Gene Gcy3 (Sea Urchin)

Gcy3

Species: Sea Urchin
Alias: Spk217, SPU_004243, Gcy3
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
Gcy3.AA Protein None 1114 None Fasta, JSON
Gcy3.kin_dom Protein Kinase Domain None 182 None Fasta, JSON

Protein domain

Protein domains of Gcy3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor Gcy3.AA ANF_receptor 19-303 16 2.3e-12 44.59 Pfam 84-364 (364) Show / Hide 
Range on Protein: 19-303
Range on HMM: 84-364/364
Sequence Identity: 16% (50 aa)

CAESKLSD--KSIYPTFARTIPTDDLL-TEAVSVLLEY-FNWYNVSIVSSSESN--RLSV---SESLQLKLPTKNIHISDVKIYASPYIPPLYEPENGVE
| .. |.|  |. ||.|.||.|.|. .  .|.. .... |.|  |... ....     ..    | .|  |  ... .  .  | | .||  ....    
CTCPCLTDKAKNRYPYFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAVIYDDDDYYYWRGGCYFMEAFQDELREHGGNCVYYA-YVSMVIPWDDDFM----

PEMRAIVRE-TYEHTRIYIFIGELWEV----YELLHEMMYHGLLENGEYMVIWANQ--ENFDYKQLHLFQGDPYLRQPSREVMMYYRTLLALFLSPATDP
 ..  .... ..  .|.... ..  ..     ......  .|.  .|.|  | ..   . .|.        ...  .   . . ..   | . .  . .|
-DYLKKIKDIIKMKARVIVMCCYPDDMGLLQRQIMQQAHELGM-MSGGYVWIYTDWWMHSYDMQ-W-----WYDDDMDNDKFREAMKGVLGFTMH-P-SP

SYDNFQRKTYKKLQEPPFNFDFGDAVDVLGIPIEAAYLYDNVYNVYAPALNETLAAGYDIRNGT---------EILRRILC-RKHASITGRPKYID-ARG
....| ..  |               .  .. . |||.|| || .|| ||...| .. .. ||.          .|....  ..   .||. .. |  . 
EFQEFMQRWKK---------------TDTEMNYYAAYAYDAVY-LYAHALHNMLRCDPNHWNGGCDIMKWHGWQLLHYMWNKVNFEGVTGDVQFDDNGGR

DAYADITVIAVK
 . ..  .. ..
RPDYMYWIMNWD
Kinase Gcy3.AA RGC 468-715 44 4.3e-136 458.42 In-house 1-300 (300) Show / Hide 
Range on Protein: 468-715
Range on HMM: 1-300/300
Sequence Identity: 44% (132 aa)

KNMLVAIKKIHKR----HVDLTRSVRKELKIIRDLRHPHLNQFIGACVDPP------NICTITEYCPKGSLQDILENDEVKLDSMFIASLIGDILKGLSC
.. .|.|||...|    |.|.|||...|||  |.|.|..|| |||.|.|||      |.| ..|||..||||||||||..|.|.||..|.| ||.||. .
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHASETHSHGNLKSSNLVVDSRWVLKITDFGL-----HQFRSGSRPP-----------EIGEHAKYEKLLWRAPELLR-DPAPRPEG--------TQKGD
||.|. ..||||||.| |||||||.|||||||     |.|..|.. |           . .||..|.|.||.|||.|| .. |...|        |||||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

MYSLGIILYEMATRQG-----PY----GKCVLGPKEIVDKVTHPLD--PNTPFRPNVMEV-----DDCPNCMLTGMQECWNENPDERPE-VKTLTTRLKP
.||.|||.||..||.|     |.    |.. | |.||...| .|.    . |||| . |      ..|..|.|. |..||.|.|.|||.  ... . || 
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase Gcy3.AA RGC 468-715 44 4.3e-136 458.42 In-house 1-300 (300) Show / Hide 
Range on Protein: 468-715
Range on HMM: 1-300/300
Sequence Identity: 44% (132 aa)

