Gene MEKK1 (Sea Urchin)

MEKK1

Species: Sea Urchin
Alias: MEKK1, Spk220, SPU_027423
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: MEKK1

Sequence

Name Sequence Type Origin Length Description Download
MEKK1.AA Protein None 1156 None Fasta, JSON
MEKK1.kin_dom Protein Kinase Domain None 266 None Fasta, JSON

Protein domain

Protein domains of MEKK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SWIM_MAP3K1 MEKK1.AA SWIM_MAP3K1 166-236 32 7.4e-26 89.3 In-house 1-77 (77) Show / Hide 
Range on Protein: 166-236
Range on HMM: 1-77/77
Sequence Identity: 32% (25 aa)

FLIGGDSPDHKYKVTIG-SQNCNCG-----KGPFCVHLLFVMLRVFKLAEDDNLLWNRTLKNYEVELLFSKYEAMKK
|...|.... .|.|.||  ..|.|      .| .|.|...||.|||.. .|.  .| ..|...||| || ..   | 
FHVKGHTSGNVYTVHIGDPHTCTCPDCQKHRGNHCKHICWVMMRVFQVPRDHPWWWQKGLTQTEVEWLFQHKHMAKR
SWIM MEKK1.AA SWIM 177-205 24 2.5e-07 24.93 Pfam 1-37 (37) Show / Hide 
Range on Protein: 177-205
Range on HMM: 1-37/37
Sequence Identity: 24% (9 aa)

YKVTIG----SQNCNCG----KGPFCVHLLFVMLRVF
| |...      .| |.    .|  | |.| |.... 
YRVQLDDDIVKCTCSCPMWQYYGYPCKHILAVLYHCN
RING_MAP3K1 MEKK1.AA RING_MAP3K1 279-336 30 3.5e-21 68.88 In-house 1-80 (80) Show / Hide 
Range on Protein: 279-336
Range on HMM: 1-80/80
Sequence Identity: 30% (24 aa)

EDEDLCPICLLEMVEGE-------------SLVECKNGCHNKLHHHCVAIWEGECKRQ------QEP---MVCPLCRAIW
. ||.||||. .| . .             ... |. || |.|||||. .| ..|..        .|    .||.||. |
DEEDMCPICYEPMCDDDDVNPNNPDGKEKEPIWWCCCGCGNNLHHHCMRMWIKHCRQTAEFLNYRDPRHSVTCPWCRCDW
Kinase MEKK1.AA MEKK1 886-1151 79 1.4e-255 855.37 In-house 1-266 (266) Show / Hide 
Range on Protein: 886-1151
Range on HMM: 1-266/266
Sequence Identity: 79% (211 aa)

WTKGAILGTGAFSSCYMARDVKTGTLMAVKQISFCRNNAGDQEDTMEEIKKEIKLMATFDHPHIVRLMGATQHDAHFNVFVEWMPGGAVSTLLKDFGAFS
||||...|||||||||||.|||||||||||||..||||..||||.||||.|||..||.|.||||.|.||||.||.|.|||.||||||.|..||||.|||.
WTKGQQIGTGAFSSCYMAQDVKTGTLMAVKQITYCRNNSSDQEDVMEEIRKEIRMMAHFNHPHIIRMMGATCHDSHYNVFIEWMPGGSVAHLLKDYGAFK

NAVTVKYIHQVCLGLAYLHDNRVIHRDLKGANLLMDSTGHHLRIADLGTAGKMNADITRTDEFKGQFLGTISFMAPEVLRGEPYGRSCDIWSVGCCIIEM
|.|...||||||.||.|||||..||||.||||||||||||||||||.|||..||.||||||||.|||||||.|||||||||..|||||||||||||||||
NSVVINYIHQVCRGLSYLHDNQIIHRDVKGANLLMDSTGHHLRIADFGTAARMNSDITRTDEFQGQFLGTIAFMAPEVLRGQQYGRSCDIWSVGCCIIEM

CTTKPPWNNTAISNHYQLLFKIASANGPPPIPESLSPALRDITLRCLEAEPSARPGVMELLKHPAF
|.|||||||...||||||.|||||||.||||||.|||.|||||||||||.|..||.||||||||.|
CCTKPPWNNEKHSNHYQLIFKIASANTPPPIPEHLSPGLRDITLRCLEAQPQDRPPVMELLKHPVF
Kinase MEKK1.AA STE11 886-1151 40 1.1e-148 500.28 In-house 1-303 (303) Show / Hide 
Range on Protein: 886-1151
Range on HMM: 1-303/303
Sequence Identity: 40% (122 aa)

