Gene Ryk (Sea Urchin)

Ryk

Species: Sea Urchin
Alias: Spk287, Ryk, SPU_010329
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: Ryk

Sequence

Name Sequence Type Origin Length Description Download
Ryk.AA Protein None 828 None Fasta, JSON
Ryk.kin_dom Protein Kinase Domain None 239 None Fasta, JSON

Protein domain

Protein domains of Ryk.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
WIF Ryk.AA WIF 1-118 29 5e-31 107.56 Pfam 12-145 (145) Show / Hide 
Range on Protein: 1-118
Range on HMM: 12-145/145
Sequence Identity: 29% (39 aa)

MGVSAELYYIREGKINRAATN-----Y------PLAVPTGINKLYYTWYS--ERQVYYSMSV-KSKSPRILYHPSLNITKDGKVPVKETVFEMQLECTGH
.|||||.|||..|..|  |..     .       ..||  .. .  || |   .  .|...| .|  . |.  | ||| . | || . ..|   | |.| 
IGVSAEIYYIHNGHVNHYAHDPNFSHFRKAQQRMPPVPSNVHYVNFTWQSLGKHKYHYNFQVLYSSDQQIMKRPTLNISHQGRVPHEAKEFSIDLPCSGN

EGGEAIIELQVNLTLYSAS--NITTLNTIRTKLC
  |.|  ........ ..   |.| |.. | | |
RSGQATFTVNLEVMHRRSKPNNNTPLRFKRKKIC
WIF Ryk.AA WIF 1-120 33 3.8e-26 94.12 SMART 15-146 (146) Show / Hide 
Range on Protein: 1-120
Range on HMM: 15-146/146
Sequence Identity: 33% (44 aa)

MGVSAELYYIREGKINRAATNY------PLAVPTGINKLYYTWYSERQ---VYYSMSVKSKSPRILYHPSLNITKDGKVPVKETVFEMQLECTGHEG--G
.||.|||||.|||.||  |.|        ..||  |. .  || .  |   |.|. .|.|    ..  | .||   | ||..  |..  . |.||    .
IGVDAELYYVREGHINHYAHNFRKAQQRMYPVPANIHYMHFTWQAVGQAHYVHYFINVQSDDQEVMPMPIVNIPHQGTVPHTLQVWQVEYKCSGHRDGVA

EAIIELQVNLTLY-SASNITTLNTIRTKLCQG
|  . ..|....  |  | | || .| | |. 
EFMVTMYVMVKYNRSTKNFTHLNFRRKKICYQ
Kinase Ryk.AA Ryk 235-473 57 1.1e-196 627.71 In-house 1-267 (292) Show / Hide 
Range on Protein: 235-473
Range on HMM: 1-267/292
Sequence Identity: 57% (153 aa)

ITLGEVLLEGTFGRVHQGVLISATG-D------------SEQDVFIKTVTDHSSEEQRHLLVKESCLLQGLS-HKNILPLLHVC--------FSD--PPF
|.......||||||...|....... .            ..||||.|||.||.|..|.|....|||||.|.| |.||||.||||        ..|  |||
IQYSCLVQEGTFGRIYHGIWNQVDDVNNGDVDDEEDTFCDCQDVFVKTVKDHASQMQVHCMLQESCLLYGISPHQNILPVLHVCSFGRFDRPIEDHDPPF

ILEAFMK-LGNLKQFLKNGRIGPGDKHQAISTRDLVHLAIQITHGMMYLGKKRLVHKDLATRNCVIDED---YNLKITDNALSRDLFPSDYHCLGDNENR
.....|. .|||||||...|......||||||..|||.|||||.|||.|.|.|.||||.|||||||||.   ...||.|.||||||||.|||||||||||
VCYPHMNNWGNLKQFLQDCRHDKPKCHQAISTHQLVHMAIQITMGMMHLHKHRIVHKDIATRNCVIDEQNGRLQVKICDSALSRDLFPMDYHCLGDNENR

PVKWMAVESLVHKKFSHASDVWSFGVTLWELVTLGQTPYMDLDPFEMATFLKSGYRMPQPPSCPDEL
|||||..|||.||..||||||||||||.|||.||||.|||..|||||...||.|||..||..|||||
PVKWMSLESLQHKHYSHASDVWSFGVTMWELMTLGQMPYMEIDPFEMYHYLKDGYRLQQPFNCPDEL
Kinase Ryk.AA Pkinase_Tyr 235-473 35 2.1e-94 320.38 Pfam 1-245 (270) Show / Hide 
Range on Protein: 235-473
Range on HMM: 1-245/270
Sequence Identity: 35% (89 aa)

