Gene MKK5 (Sea Urchin)

MKK5

Species: Sea Urchin
Alias: MKK5, SPU_009399, Spk247
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: MEK5

Sequence

Name Sequence Type Origin Length Description Download
MKK5.AA Protein None 286 None Fasta, JSON
MKK5.kin_dom Protein Kinase Domain None 201 None Fasta, JSON

Protein domain

Protein domains of MKK5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MKK5.AA MEK5 55-255 84 3e-168 565.26 In-house 53-254 (254) Show / Hide 
Range on Protein: 55-255
Range on HMM: 53-254/254
Sequence Identity: 84% (170 aa)

KCDSPFIIGFYGAFFTENRISICTEFMDGGSLEMYRCIPESILGRMTVSIVKGLNYLWNLKIMHRDVKPSNILVNTQGEIKLCDFGVSAQLVSSITRTYI
|||||.|||||||||.||||||||||||||||.|||||||.|||||||.||||||||||||||||||||||.||||||.|||||||||.|||.|||||||
KCDSPYIIGFYGAFFVENRISICTEFMDGGSLDMYRCIPEHILGRMTVAIVKGLNYLWNLKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTYI

GTNAYMAPERVLGDEYGVHSEVWSLGVFLLEMATGRFPYPATPRDQ-ELSPIALLQCIVEEHPPRLPSDKFSAPFVDFVNRCLQKRPGDRPKPQDLMQHP
||||||||||..||.||.||.|||||.|..||||||||||...||| ||.||.||||||.|||||||.||||.|||.|.|.|.||.|.||||||||||||
GTNAYMAPERISGDQYGIHSDVWSLGIFFMEMATGRFPYPQIQRDQGELMPIQLLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHP

FI
||
FI
Kinase MKK5.AA STE7 53-255 48 6.7e-129 434.54 In-house 52-288 (288) Show / Hide 
Range on Protein: 53-255
Range on HMM: 52-288/288
Sequence Identity: 48% (117 aa)

CMKCD-SPFIIGFYGAFFTENR--ISICTEFMDGGSLEMY-------------RCIPESILGRMTVSIVKGLNYLWN-LKIMHRDVKPSNILVNTQGEIK
..||. .|.|..|||||.||..  |.|| |.||||.|...             ..|||.|||...|...|||.||.. .||.||||||||||||..|..|
LHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYRGIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVK

LCDFGVSAQLVSSI--TRTYIGTNAYMAPERVLG--DEYGVHSEVWSLGVFL-LEMATGRFPYP-----ATPRDQ-------ELSPIALLQCIVEE-HPP
|||||.. ||| |.    |..|...||||||  |  . |.|.|.|||||. . .||||||.|||     .....|       |...  .|.|||.| .||
LCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLGITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPP

RLPSDKFSAPFVDFVNRCLQKRPGDRPKPQDLMQ-HPFI
|||  |||..|.||||.|||| | .|||...||. ||||
RLP--KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase MKK5.AA STE7-Unclassified 55-255 38 4.9e-93 315.39 In-house 60-301 (301) Show / Hide 
Range on Protein: 55-255
Range on HMM: 60-301/301
Sequence Identity: 38% (92 aa)

KCD-SPFIIGFYGAFFTENR---ISICTEFMDGGSLE-----MYRC----------IPESILGRMTVSIVKGLNYLWNLK-IMHRDVKPSNILVNTQGEI
||  .|.|...|||...| .   | || |.||.|||.     . .           |||..||... .. .|| ||.. . | |||.||.||||| .|..
KCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKIDIYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQV

KLCDFGVSAQLVSSI--TRTYIGTNAYMAPERVLGD-----EYGVHSEVWSLGVFLLEMATGRFPYP----ATPRDQELSP-----IALLQCIVEEHPPR
|.|||||..||....    | .|.  ||.|||  |.      |.| |..||||  ..|.|||..||.        .|  .|     . ||.|||..  ||
KICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRPSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPR

LPSDK----FSAPFVDFVNRCLQKRPGDRPKPQDLMQ-HPFI
||.|.    .|. | ||...|..| | .|| . .|   ||.|
LPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHPWI
Kinase MKK5.AA STE 53-255 31 1.3e-89 304.03 In-house 82-359 (359) Show / Hide 
Range on Protein: 53-255
Range on HMM: 82-359/359
Sequence Identity: 31% (90 aa)

CMKCD--SPFIIGFYGAFFTE-------NRISICTEFMDGGSLE-MYR-----------------CIPESILGRMTVSIVKG-LNYLWNLKIMHRDVKPS
..||.  .|.|. .||..| |       . . || |.||||||. ...                 ..|||........|.|| |.|| ...|.|||.||.
MKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPA

NILVNTQGEIKLCDFGVSAQLVSSIT----------------R--TYIGTNAYMAPERVLG------DEYGVHSEVWSLGVFLLEMATGRFPYPATPRDQ
|||.     .|||||||..||..|..                .  | .||  .||||....      ..|.. . .||||  ..|||||. |.   .  .
NILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMR

ELSPIA----------LLQCIVEEHPPRLPSD------------------KFSAPFVDFVNRCLQKRPGDRPKPQDLMQ--HPFI
 . .|.          .| |||...||.||..                  |.| .| ||.|.|||| | .||....|..  ||||
AMFMIPFNYHMQQQFEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MKK5.AA MEK3 57-255 45 7.9e-70 236.66 In-house 56-264 (264) Show / Hide 
Range on Protein: 57-255
Range on HMM: 56-264/264
Sequence Identity: 45% (97 aa)

DSPFIIGFYGAFFTENRISICTEFMDGGSL-----EMYR----CIPESILGRMTVSIVKGLNYLWN-LKIMHRDVKPSNILVNTQGEIKLCDFGVSAQLV
| |. . |||| | |  . || | ||  .|       |      |||.|||.. .|||..|.|.   ||. ||||||||.|.|..| .|.||||.| .||
DCPYTVHFYGAMFREGDVWICMEVMD-TCLDKFYRHVYKPHGMHIPEDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLV

SSITRTY-IGTNAYMAPERVLGD----EYGVHSEVWSLGVFLLEMATGRFPYPATPRDQELSPIALLQCIVEEHPPRLPSDK-FSAPFVDFVNRCLQKRP
 |.  |   |   ||||||. ..     | | | |||||. . |||.||.||     |    |   |. .||| ||.|| .| ||. ..||.|.||.| .
DSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEMAIGRYPY-----DNWHTPFQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNY

GDRPKPQDLMQHPFI
  ||. . ||.|||.
MERPSYPELMEHPFM
Kinase MKK5.AA MEK1 55-202 55 1.3e-66 226.63 In-house 53-204 (297) Show / Hide 
Range on Protein: 55-202
Range on HMM: 53-204/297
Sequence Identity: 55% (85 aa)

KCDSPFIIGFYGAFFTENRISICTEFMDGGSLEM----YRCIPESILGRMTVSIVKGLNYLW-NLKIMHRDVKPSNILVNTQGEIKLCDFGVSAQLVSSI
.| ||.|.||||||. .. |||| |.||||||..       |||.|||...| ...|| ||  . ||||||||||||||| .||||||||||| ||. |.
ECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKAGRIPEKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM

TRTYIGTNAYMAPERVLGDEYGVHSEVWSLGVFLLEMATGRFPYPATPRDQEL
   ..|| .||.|||. |  | | |..||.|. | ||| ||.| |. | ..|.
ANSFVGTRSYMSPERLQGTHYTVQSDIWSMGLSLVEMAIGRYPIPP-PDQKEY
Kinase MKK5.AA MEK4 57-255 42 2.3e-66 215.54 In-house 62-275 (275) Show / Hide 
Range on Protein: 57-255
Range on HMM: 62-275/275
Sequence Identity: 42% (92 aa)

DSPFIIGFYGAFFTENRISICTEFMDGGSLEMYRC--------IPESILGRMTVSIVKGLNYL-WNLKIMHRDVKPSNILVNTQGEIKLCDFGVSAQLVS
. | |. |||| | |    || | ||     .|.         |||.|.|. || .|. ||||  ..|| ||||||||||.. .| .||||||.. ||| 
NCPYIVKFYGACFKEGDCWICMELMDISMDKFYKYVYMVQKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVD

SITRTY-IGTNAYMAPERVLG----DEYGVHSEVWSLGVFLLEMATGRFPYPATPRDQELSPIALLQCIVEEHPPRLPSDKF----SAPFVDFVNRCLQK
|| .|   |   ||||||.      | | . |.|||||. . | |||.|||.     .. | .  .. .|.  ||.| .|..    | |...|.| || |
SIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLGITMYEVATGKFPYRKW---NDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTK

RPGDRPKPQDLMQHPFI
   .||| ..| ..||.
DRNHRPKYDNLKKFPFY
Kinase MKK5.AA MEK7 51-255 42 5.7e-62 209.03 In-house 50-269 (269) Show / Hide 
Range on Protein: 51-255
Range on HMM: 50-269/269
Sequence Identity: 42% (96 aa)

VHCMKCDSPFIIGFYGAFFTENRISICTEFM----DGGSLEMYRC----IPESILGRMTVSIVKGLNYLWNL-KIMHRDVKPSNILVNTQGEIKLCDFGV
| ||  |.|.|.  .|.| |.  . || | |    |     ..      ||| |.|.|.|.|.. |.||     ||||||||||||   .| |||||||.
VMCMCHDCPYIVQCFGYFMTDSDVWICMECMSTCCDKLLKRIKHPKLDFIPEQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGI

SAQLVSSITRTYI-GTNAYMAPERVLG-----DEYGVHSEVWSLGVFLLEMATGRFPYPATPRDQELSPIALLQCIVEE--HPPRLPSDK---FSAPFVD
|  .| |  .|   |  |||||||.       ..| . . |||||. | |.|||..|||    . |      .  | ..   ||.||  .   ||  | .
SGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVELATGQYPYPGCDMEFE-----MMTKILNDNLEPPCLPEHMKYNFSPDFCQ

FVNRCLQKRPGDRPKPQDLMQHPFI
||. |||| . .||| . |||||||
FVDKCLQKDHRMRPKYRMLMQHPFI
Kinase MKK5.AA Pkinase 55-255 28 3.1e-57 201.28 Pfam 56-293 (293) Show / Hide 
Range on Protein: 55-255
Range on HMM: 56-293/293
Sequence Identity: 28% (70 aa)

KCDSPFIIGFYGAFFTENRISICTEFMDGG----SLE------MYRCI--PESILGRMTVSIVKGLNYLWNLKIMHRDVKPSNILVNTQGEI----KLCD
....|.|. .|..| ....| ...|...||    .|       ...|.  .|  . ..   |..||.|. . .|.|||.||.|||.. .|.|    |.||
RLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICD

FGVSA---QLVSSITRTYIGTNAYMAPERVL-GDEYGVHSEVWSLGVFLLEMATGRFPYPATPRDQELSPIALLQCIVEEHPPRLPSDKF----------
||...      .| . |. ||  ||||| .. | .||  . .||.|. | ||..||.|.|  .  .. . .  .|.|..  .|.|..| .          
FGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC--WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFF

------------SAPFVDFVNRCLQKRPGDRPKPQDLMQHPFI
            | .. ||...||.| | .|| .....|||..
RHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MKK5.AA STE20 55-255 32 3.6e-53 182.95 In-house 60-288 (288) Show / Hide 
Range on Protein: 55-255
Range on HMM: 60-288/288
Sequence Identity: 32% (76 aa)

KCDSPFIIGFYGAFFTE----NRISICTEFMDGGSL-EMYR------------CIPESILGRMTVSIVKGLNYLWNLKIMHRDVKPSNILVNTQGEIKLC
.|..| |. .||... .    . . |. |...|||| ....             . |.    ..  ...||.|| . .|.|||.|  |||....||.||.
QCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLA

DFGVSAQLVS----SIT---RTYIGTNAYMAPERVLG-----DEYGVHSEVWSLGVFLLEMATGRFPYPATPRDQELSPIALLQCIV--EEHPPRLP---
||||.||| .    ..     | .||  .|||| ...      .|.  . .||||  ..|||.|. ||       ...|   .  |    . ||.|    
DFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPY------FDMHPMRAMFMIPKNQNPPPTLKDDK

SDKFSAPFVDFVNRCLQKRPGDRPKPQDLMQHPFI
..|.|  | |||..|||| | .|| ...|..||||
PHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
S_TKc MKK5.AA S_TKc 21-255 24 1.5e-47 165.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 21-255
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

