Gene ASK (Sea Urchin)

ASK

Species: Sea Urchin
Alias: SpMEKK5, Spk223, SpMAP3K5, ASK, SpASK, SPU_025219
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: ASK

Sequence

Name Sequence Type Origin Length Description Download
ASK.AA Protein None 1250 None Fasta, JSON
ASK.kin_dom Protein Kinase Domain None 185 None Fasta, JSON

Protein domain

Protein domains of ASK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ASK_nterm_v5 ASK.AA ASK_nterm_v5 21-75 56 4.4e-33 116.22 In-house 1-55 (55) Show / Hide 
Range on Protein: 21-75
Range on HMM: 1-55/55
Sequence Identity: 56% (31 aa)

NFDRLDFGETKVLDRFYAADIVVVDVSVIVQQRTLFYHMGVRESFGKEKNVVLYN
.|.|||||||...|.|| ||.|.||.|. .||..||||.|||.||....|..||.
EFMRLDFGETDMFDEFYNADVVIVDMSIDHQQPNLFYHLGVRHSFKMRNNIILYC
TPR_ASK_1 ASK.AA TPR_ASK_1 191-224 52 2.7e-20 67.0 In-house 1-38 (38) Show / Hide 
Range on Protein: 191-224
Range on HMM: 1-38/38
Sequence Identity: 52% (20 aa)

GDIVHQFLLSYREIQDYNSMVSLVEAIK---QLKND-H
|||||.|..|||.||||.||..|||..|   ...|. .
GDIVHNFMHSYRDIQDYDSMIELVEDLKEGEHIPNCCK
TPR_ASK_2 ASK.AA TPR_ASK_2 267-309 67 3.7e-34 108.25 In-house 1-46 (46) Show / Hide 
Range on Protein: 267-309
Range on HMM: 1-46/46
Sequence Identity: 67% (31 aa)

PDMFCLCGRIYKDIYTESNYLD---FESRDNAIYWYRKGFEVQPNE
|||.|.|||||||...||.| |   .||||.||.|||||||.|||.
PDMWCMCGRIYKDMFLESQYTDEAARESRDQAIHWYRKGFEIQPNH
TPR_ASK_3 ASK.AA TPR_ASK_3 355-388 76 1.3e-21 78.15 In-house 1-34 (34) Show / Hide 
Range on Protein: 355-388
Range on HMM: 1-34/34
Sequence Identity: 76% (26 aa)

YWDVATFFEISVLAGDFSKASQAAECMFKLKPPI
|||||||||||.||.|..|. ||.|||||||||.
YWDVATFFEISILACDYHKCMQACECMFKLKPPN
Kinase ASK.AA ASK 570-823 75 2.5e-181 608.09 In-house 1-254 (254) Show / Hide 
Range on Protein: 570-823
Range on HMM: 1-254/254
Sequence Identity: 75% (192 aa)

MLGRGTFGVVYAARDCRTQVTIAVKEIPITDMREVQPLHEEILLHSRLSHKNIVKYLGSDIVGNTFKIYMEQVPGGSLSALLRSKWGPLKDHEDTIIYYT
.||.||.|.|||.|| .||| ||.||||  | |.|||||||| ||..| |.|||.|||..  .. |||.|||||||||||||||||||.||.|.|. .||
VLGKGTYGIVYAGRDMHTQVRIAIKEIPERDSRYVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTMNFYT

KQILEGLRYLHDQKIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGLNPAASSFKGTLQYMAPEVIDKGLRGHGAPADIWSLGCTIVEMATGKPPFIEL
|||||||.|||...|||||||||||||||||||||||||||.|||||.||....|.||||||||||||.| ||.|.||||||.|||.||||||||||.||
KQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPCTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMATGKPPFHEL

GSPQAAMFKVGFYKDHPEIPESLSNAAKEFILRCFEPDPEKRATAHDLLQDPFL
|.|||||||||.||.||||||.||...|.||||||||||.|||.|.||||||||
GEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase ASK.AA STE11 565-823 42 5.9e-159 534.38 In-house 1-303 (303) Show / Hide 
Range on Protein: 565-823
Range on HMM: 1-303/303
Sequence Identity: 42% (129 aa)

SKDRVMLGRGTFGVVYAARDCRTQVTIAVKEIPITDMR--------EVQP------LHEEILLHSRLSHKNIVKYLGSDIV---GNTFKIYMEQVPGGSL
 . . ..|.|.||.||..... |.. .|||.|.| ...        |.|.      ..||| |.. |.|||||.|.|. .     ....|.||..|||||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

SALLRSKWGPLKDHEDTIIYYTKQILEGLRYLHDQKIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGLNPAASS----------FKGTLQ--------
|..||.||||.|..| .| .||||||||| |||...|.||||||.|.|......|.|..|||..||||. .. ...          ..||..        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

YMAPEVIDKGLRG-HGAPADIWSLGCTIVEMATGKPPFIELGS-PQAAMFKVGFY-KDHPEIPESLS------NAAKEFILRCFEPDPEKRATAHDLLQD
.||||||... |. .|..|||||||||..||||||||. .... ..|||||.| . | ||.|||..|       ....|...|||.||.||.||..|||.
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

PFL
||.
PFI
Kinase ASK.AA STE 566-823 27 3.3e-109 369.1 In-house 1-359 (359) Show / Hide 
Range on Protein: 566-823
Range on HMM: 1-359/359
Sequence Identity: 27% (102 aa)

KDR-VMLGRGTFGVVYAARDCR---------------TQVTIAVKEIPITDM-----------------REVQPLHEEILLHSRLS--HKNIVKYLGSDI
 ..  ..|.|.||.|| |..                 |.. .|.|.... .                   |.| . .|| ......  |.|||||.|. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG-------NTFKIYMEQVPGGSLSALLRSKWGPLKDH-----------EDTIIYYTKQILEG-LRYLHDQKIVHRDIKGDNVLVNTYSGVVKISDFGTS
..       ..  |.|| ..||||. ....|.|..|..           |. |.|...|||.| | |||...|.|||||..|.|.      ||..|||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

KRLAGLNP------------AAS----SFKGTLQYMAPEVIDKG----LRGHGAPADIWSLGCTIVEMATGKPPFIELGSPQAAMFKVGFY---------
..|.  ..              .    .| ||  .||||||...      |... .|||||||||.||||||||. ..  ..| . .   |         
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----KDHPEIPE-------------------SLSNAAKEFILRCFEPDPEKRATAHDLLQ--DPFL
    ...| .|.                   ..|   |.|| .|.. ||.||.||..||.   ||.
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase ASK.AA STE11-Unclassified 566-823 36 1.8e-98 333.42 In-house 2-308 (308) Show / Hide 
Range on Protein: 566-823
Range on HMM: 2-308/308
Sequence Identity: 36% (114 aa)

KDRVMLGRGTFGVVYAARDCRTQVTIAVKEIPITDMR--------E-VQPLHEEILLHSRLSHKNIVKYLGSD--IVGNTFKIYMEQVPGGSLSALLRSK
. . ..|.|.|| || . .| |   .|||.| |.|.         | .| . .|. .   |.|||||.|.|      ..   |.||..||||....|. |
QKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLN-K

WGPLKDHEDTIIYYTKQILEGLRYLHDQKIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLA------------------GLN-PAAS------SFKGTLQ
 |..   | .|  ||||||||| ||| ..|.||||||.|.|. .  |..|..|||..|  .                   .  . .|      | .||..
YGCF--DEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDF-DGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPY

---YMAPEVIDKGLR-GHGAPADIWSLGCTIVEMATGKPPFIELGS--PQAAMFKVGFYKDHPEIPESLS-----------NAAKEFILRCFEPDPEKRA
   .||||||.     ||.. .||||||||..||||||.|.  .    ...|..|..  .  |.||| ||            ..|.|. .||. ||.||.
QPFWMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRP

TAHDLLQDPFL
||  |||.||.
TANQLLQHPFI
Kinase ASK.AA S_TKc 565-823 30 3.6e-90 306.77 SMART 1-231 (231) Show / Hide 
Range on Protein: 565-823
Range on HMM: 1-231/231
Sequence Identity: 30% (84 aa)

SKDRVMLGRGTFGVVYAARDCRTQVTIAVKEIPITDMREVQPLHEEILLHSRLSHKNIVKYLGSDIVGNTFKIYMEQVPG--GSLSALLRSKWGPLK---
 .    .|.|.||.|| .|. .|.   |.|.|.       . .  || ....  |.||||....    . . . || ..|  |.|  ..... .. .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

DHEDTIIYYTKQILEGLRYLHDQKIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGLNPAASSFKGTLQYMAPEVIDKGLRGHGA-PADIWSLGCTIVE
 .| .. .|..||...| |.|...|.|||.| .|.|...   ..||.||| ...|       ..| ||. ||||||.     |.|  ..|.||.||.. |
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYE

MATGKPPFIELGSPQAAMFKVGFYKDHPEIPESLSNAAKEFILRCFEPDPEKRATAHDLLQ-------DPFL
|..|.|||      ...|||.             |  ||.|| .|.. ||||| || ..||       .|..
MLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ASK.AA Pkinase 571-823 30 2.7e-73 254.63 Pfam 7-293 (293) Show / Hide 
Range on Protein: 571-823
Range on HMM: 7-293/293
Sequence Identity: 30% (88 aa)

LGRGTFGVVYAARDCRTQVTIAVKEIPITDMREVQPLHE----EILLHSRLSHKNIVKYLGSDIVGNTFKIYMEQVPGG----SLSALLR-SKWGPL--K
.|.|.||.|| ...  |. . |||.|.  . .. .. .     || .. ||.|.|||.....   ..   . || ..||    .|..... .. |..   
IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFS

DHEDTIIYYTKQILEGLRYLHDQKIVHRDIKGDNVLVNTYSGVV----KISDFGTSKRL-AGLNPAASSFKGTLQYMAPEVIDKGLRGHGAPADIWSLGC
  |.... | .|||.|| |.|...|.|||.| .|.|..   |..    ||.||| .| .    |. ...| ||. |||||||  | ...| ..|.||.||
--EWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMWSCGC

TIVEMATGKPPFIEL-----GSPQAAMFKVGFYKDHPEIPESLS-------------------NAAKEFILRCFEPDPEKRATAHDLLQDPFL
.. ||..|.||| .       .... .....  . | ..|.. |                    ..|.|| .|...||.|| ||...||.|..
ILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ASK.AA MEKK15 566-823 40 3.6e-70 239.43 In-house 2-264 (264) Show / Hide 
Range on Protein: 566-823
Range on HMM: 2-264/264
Sequence Identity: 40% (111 aa)

KDRVMLGRGTFGVVYAARDCRTQVTIAVKEIPITDM------REVQPLHEEILLHSRLSHKNIVKYLGSDIVGNTFKIYMEQVPGGSLSALLRSKWGPLK
|   .||.| .| ||       |. |||| . . ..      .. . | ||. |   | ||||| |||  .  |.  |.|. |||||.|...  ..||| 
KKGNILGKGAYGTVYCGLTNTGQL-IAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSII-NRFGPL-

DHEDTIIYYTKQILEGLRYLHDQKIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLA--GLNPAA----SSFKGTLQYMAPEVIDKGLRGHGAPADIWSLG
  |     ||||||.|  |||.  .||||||| ||..    |..|. |||  |||.  |.| .      | .||  .||||||     |.|  .||||.|
-DEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMP-TGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIME--TGYGRKSDIWSIG

CTIVEMATGKPPFIELGSPQAAMFKVGFY-KDHPEIPESLSNAAKEFILRCFEPDPEKRATAHDLLQDPFL
||. ||||.|||. ..  . |||| .|      |..|.  |  |..|.  |   | . |.|| .||. ||.
CTVFEMATRKPPWADM-DRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase ASK.AA STE20 566-823 33 4.5e-66 225.81 In-house 2-288 (288) Show / Hide 
Range on Protein: 566-823
Range on HMM: 2-288/288
Sequence Identity: 33% (98 aa)

KDRVMLGRGTFGVVYAARDCRTQVT----IAVKEIPITDM----REVQPLHEEILLHSRLSHKNIVKYLGSDIVG----NTFKIYMEQVPGGSLSALLRS
..   .|.|..|.|| |.. .|.      .|.| ... .      |.. .  ||.  ... |.|||||.|| ...    .   | ||   ||||. ... 
ELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKH

--KWG------PLKDHEDTIIYYTKQILEGLRYLHDQKIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAG-----LNPAASSFKGTLQYMAPEVIDKGL
  |.|      |..  |. | | ....|.|| ||| ..|.|||||.||.|... .| ||..||| .  |        ..   .| ||  .|||||| .  
CMKCGKNHKGHPMN--EEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTE-DGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCME

---RGHGAPADIWSLGCTIVEMATGKPPFIELGSPQAAMFKVGFYKDHP---EI--PESLSNAAKEFILRCFEPDPEKRATAHDLLQDPFL
    |..  .|||||| |. |||.|.||. .. .|  |||..   .  |   .   |.. |   ..|. .| . |||||.|| .||. ||.
GPDKGYDYKCDIWSLGITAIEMAEGEPPYFDM-HPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase ASK.AA CAMK 570-823 18 9e-62 197.53 In-house 1-425 (425) Show / Hide 
Range on Protein: 570-823
Range on HMM: 1-425/425
Sequence Identity: 18% (79 aa)

MLGRGTFGVVYAARDCRTQ------------VTIAVKEIPITDMRE----------------------------VQPLHEEILLHSRLS-------HKNI
 ||||.||.|. ... .|.            .  |.| |. . ...                             . .  || ....|.       |.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKYLGSDI------------VGNT--------FKIYM---EQVPGG----SLSALLRSK--------------WGPLKDHEDTIIYYTKQILEGLRYLHD
.| .                  ..        . . |   | ..||     |   ....              .| .  .|.   .| .||.....|.|.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRF--TEREARRYFRQICSAVHYCHS

QKIVHRDIKGDNVLVNTYS----------------GVVKISDFGTSKRLAGL-----------------------NPAASSFKGTLQYMA-PEVIDK-G-
..|||||.| .|.|... .                . .||.||| .... .                        ..  . | ||. ||| |||. . | 
HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

----------LRGHGAPADIWSLGCTIVEMATGKPPFIE-----------LGSPQAAMFK---VGFYK-DHPEIPE-------------------SLSNA
           ...| ..|.||.|.    | .|.||| .           .|  .  .|.    | |  ..|....                    .|  
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

AKEFILRCFEPDPEKRATAHDLLQDPFL
.| .| .. ..|||||.|... |..|..
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase ASK.AA MEKK2 566-823 41 8.1e-61 208.36 In-house 2-262 (262) Show / Hide 
Range on Protein: 566-823
Range on HMM: 2-262/262
Sequence Identity: 41% (112 aa)

KDRVMLGRGTFGVVYAARDCRTQVTIAVKEIPITD-----MREVQPLHEEILLHSRLSHKNIVKYLG--SDIVGNTFKIYMEQVPGGSLSALLRSKWGPL
.   .|| | ||.||   |  |   .||| ... .      .||| |. || |   | |. ||.| |   |    |  |.|| .||||.   |.  .|.|
RRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQFDPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKA-YGAL

KDHEDTIIYYTKQILEGLRYLHDQKIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGLNPAASSFK---GTLQYMAPEVIDKGLRGHGAPADIWSLGCT
   |     ||.|||||. ||||. |||||||| |.| .  || ||..||| ||||  .       |   ||  .|.||||.    | |  ||.||.|||
--TETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDS-SGNVKLGDFGASKRLQTICMHITGMKSVTGTPYWMSPEVING--EGYGRKADVWSIGCT

IVEMATGKPPFIELGSPQAAMFKVGFYKDHPEIPESLSNAAKEFILRCFEPDPEKRATAHDLLQDPFL
.||| | |||. |     ||.||.   .  |..|...|. |..|. |||      |  |..||.  | 
VVEMLTEKPPWAEYEA-MAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase ASK.AA Dicty2 569-823 37 1.3e-55 191.05 In-house 6-264 (264) Show / Hide 
Range on Protein: 569-823
Range on HMM: 6-264/264
Sequence Identity: 37% (101 aa)

VMLGRGTFGVVYAARDCRTQVTIAVKEIP----ITDMREVQP--LHEEILLHSRLSHKNIVKYLGSDIVGNTFKIYMEQVPGGSLSALLRSKWGPLKDHE
. .|.| ||.|| . .  |    | | |      |   | |   .  || |  .|.| |||||...  . |   | .| . .||||  .  | |..   |
EKIGKGAFGTVYKGLHIETGDFVAIKQINIMKKKTKISEEQHQSIMQEIHLLKKLNHHNIVKYIEHIETENHLYIILEYIENGSLSKIIK-KFGCFP--E

DTIIYYTKQILEGLRYLHDQKIVHRDIKGDNVLVNTY--SGVVKISDFGTSKRLA-GLNPAASSFKGTLQYMAPEVIDKGLRG--HGAPADIWSLGCTIV
  .. | .|.|.|| ||| |...|||||..| |...   |||.| .|||.   ..      . .. ||   ||||||   . |  .    ||||||||| 
SLCCIYIYQVLKGLVYLHRQGVIHRDIKAANILITKEGKSGVIKLADFGVATHIDYSDDDSRYTVVGTPYWMAPEVIQ--MSGNHCCTACDIWSLGCTII

EMATGKPPFIELGSPQAAMFKVGFYKDHPEIPESLSNAAKEFILRCFEPDPEKRATAHDLLQDPFL
|. || ||   |. | .|||.     ||| .|.  | . | | ..||  ||..|.||  ||. | .
ELLTGNPPYWDLN-PMHAMFRM-VQDDHPPLPNDISPECKDFLMQCFCKDPNQRMTAKQLLHHPWI
Kinase ASK.AA STE-Unique 633-823 27 2.5e-48 166.9 In-house 367-616 (616) Show / Hide 
Range on Protein: 633-823
Range on HMM: 367-616/616
Sequence Identity: 27% (69 aa)

NTFKIYMEQVPGGSLSALLRSKWGP--------LKDHEDTIIYYTKQILEGLRYLHDQK--IVHRDIKGDNVLVNTYS----GVVKISDFGTSKRLAGL-
|.. | ||  ..|.|. .. .  .|        .   |. .|.||.|||||| ||| |.  |.|||.| .|.. .         |||.|||......   
NWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFP--ETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDH

-------------------------------------NPAASSFKGTLQYMAPEVIDKG---LRGHGAPADIWSLGCTIVEMATGKPPFIELGSPQA-AM
                                     |    .  ||  ||.|||| .      .... .|||||||.. .|..| ||. .... || . 
FEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIE

FKVGFYKDHP-----EIPESLSNAAKEFILRCFEPDPEKRATAHDLLQDPFL
     ..  |     .||....    .||  |.|..| .|..||.||....|
MCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase ASK.AA Pkinase_Tyr 570-709 29 3.5e-21 72.36 Pfam 6-156 (270) Show / Hide 
Range on Protein: 570-709
Range on HMM: 6-156/270
Sequence Identity: 29% (46 aa)

MLGRGTFGVVYAARDCR-----TQVTIAVKEI-PITDMRE--VQPLHEEILLHSRL-SHKNIVKYLGSDI-VGNT--FKIYMEQVPGGSLSALLRSK--W
.||.| ||.|| .. ..     |... ||| . . .. ..   . . .|. . . | .|.|||...|  .  |      | || .|.|.|   ||..  .
KLGEGAFGEVYKGT-WKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHRED

GPLKDHEDTIIYYTKQILEGLRYLHDQKIVHRDIKGDNVLVNTYSGVVKISDFG
..  ...| .. .  || .|. ||......|||.   |.||.  ..||||.|||
KQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-NNVVKICDFG
TyrKc ASK.AA TyrKc 564-821 23 5.8e-17 51.51 SMART 1-280 (280) Show / Hide 
Range on Protein: 564-821
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

ESKDRVMLGRGTFGVVYAARDCRTQVTIAVKEIPITDMREVQPLHEEILLHSRL--SHKNIVKYLGSDIVG-------NTFKIYMEQVPGGSLSALLRSK
 ..... ||.| ||.|| ..     .. ||| .       .. ...|. . ..|  .|.|||. .|  . .           | || .|.|.|   ||..
ITLGKK-LGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

WGPLKDHEDTIIYYTKQILEGLRYLHDQKIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAG---------LNPAAS--SFK--GTLQYMAPEVIDKGLR
 .      .. ...  || .| .|||.....|||.   |.||.    .||||||| |. .              ...  . |    .  ||||.|..|  
RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

GHGAPADIWSLGCTIVEMAT-GKPPFIE-----LGSPQA-AMFKVGFYKDHPEI------PESLSNAAKEFILRCFEPDPEKRATAHDLLQDP
 .    |.|| | .. |. | |..|  .     .   .. .  | |.. . |.       ..  .   .  ...| . |||.| |  .. .. 
TTK--SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase ASK.AA STE-Unique 566-628 30 3.6e-14 46.21 In-house 1-69 (616) Show / Hide 
Range on Protein: 566-628
Range on HMM: 1-69/616
Sequence Identity: 30% (21 aa)

KDRVMLGRGTFGVVYAARDCRTQVTIAVKEIPITDMRE------VQPLHEEILLHSRLSHKNIVKYLGS
 . .|.||| ||.|. ...  .  . |.| |..   .       |... .|| ....|.| |||||.|.
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGH
Kinase ASK.AA Pkinase_Tyr 731-820 25 2.895313 1.52 Pfam 181-269 (270) Show / Hide 
Range on Protein: 731-820
Range on HMM: 181-269/270
Sequence Identity: 25% (23 aa)

MAPEVIDKGLRGHGAPADIWSLGCTIVEMAT-GKPP-FIELGSPQAAMFKVGFYKDHPEIPESLSNAAKEFILRCFEPDPEKRATAHDLLQD
||||.|  |        |.|| | .. |. | |. | . .. |..  . ...      ..||  .    . ...| ..|||.| |  .....
MAPECINYGK--FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQ
Sam7 ASK.AA sam7 1182-1244 27 1.2e-14 49.99 In-house 1-70 (70) Show / Hide 
Range on Protein: 1182-1244
Range on HMM: 1-70/70
Sequence Identity: 27% (19 aa)

AKQEELSSWLQAVGL--DEDSIRRFIEEDL----TLPLVLNSMTRDDLRSLKI-RVGAQVRIWDAVQQHR
  .|... ||...|.  ... . .| ...     |   .|  ||..||....| |.| . .|| ..||.|
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
SAM_2 ASK.AA SAM_2 1179-1244 25 4.2e-07 27.22 Pfam 1-71 (71) Show / Hide 
Range on Protein: 1179-1244
Range on HMM: 1-71/71
Sequence Identity: 25% (18 aa)

GVEAKQEELSSWLQAVGLDEDSIRRFIEEDLTLPLVL-NSMTRDDL--R-SLKI-RVGAQVRIWDAVQQHR
 .    |....||...|....    | .  .|   .|   || |||     ..|  || . .|| ..|. .
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK
SAM ASK.AA SAM 1179-1246 18 5.5e-07 30.46 SMART 1-67 (67) Show / Hide 
Range on Protein: 1179-1246
Range on HMM: 1-67/67
Sequence Identity: 18% (13 aa)

GVEAKQEELSSWLQAVGLDEDSIRRFIEEDLTLPLVLNSMTRDDLRSLKI-RVGAQVRIWDAVQQHRMN
    . |... ||.. |...  .  |... ..  . |. ....|| ...| ..|.. .|. |.|. . .
VD-WTPEDVCDWLESIGMCQ-YKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