KNMLVAIKKIHKR----HVDLTRSVRKELKIIRDLRHPHLNQFIGACVDPP------NICTITEYCPKGSLQDILENDEVKLDSMFIASLIGDILKGLSC
.. .|.|||...|    |.|.|||...|||  |.|.|..|| |||.|.|||      |.| ..|||..||||||||||..|.|.||..|.| ||.||. .
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHASETHSHGNLKSSNLVVDSRWVLKITDFGL-----HQFRSGSRPP-----------EIGEHAKYEKLLWRAPELLR-DPAPRPEG--------TQKGD
||.|. ..||||||.| |||||||.|||||||     |.|..|.. |           . .||..|.|.||.|||.|| .. |...|        |||||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

MYSLGIILYEMATRQG-----PY----GKCVLGPKEIVDKVTHPLD--PNTPFRPNVMEV-----DDCPNCMLTGMQECWNENPDERPE-VKTLTTRLKP
.||.|||.||..||.|     |.    |.. | |.||...| .|.    . |||| . |      ..|..|.|. |..||.|.|.|||.  ... . || 
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase Gcy3.AA TKL 465-713 23 1.5e-53 184.18 In-house 12-364 (364) Show / Hide 
Range on Protein: 465-713
Range on HMM: 12-364/364
Sequence Identity: 23% (85 aa)

GTYKN----------MLVAIKKIHKRHVDLT---------------------------RSVRKELKIIRDLRHPHLNQFIGACVDPPN------------
|....            ||.||......|..                              ..|..... ||||.. ||.|.| .||.            
GKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWG

-ICTITEYCPKGSLQDILENDEVKLDSMFIASLIGDILKGLSCLHASET-------HSHGNLKSSNLVVDSRWV--------------LKITDFGLHQFR
 .| ..||||.||| ..|           . ... || .|.. ||....         | .|||.|. ||. |               .||.|||| .| 
QLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFM

SGSRPPEIGEHA-------------KYEKL---LWRAPELLRDPAPRP------------EGTQKGDMYSLGIILYEMATRQGPYGKCVLGP--------
|.|   . ....             .. .     | |||.||.  . .            | ..| |.|| ||.|.|..||. || .    |        
SQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFE

---KEIVDKVTHPLDPNTPF--RPNVMEV---DDCPNCMLTGMQECWNENPDERPEVKTLTTRL
   . ..||  .|. |...   .   . .   .|||  |   ||.||...|..||  .... ||
EMFMMVCDKGLRPPIPPIWQNHH---K-MCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Gcy3.AA TKL-Unique 465-653 32 3.4e-40 139.48 In-house 16-237 (290) Show / Hide 
Range on Protein: 465-653
Range on HMM: 16-237/290
Sequence Identity: 32% (72 aa)

GTYKNMLVAIKKIHK---RHVDLTRSVRKELKIIRDLR-HPHLNQFIGACV----DPPNICTITEYCPKGSLQDILE---------NDEVKLDSMFIASL
|...   ||||..|.    . ....  ..|....  |. || . ...|.|.    .||| | ..|||| ||| | |          |.. ||.   . ..
GKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKM

IGDILKGLSCLHASET-HSHGNLKSSNLVVDSR-----WVLKITDFGLHQFRSGSRPPEIGEH------AKYEKLLWRAPELLRDPAPRPEGTQKGDMYS
. || .|.  || .|.   |..|||||. ||..     |  || ||||  |.| .    ..||       .   ..|.|||.||..      ..| | ||
AIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF--CQYSEKSDVYS

LGIILYEMATRQG------PYGKC
 ||.|.|.|||.       || ..
FGIVLWEIATRKITKTYKKPYQGM
Kinase Gcy3.AA DRK 472-589 36 1.1e-27 90.85 In-house 25-146 (258) Show / Hide 
Range on Protein: 472-589
Range on HMM: 25-146/258
Sequence Identity: 36% (44 aa)

VAIKKIHKRHVD---LTRSVRKELKIIRDLRHPHLNQFIGACVDPPNICTITEYCPKGSLQDILENDEVKLDSMFIASLIGDILKGLSCLHASE-THSHG
||.|.     ..   .    ..|  ..  ||||   ||.|.|  || || ..|| |.|||  || .. ...|   . ..  |. ||.  || ..    | 
VAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHR

NLKSSNLVVDSRWVLKITDFGL
 ||| || ||  |  |. ||||
DLKSHNLLVDEHWQVKVADFGL
Kinase Gcy3.AA Dicty4 472-589 35 6.4e-26 83.57 In-house 25-160 (277) Show / Hide 
Range on Protein: 472-589
Range on HMM: 25-160/277
Sequence Identity: 35% (48 aa)

VAIKKI--HKRH--VDLTRSVRKELKIIRDLRHPHLNQFIGACV----DPPNICTITEYCPKGSLQDILEN------DEVKLDSMFIAS---LIGDILKG
||.||   |.     ..  . ||| .|   .|||.. .| |||      |. .|  |||.|||.|  .| .      ...|||.  | .   .  |. .|
VAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARG

LSCLHASE-THSHGNLKSSNLVVDSRWVLKITDFGL
.  ||..     |  |||.|| ||  |. |..||||
MNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGL
Kinase Gcy3.AA MLK 465-650 25 2.1e-22 74.6 In-house 18-236 (291) Show / Hide 
Range on Protein: 465-650
Range on HMM: 18-236/291
Sequence Identity: 25% (58 aa)

GTYKNML-----VAIKKIH---KRHVDLT----RSVRKELKIIRDLRHPH----LNQFIGACVDPPN-ICTITEYCPKGSLQDILENDE-----------
|...|..     ||.|...      .  |    . ...| .. | |.||       || |.| .||.  | ..|||..||| ..| . .           
GRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQK

--VKLDSMFIASLIGDILKGLSCLHASETH--SHGNLKSSNLVVDS------RWVLKITDFGLHQFRSGS---RPPEIGEHAKYEKLLWRAPELL-RDPA
  .  |  ....   .. .|.. ||. . .   |  |||.|...|         .|||.|||.  . . .   ..  .|  |      |.||| . .  .
NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYA------WMAPEVIQQ--F

PRPEGTQKGDMYSLGIILYEMATRQGPY
.    . | |..| |..|.|| ||. ||
RCEKYSEKCDVWSWGVVLWEMLTREVPY
Kinase Gcy3.AA TKL-ciliate2 467-714 29 4.2e-22 70.08 In-house 20-273 (273) Show / Hide 
Range on Protein: 467-714
Range on HMM: 20-273/273
Sequence Identity: 29% (79 aa)

YKNMLVAIKKIHKRHVDL--TRSVRKELKIIRDLRHPHLNQFIGACVDPPNICTITEYCPKGSLQDILENDEVKLDSMFIASLIGDILKGLSCLHASETH
.. . ||.||    | .    |    | . .  |||| .  |.||| . || | | ||| .|||  .| |..|.|       .  || .|   ||.|.  
WREIVVAVKKFKMDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWEDRRRIALDIARGVHYLHSSNPP

S-HGNLK--------------------SSNLVVDSRWVLKITDFGLHQFRSGSRPPEIGEHAKYEKLLWRAPELLRDPAPRPEGTQKGDMYSLGIILYEM
  |  ||                    | |..||     |.||||    .    | .    .|     | ||| ..        | | |..| .|||.|.
IIHRDLKRQIKHKEKNLINIITLIKINSLNVLVDDNFRCKLTDFGWTRVK----PQDNYMTNKIGTYQWMAPEVIKAFY----YTEKADVFSYSIILWEI

ATRQGPYGKCVLGPKEIVDKVTHPLDPNTPFRPNVMEVDDCPNCMLTGMQECWNENPDERPEVKTLTTRLK
| |  || . . |    .. .   | |  |         .||  .   || ||..| . ||    .   |.
ASREPPY-RNKKGDVVAEKVMCNNLRPTIP--------KNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
S_TKc Gcy3.AA S_TKc 456-716 18 1.3e-17 65.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 456-716
Range on HMM: 1-231/231
Sequence Identity: 18% (53 aa)

YRCQIFTEVGTY----------KNMLVAIKKIHKRHVDLTRSVRKELKIIRDLRHPHLNQFIGACVDPPNICTITEYCPK--GSLQDILENDEVK-----
|.       |..           . .||||.|.       ...|.|..| .  .||.. .......|  ... ..|||.   |.| |....   .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LDSMFIASLIGDILKGLSCLHASETHSHGNLKSSNLVVDSRWVLKITDFGLHQFRSGSRPPEIGEHAKYEK---LLWRAPELLRDPAPRPEGTQKGDMYS
..   .....  |...|  .|      |  || .|. .|.  ..||.||||  .              .     . ..|||.|      . |. | |..|
FPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL------GYGKCKCDWWS