ITLGEVLLEGTFGRVHQGVLISATGDSEQDVFIKTVTDHSSEEQ--RHLLVKESCLLQGL-SHKNILPLLHVCF--SDP--PFILEAFMKLGNLKQFLKN
||.|..| || ||.|..|..    .. ...| .|.. .....||  |  . .|  ..  | .|.||. |. ||   ..|  ..|   .|..|.|. .|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

GRIGPGDKHQAISTRDLVHLAIQITHGMMYLGKKRLVHKDLATRNCVIDEDYNLKITDNALSRDLFPSDYH-CLGDNENRPVKWMAVESLVHKKFSHASD
 |    .  |.... ||.. ..||  || ||  |...| |||.||| ..|.   ||.|  |.||... ||    ...   |.|||| |.. ..||...||
HR----EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSD

VWSFGVTLWELVTLGQTP-YMDLDPFEMATFL-KSGYRMPQPPSCPDEL
||||||..||..|.|..| | .....|.  .. ..|||||.|. ||||.
VWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEI
Kinase Ryk.AA TyrKc 235-493 31 9.5e-87 295.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 235-493
Range on HMM: 1-280/280
Sequence Identity: 31% (95 aa)

ITLGEVLLEGTFGRVHQGVLISATGDSEQDVFIKTVTDHSSEEQRHLLVKESCLLQGL--SHKNILPLLHVCFS--------DPPFILEAFMKLGNLKQF
||||..| || ||.|..|...       ..| .|.. ...    |  . .|  ..  |  .|.||. |. || .        .|..|.  .|..|.||..
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LKNGRIGPGDKHQAISTRDLVHLAIQITHGMMYLGKKRLVHKDLATRNCVIDEDYNLKITDNALSRDLFPS-------DYHCL--GDNEN--RPVKWMAV
|.. |         ....||.. ..||  || || .|...| |||.||| ..|..  ||.|  ||||.          ||     .....   |..||| 
LRKHRPK-------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

ESLVHKKFSHASDVWSFGVTLWELVTLGQTPYMD-----LDPFEMATFLKSGYRMPQPPS--------CPDELLPPYTRHLHL------SFLKLASQCL
|.. ..||...||||||||..||. |.||.|| .     ....|.  ..|.||||||||.        ||||.    ..  |       .|  .  .|.
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase Ryk.AA TK 235-474 19 1.5e-80 269.57 In-house 1-461 (486) Show / Hide 
Range on Protein: 235-474
Range on HMM: 1-461/486
Sequence Identity: 19% (89 aa)

ITLGEVLLEGTFG---RVHQGVLISATGDSEQD-----------------------VFIKTVTDHSSEEQRHL--------------LVKESCLLQG--L
||||..| || ||   .|..| ...  .. ...                       | ... .|..|.|....              .. | ....   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

SHKNILPLLHVCFSD-------------PPFILEAFMKLGN----LKQFLKNGR----------------------------------------------
 |.||. |. ||. .             |. |.. .|..|.    |...|.. |                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------IGPGDKHQ-----------AISTRDLVHLAIQITHGMMYLGKK------RLVHKDLATRNCVIDEDYN-----------LKITDNA---
           ..  | .|            .....|.  . ||  || || .|      ..|| |||.||| ..|...            ||.|     
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRDLFPSDYHCLGD------------------------NENRPVKWMAVESLV---------HKKFSHASDVWSFGVTLWELVTLG-QTPYMDL
     |.||. ..|. .  .                        .   |..||| |.|          ..||...||||||||..||..|.| ...| ..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

DP---------FEMATFLKSG--------------YRMPQPPSCPD-------------ELL
.           |.  .|..|              .|||||| |||             |..
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEY
Kinase Ryk.AA TK-Unique 235-473 32 1.3e-60 207.73 In-house 1-269 (294) Show / Hide 
Range on Protein: 235-473
Range on HMM: 1-269/294
Sequence Identity: 32% (88 aa)

ITLGEVLLEGTFGRVHQGVLISATGDSEQD--VFIKTVTDHSSEEQRHLLVKESCLLQGLS-HKNILPLLHVCF-SD-PPFILEAFMKLGNLKQFLKNGR
...|.|. || || |. | . . .......  | .|.. |.......  . ||  ... |  |.||. .| .|  || |..|.  ..  |||  .|.. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

IG-----------------PGDKHQA-ISTRDLVHLAIQITHGMMYLGK--KRLVHKDLATRNCVIDEDYNLKITDNALSRDLF-PSDYHCLGDNENRPV
 .                 | ..  . || .||.| |.||  ||.|| .  |. ||.||..||. . ||...||.|  ..||.  . .|   .  .  |.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

KWMAVESLV--HKKF-SHASDVWSFGVTLWELVTLGQTPYMDLDPFEMATFLKSGYRMPQPPSC-PDEL
.||| |||   |. . .  ||||||||..||..|||..|| .... .. . .. |||||||..| ..|.
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEM
Kinase Ryk.AA EGFR 235-469 31 1.9e-60 199.31 In-house 1-228 (258) Show / Hide 
Range on Protein: 235-469
Range on HMM: 1-228/258
Sequence Identity: 31% (75 aa)

ITLGEVLLEGTFGRVHQGVLISATGDSEQDVFIKTVTDHSSEEQRHLLVKESCLLQGLSHKNILPLLHVCFSDPPFILEAFMKLGNLKQFLKNGRIGPGD
. .. ||  | ||.|. |. |         | || . ....... . .. |   . .. |.... || || ..   .   .| .|.|  .... .     
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHK-----

KHQAISTRDLVHLAIQITHGMMYLGKKRLVHKDLATRNCVIDEDYNLKITDNALSRDLFPSDYHCLGDNENRPVKWMAVESLVHKKFSHASDVWSFGVTL
   .|  ..|.  ..||  ||.|| ..|.|| |||.||  .      ||||  |.. | . .     .    |.||||.|.. |... |.|||||.|||.
--DNIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTC

WELVTLGQTPYMDLDPFEMATFLKSGYRMPQPPSC
|||.| || ||  .   |   .|. | |.|||| |
WELMTFGQKPYDGIPAREIPDLLEKGERLPQPPIC
Kinase Ryk.AA Met 236-473 31 4.3e-56 182.26 In-house 1-251 (271) Show / Hide 
Range on Protein: 236-473
Range on HMM: 1-251/271
Sequence Identity: 31% (82 aa)

TLGEVLLEGTFGRVHQGVLISATGDSEQDVFIKTVT--DHSSEEQRHLLVKESCLLQGLSHKNILPLLHVCFSD---PPFILEAFMKLGNLKQFLKNGRI
 ...|.  | || |  | ..   |  .. . .|.        ...     .|  .  ...| |.| |. .| ..    | ..  .|| | ||.| .|   
HFDDVIGQGHFGCVYHGMYHDNDGNEHH-CACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRN---

GPGDKHQAISTRDLVHLAIQITHGMMYLGKKRLVHKDLATRNCVIDEDYNLKITDNALSRDL-FPSDYHCLGDNEN---RPVKWMAVESLV--------H
       ..  |||.  . |.  ||||.  .. || ||| ||| .||.   |. |  |.||.     |    .       |||||| |.|          
----PQNNPCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPT

KK-FSHASDVWSFGVTLWELVTLGQTPYMDLDP-FEMATFLKSG--YRMPQPPSCPDEL
 . |. .|||||||| .||| | | .|| . |. |   ..|. |   | |||. ||| |
YRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHL
Kinase Ryk.AA UTK 235-473 29 2.6e-55 187.65 In-house 1-271 (296) Show / Hide 
Range on Protein: 235-473
Range on HMM: 1-271/296
Sequence Identity: 29% (79 aa)

ITLGEVLLEGTFGRVHQGVLISATGDSEQ-DVFIKTVTDHSSEEQRHL----LVKESC---LLQGLS-HKNILPLLHVCFSDPPF-ILEAFMKLGNLKQF
. ||. | .| || || . .  ... ... || .|.   |.. .| .     . .|.    ... .. | |.| |..||... |. |.  .|. |.| ..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LKNGRIGPGDKHQAISTRDLVHLAIQITHGMMYLGKKRLVHKDLATRNCVIDED-------YNLKITDNA---LSRDLFP--------SDYHCLGDNENR
| . |  |..   . . ..... | .| .|| ||  ...|| ||| ||| ....       .  || |     .||..          ..| .  .. .|
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

-PVKWMAVESLVHK-KFSHASDVWSFGVTLWELVTLGQTPYMDLDPFEMATFLKSG--YRMPQPPSCPDEL
 |..||| |.|.|  .|...||||||||..||..| |..|| ..   . ....  |  ||||.|..||...
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPV
Kinase Ryk.AA Axl 235-473 36 5e-52 179.17 In-house 1-244 (267) Show / Hide 
Range on Protein: 235-473
Range on HMM: 1-244/267
Sequence Identity: 36% (89 aa)

ITLGEVLLEGTFGRVHQGVLISATGDSEQDVFIKTV-TDHSSEEQRHLLVKESCLLQGLSHKNILPLLHVCF--SD-----PPFILEAFMKLGNLKQFLK
..|| .| || || |  | |    | | . | .|..  | ... .    ..|   ..  .| |.. |. ||.  |.      | ..  ||| | |  || 
FVLGKMLGEGEFGSVMEGQLKQEDG-SFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLL

NGRIGPGDKHQAISTRDLVHLAIQITHGMMYLGKKRLVHKDLATRNCVIDEDYNLKITDNALSRDLFPSDYHCLGDNENRPVKWMAVESLVHKKFSHASD
  |.| . ..  . .  ||.  . |  || || ... .|.||| |||.. ||    . |  ||. ..  ||   |     ||||.|.|||  . .   ||
YSRLGDQPFY--LPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQGCIAKMPVKWIAIESLADRVYTSKSD

VWSFGVTLWELVTLGQTPYMDLDPFEMATFLKSGYRMPQPPSCPDEL
||.||||.||..| |||||  ..  ||  .|  | |. ||. | |||
VWAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDEL
Kinase Ryk.AA Src 235-473 32 1.9e-51 173.0 In-house 1-229 (255) Show / Hide 
Range on Protein: 235-473
Range on HMM: 1-229/255
Sequence Identity: 32% (78 aa)

ITLGEVLLEGTFGRVHQGVLISATGDSEQDVFIKTVTDHSSEEQRHLLVKESCLLQGLSHKNILPLLHVCFSD-PPFILEAFMKLGNLKQFLKNGRIGPG
|.| . | .| || | .|.    |     .| .||    .   . . . .|  ..  |.|.... |. ||  . | .|   .|. |.| ..||.      
IKLCRKLGQGQFGEVWMGYWNGNT-----KVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-----D

DKHQAISTRDLVHLAIQITHGMMYLGKKRLVHKDLATRNCVIDEDYNLKITDNALSRDLFP--SDYHCLGDNENRPVKWMAVESLVHKKFSHASDVWSFG
.. .... ..|. .| |.  ||.||......| ||| ||  ..|.   |. |  | | |.    |  |     . |.||.| | . . .|.  |||||||
GEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFG

VTLWELVTLGQTPYMDLDPFEMATFLKSGYRMPQPPSCPDEL
. |.|.|| |..||   .  |  . .. |||||.|. |||||
ILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDEL
Kinase Ryk.AA RTKB 235-472 32 1e-49 165.75 In-house 1-238 (264) Show / Hide 
Range on Protein: 235-472
Range on HMM: 1-238/264
Sequence Identity: 32% (79 aa)

ITLGEVLLEGTFGRVHQGVLISATGDSEQDVFIKTVTDHSSEEQRHLLVKESCLLQGL-SHKNILPLLHVCFSD-PPFILEAFMKLGNLKQFLKNGRIGP
. ||| | .| || | |. .     . || .  |.     |.|.|    .|  ..  |  | |.. ..  |. | |. .|  .  ||||  .|. .| ..
VWLGEKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCR-AS

GDKHQAISTRDLVHLAIQITHGMMYLGKKRLVHKDLATRNCVIDEDYNLKITDNALSRDLFPSDYHCLGDNENRPVKWMAVESLVHKKFSHAS-DVWSFG
  . | .. . || .. ||  || .| ..  .| ||. || ..| .   || | ...| .   .|    .    |.|||| ||. |. ..  | ||||||
QHNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYETTCT--RLPIKWMAPESWAHRIYTTKSGDVWSFG

VTLWELVTLGQTPYMDLDPFEMATFLKSGYRMPQPPSCPDE
|| ||  .|| |||  .  ...  .| ||.|.|.| . | .
VTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQA
Kinase Ryk.AA FGFR 235-473 33 3.1e-48 162.46 In-house 1-268 (293) Show / Hide 
Range on Protein: 235-473
Range on HMM: 1-268/293
Sequence Identity: 33% (89 aa)

ITLGEVLLEGTFGRVHQGVLISATGD---SEQDVFIKTVTDHSSEEQRHLLVKESCLLQGL-SHKNILPLLHVCFSD-PPFILEAFMKLGNLKQFLKNGR
 |||..| || ||.|  .  .    |    |  | .| . .  ...    || |   .     ||||. || .|  . |....  . . |||. ||.  |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

IGP----GDKH-----------QA--------ISTRDLVHLAIQITHGMMYLGKKRLVHKDLATRNCVIDEDYNLKITDNALSRDLFPSDYHCLGDNENR
 .      |             |         .. .||| .| |.  || ||  .. .| ||| ||  . .|| .|| |  |.||    ||     |   
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVKWMAVESLVHKKFSHASDVWSFGVTLWELVTLGQTPYMDLD-PFEMATFLKSGYRMPQPPSCPDEL
|.|||| |.|  ... | |||||.|| |||  |.|..||       |. ..||.|.||  |. |. |.
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEI
Kinase Ryk.AA S_TKc 235-505 17 9.1e-15 39.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 235-505
Range on HMM: 1-231/231
Sequence Identity: 17% (51 aa)

ITLGEVLLEGTFGRVHQGVLISATGDSEQDVFIKTVTDHSSEEQRHLLVKESCLLQGLSHKNILPLLHVCFSDPPFILEAFMKL--GNLKQFLKNGRIGP
 ...... .|.||.|.... ..    . . | || .           . .|  .|.   |.||  |. |. .|  ..   ..    |.|....|. . ..
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHG

GDKHQAISTRDLVHLAIQITHGMMYLGKKRLVHKDLATRNCVIDEDYNLKITDNALSRDLFPSDYHCLGDNENRPVKWMAVESLVHKKFSH-ASDVWSFG
  ... ..  .  ... ||  .. |. ... .| ||   |  .||  ..||.|  |.| |    ... |        .|| | |   .... ..|.||.|
--LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCG-----TPWYMAPEVL---GYGKCKCDWWSCG

VTLWELVTLGQTPYMDLDPFEMATFLKSGYRMPQPPSCPDELLPPYTRHLHLSFLKLASQCLSAQSS------NLT-------HQKV
..|.|... |..|.   ....|   ..                         ... . ..||    .       |.       |. .
CILYEMLC-GYPPFP--QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase Ryk.AA Pkinase 235-385 19 7.6e-08 28.82 Pfam 1-155 (293) Show / Hide 
Range on Protein: 235-385
Range on HMM: 1-155/293
Sequence Identity: 19% (32 aa)

ITLGEVLLEGTFGRVHQGVLISATGDSEQD-VFIKTV-TDHSSEEQRHLLVK--ESCLLQGLSHKNILPLLHVC--FSDPPFILEAFMKLG----NLKQF
...|... .|.||.|       ..  .... | .|..  .| .....  ...  | .... |.|.||. |....   ... ...| ..  |     |. .
YHIGRKIGSGSFGCV-----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVME-YCEGGLYVMDLFDY

LKNGRIGPGDKHQAI--STRDLVHLAIQITHGMMYLGKKRLVHKDLATRNCVIDEDYNL----KITD
..       ..| ..  | ... . . ||  |. |. ... .| ||   |. ||.....    ||.|
IST------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICD
Kinase Ryk.AA Pkinase 410-453 25 9e-08 28.57 Pfam 177-226 (293) Show / Hide 
Range on Protein: 410-453
Range on HMM: 177-226/293
Sequence Identity: 25% (13 aa)

WMAVESLV-HKKFSHASDVWSFGVTLWELVTLGQTPYMDL------DPFEM
.|| | .  ... ....|.||.|..|.|... |..|. .       |. .|
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQM