Gene Syk (Sea Urchin)

Syk

Species: Sea Urchin
Alias: Syk, SPU_006988, Spk297
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: Syk

Sequence

Name Sequence Type Origin Length Description Download
Syk.AA Protein None 693 None Fasta, JSON
Syk.kin_dom Protein Kinase Domain None 256 None Fasta, JSON

Protein domain

Protein domains of Syk.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 Syk.AA SH2 10-87 39 9.1e-28 83.35 Pfam 1-81 (81) Show / Hide 
Range on Protein: 10-87
Range on HMM: 1-81/81
Sequence Identity: 39% (32 aa)

FYHGRITREEAEARLRNAGCHQGMFLLRESLGREGNYALSLCYED---DVYHYAIERQYDGTVAIKDGKNFAGPIELVSNH
.||| |.|.||| .|.| | . | ||.|||   .| |.||.....    |.|| | |. .|.. | ... |.   |||. .
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 Syk.AA SH2 8-93 38 1.4e-26 95.59 SMART 1-87 (87) Show / Hide 
Range on Protein: 8-93
Range on HMM: 1-87/87
Sequence Identity: 38% (34 aa)

RRFYHGRITREEAEARLRNAGCHQGMFLLRESLGREGNYALSLCYEDDVYHYAIERQYDGTVAIKD--GKNFAGPIELVSNHMNREDG
  .|||.|.|||||. |.| |.. | ||.|.|    | |.||..... |.|| |.|. || . | .  .. |    |||  ..   .|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 Syk.AA SH2 165-241 38 1.1e-33 100.68 Pfam 1-81 (81) Show / Hide 
Range on Protein: 165-241
Range on HMM: 1-81/81
Sequence Identity: 38% (31 aa)

WFHHKLSREEAEQRIVSAGLQEGKFLVRERT-EEGSFALSLCYNN---FVYHYKIDKDCTGQLSIKEGPKFDSLIQMVDHY
|.| |.||.|||..  . | ..| |||||.  ..|...||.....    |.||.| ....|.. | ...||.|| ..|.||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 Syk.AA SH2 163-247 39 5.1e-29 103.65 SMART 1-87 (87) Show / Hide 
Range on Protein: 163-247
Range on HMM: 1-87/87
Sequence Identity: 39% (35 aa)

KPWFHHKLSREEAEQRIVSAGLQEGKFLVRERTE-EGSFALSLCYNNFVYHYKIDKDCTGQLSIKE--GPKFDSLIQMVDHYQLKKDG
 ||.| ..|||||||   . | ..| ||||..    |...||..... |.||.| .. .|. .| |  ..||.|| ..|.|||  ..|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase Syk.AA Syk 419-668 62 2e-205 688.77 In-house 1-257 (257) Show / Hide 
Range on Protein: 419-668
Range on HMM: 1-257/257
Sequence Identity: 62% (160 aa)

LNQGDQIGKGNFGSVLKGTCMAN-----GQLIPVAVKTLKADFGIPNSEPEIVREAELMAGLDHPHIVRMIGICHAAEMMLVLELAELGPLHKYLKKHQ-
|.|...||.||||||.||..|..     .|.|.||.|.||||...|....|..|||..|..||||.||||||||||..||.|.|.|||||.||||..|. 
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRH

EMSTRNVLELMY-QVAQGMCYLESRQFVHRDLAARNVLLVDETFAKISDFGMSKALGLDSQYYVAETAGKWPLKWYAPECIYKFKFSSKSDVWSYGVTLW
|....|||||.. |||.||||||...||||||||||||||....|||||||||||||.|||||.|.|.||||.|||||||||..|||.||||||.|||.|
EITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMW

EALSYGKRPYASMRGQELMQFIENGDRLSQPDRCPDDVYSLMRRCWLSEAKDRPGFG
|..|||..||..|.|||.|.|||||.|...|..||...|.||..||.....|||.|.
EMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase Syk.AA TyrKc 419-674 37 1e-117 398.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 419-674
Range on HMM: 1-280/280
Sequence Identity: 37% (109 aa)

LNQGDQIGKGNFGSVLKGTCMANGQLIPVAVKTLKADFGIPNSEPEIVREAELMAGL--DHPHIVRMIGICHA--------AEMMLVLELAELGPLHKYL
.  |...| |.|| | |||       |.||||.||.|      . .. |||..|  |  .||.|||..|.|            .|.|.|....| |..||
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKHQE-MSTRNVLELMYQVAQGMCYLESRQFVHRDLAARNVLLVDETFAKISDFGMSKALGLD------SQYYVAET--AGK--WPLKWYAPECIYKFKF
.||..  ...  |. ..|.|.|| ||.|....||||||||.|. ..  .||||||.|.... |      ..||.. .   ||  .|..|.||||| . ||
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SSKSDVWSYGVTLWEALSYGKRPYAS-----MRGQELMQFIENGDRLSQPDR--------CPDDVYSLMRRCWLSEAKDRPGFGDIESVL
..||||||.||..|| ..||. ||       |  ||.......|.|. ||.         |||..|..|..||  ...||| | .| . .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Syk.AA Pkinase_Tyr 419-674 40 1.2e-116 395.65 Pfam 1-270 (270) Show / Hide 
Range on Protein: 419-674
Range on HMM: 1-270/270
Sequence Identity: 40% (111 aa)

LNQGDQIGKGNFGSVLKGTCM--ANGQLIPVAVKTLKADFGIPN--SEPEIVREAELMAGL-DHPHIVRMIGICH--AAE--MMLVLELAELGPLHKYLK
.  | ..|.|.||.| |||.     .. ||||||.|| .   ..  .| .  |||..|  | .||.|||..|.|        ...|.|....| |..||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCRE-DFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KH----QEMSTRNVLELMYQVAQGMCYLESRQFVHRDLAARNVLLVDETFAKISDFGMSKALGLDSQYY-VAETAGKWPLKWYAPECIYKFKFSSKSDVW
||    |  ..   |.  .|.|.|| ||||....||||||||.|. .. ..||.|||.....  .  || .. . ||.| ||.|||||   ||..|||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SYGVTLWEALSYGKRP-YASMRGQELMQFI-ENGDRLSQPDRCPDDVYSLMRRCWLSEAKDRPGFGDIESVL
|.||..|| ..||. | |. |  .|....| |.| |. .|. |||..|.||..||  ...||| | .| . |
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Syk.AA TK 419-674 21 1.5e-103 348.06 In-house 1-486 (486) Show / Hide 
Range on Protein: 419-674
Range on HMM: 1-486/486
Sequence Identity: 21% (107 aa)

LNQGDQIGKGNFG---SVLKGTCMA-----------------------NGQLIPVAVKTLKADFGIPNSEPEI---------------VREAELMAG--L
.  |...|.|.||    | ||.                          .|. .|||||.||.. .    | .                ..|...|    .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DHPHIVRMIGICHAAE-------------MMLVLELAELGP----LHKYLKKHQE---------------------------------------------
.||.|||..|.|.  |             .|.|.|....|     |..||.|. .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------MSTRNVLELMYQVAQGMCYLESR------QFVHRDLAARNVLLVDETF-----------AKISDFGMS-
                               ....  |  ..|.|.|| ||.|.      .||||||||||.|. ..             .||.|||.| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------KALGLDSQYYVAE-----------------------TAGKWPLKWYAPECIY---------KFKFSSKSDVWSYGVTLWEALSYGKRPYASMR
       .... |. ||...                       . ||.|..|.||||.          . ||..||||||.||..|| ..||. ||. . 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

G----------QELMQFIENGDRL--------------SQPDRCP--------------DDVYSLMRRCWLSEAKDRPGFGDIESVL
           ||.|.....| ||               ||. ||              ...| ||..||  ...||| | .. . |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Syk.AA Ack 419-674 41 4.9e-99 334.72 In-house 1-266 (266) Show / Hide 
Range on Protein: 419-674
Range on HMM: 1-266/266
Sequence Identity: 41% (111 aa)

LNQGDQIGKGNFGSVLKGTCMA-NGQLIPVAVKTLKAD-FGIPNSEPEIVREAELMAGLDHPHIVRMIGICHAAEM-MLVLELAELGPLHKYLKKHQE--
.  . ..| | ||.| .|.  . .|. |.|||| |. |    ||   . .||.  |  |||||.||  |.  .  | |.| |||..| |.  |.||.   
ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRTA

-MSTRNVLELMYQVAQGMCYLESRQFVHRDLAARNVLLVDE-TFAKISDFGMSKALGLDSQYYVAETAG--KWPLKWYAPECIYKFKFSSKSDVWSYGVT
 ..    ..   |.|.|| |||.. ..||||||||.||      .||.||| . |||.  .||. |     | |. | ||||. . .||..||||..|||
FFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGVT

LWEALSYGKRPYASMRGQELMQFIE-NGDRLSQPDRCPDDVYSLMRRCWLSEAKDRPGFGDIESVL
|||  |||  |.| ..| . .| |. .| || .|| || |.|..| .||  .. ||| |..|.  |
LWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase Syk.AA UTK 419-674 33 2.1e-96 326.55 In-house 1-296 (296) Show / Hide 
Range on Protein: 419-674
Range on HMM: 1-296/296
Sequence Identity: 33% (99 aa)

LNQGDQIGKGNFGSVLKGTC-MAN--GQLIPVAVKTLK-ADFGIPNSE--PEIVREAE---LMAGLD-HPHIVRMIGICHAAE-MMLVLELAELGPLHKY
. .|.|.|.|.|| | |..   ..  ...  ||||...  ...  ..|  |.. .||    .|. .. ||...|..|.| . | .|.|.|..| | | .|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LKKHQE--------MSTRNVLELMYQVAQGMCYLESRQFVHRDLAARNVLLVDE-------TFAKISDFG---MSKALGL--------DSQYYVAETAGK
| .| .         . .  |. ....| || ||.|..||||||||||.|. .        ...||.|||   ||....         .|.|| |  ...
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

WPLKWYAPECIYKF-KFSSKSDVWSYGVTLWEALSYGKRPYASMRGQELMQFIENGD--RLSQPDRCPDDVYSLMRRCWLSEAKDRPGFGDIESVL
||..|.|||....  .|..||||||.||..|| ...|..||. |  ... ....||.  |. .|..||..|| ||.||| ..  .|| | |.....
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase Syk.AA EGFR 419-675 40 6e-90 298.83 In-house 1-258 (258) Show / Hide 
Range on Protein: 419-675
Range on HMM: 1-258/258
Sequence Identity: 40% (106 aa)

LNQGDQIGKGNFGSVLKGTCMANGQL--IPVAVKTLKADFGIPNSEPEIVREAELMAGLDHPHIVRMIGICHAAEMMLVLELAELGPLHKYLKKHQE-MS
| ..   | | || | ||  . .|.   ||||.| |.   | |..  |...||  ||..||||.||..|.| . .|.||  .  .| |  |...|.. . 
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTG-PKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDNIG

TRNVLELMYQVAQGMCYLESRQFVHRDLAARNVLLVDETFAKISDFGMSKALGLDSQYYVAETAGKWPLKWYAPECIYKFKFSSKSDVWSYGVTLWEALS
 .. |   .|.|.|| ||| .. |||||||||||.      || |||..| |  |.. | |.  || | || | ||| . .. ..|||||||||.|| . 
SQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQ-GGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMT

YGKRPYASMRGQELMQFIENGDRLSQPDRCPDDVYSLMRRCWLSEAKDRPGFGDIESVLS
.|..||. .. .|  ...|.|.||.||. |  ||| .| .||.  .. ||.|  . ....
FGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase Syk.AA TK-Unique 419-674 32 3.3e-80 272.76 In-house 1-294 (294) Show / Hide 
Range on Protein: 419-674
Range on HMM: 1-294/294
Sequence Identity: 32% (95 aa)

LNQGDQIGKGNFGSVLKGTCMA----NGQLIPVAVKTLKADFGIPNSEPEIVREAELMAGLD-HPHIVRMIGICH-AA-EMMLVLELAELGPLHKYLKKH
|. ||.||.|.|| | .|.       ... . ||||.||...  . .. .  .|...|  |. ||.||...|.|      .|...| .. | | .||.. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNA-TDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

Q--------------------------EMSTRNVLELMYQVAQGMCYLES--RQFVHRDLAARNVLLVDETFAKISDFGMSKALGLDSQYYVAETAGKWP
.                          . | . ..  ..|.|.|| ||.|  ...|||||.|||||| .   .||.||||.. .  . .|   .. |. |
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

LKWYAPECIY--KFKF-SSKSDVWSYGVTLWEALSYGKRPYASMRGQELMQFIENGDRLSQPDRC-PDDVYSLMRRCWLSEAKDRPGFGDIESVL
..| ||| ..  .  . ..||||||.||..|| ...|..|| .|.  ..|. |..|.|. ||. | ....|.||..|| .|...|| | .| ..|
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase Syk.AA FAK 419-679 36 4e-78 261.36 In-house 1-285 (285) Show / Hide 
Range on Protein: 419-679
Range on HMM: 1-285/285
Sequence Identity: 36% (104 aa)

LNQGDQIGKGNFGSVLKGTCMANGQ-------------------------LIPVAVKTLKADFGIPNSEPEIVREAELMAGLDHPHIVRMIGICHAAEMM
   .  || | || | .|. .   .                          | ||.|| |..    | | . . ||  |  .||||||..||||    . 
ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCDDDNKE-KFMQEAYIMKQFDHPHIVKLIGICEEMPIW

LVLELAELGPLHKYLKKH-QEMSTRNVLELMYQVAQGMCYLESRQFVHRDLAARNVLLVDETFAKISDFGMSKALGLDSQYYVAETAGKWPLKWYAPECI
...||...| | .||. . ....    .   ||... | ||||..||||| |||||| . ..  |  |||.|  .  |..|| |   || | || .|| |
IIMELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWM-HDHSYYKASPKGKLPIKWMSPESI

YKFKFSSKSDVWSYGVTLWEALSYGKRPYASMRGQELMQFIENGDRLSQPDRCPDDVYSLMRRCWLSEAKDRPGFGDIESVLSDILK
    | . |||| .|| .|| |.||..|.  .. ..    ||||.||  |. ||   |||| |||  .  .|| | ..   |.|| .
NFRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
Kinase Syk.AA Src 419-674 37 6.8e-78 264.23 In-house 1-255 (255) Show / Hide 
Range on Protein: 419-674
Range on HMM: 1-255/255
Sequence Identity: 37% (99 aa)

LNQGDQIGKGNFGSVLKGTCMANGQLIPVAVKTLKADFGIPNSEPEIVREAELMAGLDHPHIVRMIGICHAAE-MMLVLELAELGPLHKYLKKHQEMSTR
.   ...|.|.|| | .|.   |   ..|||||||..     |     .||..|  |.|...|..  .|   |    | |. . | | .|||| .| .. 
IKLCRKLGQGQFGEVWMGYWNGN---TKVAVKTLKPGT---MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

NVLELMY---QVAQGMCYLESRQFVHRDLAARNVLLVDETFAKISDFGMSKALGLDSQYYVAETAGKWPLKWYAPECIYKFKFSSKSDVWSYGVTLWEAL
.. .| .   |||.||.||||....||||||||||  ..  .|. |||  . .  |   |.|..  | | || |||.|   .|. ||||||.|. |.|  
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIV

SYGKRPYASMRGQELMQFIENGDRLSQPDRCPDDVYS-LMRRCWLSEAKDRPGFGDIESVL
.||. ||  |. .| .| .|.| |. .|. ||| .|  .|..|| .....|| |  . ..|
TYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase Syk.AA Fer 419-675 32 2.8e-75 255.79 In-house 1-283 (283) Show / Hide 
Range on Protein: 419-675
Range on HMM: 1-283/283
Sequence Identity: 32% (92 aa)

LNQGDQIGKGNFGSVLKG----TCMANGQLI----PVAVKTLKADFGIPNSEPEIVREAELMAG-LDHPHIVRMIGICHAAE-MMLVLELAELGPLHKYL
 . |...|.|.|| | ||    .|.  ...     .|.||..|... .     |. .|| .|   .|||..|. .|.|.  .  |.|.|..  | | .||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

KKHQE--MSTRNVLELMYQVAQGMCYLESRQFVHRDLAARNVLLVDETFAK---ISDFGMSKA-LGLDSQYYVAETAGKWPLKWYAPECIYKFKFSSKSD
|| ..  .|..  ..  ||.|.|| ||.|.. .|||.||||.|. .. . |   |||||||..  .  ..|. .|.| | | .| |||.. .. .|.|.|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWSYGVTLWEALSYGKRPYAS----MRGQEL-----MQFIENGDRLSQPDRCPDDVYSLMR-RCWLSEAKDRPGFGDIESVLS
|||.||..||  . |. ||.     |.  ..     .. |..| ..  |...|......|  .||  . .||| . .|   | 
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase Syk.AA Csk 419-674 37 7.8e-74 251.32 In-house 1-251 (251) Show / Hide 
Range on Protein: 419-674
Range on HMM: 1-251/251
Sequence Identity: 37% (99 aa)

LNQGDQIGKGNFGSVLKGTCMANGQLIPVAVKTLKAD-FGIPNSEPEIVREAELMAGLDHPHIVRMIGICHAAE--MMLVLELAELGPLHKYL--KKHQE
|  |..||.|.|| |. |.   .     |||| .| |  |   .   .. ||  | .| ||  |..||.       . .|.|    | |  ||    .. 
LHLGECIGHGEFGDVMQGEYQNRK----VAVKCIKCDGNGMAQA---FLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHV

MSTRNVLELMYQVAQGMCYLESRQFVHRDLAARNVLLVDETFAKISDFGMSKALGLDSQYYVAETAGKWPLKWYAPECIYKFKFSSKSDVWSYGVTLWEA
...|  |   . |..||||||...||||||||||.|. ..  ||.|||| .|.  . .      | || | || |||   . |||.||||||.|. ||| 
ITRRQLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAKEECSQQD---DSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEI

LSYGKRPYASMRGQELMQFIENGDRLSQPDRCPDDVYSLMRRCWLSEAKDRPGFGDIESVL
 |.|  ||  .  ..  . .| | |   |. ||. || .|. ||  ....|| |. . . |
YSFGRVPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase Syk.AA S_TKc 419-679 23 6.1e-48 166.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 419-679
Range on HMM: 1-231/231
Sequence Identity: 23% (65 aa)

LNQGDQIGKGNFGSVLKGTCMANGQLIPVAVKTLKADFGIPNSEPEIVREAELMAGLDHPHIVRMIGICHAAEMMLVLELAEL--GPLHKYLKKHQE---
   ...|||| ||.| |..    |..  ||.| .|           | || ...   .||.||.......  .. .|.|...   | |..|.||..    
YEILRKIGKGAFGKVYKCRHKKTGRI--VAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---MSTRNVLELMYQVAQGMCYLESRQFVHRDLAARNVLLVDETFAKISDFGMSKALGLDSQYYVAETAGKWPLKWYAPECIYKFKFSS-KSDVWSYGVT
   ..   .  .|||..... |. |....||||   |.|| .    ||.|||... |          |     . . ||| .   ...  |.|.|| |..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LWEALSYGKRPYASMRGQELMQFIENGDRLSQPDRCPDDVYSLMRRCWLSEAKDRPGFGDIES----VLSDILK
|.| |. |. |.     |.... |            .... ...|.|.  . ..||.  ..      . ..   
LYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Syk.AA Pkinase 419-677 24 5.6e-39 138.89 Pfam 1-293 (293) Show / Hide 
Range on Protein: 419-677
Range on HMM: 1-293/293
Sequence Identity: 24% (75 aa)

LNQGDQIGKGNFGSVLKGTCMANGQLIPVAVKTLKADFGIPNSEPEIVR--EAELMAGLDHPHIVRMIGICH-AAEMMLVLELAELG----PLHKYLK--
.  | .||.|.||.| |..   .|.   ||||..| .   .. . . .|  |...|. |.||.|||......   .. .|.|..| |     |. |..  
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

KHQEM--STRNVLELMYQVAQGMCYLESRQFVHRDLAARNVLLVDETFA----KISDFGMSKAL-GLDSQYYVAETAGKWPLKWYAPECIY-KFKFSSKS
.|  .  | . .   |||...|. |. |. ..||||   |.|....       ||.||| .| .    .. .   .   |   . ||| |    . ..|.
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGPKV

DVWSYGVTLWEALSYGKRPYASM----RGQELMQFIENGDR----LSQPDRCP-------------------DDVYSLMRRCWLSEAKDRPGFGDIESVL
|.||.|..|.| |. |. |. .     .  . || |..  .     . |  |.                   ..  .....|.    |.||.   .| .|
DMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQIL

SD--I
 .  .
QHPWF