LGIILYEMATRQGPYGKCVLGPKEIVDKVTHPLDPNTPFRPNVMEVDDCPNCMLTGMQECWNENPDERPEVKTLTT------RLKPL
.|.|||||.... |.      .... .|.                    .  ..  .. |.. .|..|| .  . .          .
CGCILYEMLCGYPPFP----QMQMMFKKIG-------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Gcy3.AA Pkinase 469-589 27 9.9e-17 60.24 Pfam 24-158 (293) Show / Hide 
Range on Protein: 469-589
Range on HMM: 24-158/293
Sequence Identity: 27% (37 aa)

NMLVAIKKIHKRHVDL--TRSVRK--ELKIIRDLRHPHLNQFIGACVDPPNICTITEYCPKG----SLQDILE-NDEVKL--DSMFIASLIGDILKGLSC
. .||.|.| ||| .    .. |.  |..| . |.||.  ...... |...|. ..|||..|    .| |...  .. ..  .   . . .  ||.||  
GKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEY

LHASETHSHGNLKSSNLVVDSRWVL----KITDFGL
.|. .   |  ||..|. .|.. ..    ||.||||
CHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGL
TyrKc Gcy3.AA TyrKc 459-713 22 5.6e-14 3.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 459-713
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

QIFTEV-----------GTYKNMLVAIKKIHKRHVDLTRSVRKELKIIRDL--RHPHLNQFIGACVDP-------PNICTITEYCPKGSLQDILENDEVK
  . ..           ||.| . ||.|.... .    .  ..|..| . |  .||.. ...|.|...       . .. ..||.|.|.|.| | . . |
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LDSMFIASLIGDILKGLSCLHASETHSHGNLKSSNLVVDSRWVLKITDFGLHQFRSGS-----RPPEIGE----HAKY-EKLLWRAPELLRDPAPRPEG-
|      |   .| .| . ||      |  |   |  |... . ||.||||  .         .   .      ..|.   . | ||| .       .| 
LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI------NYGK

-TQKGDMYSLGIILYEMATR-QGPYGK---CVLGPKEIVDKVTHPLDPNTPFRPNVMEVDD-----CPNCMLTGMQECWNENPDERPEVKTLTTRL
 | | | .| |. ..|. |. | ||      .. ..|.. .|    . . . .|   .        ||  | . |..||.|.|..||  ...  ..
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV---KQGYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Gcy3.AA Dicty4-Unclassified 489-589 30 5.4e-13 40.8 In-house 46-155 (263) Show / Hide 
Range on Protein: 489-589
Range on HMM: 46-155/263
Sequence Identity: 30% (34 aa)

RKELKIIRDLRHPHLNQFIGACVDP----PNICTITEYCPKGSLQDILE------NDEVKLDSMFIASLIGDILKGLSCLHASETHSHGNLKSSNLVVDS
.||  |   . || | .  |.|. |      .| ..|  .|| |  .        .  .|||.  |     || .|.  ||  .   |  .||||. .| 
KKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFI-HRDIKSSNILMDK

RWVLKITDFGL
    || |||.
HFNIKIADFGI
Kinase Gcy3.AA Pkinase_Tyr 465-532 29 1.2e-12 43.44 Pfam 18-98 (270) Show / Hide 
Range on Protein: 465-532
Range on HMM: 18-98/270
Sequence Identity: 29% (24 aa)

GTYK------NMLVAIKKIHKRHVDLT----RSVRKELKIIRDL-RHPHLNQFIGACV--DPP-NICTITEYCPKGSLQDIL
||.|      .. ||.|.. | . .      ..  .|.|| . | .||.. ...|.|.  . | .|. ..||.|.|.| | |
GTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL
Kinase Gcy3.AA Shk 472-543 35 3.6e-11 36.58 In-house 25-100 (269) Show / Hide 
Range on Protein: 472-543
Range on HMM: 25-100/269
Sequence Identity: 35% (27 aa)

VAIKKIHKRHVDLT--RSVRKELKIIRDLRHPHLNQFIGACV-DPPNICTITEYCPKGSLQDILENDEVKLD-SMF
||.|. ||  .|.    | ||| .|   ..||..  | |||   |  .  .|| .|||.|   | ...||.. . .
VAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLHDQMVKKPFILY
Kinase Gcy3.AA Dicty4 611-650 42 1.7e-07 21.22 In-house 182-217 (277) Show / Hide 
Range on Protein: 611-650
Range on HMM: 182-217/277
Sequence Identity: 42% (17 aa)

LWRAPELLRDPAPRPEGTQKGDMYSLGIILYEMATRQGPY
.| ||| ..      . ..| | || ||.|.|..||| ||
CWMAPEVMM----HQPYNEKADVYSFGIVLWEILTRQEPY
Kinase Gcy3.AA DRK 612-650 47 2.6e-07 20.83 In-house 168-202 (258) Show / Hide 
Range on Protein: 612-650
Range on HMM: 168-202/258
Sequence Identity: 47% (19 aa)

WRAPELLRDPAPRPEG-TQKGDMYSLGIILYEMATRQGPY
| ||| ||.     .. | | | || .|.| |..||| ||
WTAPEVLRN-----QRYTEKADVYSFAIVLWECVTRQDPY
Kinase Gcy3.AA Pkinase 612-663 30 8.6e-07 25.1 Pfam 177-223 (293) Show / Hide 
Range on Protein: 612-663
Range on HMM: 177-223/293
Sequence Identity: 30% (16 aa)

WRAPELLRDPAPRPEGTQKGDMYSLGIILYEMATRQGPYGKCVLGPKEIVDK
..|||..|    ... ..| ||.|.|.|||||.... |.  .. .... .|.
YMAPEVIR---GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQ
Kinase Gcy3.AA Dicty4-Unclassified 612-650 41 1e-06 18.76 In-house 174-208 (263) Show / Hide 
Range on Protein: 612-650
Range on HMM: 174-208/263
Sequence Identity: 41% (16 aa)

WRAPELLRDPAPRPEGTQKGDMYSLGIILYEMATRQGPY
| .|| |.  .     .|| | || ...|||.||   ||
WESPECLMHES----YNQKSDVYSYAMMLYELATGDEPY
Kinase Gcy3.AA Shk 566-589 50 4e-06 18.34 In-house 126-149 (269) Show / Hide 
Range on Protein: 566-589
Range on HMM: 126-149/269
Sequence Identity: 50% (12 aa)

HGNLKSSNLVVDSRWVLKITDFGL
|  ||..|| ||  |. |..|||.
HRDLKTANLLVDQNWRVKVCDFGF
Kinase Gcy3.AA Shk 630-650 61 5e-06 17.91 In-house 186-206 (269) Show / Hide 
Range on Protein: 630-650
Range on HMM: 186-206/269
Sequence Identity: 61% (13 aa)

KGDMYSLGIILYEMATRQGPY
| | || ||||.|..|.| ||
KADVYSFGIILWEILTCQEPY
Kinase Gcy3.AA TKL-Unique 692-713 36 8e-06 16.75 In-house 269-290 (290) Show / Hide 
Range on Protein: 692-713
Range on HMM: 269-290/290
Sequence Identity: 36% (8 aa)

MQECWNENPDERPEVKTLTTRL
.|.||. .|..|| . .  .||
IQQCWHHDPSQRPSFDEIIHRL
Kinase Gcy3.AA MLK 692-713 36 2.8e-05 14.42 In-house 270-291 (291) Show / Hide 
Range on Protein: 692-713
Range on HMM: 270-291/291
Sequence Identity: 36% (8 aa)

MQECWNENPDERPEVKTLTTRL
|..|||..| .||  .   . |
MKQCWNQDPHKRPSFRQIVQHL
Kinase Gcy3.AA Pkinase_Tyr 692-713 31 5.4e-05 17.54 Pfam 249-270 (270) Show / Hide 
Range on Protein: 692-713
Range on HMM: 249-270/270
Sequence Identity: 31% (7 aa)

MQECWNENPDERPEVKTLTTRL
|..||...|..||  . .  .|
MKQCWHYDPEDRPTFSEIHEQL
Kinase Gcy3.AA DRK 692-715 41 0.000285 10.41 In-house 235-258 (258) Show / Hide 
Range on Protein: 692-715
Range on HMM: 235-258/258
Sequence Identity: 41% (10 aa)

MQECWNENPDERPEVKTLTTRLKP
|..||||.|  ||       ||  
MNDCWNEDPQHRPSMQECLERLEA
Kinase Gcy3.AA Dicty4-Unclassified 682-713 28 0.00292 6.98 In-house 232-263 (263) Show / Hide 
Range on Protein: 682-713
Range on HMM: 232-263/263
Sequence Identity: 28% (9 aa)

DDCPNCMLTGMQECWNENPDERPEVKTLTTRL
| |.| .      || . |  ||     . .|
DNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase Gcy3.AA Dicty4 682-704 39 0.003094 6.84 In-house 242-264 (277) Show / Hide 
Range on Protein: 682-704
Range on HMM: 242-264/277
Sequence Identity: 39% (9 aa)

DDCPNCMLTGMQECWNENPDERP
|.||.   . .|.||...|  ||
DWCPPSWKHLIQWCWDHDPQHRP
Kinase Gcy3.AA Shk 682-704 47 0.250121 0.98 In-house 231-253 (269) Show / Hide 
Range on Protein: 682-704
Range on HMM: 231-253/269
Sequence Identity: 47% (11 aa)

DDCPNCMLTGMQECWNENPDERP
||||    .  | ||  ||  ||
DDCPKSLKHLIQKCWDHNPQRRP
CYCc Gcy3.AA CYCc 752-946 49 1.1e-105 358.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 752-946
Range on HMM: 1-231/231
Sequence Identity: 49% (114 aa)

EEKKKTDNLLHQMLPKPVANQLKRGM-QVVPESFECVTIFFSDIVGFTSLSSESTPFEVVDMLNDLYTLFDEIISYYD-----VYKVETIGDAYMLVSGL
.||.|.| ||.||||. ||||||.|   |.|....|||| |.||||||.|.|..||..||.||||.|| ||.||. ..     .||||||||||| |||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PLRNE-------------------KKHAAEIASTSLHLLEDVKAFKVRHR----PEVNLKLRIGIHSGSTVSGVVGLTMPRYCLFGDTVNTASRMESNGE
| |||                     || .||. .|. .| .| |.|.|.    |. .|..|||||.|..| ||||..|||||.||||||.||||||.|.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

ALKIHTSSETKNLL-------EQMGGFVVEE
. .|| |.||...|          |.|..|.
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc Gcy3.AA Guanylate_cyc 779-965 42 1.3e-87 302.16 Pfam 1-214 (214) Show / Hide 
Range on Protein: 779-965
Range on HMM: 1-214/214
Sequence Identity: 42% (90 aa)

VVPESFECVTIFFSDIVGFTSLSSEST----PFEVVDMLNDLYTLFDEIISYY--DVYKVETIGDAYMLVSGLPLR-----NEKKHAAEIASTSLHLLED
|......||||.|.||||||...|...    |...|.||||.|| ||.... .  ..|||.||||.|| ||||| .     .   ||. .|  .| ..|.
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

VKAFKVRHRPEVN-----LKLRIGIHSGSTVSGVVG--LTMPRYCLFGDTVNTASRMESNGEAL--KIHTSSETKNLLEQMGGFVVE----ERGLISMKG
.. . | | .  .     ...|||||.|..|.||.|  . |||||..|||||.||||||.|...  ||| | ||. .|.. ..|. |    .|| |..||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGQ---LVTYWLIS
||.   ..||.|. 
KGKMGEMETYFLHG
HNOBA Gcy3.AA HNOBA 747-773 62 2.3e-11 42.67 Pfam 208-234 (234) Show / Hide 
Range on Protein: 747-773
Range on HMM: 208-234/234
Sequence Identity: 62% (17 aa)

THQLIEEKKKTDNLLHQMLPKPVANQL
.. | ||||||| ||..|.||.|||.|
HRELEEEKKKTDDLLYSMFPKSVANRL
PhoPQ_related Gcy3.AA PhoPQ_related 1030-1104 35 4.5e-19 53.66 Pfam 44-125 (399) Show / Hide 
Range on Protein: 1030-1104
Range on HMM: 44-125/399
Sequence Identity: 35% (29 aa)

DSDSAIWFHYLTITIPER--IVNSEHAFLFITGGS-----TKSSPPDPRTDKEIRRTSNIAVGAGIVGATLRQVPNQPIVFK
..| ..|.| .|| .|.    .....|.|||||||     .   .| | .|.|.   ..||   . | |.| .|||||. |.
LVDPSQWKHWVTIYVPDEYNYQYPHRALLFITGGSWKRHWENGNWPGPPPDFEPEYYAWIARQTNTVVAILSDVPNQPLTFD