TDFIEE----------------SHKSIICKKAWPKTWQVTATCTQCVHCMKCDSPFIIGFYGAFFTENRISICTEFMDG--GSLEMYRC----------I
 .....                ...   .|.          ..     ..| . |.|. .|..| . ... ...|..||  |.|  | .          .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PESILGRMTVSIVKGLNYLWNLKIMHRDVKPSNILVNTQGEIKLCDFGVSAQLVSSITRTYIGTNAYMAPERVLGDEYGV-HSEVWSLGVFLLEMATGRF
||    ...  |...|.|. ...|.|||.||.|||...  .||.||||...||     .|..||  ||||| .    ||   . .||.|. | ||..|. 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYP

PYPATPRDQELSPIALLQCIVEEHPPRLPSDKFSAPFVDFVNRCLQKRPGDRPKPQDLMQ-------HPFI
|.|         . .... |.            | .. ||...|||| | .||   ...|       ||..
PFP--------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MKK5.AA Ciliate-E2 53-255 21 6.1e-46 155.68 In-house 86-365 (365) Show / Hide 
Range on Protein: 53-255
Range on HMM: 86-365/365
Sequence Identity: 21% (64 aa)

CMKCDSPFIIGFYGAFF--TENRISICTEFMDGGSLEMYRC---------------IPESILGRMTVSIVK---------------GLNYLWNLK-IMHR
. . ..|.|| .| .|   ..| | . .|. .||.|. |                 . |   ....  |..               .|.|| . . |.||
LEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHR

DVKPSNILVNTQGEIKLCDFGVSAQLVSS---------------------------------ITRTYIGTNAYMAPERVLGDE---------YGVHSEVW
| ||.|||.     ||..||| | ..  .                                 ...|..||  ||||| . | .         |.  . .|
DIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIW

SLGVFLLEMATGRFPYPATPRDQELSPIALLQCIVEEHPPRLP-----------------SDKFSAPFVDFVNR----CLQKRPGDRPK-PQDLMQHPFI
|||| | || .|..|.               | . .. . ..|                  .| |    |. ..    .||| |  |.  ......||..
SLGVILYEMLFGKPPF---------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MKK5.AA MEK1 207-255 48 1.6e-16 52.53 In-house 249-297 (297) Show / Hide 
Range on Protein: 207-255
Range on HMM: 249-297/297
Sequence Identity: 48% (24 aa)

LLQCIVEEHPPRLPSDKFSAPFVDFVNRCLQKRPGDRPKPQDLMQHPFI
.|. ||.|.||.||.  ||  |.|||. ||.|.| .|   . ||.|.||
MLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
TyrKc MKK5.AA TyrKc 4-258 19 1.5e-11 -35.9 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

IKLKCLL---HFKEFAMTFYTDFIEESHKSIICKKAWPKTWQVTATCTQCVHCMKC--DSPFIIGFYGAFFTE-------NRISICTEFMDGGSLEMYR-
|.|.  |   .| |     ..            |.  . .  . . .      .|   . | |. .||.  ..         . | .|.|..|.|  |  
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

---C-IPESILGRMTVSIVKGLNYLWNLKIMHRDVKPSNILVNTQGEIKLCDFGVSAQLVSS-----ITRTYI-----GTN-----AYMAPERVLGDEYG
     .. . |  . . | .| .||   .. |||    |.||. .. .| .||| |  . .       . .|      |..       ||||     .. 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

VHSEVWSLGVFLLEMATGRFPYPATPRDQE----LSPIALLQCIVEEHPPRLPSD-------KFSAPFVDFVNRCLQKRPGDRPKPQDLMQHPFIRIF
  | ||| || . |. |    | ..|   .    .|.. ..... . . .. | .         ..   .   .| .  | |||  ...     ...|
TKSDVWSFGVCMWEIFT----YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase MKK5.AA Pkinase_Tyr 125-194 30 0.000347 14.8 Pfam 141-217 (270) Show / Hide 
Range on Protein: 125-194
Range on HMM: 141-217/270
Sequence Identity: 30% (24 aa)

NILVNTQGEIKLCDFGVSAQL-VSSITRTYIGTNAY-----MAPERVLGDEYGVHSEVWSLGVFLLEMAT-GRFP-YP
|.||. .. .| |||| .  .   .   .. ....      ||||     .. . | ||| || . |. | |. | ||
NCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYP