Gene RET (Sea Urchin)

RET

Species: Sea Urchin
Alias: Spk285, SPU_016716, RET
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: Ret

Sequence

Name Sequence Type Origin Length Description Download
RET.AA Protein None 998 None Fasta, JSON
RET.kin_dom Protein Kinase Domain None 267 None Fasta, JSON

Protein domain

Protein domains of RET.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RET.AA Ret 668-934 71 3e-236 791.15 In-house 1-267 (293) Show / Hide 
Range on Protein: 668-934
Range on HMM: 1-267/293
Sequence Identity: 71% (190 aa)

LLFEDELGEGHFGRVVRAQALSIRGHTGYTTVAVKMLKRDTATSAELHDLLTELELLKLLNHTNVIRLLGACIPKDPFETCVIVEYCKYGCLREFLRLNR
|...|.|||||||.||.|||..||||.||||||||||||.||.|.|.||||.|..|||..||..||.|.||||..|||.||.||||||||||||||||.|
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQVNHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLSR

KKALYTEYSISNESSSIPGLSRGKDVIKRFDIGFKEIASFAWQICKGMHYISSLKVVHRDLAARNVLVAEGLLLKISDFGLTRDVYERGLYERQSKSLLP
|...|.||||.|...||.....|||||.|||||.|.|.||||||||||||.|..|.|||||||||||||||...|||||||||||||...|...||...|
KIGPYYEYSIGNRNCSIVDHPDGKDVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIP

VKWMAVEALYDNVFTVKSDVWSFGILLWEIVTMGAIPYPGVTAERLCQLLRDGYRMDRPEECSEELF
|||||.|.|||.|.|.||||||||.|.||||||||.||||...|||.|||..||||||||.||||..
VKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGANPYPGIPPERLWQLLKTGYRMDRPENCSEEMY
Kinase RET.AA Pkinase_Tyr 668-933 36 1.7e-113 385.04 Pfam 1-245 (270) Show / Hide 
Range on Protein: 668-933
Range on HMM: 1-245/270
Sequence Identity: 36% (100 aa)

LLFEDELGEGHFGRVVRAQALSIRGHTGYTTVAVKMLKRDTATSAE--LHDLLTELELLKLL-NHTNVIRLLGACI-PKDPFETCVIVEYCKYGCLREFL
. |  .||||.||.|... .    .  . ..|||||| ...|.. .  . |.. |....| | .| |..||.|.|.  ..| . ....||...|.|...|
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RLNRKKALYTEYSISNESSSIPGLSRGKDVIKRFDIGFKEIASFAWQICKGMHYISSLKVVHRDLAARNVLVAEGLLLKISDFGLTRDVYERGLY-ERQS
| .|                            .  .  |.. ...|||.||| | .| . .||||||||.||.|..  ||.||||.||.|. . |   ..
RKHR--------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRG

KSLLPVKWMAVEALYDNVFTVKSDVWSFGILLWEIVTMGAIP-YPGVTAERLCQLL-RDGYRMDRPEECSEEL
.. ||.|||| |.. ...||.||||||||.|.|||.| |..| |||.. |...... .|||||..|| |..|.
GGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEI
Kinase RET.AA FGFR 668-935 42 3.2e-106 359.19 In-house 1-270 (293) Show / Hide 
Range on Protein: 668-935
Range on HMM: 1-270/293
Sequence Identity: 42% (116 aa)

LLFEDELGEGHFGRVVRAQALSIRGH--TGYTTVAVKMLKRDTATSAELHDLLTELELLKLL-NHTNVIRLLGACIPKDPFETCVIVEYCKYGCLREFLR
|     |||| ||.|..| |  |        .|||||||| . .|  .| ||  |.| .|.   | |.|.|||.|    |    ||||||. | ||.|||
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMN-HTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPL--YVIVEYCHHGNLRDFLR

LNRKKALYTEYSISNESSSIPGLSRGK-DVIKRFDIGFKEIASFAWQICKGMHYISSLKVVHRDLAARNVLVAEGLLLKISDFGLTRDVYERGLYERQSK
 .| ..   ......     |  . .. |.    ....|.  |.|.|. .|| |  | |..||||||||||| ..  .||.|||| ||. .   |   . 
ARRPPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTN

SLLPVKWMAVEALYDNVFTVKSDVWSFGILLWEIVTMGAIPYPGVT-AERLCQLLRDGYRMDRPEECSEELFV
  ||.|||| ||| |.|.|..|||||.|.||||| | |  |||..  .| | ..|. |.||..|..||.|...
GRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYH
Kinase RET.AA TK 668-934 23 1.9e-102 344.35 In-house 1-462 (486) Show / Hide 
Range on Protein: 668-934
Range on HMM: 1-462/486
Sequence Identity: 23% (109 aa)

LLFEDELGEGHFG---RVVRAQALSIR--------------------GHTGYTTVAVKMLKRDTATSAELHDL---------------LTELELLK--LL
. ....||||.||   .| .... ...                    .  | |.||||||| ..|.|.| . .               . |.....  |.
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

NHTNVIRLLGACIPKDP----------FETCVIVEYCKYGC----LREFLRLNRKKALYTEYSIS---------------------NESSSIPGLSRGKD
.| |..||.|.|  ..|             ....||...|.    ||..|| .|.|.   .....                     . .|. |  ....|
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

VIK------RFDIGFKEIAS-------------------FAWQICKGMHYISSL------KVVHRDLAARNVLVAEGLL-----------LKISDFG---
...        ....|.  .                   ..|||..|| |..|.      ..|||||||||.||.|..             ||.|||   
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LTRDVYERGLYERQS------------------------KSLLPVKWMAVEALYDNV---------FTVKSDVWSFGILLWEIVTMGAIPYPG-V
     |.||.|... | |.|                        .  ||..||| |.| |.|         || ||||||||.|.|||.| |. ||.| .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TA---------ERLCQLLRDG--------------YRMDRPEECS--------------EELF
.          . ....||.|              .|| .|. |.              ||..
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYY
Kinase RET.AA TyrKc 668-950 30 4.2e-102 346.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 668-950
Range on HMM: 1-280/280
Sequence Identity: 30% (100 aa)

LLFEDELGEGHFGRVVRAQALSIRGHTGYTTVAVKMLKRDTATSAELHDLLTELELLKLL--NHTNVIRLLGACIPK-------DPFETCVIVEYCKYGC
. ....||||.||.|.....         ..||||||| |.     . |.. |..... |  .| |..||.|.|. .       .|   ....||...|.
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPL--MIVMEYMPHGD

LREFLRLNRKKALYTEYSISNESSSIPGLSRGKDVIKRFDIGFKEIASFAWQICKGMHYISSLKVVHRDLAARNVLVAEGLLLKISDFGLTRDVYER---
|...|| .|.|                             .  |.  ||.|||..|| |..| ...||||||||.||.|..  |||||||.||.|.    
LKDYLRKHRPK-----------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQ

----GLYER----QSKSLLPVKWMAVEALYDNVFTVKSDVWSFGILLWEIVTMGAIPYPG-----VTAERLCQLLRDGYRMDRPEE--------CSEELF
      |      ..|..||..||| |.. ...|| ||||||||...||| | |. ||||     ...... .....||||..|..        |..|..
GESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMY

VPQSEYLDL--------SDINGDL
   ..  .         |.|  ..
QIMKQCWHEDPEDRPTFSEIHECF
Kinase RET.AA TK-Unique 668-934 39 4.2e-94 318.94 In-house 1-270 (294) Show / Hide 
Range on Protein: 668-934
Range on HMM: 1-270/294
Sequence Identity: 39% (115 aa)

LLFEDELGEGHFGRVVRAQALSIRGHTGYT-TVAVKMLKRDTATSAELHDLLTELELLKLLN-HTNVIRLLGACIPKDPFETCVIVEYCKYGCLREFLRL
| ..|..||| || | |... .| .| . .  |||||||.. ||  .  |.| |....| |  | |....||.|. .| . .. | ||| .|.|. .|| 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDN-ATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRT

NRKK--ALYTEYSISNESSSIPGLSRGKDVIKRFD------------IGFKEIASFAWQICKGMHYISS--LKVVHRDLAARNVLVAEGLLLKISDFGLT
.|..    .  | . .                 ||            |  |  ..|||||..|| |..|   |.|||||.|||||..|.. .||.|||..
CRPAMRQHQ-TYGNLK-----------------FDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMA

RDVYERGLYERQ-SKSLLPVKWMAVEALY--DNVF-TVKSDVWSFGILLWEIVTMGAIPYPGVTAERLCQLLRDGYRMDRPEEC-SEELF
|||| .| |... |.. .|..||| |.|.  .... | ||||||||.|.|||.|.|| ||||. .... ...||||||..||.| |.|..
RDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMY
Kinase RET.AA VEGFR 674-927 37 1.2e-87 297.49 In-house 7-301 (332) Show / Hide 
Range on Protein: 674-927
Range on HMM: 7-301/332
Sequence Identity: 37% (111 aa)

LGEGHFGRVVRAQALSIRGHTGYTTVAVKMLKRDTATSAELHDLLTELELLKLL-NHTNVIRLLGACI---PKDPFETCVIVEYCKYGCLREFLRLNRKK
||.| || |. |.|  ||.  . |||||||||  .||. |   |..||..|. . .| ||  .||.|    .| |    ||||||..| |  .||  |. 
LGRGAFGQVHEASAFGIRKMETCTTVAVKMLK-EGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPL--MVIVEYCCFGNLSNYLRTKRMY

-ALYTEY------------------------SISNESSSIPGLSRGKDVIKRFD------------IGFKEIASFAWQICKGMHYISSLKVVHRDLAARN
  .| .                         |..   ||  . .| | .. .              .  ..  ... |. .|| . .| |..||||||||
FVPYPDKSPHMRQRKECMGPQDHQDHKRRRDSGNSFQSSFGSFFRMKKSYDDVEPDEVFEDMWKDPLTMEDLICYSFQVARGMEFLASRKCIHRDLAARN

VLVAEGLLLKISDFGLTRD-VYERGLYERQSK-SLLPVKWMAVEALYDNVFTVKSDVWSFGILLWEIVTMGAIPYPGVT-AERLCQLLRDGYRMDRPE
.|..|   .||.|||| |.  |    | |. .   || |||| |.. |.|.| .|||||.|..|||| . |. |||||   | .|. |.||||| .|.
ILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPD
Kinase RET.AA UTK 668-934 30 4.7e-80 272.27 In-house 1-272 (296) Show / Hide 
Range on Protein: 668-934
Range on HMM: 1-272/296
Sequence Identity: 30% (92 aa)

LLFEDELGEGHFGRVVRAQALSIRGHTGYTTVAVKMLKRDTATSAELH---DLLTELE---LLKLLN-HTNVIRLLGACIPKDPFETCVIVEYCKYGCLR
. . ..||.|.|| | .| .  ...| .   |||| .... ..  |     |.. |     ..| .. | ||.||.| |    |  .....||.. | ||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP--WMIVTEYMENGDLR

EFLRLNRKKALYTEYSISNESSSIPGLSRGKDVIKRFDIGFKEIAS------FAWQICKGMHYISSLKVVHRDLAARNVLVAEG-------LLLKISDFG
 .|| .|...                             .. .. .      .||.|  ||.|..| ..|||||||||.||..        .. ||.|||
SYLRRHRPTPP----------------------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFG

---LTRDVY---------ERGLYERQSKSLLPVKWMAVEALYDN-VFTVKSDVWSFGILLWEIVTMGAIPYPGVTAERLCQLLRDG--YRMDRPEECSEE
   ..|.|.         |  .| .|.   .|..||| |||...  || ||||||||...|||.|.|. |||| ....... ...|  ||| .|..|...
RGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHP

LF
..
VY
Kinase RET.AA Src 668-934 33 4.8e-74 250.96 In-house 1-230 (255) Show / Hide 
Range on Protein: 668-934
Range on HMM: 1-230/255
Sequence Identity: 33% (91 aa)

LLFEDELGEGHFGRVVRAQALSIRGHTGYTTVAVKMLKRDTATSAELHDLLTELELLKLLNHTNVIRLLGACIPKDPFETCVIVEYCKYGCLREFLRLNR
. ....||.|.|| |  .         | | |||| ||..|    . ...| | ...| | | ....|.  |  ..|.    . || . |.| ..|.   
IKLCRKLGQGQFGEVWMGY------WNGNTKVAVKTLKPGT---MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPI--YIVTEYMSHGSLLDYLKK--

KKALYTEYSISNESSSIPGLSRGKDVIKRFDIGFKEIASFAWQICKGMHYISSLKVVHRDLAARNVLVAEGLLLKISDFGLTRDVYERG--LYERQSKSL
                           .   . ...  ..|.|. .|| |..| ...||||||||||| |... |. |||| | . . .   |. .. . 
-------------------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAK

LPVKWMAVEALYDNVFTVKSDVWSFGILLWEIVTMGAIPYPGVTAERLCQLLRDGYRMDRPEECSEELF
.|.||.| ||.  ..||.|||||||||||.|||| | .|||| | .   | .  |||| .|..| .||.
FPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELY
Kinase RET.AA InsR 668-934 34 8.2e-62 206.36 In-house 1-252 (278) Show / Hide 
Range on Protein: 668-934
Range on HMM: 1-252/278
Sequence Identity: 34% (94 aa)

LLFEDELGEGHFGRVVRAQALSIRGHTGYT--TVAVKMLKRDTATSAELHDLLTELELLKLLNHTNVIRLLGACIPKDPFETCVIVEYCKYGCLREFLRL
.    |.|.| || |    | .|    . .   .|.| .. . |.. |  . | | .  |  |. .|.|||| |    |  . |. |  .|| |. .|| 
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVN-ENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQP--MYVVMEMMTYGDLKSYLRS

NRKKALYTEYSISNESSSIPGLSRGKDVIKRFD-IGFKEIASFAWQICKGMHYISSLKVVHRDLAARNVLVAEGLLLKISDFGLTRDVYERGLYERQSKS
 |  .                     ....... .   .. . | .|| || |  ..| ||||||.|| .|.. .  || |||.|||.||   | .  |.
RRPEEEF----------------NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKG

LLPVKWMAVEALYDNVFTVKSDVWSFGILLWEIVTMGAIPYPGVTAERLCQLL-RDGYRMDRPEECSEELF
.||| ||| | | | ||| .|||||||..|||.||.|. || |   |   .   .||  ...|| |.| ..
MLPVRWMAPESLKDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQ
Kinase RET.AA PDGFR 806-927 48 1.3e-50 160.49 In-house 205-327 (358) Show / Hide 
Range on Protein: 806-927
Range on HMM: 205-327/358
Sequence Identity: 48% (60 aa)

SFAWQICKGMHYISSLKVVHRDLAARNVLVAEGLLLKISDFGLTRDVYERGLYERQSKSLLPVKWMAVEALYDNVFTVKSDVWSFGILLWEIVTMGAIPY
.|. |. ||| .  |   |||||||||||...| . || |||| ||. .   |       ||||||| | ..|.|.|..|||||.||||||| . |  ||
CFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIFSLGGNPY

PGVTA-ERLCQLLRDGYRMDRPE
||.   ..   . ..||||..|.
PGMPVDSKFYKMIKEGYRMAQPF
Kinase RET.AA Fer 807-933 33 2.3e-46 155.91 In-house 116-256 (283) Show / Hide 
Range on Protein: 807-933
Range on HMM: 116-256/283
Sequence Identity: 33% (48 aa)

FAWQICKGMHYISSLKVVHRDLAARNVLVAE-GLLLK--ISDFGLTRD--VYERGLYER--QSKSLLPVKWMAVEALYDNVFTVKSDVWSFGILLWEIVT
.. |...|| |. | ...|||.||||.|. . .. .|  |||||. |.  .|.   ...  . |  .|..|.| |.. . ... |.||||||...||| |
MCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACK--VPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFT

MGAIPYPG----VTAERL-----CQLLRDGYRMDRPEECSEEL
 || ||||    ...  .     ..  ..||.|  |... .|.
NGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEI
Kinase RET.AA Pkinase 668-933 21 2.7e-30 108.21 Pfam 1-266 (293) Show / Hide 
Range on Protein: 668-933
Range on HMM: 1-266/293
Sequence Identity: 21% (66 aa)

LLFEDELGEGHFGRVVRAQALSIRGHTGYTTVAVKMLKRDTATSAEL-HDLL-TELELLKLLNHTNVIRLLGACIPKDPFETCVIVEYCKYG----CLRE
. ..  .|.| ||.| ...  . .      .|||| .|.... | .. .... .|....| ||| |..||....    . . ... |||  |     | .
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFD

FLRLNRKKALYTEYSISNESSSIPGLSRGKDVIKRFDI--GFKEIASFAWQICKGMHYISSLKVVHRDLAARNVLVA-EGLL---LKISDFGLTRDVYER
...                              ..  .    .|. ....||..|. |. | ...||||   |.|.  .| .   .||.|||| . ..  
YIST----------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--

GLYERQSKSLLPV---KWMAVEALY-DNVFTVKSDVWSFGILLWEIVTMGAIPYPGV-------TAERLCQLLRDGYRMDRPEECS--------------
  | ..|    ..    .|| | .  ..  . |.|.||.|..|.| .. |  |.||          ...|. ..  .. |.|..||              
--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWT

-----EEL
     ||.
FHNWSEEC
Kinase RET.AA S_TKc 668-941 19 4e-22 80.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 668-941
Range on HMM: 1-231/231
Sequence Identity: 19% (58 aa)

LLFEDELGEGHFGRVVRAQALSIRGHTGYTTVAVKMLKRDTATSAELHDLLTELELLKLLNHTNVIRLLGACIPKDPFETCVIVEYCKY--GCLREFLRL
  . ...|.| ||.| ...  .         ||.|..|          ... |...||  .| |...|....      . ... |||    | |..... 
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKK

NRKKALYTEYSISNESSSIPGLSRGKDVIKRFDIGFKEIASFAWQICKGMHYISSLKVVHRDLAARNVLVAEGLLLKISDFGLTRDVYERGLYERQSKSL
.... |                        || .   .......|||... |. |....||||   |.|. |   .||.|||| | .         .   
RGRHGL------------------------RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFC

LPVKWMAVEALYDNVFTV-KSDVWSFGILLWEIVTMGAIPYPGVTAERLCQLLRDGYRMDRPEECS---EELFVP-----------Q-------SEYL
    .|| | |    ..  |.|.||.|..|.| .. |  |.|  . ... ....       ..|.    . ...            |        ...
GTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase RET.AA PDGFR 668-769 41 2.7e-18 54.97 In-house 1-100 (358) Show / Hide 
Range on Protein: 668-769
Range on HMM: 1-100/358
Sequence Identity: 41% (43 aa)

LLFEDELGEGHFGRVVRAQALSIRGHTGYTTVAVKMLKRDTATSAELHDLLTELELLKLL-NHTNVIRLLGACIPKDPFETCVIVEYCKYGCLREFLRLN
| |   || | ||.|| | |  .       .|||||||  || | |   |  ||  .  | .| |.. |||||    |  . .| ||| || | ..|. .
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLK-PTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGP--IYIITEYCCYGDLLNYLHRK

RKK
| .
RHS
Kinase RET.AA Fer 668-764 25 1.7e-15 49.31 In-house 1-101 (283) Show / Hide 
Range on Protein: 668-764
Range on HMM: 1-101/283
Sequence Identity: 25% (26 aa)

LLFEDELGEGHFGRVVRAQ-ALSIRGHTGYT----TVAVKMLKRDTATSAELHDLLTELELLKL-LNHTNVIRLLGACIPKDPFETCVIVEYCKYGCLRE
  ... ||||.|| | ... .| .  ... .     |.||..| . || ... ... |  ...  ..| ||... | |  . |.   .. |.|. |.|..
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPI--MIVMEFCNGGSLDS

FLR
.|.
YLK