Gene Gcy1 (Sea Urchin)

Gcy1

Species: Sea Urchin
Alias: SPU_024339, Gcy1, Spk214
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
Gcy1.AA Protein None 1125 None Fasta, JSON
Gcy1.kin_dom Protein Kinase Domain None 237 None Fasta, JSON

Protein domain

Protein domains of Gcy1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor Gcy1.AA ANF_receptor 60-440 20 1.7e-77 268.59 Pfam 1-364 (364) Show / Hide 
Range on Protein: 60-440
Range on HMM: 1-364/364
Sequence Identity: 20% (82 aa)

PALGALPLAISLANQDSN-ILNGFDVQFEWVDTH---CDINIGMHAVSDWWKRGFVGVIGPGCGC--TYEGRLASALNIPMIDYVCDENPVSD--KSIYP
....|...||.  |.| . .| |....... |..   .. . .. |. .|. .| |..|||.| .  .. .|.|...||||| . |..  ..|  |. ||
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCYCSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCLTDKAKNRYP

TFLRTIPPSIQV-VEAMILTLQR-YDWDQVSVVVENITK--YRNI---FNTMKDKFDERDYEILHEEYYAGFDPWDYEMDDPFSEIIQRTKETTRIYVFF
.|.||.|.. .. ..||.  .|. ..|..|.|.... ..  .|..    ....| . |. ..... .|.....|||... |. ..| ...| ..|..|..
YFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAVIYDDDDYYYWRGGCYFMEAFQDELREHGGNCVYYAYVSMVIPWDDDFMDYLKKIKDIIKMKARVIVMC

GDASDL----RQFAMTALDEGILDSGDYVILGAVVDLEVRDSQDYHSLDYILDTSEYLNQINPDYARLFKNREYTRSDNDRALEALKSVIIVTGAPVLKT
. . |.    ||... | ..|. .||.||....  ... .|.| .                          ....  |||...||.|.|...|   .  .
CYPDDMGLLQRQIMQQAHELGM-MSGGYVWIYTDWWMHSYDMQ-W--------------------------WYDDDMDNDKFREAMKGVLGFTMH-P-SP

RNWDRFSTFVIDNALDAPFNGELELRAEIDFASVYMFDATMQLLEALDRTHAAGGDIYDGE--------EVVSTLLNS-TYRSKTDTFYQFDENGDGVKP
 ... ....               .  |... . |..||.. . .||.... .......|         . ..  ..  ..        |||.||. . .
EFQEFMQRWKK-------------TDTEMNYYAAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKWHGWQLLHYMWNKVNFEGVTGDVQFDDNGGRRPD

YVLLHLIPI
| .  . ..
YMYWIMNWD
Kinase Gcy1.AA RGC 593-841 38 1.1e-134 453.79 In-house 1-300 (300) Show / Hide 
Range on Protein: 593-841
Range on HMM: 1-300/300
Sequence Identity: 38% (114 aa)

RGTVCALHAVHKN----HIDLTRAVRTELKIMRDMRHDNICPFIGACIDRP------HISILMHYCAKGSLQDILENDDIKLDSMFLSSLIADLVKGIVY
.|.. ... ....    |.|.||....||| ||...|||...|||.||| |      ...|...||..|||||||||||||.|.|| .|.| |.|||. |
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHSSEIKSHGHLKSSNCVVDNRWVLQITDYGL-----NEFKKGQK----------QDVDLGDHAKLARQLWTSPEHLRQEGSMPTAG--------SPQGD
||.|.|..||.|||.||||| |||..|||.||     ..||.||.          .  . ..|.. ...|||.|||||....... |        ...||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