WTKGAILGTGAFSSCYMARDVKTGTLMAVKQISFCRNNA--GDQEDTMEE------IKKEIKLMATFDHPHIVRLMGATQH---DAHFNVFVEWMPGGAV
|.||.|.|.|||...|....|.||.||||||| ...||   .|||. ...      |..||||| ...|..||| .|...|   . |.|.| |..||| .
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

STLLK-DFGA--FSNAVTVKYIHQVCLGLAYLHDNRVIHRDLKGANLLMDSTGHHLRIADLGTAGKMNADITRTDEFKG------QFLGTIS--------
| .|.  .|.  |. .|. ||..|.. ||.|||....||||.||||.|.||.|.....|| |.| ......|.|.....      .. ||.         
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

FMAPEVLRGEP---YGRSCDIWSVGCCIIEMCTTKPPWNNTAISNHYQLLFKIASA-NGPPPIPESLS------PALRDITLRCLEAEPSARPGVMELLK
.|||||...|.   |||..||||.||..|||.|.||||.|    ||.. .|||... . .|||||..|      ...||. ..|.| .|. || ...||.
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDH-NHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQ

HPAF
|| .
HPFI
Kinase MEKK1.AA STE 886-1151 26 8.1e-93 314.67 In-house 1-359 (359) Show / Hide 
Range on Protein: 886-1151
Range on HMM: 1-359/359
Sequence Identity: 26% (96 aa)

WTKGAILGTGAFSSCYMARDVK---------------TGTLMAVKQISFCRNNAGDQE------------DTMEEIKKEIKLMATFD--HPHIVRLMGAT
|..  ..| ||| . | |...|               ||..||.||......|. | |            . |..|.||||.|  ..  ||.||.  |. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

QHDA-------HFNVFVEWMPGGAVSTLLK-DFGA-------------FSNAVTVKYIHQVCLG-LAYLHDNRVIHRDLKGANLLMDSTGHHLRIADLGT
 ..        . ... |.|.|| .. ..|  .|              |.  .  ....|.. | |.|||....||||.|.|| |.        ..| |.
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGV

AGKMNADIT------------RTDEFKGQFLGTISFMAPEVLRG------EPYGRSCDIWSVGCCIIEMCTTKPPWNN-TAISNHYQLLFKIASAN----
.|... ...             ...    | ||  .|||||...       .|...|||||.||.||||.| |||| . .  .. .. .|......    
CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQ

------GPPPIPE-------------------SLSPALRDITLRCLEAEPSARPGVMELLK--HPAF
      .|||.|.                   ..|| ..|   .||. .|. || . .|||  || .
LCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MEKK1.AA S_TKc 886-1151 30 1e-87 298.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 886-1151
Range on HMM: 1-231/231
Sequence Identity: 30% (86 aa)

WTKGAILGTGAFSSCYMARDVKTGTLMAVKQISFCRNNAGDQEDTMEEIKKEIKLMATFDHPHIVRLMGATQHDAHFNVFVEWMPG--GAVSTLLKDFGA
.... ..| |||...| .|..||| ..|.|.|.             | |..||...   .||.||.| .. |.  |. .. | ..|  | . ...|. | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------FSNAVTVKYIHQVCLGLAYLHDNRVIHRDLKGANLLMDSTGHHLRIADLGTAGKMNADITRTDEFKGQFLGTISFMAPEVLRGEPYGR-SCDIW
      |.  .. .|..|.|..|.|.|....|||||| .|.|.|.   |. |.| | | ..             | ||  .||||||   .||. .||.|
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDWW

SVGCCIIEMCTTKPPWNNTAISNHYQLLFKIASANGPPPIPESLSPALRDITLRCLEAEPSARPGVMELLK-------HPAF
|.||...||.. .||.       ..|..||.             || ..|.  .||. .|. ||.. |.|.       || |
SCGCILYEMLCGYPPFP------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MEKK1.AA STE11-Unclassified 886-1151 33 8.5e-80 271.42 In-house 1-308 (308) Show / Hide 
Range on Protein: 886-1151
Range on HMM: 1-308/308
Sequence Identity: 33% (103 aa)

WTKGAILGTGAFSSCYMARDVKTGTLMAVKQISFCRNN--AGDQEDT-MEEIKKEIKLMATFDHPHIVRLMGAT--QHDAHFNVFVEWMPGGAVSTLLKD
| ||...|.|.| . | . ...|| .||||||    .|    | ...  . |.||.|.. ...|..||.  |.   .|  . |.| | |||| .. .|. 
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

FGAFSNAVTVKYIHQVCLGLAYLHDNRVIHRDLKGANLLMDSTGHHLRIADLGTAG---------------------KMNADITRTDEFKGQFLGTIS--
.|.|. .|. ||  |.  |||||| . .||||.||||.| |. |    ..| |.|                      |   .|    ..     ||.   
YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDG-ICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQP

-FMAPEVLR---GEPYGRSCDIWSVGCCIIEMCTTKPPWNNTAISNHYQLLFKIASANGPPPIPESLS-----------PALRDITLRCLEAEPSARPGV
  |||||..    . ..|. ||||.|| .||| | |.|| |    |  ....||...| .|.||| ||           ....|.  .|..  |. || .
FWMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTA

MELLKHPAF
 .||.||  
NQLLQHPFI
Kinase MEKK1.AA Pkinase 886-1151 27 4.2e-72 250.65 Pfam 1-293 (293) Show / Hide 
Range on Protein: 886-1151
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

WTKGAILGTGAFSSCYMARDVKTGTLMAVKQISFCRNNAGDQED---TMEEIKKEIKLMATFDHPHIVRLMGATQHDAHFNVFVEWMPGG----AVSTLL
...| ..| |.|...| .....|| . |||.|. .... . ..    .      ||..|. ..||.|||| .. . . |  .  |...||      ....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

K--DFGAF--SNAVTVKYIHQVCLGLAYLHDNRVIHRDLKGANLLMDSTGHH---LRIADLGTAGKMNADITRTDEFKGQFLGTISFMAPEVLR-GEPYG
.  . |.|  |  .  .|. |.. ||.|.|....|||||| .|.|.|..||    ..|.| | | ...   .  ..    | ||. .|||||.| |..||
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

RSCDIWSVGCCIIEMCTTKPPWNNT----AISNHYQLLFKIASANGPPPIPESLS-------------------PALRDITLRCLEAEPSARPGVMELLK
...|.||.|| ..||.. .||. .        ...|....| ..  . ..|.. |                   ....|.  .||.  |. ||. ...|.
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

HPAF
|| |
HPWF
Kinase MEKK1.AA MEKK2 886-1152 37 1.4e-67 230.82 In-house 1-262 (262) Show / Hide 
Range on Protein: 886-1152
Range on HMM: 1-262/262
Sequence Identity: 37% (101 aa)

WTKGAILGTGAFSSCYMARDVKTGTLMAVKQISFCRNNAGDQEDTMEEIKKEIKLMATFDHPHIVRLMGATQHDA--HFNVFVEWMPGGAVSTLLKDFGA
| .| .|| |||   |.  || ||  .||||. |  ..  .    .. .. ||.|.    |. ||   |  .  .     .|.|.||||.|   || .||
WRRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQF-DPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKAYGA

FSNAVTVKYIHQVCLGLAYLHDNRVIHRDLKGANLLMDSTGHHLRIADLGTAGKMNADITRTDEFKGQFLGTISFMAPEVLRGEPYGRSCDIWSVGCCII
  ..|| ||  |.  |..||||. ..|||.||||.| ||.|  ....| | . ..          |    ||  .|.|||. || |||  |.||.|| ..
LTETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSG-NVKLGDFGASKRLQTICMHITGMK-SVTGTPYWMSPEVINGEGYGRKADVWSIGCTVV

EMCTTKPPWNNTAISNHYQLLFKIASANGPPPIPESLSPALRDITLRCLEAEPSARPGVMELLKHPAFT
|| |.||||   |       .||||  .  | .|...|   ||   ||       ||   |||.|  | 
EMLTEKPPW---AEYEAMAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRH-HFV
Kinase MEKK1.AA AGC 886-1151 21 4.3e-65 166.26 In-house 1-395 (395) Show / Hide 
Range on Protein: 886-1151
Range on HMM: 1-395/395
Sequence Identity: 21% (86 aa)

WTKGAILGTGAFSSCYMARDV------KTGTLMAVKQISFCR----NNAGDQEDTMEE--------IKKEIKLMATFD----------HPHIVR-LMGAT
     ..|.|.|. .| .|..       || . |.| ..  .    ..  ..| || |        ...| . ... .          || ||. |  . 
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QHDAH--FNVFVEWMP---------GG-AVSTLLK---DFGAFSNAVTVKYIHQ-------VCLGLAYLHD-NRVIHRD-LKGANLLMDSTGHHLRIADL
| . |       | ||         ||    . |.   . | |.  ..  |. .       ..|.| |||. . .|||| ||  |.|.|. | |....| 
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDG-HIKLTDF

GTAGKMNAD-----------------------------------------------ITRTDEFKGQFLG--TISFMAPEVLRGEPYGRSCDIWS--VGCC
| . ... |                                               .   ..    | |  |  .||||.|    ||..||.||  .||.
GLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTR-KKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCL

IIEMCTTKPPWNNTAIS-------NHYQLLFKIASA----NGPPPIP----------ESLSPALRDITLRCLEAEPSARPG----------VMELLKHPA
. || | .|| ..           |....  || .     | ....|          ...|| ..|.  ..|. .|. |.|          . |. .|| 
MYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPW

F
|
F
Kinase MEKK1.AA MEKK15 886-1151 35 1e-62 214.66 In-house 1-264 (264) Show / Hide 
Range on Protein: 886-1151
Range on HMM: 1-264/264
Sequence Identity: 35% (96 aa)

WTKGAILGTGAFSSCYMARDVKTGTLMAVKQISFCRNNAGDQEDTMEEIKKEIKLMATFDHPHIVRLMGATQHDAHFNVFVEWMPGGAVSTLLKDFGAFS
|.|| ||| ||.   |      || |.||||.     .    .     .. |..|. |  |  ||  .| . .|   |.|....|||..| ..  ||.  
WKKGNILGKGAYGTVYCGL-TNTGQLIAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSIINRFGPLD

NAVTVKYIHQVCLGLAYLHDNRVIHRDLKGANLLMDSTGHHLRIADLGTAGKMNAD-ITRTD-EFKGQFLGTISFMAPEVLRGEPYGRSCDIWSVGCCII
  |  || .|.  | .|||.| |.|||.||.|... .||  ... | | | ..    | ||  .      ||  .|||||.    |||  ||||.|| . 
EMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTG-IIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYGRKSDIWSIGCTVF

EMCTTKPPWNNTAISNHYQLLFKIASANGP-PPIPESLSPALRDITLRCLEAEPSARPGVMELLKHPAF
|| | ||||   |  .    .| | .  .| |..|.  |   |.    ||  .   ||  ..|||||  
EMATRKPPW---ADMDRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase MEKK1.AA ASK 891-1151 33 1.3e-55 183.31 In-house 1-254 (254) Show / Hide 
Range on Protein: 891-1151
Range on HMM: 1-254/254
Sequence Identity: 33% (90 aa)

ILGTGAFSSCYMARDVKTGTLMAVKQISFCRNNAGDQEDTMEEIKKEIKLMATFDHPHIVRLMGATQHDAHFNVFVEWMPGGAVSTLLK-DFGAFS-NAV
.|| |..   | .|| .|   .|.| |    ..          .. ||.|  .  |  ||. .|.. ....| .|.| .|||..| ||.  .| .  |  
VLGKGTYGIVYAGRDMHTQVRIAIKEIPERDSR------YVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNEN

TVK-YIHQVCLGLAYLHDNRVIHRDLKGANLLMDSTGHHLRIADLGTAGKMNADITRTDEFKGQFLGTISFMAPEVLRGEP--YGRSCDIWSVGCCIIEM
|.. | .|.  || |||.|...|||.|| | |.      ..|.| ||. .. | |.   |    | ||. .|||||.   .  ||.. ||||.|| ..||
TMNFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRL-AGINPCTE---TFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEM

CTTKPPWNNTAISNHYQLLFKIASANGPPPIPESLSPALRDITLRCLEAEPSARPGVMELLKHPAF
 | |||.    . .    .||.      |.|||.|| . ..  ||| | .|  |.   .||. |  
ATGKPPF--HELGEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase MEKK1.AA TKL 892-1140 19 1.7e-52 180.68 In-house 1-355 (364) Show / Hide 
Range on Protein: 892-1140
Range on HMM: 1-355/364
Sequence Identity: 19% (69 aa)

LGTGAFSSCYMARDVK--------TGTLMAVKQISFCRN---------------------NAGDQEDTMEEIKKEIKLMATFDHPHIVRLMGATQHDAH-
.| |.|.  | ..           ||. .|||...   .                     |. ...  ......||..|  ..||.||..||. .   . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FNVFVEWMPGGA-VSTLLKDFGAFSNAVTVKYIHQVCLGLAYLHDNR--------VIHRDLKGANLLMDSTGHH-------------L
            .    |..|||   ..|.         .... ......|..||| ..        .|||||| .|.| |. ...             .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

RIADLGTAGKMNADITRTDEF---------------KGQFLGTISFMAPEVLRGE----------------PYGRSCDIWSVGCCIIEMCTTKPPWNNTA
 |.|.|..  |. .   .|                 ..   ||. .||||||||.                .|  .||..| | .. |..| ..|. .  
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

ISNHY------QLLFKIASANGPPPIP------------ESLSPALRDITLRCLEAEPSARP
 . ..      . . .... . .||||            ..  | ....  .| ...|..||
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRP
Kinase MEKK1.AA CAMK 891-1151 18 3e-52 166.28 In-house 1-425 (425) Show / Hide 
Range on Protein: 891-1151
Range on HMM: 1-425/425
Sequence Identity: 18% (77 aa)

ILGTGAFSSCYMARDVKTG------------TLMAVKQIS---------------------FCRNNAGD-QEDTMEEIKKEIKLMAT-------FDHPHI
.||.|.|.  . ... .|.            .  |.| |.                      |.... . .. .......||..| .        |||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRLMG---------------ATQH-----DAHFNVFV---EWMPGG----AVSTLLKDF---------------GAFSNAVTVKYIHQVCLGLAYLHDNR
..|                   ..     | |.  .    | ..||     .   ...                | |. . . .|..|.| ...|.|.. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VIHRDLKGANLLMDSTG----------------HHLRIADLGTAGKMNA-------------------DITRTDEFKGQFLGTISFMA-PEVLRG-----
..|||||  |.|.|. .                . . |.| | | |..                    ... ...    | || ..|| ||||.|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------EPYGRSCDIWSVGCCIIEMCTTKPPWNNTAIS----------NHYQLLFKIASAN---GPPPIPE-------------------SLSPALR
         ..||..||.||.|.    | . .||..    .          | |.|. || ...    ||....                    .|.  .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DITLRCLEAEPSARPGVMELLKHPAF
|   ..|. .|. |. . . |.|| .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MEKK1.AA Pkinase_Tyr 886-1033 26 8.2e-22 74.49 Pfam 1-156 (270) Show / Hide 
Range on Protein: 886-1033
Range on HMM: 1-156/270
Sequence Identity: 26% (43 aa)

WTKGAILGTGAFSSCYMARDV----KTGTLMAVKQISFCRNNAGDQEDTMEEIKKEIKLMATF-DHPHIVRLMGATQ-HDAH--FNVFVEWMPGGAVSTL
 |.|  || ||| . |...      .|..  ||| .   ...| ...  .|.  .|.|.| .. .||.||||.|.   .. .    . .| ||.|   . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML---KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LKD----FGAFSNAVTVKYIHQVCLGLAYLHDNRVIHRDLKGANLLMDSTGHHLRIADLG
|..     ....    ... .|.. |..||.... |||||   | | .... . .|.| |
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFG
Kinase MEKK1.AA TyrKc 886-1151 23 3.2e-17 55.68 SMART 1-280 (280) Show / Hide 
Range on Protein: 886-1151
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

WTKGAILGTGAFSSCYMARDVKTGTLMAVKQISFCRNNAGDQEDTMEEIKKEIKLMATF--DHPHIVRLMGATQHD-------AHFNVFVEWMPGGAVST
 |.| .|| |||   | ..     .  ||| .  .          .|.. .|...|  .  .||.|||| |.  ..           . .| ||.|.   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

LLKDFGA-FSNAVTVKYIHQVCLGLAYLHDNRVIHRDLKGANLLMDSTGHHLRIADLGTAGKMNAD--------ITRTDE-FKGQFLGTISFMAPEVLRG
 |.. .  ....  ... .|.. | .|||....|||||   | | .. . . .|.| | . .   |          |. |   | ..  |  ||||... 
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

EPYGRSCDIWSVGCCIIEMCTT-KPPWNN-TA--ISNHYQLLFKIASANGPPPIPE-------SLSPALRDITLRCLEAEPSARPGVMELLKHPAF
  .    |.|| | |. |..|  ..|. . .   .|| .... .. . . .|. |.         .... .| ..| ...|. ||   |.  |  |
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSN-QEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MEKK1.AA Pkinase_Tyr 1059-1140 24 0.035113 8.01 Pfam 181-261 (270) Show / Hide 
Range on Protein: 1059-1140
Range on HMM: 181-261/270
Sequence Identity: 24% (21 aa)

MAPEVLRGEPYGRSCDIWSVGCCIIEMCT-TKPPWNNT--AISNHYQLLFKIASANGPPPIPESLSPALRDITLRCLEAEPSARP
||||...   .    |.|| | .. |..|  . |   |   .   .... .|.  ..  |.||  .. . |. ..| ...|. ||
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQP---TYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRP