity: 26% (68 aa)

AIKRVNRQRVELN---RNVLMEIKHVRDL-QHDHVIKFIGACI-DAPN--ISIMTEYCPKGSLQDILEND---SIELDELFKYSLMYDIVKGMLYLHNSV
|.| .. .  . .   .  . |.|  . | .|.......|.|. .     | | .||.|.|.| | | .       |.   . .  ..| ||| ||..  
AVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN

IQTHGNLKSSNCVVDSRFVLKITDFGLTSFREPDHAFEPDEEDSYKYYQRR------LWTAPELLRLPEIPSGGTQKGDVYSFGIILQEIMYREGVF-YI
.  |  |   || |.. .| ||.||||.            ..| | |..|        |.||| ..  .     | | ||.|||. . ||. . .   | 
C-IHRDLAARNCLVTENNVVKICDFGLARDI--------YNDDYY-YRKRGGGKLPIKWMAPECINYGK----FTTKSDVWSFGVLMWEIFTYGEQPTY-

KDVDLMPEEIVKKV-ANGYKPAFRPTIDRVTCSQEMMTLITNCWKEDSTIRPDYSQLRGTM
   .. .||.....  .||  .  |      |..|. .|.. ||..|   ||  |...  .
--PGMSNEEVYEYIYEDGYRMPC-P----ENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Npr1.AA TK-Unique 116-295 23 2.9e-21 70.18 In-house 29-233 (294) Show / Hide 
Range on Protein: 116-295
Range on HMM: 29-233/294
Sequence Identity: 23% (50 aa)

KGNVIAIKRVN-RQRVELNRNVLMEIKHVRDLQ-HDHVIKFIGACIDAP-NISIMTEYCPKGSLQDILE----------------------NDSIE---L
| ...|.| .. . . .  .. | ||.. . |  | ......|.|..   .  |. ||||.|.||. |                       .|. .   .
KQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPI

DELFKYSLMYDIVKGMLYLHN--SVIQTHGNLKSSNCVVDSRFVLKITDFGLTSFREPDHAFEPDEEDSYKYYQRRLWTAPELLRLPEIPSGGTQ---KG
.. . |. ...| .|| ||.     | .|..| ..|. . ...|.||.|||..   . ... .  .. .  ..    | ||| |.      .|.    |.
SPKDLYHFAWQIACGMEYLASQRKKI-VHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIR---WMAPESLKCY----HGMYHTTKS

DVYSFGIILQEIM
||.|||... ||.
DVWSFGVLMWEIF
TyrKc Npr1.AA TyrKc 88-363 23 1.1e-19 72.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 88-363
Range on HMM: 1-280/280
Sequence Identity: 23% (74 aa)

MSLAS-------GSVESGTSVWGNNQQIFTVTGFYKGNVIAIKRVNRQRVELNRNVLMEIKHVRDL--QHDHVIKFIGACIDA-------PNISIMTEYC
 .|         | |  ||                     |.| ..       .  . |..  . |  .|.......|.|..        . . | .||.
ITLGKKLGEGAFGEVYKGTWK----------------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM

PKGSLQDILENDSIELDELFKYSLMYDIVKGMLYLHNSVIQTHGNLKSSNCVVDSRFVLKITDFGLTSFREPD-HAFEPDEEDSYKYY----QRR--L--
|.|.|.| | .   .|    . | ...| .|| |||   .  |  |   || |..... ||.||||. . . | ..    |...|.      ...  |  
PHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNC-IHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLPI

-WTAPELLRLPEIPSGG--TQKGDVYSFGIILQEIMYREGVFYIKDVD--LMPEEIVKKVANGYKPAFRPT-----IDRVTCSQEMMTLITNCWKEDSTI
 |.||| .        |  | | ||.|||. . ||. . .  |  ..   . ..|....| .|| .   |         |.|..|| .... ||.||   
RWMAPECI------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQCWHEDPED

RPDYSQLRGTM
||  |...  .
RPTFSEIHECF
Kinase Npr1.AA Pkinase 117-363 19 3.9e-17 61.66 Pfam 24-293 (293) Show / Hide 
Range on Protein: 117-363
Range on HMM: 24-293/293
Sequence Identity: 19% (57 aa)

GNVIAIKRVNRQRVELNRNVL----MEIKHVRDLQHDHVIKFIGACIDAPNISIMTEYCPKG----SLQDILE---NDSI--ELDELFKYSLMYDIVKGM
| . |.|...... . . ..     .||.  . |.|.......... | ..| . .|||..|    .| |...   . ..  . .|. .|  || |..|.
GKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFY--MYQILRGL

LYLHNSVIQTHGNLKSSNCVVDSRFVL----KITDFGLTSFREPDHAFEPDEEDSYKYYQR---RLWTAPELLRLPEIPSGGTQKGDVYSFGIILQEIMY
 |.|.  |  |  ||..|. .|.. ..    ||.||||  . .        .  .  .. .   . . |||..|     .. ..| |..|.|.|| | . 
EYCHSMGI-IHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--------Y-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPKVDMWSCGCILYEMLC

REGVFYIK---DVDLMPEEIVKKVANGYKPAFRPTIDRVT---------------CSQEMMTLITNCWKEDSTIRPDYSQLRGT--M
..  |. .   |  . . ......  .  .  .|. ...                 |.|.  .|..|.. | . ||   |.     .
GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
S_TKc Npr1.AA S_TKc 78-361 20 1.1e-16 62.71 SMART 1-220 (231) Show / Hide 
Range on Protein: 78-361
Range on HMM: 1-220/231
Sequence Identity: 20% (61 aa)

GDKMRKLGSRMSLASGSVESGTSVWGNNQQIFTVTGFYKGNVIAIKRVNRQRVELNRNVLMEIKHVRDLQHDHVIKFIGACIDAPNISIMTEYCPK--GS
 ...||.|   . | |.|  .. .               | . |||...       .... ||.  .  .|....|..... |  .. . .|||.   |.
YEILRKIG---KGAFGKVYKCRHKK-------------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGD

LQDILENDSIE-----LDELFKYSLMYDIVKGMLYLHNSVIQTHGNLKSSNCVVDSRFVLKITDFGLTSFREPDHAFEPDEEDSYKYYQRRLWTAPELLR
| |....   .     ..|    ..|| |.... |.|.  |  |  || .|  .|.  ..||.||||  .              . .   . . |||.| 
LFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGI-IHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL-

LPEIPSGGTQ-KGDVYSFGIILQEIMYREGVFYIKDVDLMPEEIVKKVANGYKPAFRPTIDRVTCSQEMMTLITNCWKEDSTIRPDYSQLRG
      | .  | |..|.|.|| | ....  |.       .... ||.                 |.|.  .| .|.. | . ||   ..  
------GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQ
Kinase Npr1.AA MLK 279-363 29 1.2e-07 22.68 In-house 214-291 (291) Show / Hide 
Range on Protein: 279-363
Range on HMM: 214-291/291
Sequence Identity: 29% (25 aa)

TQKGDVYSFGIILQEIMYREGVFYIKDVDLMPEEIVKKVANGYKPAFRPTIDRVTCSQEMMTLITNCWKEDSTIRPDYSQLRGTM
. | ||.|.|..| |.. || | |  ..| | . . . ..||  |. ..|     |.  .  |...||..|.  ||. .|     
SEKCDVWSWGVVLWEMLTRE-VPYKQHYDPM-AIAWWVAYNGLRPPIPST-----CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase Npr1.AA DRK 263-298 50 7.6e-07 19.26 In-house 168-199 (258) Show / Hide 
Range on Protein: 263-298
Range on HMM: 168-199/258
Sequence Identity: 50% (18 aa)

WTAPELLRLPEIPSGGTQKGDVYSFGIILQEIMYRE
||||| ||      . | | |||||.|.| |.. |.
WTAPEVLRN----QRYTEKADVYSFAIVLWECVTRQ
Kinase Npr1.AA Dicty4 262-294 45 2e-06 17.32 In-house 182-210 (277) Show / Hide 
Range on Protein: 262-294
Range on HMM: 182-210/277
Sequence Identity: 45% (15 aa)

LWTAPELLRLPEIPSGGTQKGDVYSFGIILQEI
.|.||| ..  .     ..| |||||||.| ||
CWMAPEVMMHQPY----NEKADVYSFGIVLWEI
Kinase Npr1.AA TK-Unique 334-363 32 7.9e-05 12.73 In-house 264-294 (294) Show / Hide 
Range on Protein: 334-363
Range on HMM: 264-294/294
Sequence Identity: 32% (10 aa)

C-SQEMMTLITNCWKEDSTIRPDYSQLRGTM
| |.||  |. .||... . ||. .|..   
CCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase Npr1.AA TKL-Unique 341-354 50 0.033779 3.77 In-house 268-281 (290) Show / Hide 
Range on Protein: 341-354
Range on HMM: 268-281/290
Sequence Identity: 50% (7 aa)

LITNCWKEDSTIRP
||. ||. |...||
LIQQCWHHDPSQRP
CYCc Npr1.AA CYCc 403-597 46 5.1e-108 366.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 403-597
Range on HMM: 1-231/231
Sequence Identity: 46% (108 aa)

EEKRKAEELLYQILPRPVAEELKKGK-PVTAESFECVTIYFSDIVGFTKLSSASTPLEVVDLLNDLYTCFDAVIDNFN-----VYKVETIGDAYMCVSGL
.||.|...||.|.||| ||..|| |. || .....||||.|.||||||.|.|..||..||..|||.||.|| .||..      .|||||||||||.|||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PIRNGD-------------------FHAREIARMSLALLHEITSFRIRHR----PEERLRLRIGVHTGPVVAGVVGLKMPRYCLFGDTVNTASRMESNGE
| ||..                    ||..|| ..|  . ....| ..|.    |.. ||.|||.||||||.||||..|||||.||||||.||||||.|.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

AMKIHLSNQTKKIL-------ELFGTFILEL
...||.| .|...|         .|.| .| 
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc Npr1.AA Guanylate_cyc 430-616 44 1.4e-99 341.97 Pfam 1-214 (214) Show / Hide 
Range on Protein: 430-616
Range on HMM: 1-214/214
Sequence Identity: 44% (95 aa)

VTAESFECVTIYFSDIVGFTKLSSAST----PLEVVDLLNDLYTCFDAVIDNF--NVYKVETIGDAYMCVSGLPIR-----NGDFHAREIARMSLALLHE
|.|....||||.|.||||||...|...    |...|..|||.||||| ..|..   .|||.||||.|||||||| .     ..  ||. .| |.|...  
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

ITSFRIRHRPEER-----LRLRIGVHTGPVVAGVVG--LKMPRYCLFGDTVNTASRMESNGEAM--KIHLSNQTKKILELFGTFILEL----RGEVEMKG
...... | . |.     ...|||.|||||||||.|  ..|||||..|||||.||||||.|..   |||.|. |...|.  ..|  |.    |||...||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGTQ---TTFWLKG
|| .   .|..|.|
KGKMGEMETYFLHG
HNOBA Npr1.AA HNOBA 403-424 50 2.5e-08 31.71 Pfam 213-234 (234) Show / Hide 
Range on Protein: 403-424
Range on HMM: 213-234/234
Sequence Identity: 50% (11 aa)

EEKRKAEELLYQILPRPVAEEL
|||.| ..|||...|..||..|
EEKKKTDDLLYSMFPKSVANRL