IYSFAIILTELYSRQE-----PFHEN----EMDLADIIARVKI----GEVPPYRPILNAVNA----AAPDCVLSAIRACWPEDPDDRPN-IMAVRTMLAP
.|||.||. |.. |..     ||...    |.....|| .||.    |. .|.|| ..  ..    ....|.|. .|.|| |||..||. .  .|..|. 
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase Gcy1.AA RGC 593-841 38 1.1e-134 453.79 In-house 1-300 (300) Show / Hide 
Range on Protein: 593-841
Range on HMM: 1-300/300
Sequence Identity: 38% (114 aa)

RGTVCALHAVHKN----HIDLTRAVRTELKIMRDMRHDNICPFIGACIDRP------HISILMHYCAKGSLQDILENDDIKLDSMFLSSLIADLVKGIVY
.|.. ... ....    |.|.||....||| ||...|||...|||.||| |      ...|...||..|||||||||||||.|.|| .|.| |.|||. |
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHSSEIKSHGHLKSSNCVVDNRWVLQITDYGL-----NEFKKGQK----------QDVDLGDHAKLARQLWTSPEHLRQEGSMPTAG--------SPQGD
||.|.|..||.|||.||||| |||..|||.||     ..||.||.          .  . ..|.. ...|||.|||||....... |        ...||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

IYSFAIILTELYSRQE-----PFHEN----EMDLADIIARVKI----GEVPPYRPILNAVNA----AAPDCVLSAIRACWPEDPDDRPN-IMAVRTMLAP
.|||.||. |.. |..     ||...    |.....|| .||.    |. .|.|| ..  ..    ....|.|. .|.|| |||..||. .  .|..|. 
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase Gcy1.AA TKL 590-839 18 3.3e-35 123.28 In-house 12-364 (364) Show / Hide 
Range on Protein: 590-839
Range on HMM: 12-364/364
Sequence Identity: 18% (68 aa)

GTYRG----------TVCALHAVHKNHIDLT---------------------------RAVRTELKIMRDMRHDNICPFIGACIDRPH------------
|..||          .. |    .... |..                              . |...|.  ||.||..|.|.|.. |.            
GKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWG

-ISILMHYCAKGSLQDILENDDIKLDSMFLSSLIADLVKGIVYLHSSEI-------KSHGHLKSSNCVVDNRWV--------------LQITDYGLNEFK
 . | | || .||| ..|           . ... |  .|. ||||..          |  |||.|. ||. |               . |.|.||  |.
QLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFM

KGQKQDVDLGDH------------AKLARQ---LWTSPEHLRQEGSMPT-----------AGSPQGDIYSFAIILTELYSRQEPFHENEMDLADII----
.. ... | . .            ..  .     | .|| ||...  .              |.. |.|||.|.| |...|..|.... ..  ..     
SQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFE

ARVKIGEVPPYRPILN---------AVNAAAPDCVLSAIRACWPEDPDDRPNIMAVRTML
.  ..  .  .|| .            .  .|. . . .  || .||..||.   .   |
EMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Gcy1.AA TKL-Unique 616-779 29 5.2e-25 85.23 In-house 45-236 (290) Show / Hide 
Range on Protein: 616-779
Range on HMM: 45-236/290
Sequence Identity: 29% (58 aa)

ELKIMRDMR-HDNICPFIGACI----DRPHISILMHYCAKGSLQDILE---------NDDIKLDSMFLSSLIADLVKGIVYLHSSE--IKSHGHLKSSNC
|...|   . |.||  ..|.|.    . |. .| | ||  ||| | |          |. .||.     ... | ..|  |||..|  |  |. ||||| 
EVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPI-IHRDLKSSNF

VVDNR-----WVLQITDYGLNEFKKGQ-KQDVD----LGDHAKLARQLWTSPEHLRQEGSMPTAGSPQGDIYSFAIILTELYSRQE------PFHE
 |||.     |  .| | ||  |..   |  .      ..  ...  .| .|| ||..    .  | . |.|||.|.| |...|.       |...
LVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF---CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQG
Kinase Gcy1.AA DRK 590-719 37 1.4e-22 73.29 In-house 18-152 (258) Show / Hide 
Range on Protein: 590-719
Range on HMM: 18-152/258
Sequence Identity: 37% (50 aa)

GTYRGTVCALHAVHKNHID---LTRAVRTELKIMRDMRHDNICPFIGACIDRPHISILMHYCAKGSLQDILENDDIKLDSMFLSSLIADLVKGIVYLHSS
|| |||  |        |.   .    . |  .|   || ||| |.|.|   | | | | |  .|||  || .. |..|   . ..  |  ||. |||..
GTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCC

E-IKSHGHLKSSNCVVDNRWVLQITDYGLNE-FKK
. |  |  ||| |  ||  |   . |.||   |||
NPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKK
Kinase Gcy1.AA TK 590-839 12 4.8e-20 63.2 In-house 21-486 (486) Show / Hide 
Range on Protein: 590-839
Range on HMM: 21-486/486
Sequence Identity: 12% (63 aa)

GTYRG---------------------------TVCALHAVHKNHIDLTRAVRT--------------ELKIMRDMR-----HDNICPFIGACIDR-----
|..||                           | .|   ... . .  .. .               |. .|  |.     |.||  ..|.| .      
GEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPC

-------PHISILMHYCAKGS----LQDILENDD--------------------------------------------------IKLDSMFLSS------
       ... |.| |...|.    |.| | . .                                                  ||.... |.       
FEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQM

------------------LIADLVKGIVYLHSSEIK-----SHGHLKSSNCVVDNRWV-----------LQITDYG------LNEFKKGQKQDVDLGDHA
                    ... .|  ||||  ..      |. |   || |... |             |.|.|      .                 
AWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSG-----------------

KLARQL-----------------------------------------WTSPEHLR--QEGSM--PTAGSPQGDIYSFAIILTELYSRQ-EPFHENEMD--
 ||| .                                         |..|| |.  .. .       ... |..|| . . |....  ||....  .  
VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQD

------LADIIARVKIG-----------------EVPPYRP-----ILNAVNAAAPDCVLSA-IRACWPEDPDDRPNIMAVRTML
      ..... ... |                 . ||. |        .    .|. ..   .. || .||.|||.  ... .|
VWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Gcy1.AA RIPK 616-839 25 1.2e-15 49.8 In-house 46-290 (290) Show / Hide 
Range on Protein: 616-839
Range on HMM: 46-290/290
Sequence Identity: 25% (63 aa)

ELKIMRDMRHDNICPFIGACIDR-----PH-ISILMHYCAKGSLQDILENDDIKLDSMFLSSL----IADLVKGIVYLHSSE---IKSHGHLKSSNCVVD
| |.|  .|...| |  | |..      .  ..| | | ..||| . |     ...   . .|    |   . |  ||||     |  |  || .|  ||
EAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLHSMNPPII--HRDLKPENILVD

NRWVLQITDYGLNEFKKGQ--KQDVD-----LGDHAKLA--RQLWTSPEHLRQEGSMPT-AGSPQGDIYSFAIILTELYSRQEPFHENEMDLADIIARVK
|     | | ||  .. .   .|| .     ..   |.         |||.|   . |.   .|  |.|||||.. |. .. .|. . . ..  |....|
NNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMM-IMMCCK

IGEVPPYRPILNAVNAA-APDCVLSAIRACWPEDPDDRPNIMAVRTML
 |  |.  |.  .   . .     . .. ||  ||.|||.   ..   
QGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase Gcy1.AA Dicty4 614-723 32 1.5e-15 48.53 In-house 46-170 (277) Show / Hide 
Range on Protein: 614-723
Range on HMM: 46-170/277
Sequence Identity: 32% (41 aa)

RTELKIMRDMRHDNICPFIGACI----DRPHISILMHYCAKGSLQDILEN------DDIKLD-SMFLS-SLIA-DLVKGIVYLHSSE-IKSHGHLKSSNC
| | .||   || ||| | |||.      . ..| . |. ||.|  .| .      . |||| . ...  ..| | ..|. .||..  .  |  |||.| 
RKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNL

VVDNRWVLQITDYGLNE-FKKGQKQ
 ||  |.  ..| ||   .||.  .
LVDKNWRVKVCDFGLSQYMKKHEDH
Kinase Gcy1.AA TKL-ciliate2 616-687 40 1.5e-15 47.8 In-house 46-117 (273) Show / Hide 
Range on Protein: 616-687
Range on HMM: 46-117/273
Sequence Identity: 40% (29 aa)

ELKIMRDMRHDNICPFIGACIDRPHISILMHYCAKGSLQDILENDDIKLDSMFLSSLIADLVKGIVYLHSSE
| . |  .|| ||  |.||| . |  .|.| || .|||  .| |.|..|       .  |  .|. |||||.
ECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWEDRRRIALDIARGVHYLHSSN
Kinase Gcy1.AA MLK 590-714 24 9.2e-15 47.75 In-house 18-179 (291) Show / Hide 
Range on Protein: 590-714
Range on HMM: 18-179/291
Sequence Identity: 24% (40 aa)

GTYRGTV-----CALHAVHKNHIDLTRA------VRTELKIMRDMRHDN----ICPFIGACIDRPH-ISILMHYCAKGSLQDILEN-------------D
|..|..       |. .|. . .|  ..      ...| .. | ..| |    |..| |.|.. |.   |.|.||..||| ..| .              
GRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKN

DIKLDSMFLSSLIADLVKGIVYLHSSEIK--SHGHLKSSNCVVDN------RWVLQITDYGL
|.  |  .. .   .  .|. |||| . |   | .|||.| ..|.        .| |.| |.
DRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGT
TyrKc Gcy1.AA TyrKc 577-839 21 1.4e-13 -3.27 SMART 1-280 (280) Show / Hide 
Range on Protein: 577-839
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

ISNAEK--QQIFATI--GTYRGTVCALHAVHKNHIDLTRAVRTELKIMRDM--RHDNICPFIGACIDR-------PHISILMHYCAKGSLQDILENDDIK
|.  .|     | ..  ||.. . .|   .....    .. . |..||.    .|.||  ..|.|..        . . |.| |...|.|.| | .   |
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LDSMFLSSLIADLVKGIVYLHSSEIKSHGH-----LKSSNCVVDNRWVLQITDYGLNEFKKGQ-----KQDVDLGDHAKLARQL----WTSPEHLRQEGS
|    | |   .  .|  ||||       .     |   || |... .  |.| ||  . .        .|.      | .. .    |..|| .     
LCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----

MPTAG--SPQGDIYSFAIILTELYSRQEPFHENE----MDLADIIARVKIGEVPPYRPI-----LNAVNAAAPDCVLSAIRACWPEDPDDRPNIMAVRTM
    |  ... |..|| . . |.... .. ....    |. ...|..|| |. .|  |             .|| . . .. || |||.|||.  ...  
--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF----VCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

L
.
F
S_TKc Gcy1.AA S_TKc 568-839 16 3.8e-13 15.89 SMART 1-231 (231) Show / Hide 
Range on Protein: 568-839
Range on HMM: 1-231/231
Sequence Identity: 16% (48 aa)

NMVMSAISVISNAEKQQIFATIGTYRGTVCALHAVHKNHIDLTRAVRTELKIMRDMRHDNICPFIGACIDRPHISILMHYCAK--GSLQDILENDDIK--
  ..  |   . ..  .   .     | ..|.  ..       . .| |..|..  .|.||. ..... |  |. . | ||    |.| |....   .  
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LDSMFLSSLIADLVKGIVYLHSSEIKSHGHLKSSNCVVDNRWVLQITDYGLNEFKKGQKQDVDLGDHAKLARQLWTSPEHLRQEGSMPTAGSPQGDI
   ..     .... ..... |.||     |  || .|  .|.  .. |.| ||  .            .       . .|| |         | .  |.
RFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL-------GYGKCKCDW

YSFAIILTELYSRQEPFHENEMDLADIIARVKIGEVPPYRPILNAVNAAAPDCVLSAIRACWPEDPDDRPNIMAVRT---------ML
.|. .|| |..... ||. ... . ..|                      .. ... || |.  ||..|| .  . .          .
WSCGCILYEMLCGYPPFP-QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Gcy1.AA Pkinase 599-714 25 9.2e-13 46.2 Pfam 32-158 (293) Show / Hide 
Range on Protein: 599-714
Range on HMM: 32-158/293
Sequence Identity: 25% (32 aa)

LHAVHKNHIDLTRAVR-TELKIMRDMRHDNICPFIGACIDRPHISILMHYCAKG----SLQDILE-NDDIKL--DSMFLSSLIADLVKGIVYLHSSEIKS
.  .|...  . ...| .|..||. ..|.||. ..... |..|| . | || .|    .| |...  .. ..  .   . . .  ...|. |.||  |  
IKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGI-I

HGHLKSSNCVVDNRWVL----QITDYGL
|  ||..|. .||. ..     |.| ||
HRDLKPENILIDNNGHIDACVKICDFGL
Kinase Gcy1.AA Pkinase_Tyr 616-685 31 1.6e-09 32.84 Pfam 53-129 (270) Show / Hide 
Range on Protein: 616-685
Range on HMM: 53-129/270
Sequence Identity: 31% (24 aa)

ELKIMRDM-RHDNICPFIGACI-DRPH--ISILMHYCAKGSLQDILEND---DIKLDSMFLSSLIADLVKGIVYLHS
|.|||. . .|.||  ..|.|. .. .  | | | |...|.| | | .    . .|.   | .  ..  ||  ||.|
EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase Gcy1.AA MLK 738-839 22 3.6e-07 21.06 In-house 199-291 (291) Show / Hide 
Range on Protein: 738-839
Range on HMM: 199-291/291
Sequence Identity: 22% (23 aa)

WTSPEHLRQ-EGSMPTAGSPQGDIYSFAIILTELYSRQEPFHENEMD-LADIIARVKIGEVPPYRPILNAVNAAAPDCVLSAIRACWPEDPDDRPNIMAV
| .|| . | .... .  .   |..|....| |. .|..|.. ...| .| ..  .  |. || ..        .|.   . .  || .|| .||.   .
WMAPEVIQQFRCEKYSEKC---DVWSWGVVLWEMLTREVPYK-QHYDPMAIAWWVAYNGLRPPIPST-------CPEHWKKLMKQCWNQDPHKRPSFRQI

RTML
 . |
VQHL
Kinase Gcy1.AA DRK 738-777 45 1.2e-05 15.08 In-house 168-202 (258) Show / Hide 
Range on Protein: 738-777
Range on HMM: 168-202/258
Sequence Identity: 45% (18 aa)

WTSPEHLRQEGSMPTAGSPQGDIYSFAIILTELYSRQEPF
||.|| || ..    |     |.|||||.| |.  || |.
WTAPEVLRNQRYTEKA-----DVYSFAIVLWECVTRQDPY
Kinase Gcy1.AA TKL-Unique 818-839 36 8.6e-05 13.03 In-house 269-290 (290) Show / Hide 
Range on Protein: 818-839
Range on HMM: 269-290/290
Sequence Identity: 36% (8 aa)

IRACWPEDPDDRPNIMAVRTML
|..||  ||..||.   ... |
IQQCWHHDPSQRPSFDEIIHRL
Kinase Gcy1.AA Dicty4 759-779 50 0.000633 9.17 In-house 199-220 (277) Show / Hide 
Range on Protein: 759-779
Range on HMM: 199-220/277
Sequence Identity: 50% (11 aa)

DIYSFAIILTELYSRQEPFH-E
| |||.|.| |.  ||||.  .
DVYSFGIVLWEILTRQEPYQKH
Kinase Gcy1.AA Pkinase 755-839 16 0.003121 12.51 Pfam 190-293 (293) Show / Hide 
Range on Protein: 755-839
Range on HMM: 190-293/293
Sequence Identity: 16% (18 aa)

SPQGDIYSFAIILTELYSRQEPFHENE-----MDLADIIARVKIGEVPPYRPILNA--------------VNAAAPDCVLSAIRACWPEDPDDRPNIMAV
.|  |..|. .|| |..... ||  ..     .|   .|.|.. ....  .| ..               .  ....  .. |. |.  || .||... .
GPKVDMWSCGCILYEMLCGRPPFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQI

RTM--L
     .
LQHPWF
Kinase Gcy1.AA Pkinase_Tyr 818-839 36 0.07121 6.97 Pfam 249-270 (270) Show / Hide 
Range on Protein: 818-839
Range on HMM: 249-270/270
Sequence Identity: 36% (8 aa)

IRACWPEDPDDRPNIMAVRTML
.. || .||.|||   ... .|
MKQCWHYDPEDRPTFSEIHEQL
CYCc Gcy1.AA CYCc 878-1072 45 4.1e-104 353.11 SMART 1-231 (231) Show / Hide 
Range on Protein: 878-1072
Range on HMM: 1-231/231
Sequence Identity: 45% (105 aa)

KEKTKTEQLLHRMLPPSIASQLIKGI-AVLPETFEMVSIFFSDIVGFTALSAASTPIQVVNLLNDLYTLFDAIISNYD-----VYKVETIGDAYMLVSGL
.|| |...||..|||...| ||  |  .| |.....|.| |.||||||.|....||.||||.|||.|| || ||....     .||||||||||| |||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PLRNGD-------------------RHAGQIASTAHHLLESVKGFIVPHK----PEVFLKLRIGIHSGSCVAGVVGLTMPRYCLFGDTVNTASRMESNGL
| ||..                   .|| .||. | . .|..|.|.|.|.    |.  |..|||||.|..|.||||..|||||.||||||.||||||.|.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

ALRIHVSPWCKQVL-------DKLGGYELED
. .||||.. ...|        . |..|.| 
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc Gcy1.AA Guanylate_cyc 905-1091 40 2.7e-85 294.49 Pfam 1-214 (214) Show / Hide 
Range on Protein: 905-1091
Range on HMM: 1-214/214
Sequence Identity: 40% (86 aa)

VLPETFEMVSIFFSDIVGFTALSAAST----PIQVVNLLNDLYTLFDAIISNY--DVYKVETIGDAYMLVSGLPLR-----NGDRHAGQIASTAHHLLES
| .. .. |.|.|.|||||||......    |.|.|..|||.|| || .....  ..|||.||||.|| ||||| .     ..  || ..|  |  ..|.
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

VKGFIVPHKP--EV---FLKLRIGIHSGSCVAGVVG--LTMPRYCLFGDTVNTASRMESNGLAL--RIHVSPWCKQVLDKLGGYELE----DRGLVPMKG
.. . |.|..  ..    ...|||||.|..||||.|  . |||||..|||||.||||||.|...  .||||.  ...| ...... |    .|| .|.||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGE---IHTFWLLG
||.   . |..| |
KGKMGEMETYFLHG
HNOBA Gcy1.AA HNOBA 873-899 48 1.4e-08 32.64 Pfam 208-234 (234) Show / Hide 
Range on Protein: 873-899
Range on HMM: 208-234/234
Sequence Identity: 48% (13 aa)

TQELQKEKTKTEQLLHRMLPPSIASQL
..|| .|| ||..||. |.|.|.| .|
HRELEEEKKKTDDLLYSMFPKSVANRL