Gene TSPK1 (Sea Urchin)

TSPK1

Species: Sea Urchin
Alias: TSPK1, Spk085, SPU_006004
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: TK-Unique

Sequence

Name Sequence Type Origin Length Description Download
TSPK1.AA Protein None 1394 None Fasta, JSON
TSPK1.kin_dom Protein Kinase Domain None 264 None Fasta, JSON

Protein domain

Protein domains of TSPK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
TSP1 TSPK1.AA TSP1 58-110 32 9e-14 52.99 SMART 1-66 (66) Show / Hide 
Range on Protein: 58-110
Range on HMM: 1-66/66
Sequence Identity: 32% (23 aa)

WSDWGEWHTCT-ESCEGG-----LTVRFR-----RCNNPMP--SDGGANCTGFSMEQGACNID----PCP
|..|.|| .|. ..| ||       .| |      ||.| |    ||..|.    |. .|| .    |||
WWEWSEWSPCSGVTCGGGGRTEGTQTRTRTPIRMCCNPPPPRYQNGGQPCP----ETRPCNMQPNLQPCP
TSP_1 TSPK1.AA TSP_1 59-109 37 2e-11 41.17 Pfam 1-53 (53) Show / Hide 
Range on Protein: 59-109
Range on HMM: 1-53/53
Sequence Identity: 37% (20 aa)

SDWGEWHTCTESCEGGLTVRFRRCNNPMPSDGGANCTGFSME-QGAC-NIDPC
|.|.||  |. .| .| ..| |.||.| |...|..|||   .   .| . |.|
SPWSEWSPCSVTCGMGMRMRQRMCNHPAPQHCGEPCTGDDQQETQMCNMMDKC
TSP1 TSPK1.AA TSP1 115-167 38 1.3e-17 65.78 SMART 1-66 (66) Show / Hide 
Range on Protein: 115-167
Range on HMM: 1-66/66
Sequence Identity: 38% (27 aa)

WSSYSDWDACS-VSCGGG-----NQTRTRT----CSDPDP---AYGGANCTGENIEVRACGEG----ICP
|.. |.| .|| |.||||      ||||||    | .| |     ||..|.    |.|.| .      ||
WWEWSEWSPCSGVTCGGGGRTEGTQTRTRTPIRMCCNPPPPRYQNGGQPCP----ETRPCNMQPNLQPCP
TSP_1 TSPK1.AA TSP_1 116-166 37 1.1e-15 55.56 Pfam 1-53 (53) Show / Hide 
Range on Protein: 116-166
Range on HMM: 1-53/53
Sequence Identity: 37% (20 aa)

SSYSDWDACSVSCGGGNQTRTRTCSDPDPAYGGANCTGENIE-VRAC-GEGIC
|  | | .|||.||.| ..|.|.|  | | ..|..|||. .. ...|     |
SPWSEWSPCSVTCGMGMRMRQRMCNHPAPQHCGEPCTGDDQQETQMCNMMDKC
TSP1 TSPK1.AA TSP1 172-224 34 1.7e-14 55.37 SMART 1-66 (66) Show / Hide 
Range on Protein: 172-224
Range on HMM: 1-66/66
Sequence Identity: 34% (24 aa)

WSDWGEWHTCT-ESCEGG-----LTVRFR-----RCNNPMP--SNGGANCTGFSMEQGACNTD----PCP
|..|.|| .|. ..| ||       .| |      ||.| |   |||..|.    |. .||..    |||
WWEWSEWSPCSGVTCGGGGRTEGTQTRTRTPIRMCCNPPPPRYQNGGQPCP----ETRPCNMQPNLQPCP
TSP_1 TSPK1.AA TSP_1 173-223 37 2.6e-10 37.44 Pfam 1-53 (53) Show / Hide 
Range on Protein: 173-223
Range on HMM: 1-53/53
Sequence Identity: 37% (20 aa)

SDWGEWHTCTESCEGGLTVRFRRCNNPMPSNGGANCTGFSME-QGAC-NTDPC
|.|.||  |. .| .| ..| |.||.| |. .|..|||   .   .| . |.|
SPWSEWSPCSVTCGMGMRMRQRMCNHPAPQHCGEPCTGDDQQETQMCNMMDKC
TSP1 TSPK1.AA TSP1 229-281 38 3e-17 64.56 SMART 1-66 (66) Show / Hide 
Range on Protein: 229-281
Range on HMM: 1-66/66
Sequence Identity: 38% (27 aa)

WSSYSDWDACS-VSCGGG-----NQTRTRT----CSDPTP---AYGGANCTGENIEVRACGEG----ICP
|.. |.| .|| |.||||      ||||||    | .| |     ||..|.    |.|.| .      ||
WWEWSEWSPCSGVTCGGGGRTEGTQTRTRTPIRMCCNPPPPRYQNGGQPCP----ETRPCNMQPNLQPCP
TSP_1 TSPK1.AA TSP_1 230-280 37 8.3e-16 55.91 Pfam 1-53 (53) Show / Hide 
Range on Protein: 230-280
Range on HMM: 1-53/53
Sequence Identity: 37% (20 aa)

SSYSDWDACSVSCGGGNQTRTRTCSDPTPAYGGANCTGENIE-VRAC-GEGIC
|  | | .|||.||.| ..|.|.|  | | ..|..|||. .. ...|     |
SPWSEWSPCSVTCGMGMRMRQRMCNHPAPQHCGEPCTGDDQQETQMCNMMDKC
TSP1 TSPK1.AA TSP1 286-335 27 2.7e-09 38.1 SMART 1-66 (66) Show / Hide 
Range on Protein: 286-335
Range on HMM: 1-66/66
Sequence Identity: 27% (19 aa)

WSAYGSFSLCN-TDC--------QKTRYRT----CTNPAP---KDGGDDCPDSEVDVSYCSVL----DCP
|.. .. | |    |         .||.||    | ||.|   . || .||    ..  |..     .||
WWEWSEWSPCSGVTCGGGGRTEGTQTRTRTPIRMCCNPPPPRYQNGGQPCP----ETRPCNMQPNLQPCP
TSP_1 TSPK1.AA TSP_1 300-334 27 0.000261 17.24 Pfam 17-53 (53) Show / Hide 
Range on Protein: 300-334
Range on HMM: 17-53/53
Sequence Identity: 27% (10 aa)

QKTRYRTCTNPAPKDGGDDCPDSEVD-VSYC-SVLDC
...|.|.| .|||...| .|..  .. .  | ..  |
MRMRQRMCNHPAPQHCGEPCTGDDQQETQMCNMMDKC
TSP1 TSPK1.AA TSP1 337-389 30 1e-06 29.28 SMART 1-66 (66) Show / Hide 
Range on Protein: 337-389
Range on HMM: 1-66/66
Sequence Identity: 30% (22 aa)

NGQWSEWSVITCD-ETC-RG-----SKRRT------CSNPPP---LRGGADCVGSSREEYGICTGF----KCV
 ..|||||  .|. .|| .|      ..||      | ||||     ||..|      |. .|..     .| 
WWEWSEWS--PCSGVTCGGGGRTEGTQTRTRTPIRMCCNPPPPRYQNGGQPCP-----ETRPCNMQPNLQPCP
TSP_1 TSPK1.AA TSP_1 338-388 34 0.001486 14.7 Pfam 1-53 (53) Show / Hide 
Range on Protein: 338-388
Range on HMM: 1-53/53
Sequence Identity: 34% (19 aa)

GQWSEWSVITCDETCRG---SKRRTCSNPPPLRGGADCVGSSREEYGIC-TGFKC
..|||||   |. || .   . .|.| .|.|  .|..|.|  ..|  .| .  ||
SPWSEWS--PCSVTCGMGMRMRQRMCNHPAPQHCGEPCTGDDQQETQMCNMMDKC
TSP1 TSPK1.AA TSP1 394-449 34 3.9e-18 67.5 SMART 1-66 (66) Show / Hide 
Range on Protein: 394-449
Range on HMM: 1-66/66
Sequence Identity: 34% (25 aa)

WSDWAPWSSCS-KTCDRG----GISHRRR----HCSNPHP---RNGGKDCPAVDPDYDEKSCFSH----PCP
|..| .||.|| .|| .|    |. .|.|    .| ||.|   .|||..||      . . |. .    |||
WWEWSEWSPCSGVTCGGGGRTEGTQTRTRTPIRMCCNPPPPRYQNGGQPCP------ETRPCNMQPNLQPCP
TSP_1 TSPK1.AA TSP_1 395-448 34 1.7e-12 44.81 Pfam 1-53 (53) Show / Hide 
Range on Protein: 395-448
Range on HMM: 1-53/53
Sequence Identity: 34% (19 aa)

SDWAPWSSCSKTCDRGGISHRRRHCSNPHPRNGGKDCPAVDPDYDEKSC-FSHPC
|.| .||.||.||  .|.. |.| | .| |. .|..|.. | . . . |   ..|
SPWSEWSPCSVTCG-MGMRMRQRMCNHPAPQHCGEPCTGDDQQ-ETQMCNMMDKC
Kinase TSPK1.AA TK-Unique 1110-1372 37 6.6e-123 414.61 In-house 1-294 (294) Show / Hide 
Range on Protein: 1110-1372
Range on HMM: 1-294/294
Sequence Identity: 37% (110 aa)

IELEQEIAEGAYGSIHRAGVWLPGQKEDEEPTSILIKVLNRNVSPTSKAAYLQEIETMKKLKAHPNVIAFVGCCTKSD-PFFMILEYASKGPLQTFLRRN
.|....| |||.| ..|..|| .  |..........| |..|...|.|...|.||. ||.|..|||.. ..||||||| |...|.||...| ||..||..
LEVGDVIGEGAFGQVWRGEVWGIW-KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

RPG---------------TPGAKPPPAEIF----LRFAIHTAKGMTFLQT--QKVAHGELTSRNILLNDYLRAKVNNS---YRIRTPTDIVTQ---GRMG
||.               .. .||....|     ..||.  |.|| .|.   .|. |. | .||.||......|...    ....|.......   ||. 
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

VRWMGPEVLG--GGSY-TPANDVWSFGILLWELVCFGATPYTGMSSRDVKTRIPAGHRLEQPPQC-PDETYELMKSCWQADPSQRPSFRVLVHEL
.||| ||.|   .| | |. .||||||.|.||....||.||.||...|. ..|..|.|..||..| ..|.|.||||||| .|..||||| ..|.|
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase TSPK1.AA TK 1110-1372 17 2.6e-78 261.99 In-house 1-486 (486) Show / Hide 
Range on Protein: 1110-1372
Range on HMM: 1-486/486
Sequence Identity: 17% (85 aa)

IELEQEIAEGAYG---SIHRAGVWLPGQK------------------EDEEPTSILIKVLNR--NVSPTSKAA-----------YLQEIETMKKLKA---
|.|.... ||..|    .... .  .. .                  .....|   .|.|    . |.. . .           .|.| | ||....   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNVIAFVGCCTKS------------DPFFMILEYASKGP----LQTFLRRNRPGTPGAKPPPAE----------------------------------
 |||.. ..|.||..             |. ...||...|     |...||..||..    . |..                                  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---------------IFLR-------------------FAIHTAKGMTFLQTQ------KVAHGELTSRNILLNDYLR-----------AKVNNSY----
                .|.                   ..   |.|| .|  .      .. |. |  ||.|... ..           .|.        
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----RIRTP---TDIVTQG--------------------------RMGVRWMGPEVLGGGS---------YTPANDVWSFGILLWELVCFG-ATPYTGMS
    . |     .| ....                          .. .||| ||.| ..          .|.. ||||||.|.||.. .| ...| |||
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

S---------RDVKTRIPAG--------------HRLEQPPQCP--------------DETYELMKSCWQADPSQRPSFRVLVHEL
.         ..|  .. .|              .|..|||.||              .| |.||..||..||..||.|. |...|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TSPK1.AA TyrKc 1110-1372 28 3.8e-71 243.6 SMART 1-280 (280) Show / Hide 
Range on Protein: 1110-1372
Range on HMM: 1-280/280
Sequence Identity: 28% (84 aa)

IELEQEIAEGAYGSIHRAGVWLPGQKEDEEPTSILIKVLNRNVSPTSKAAYLQEIETMKKL-KAHPNVIAFVGCCTKS-------DPFFMILEYASKGPL
|.|.... |||.| ... |.|          .   .|.|. .     ... ..|.. |.|| . |||.....|.||..       .| ....||...| |
ITLGKKLGEGAFGEVYK-GTWK---------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

QTFLRRNRPGTPGAKPPPAEIFLRFAIHTAKGMTFLQTQKVAHGELTSRNILLNDYLRAKV------NNSYRI-----RTPTDIVT---QGR--MGVRWM
. .||..||        . . .| |..  |.|| .|  ... |  |  ||.|... ...|.       . |       .. .  ..   .|.  . .|||
KDYLRKHRPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

GPEVLGGGSYTPANDVWSFGILLWELVCFGATPYTG-----MSSRDVKTRIPAGHRLEQPPQ--------CPDETYELMKSCWQADPSQRPSFRVLVHEL
 ||..  | .|.. ||||||...||.  .|..|| |     || ..|  .. .|.|..|||         |||| |..||.||..||..||.|. .....
APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase TSPK1.AA Tie 1118-1372 33 1.4e-60 182.85 In-house 1-267 (267) Show / Hide 
Range on Protein: 1118-1372
Range on HMM: 1-267/267
Sequence Identity: 33% (92 aa)

EGAYGSIHRAGVWLPGQKEDEEPTSILIKVLNRNVSPTSKAAYLQEIETMKKLKAHPNVIAFVGCCTKSDPFFMILEYASKGPLQTFLRRNR-----PGT
|| .| . .| .     | |     . || .    |   .  .  |.| | |.  |||.|  || | .    .. .|||  | |  |||. |     |  
EGNFGQVMKAMI-----KKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAF

PGAKPP----------PAEIFLRFAIHTAKGMTFLQTQKVAHGELTSRNILLNDYLRAKVNNSYRIRTPTDIV--TQGRMGVRWMGPEVLGGGSYTPAND
. ..             ..  |.||   |.|| .|  ... | .|  ||||  . . .|.      |     |  | ||. ||||  | |    ||   |
AREHTTRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRGDEVYVKKTMGRLPVRWMAIESLNYSVYTTKSD

VWSFGILLWELVCFGATPYTGMSSRDVKTRIPAGHRLEQPPQCPDETYELMKSCWQADPSQRPSFRVLVHEL
|||.|.||||.| .| ||| ||   ..  ..| |.|.|||  | || |.||. ||.  | .||.|  .. .|
VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase TSPK1.AA RTKB 1110-1372 30 1.4e-53 178.98 In-house 1-264 (264) Show / Hide 
Range on Protein: 1110-1372
Range on HMM: 1-264/264
Sequence Identity: 30% (82 aa)

IELEQEIAEGAYGSIHRAGVWLPGQKEDEEPTSILIKVLNRNVSPTSKAAYLQEIETMKKLKAHPNVIAFVGCCTKSDPFFMILEYASKGPLQTFLRRNR
. | ..  .||.|   .| | .... .     |.  |||   .| . . . ..|.  || | .|||||  .| | .  |     |..  | |  .||  |
VWLGEKLGNGAFGEVFQAWVRNRHMNTEQ---SCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCR

PGTPGAKPPPAEIFLRFAIHTAKGMTFLQTQKVAHGELTSRNILLNDYLRAKVNNS--YR-IRTPTDIVTQGRMGVRWMGPEVLGGGSYTPAN-DVWSFG
    .. .  ..  . |.   |.|| ||  ..| |. |  ||.|.   |  |.      | |       |  |. ..|| || ..   ||    ||||||
ASQHNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFG

ILLWELVCFGATPYTGMSSRDVKTRIPAGHRLEQPPQCPDETYELMKSCWQADPSQRPSFRVLVHEL
.  ||   .|.|||   . .|..     ||||..| | | .....|. |||.....||.|  || ..
VTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase TSPK1.AA CTKA 1110-1372 29 1.9e-51 171.04 In-house 1-290 (290) Show / Hide 
Range on Protein: 1110-1372
Range on HMM: 1-290/290
Sequence Identity: 29% (87 aa)

IELEQEIAEGAYGSIHRAGVWLPGQKE-----DEEPTSILIKVLNRNVSPTSKAAYLQEIETMK-KLKAHPNVIAFVGCCTKSDPFFMILEYASKGPLQT
     .| || || . ||  || .. .         . . .| |  .       |.| |  .    .  ||||.. .| ||.. | .|| |. . | |. 
HCIMFKIGEGHYGQVFRA--WLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDLHC

FLRRNRPGT-----------------PGAKPPPAEIFLRFAIHTAKGMTFLQTQKVAHGELTSRNILLNDYLRAKVNN---SYRIRTP-TDIVTQ--GRM
.||. ||                   | .   .  ..   |   | || .|      |  |  ||.||  |   |. .   .   ||  .. . .  ..|
YLRACRPADGQVCPARARRSIPRSFHPIEVHAHEQVYM--AMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRVM

GVRWMGPEVLGGGSYTPANDVWSFGILLWELVCFGATPYTGMSSRDVKTRIPAG--HRLEQPPQCPDETYELMKSCWQADPSQRPSFRVLVHEL
 |||| || |  | .. | |||.||.||||.  .| .|. .|| . |.. . ..   ||  |. ||.  | .|. ||.  | |||.|  |  .|
PVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase TSPK1.AA Csk 1159-1372 34 4.2e-46 155.32 In-house 40-251 (251) Show / Hide 
Range on Protein: 1159-1372
Range on HMM: 40-251/251
Sequence Identity: 34% (75 aa)

AYLQEIETMKKLKAHPNVIAFVGCCTKSD-PFFMILEYASKGPLQTFLRRNRPGTPGAKPPPAEIFLRFAIHTAKGMTFLQTQKVAHGELTSRNILLNDY
| | |   | .|. ||| ....|   ..    ....|| ||| |  .||     . | .    .  | ||.....|| .|   |. |  |  ||||. . 
AFLAEASVMTQLR-HPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLR-----SRGRHVITRRQLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSED

LRAKVNN---SYRIRTPTDIVTQGRMGVRWMGPEVLGGGSYTPANDVWSFGILLWELVCFGATPYTGMSSRDVKTRIPAGHRLEQPPQCPDETYELMKSC
. |||     .   ..  |  | |.. . |  || |  . ..   |||||||||||.  ||  ||  .. .||  ..  | | | |  ||.. |..||.|
CVAKVSDFGLAKEECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQC

WQADPSQRPSFRVLVHEL
|...| .||.|| ..  |
WHLNPAKRPTFRQVREQL
Kinase TSPK1.AA Pkinase_Tyr 1282-1372 45 3.1e-44 150.46 Pfam 178-270 (270) Show / Hide 
Range on Protein: 1282-1372
Range on HMM: 178-270/270
Sequence Identity: 45% (42 aa)

VRWMGPEVLGGGSYTPANDVWSFGILLWELVCFGATP-YTGMSSRDVKTRI-PAGHRLEQPPQCPDETYELMKSCWQADPSQRPSFRVLVHEL
..|| ||..  | .| . ||||||.|.||.. .|..| | |||  .|. .|   |.|...|. |||| |.|||.||..||..||.|. ....|
IKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TSPK1.AA UTK 1277-1372 41 4.4e-42 141.76 In-house 198-296 (296) Show / Hide 
Range on Protein: 1277-1372
Range on HMM: 198-296/296
Sequence Identity: 41% (41 aa)

QGRMGVRWMGPEVLGGG-SYTPANDVWSFGILLWELVCFGATPYTGMSSRDVKTRIPAG--HRLEQPPQCPDETYELMKSCWQADPSQRPSFRVLVHEL
|.|. .||| ||.|  .  .| ..||||||...||.. .|..|| ||| ..| ... .|  .|...|..||.. |.||..||..||. ||.|. || ..
QDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase TSPK1.AA Src 1282-1372 45 5.5e-37 123.17 In-house 164-255 (255) Show / Hide 
Range on Protein: 1282-1372
Range on HMM: 164-255/255
Sequence Identity: 45% (42 aa)

VRWMGPEVLGGGSYTPANDVWSFGILLWELVCFGATPYTGMSSRDVKTRIPAGHRLEQPPQCPDETYE-LMKSCWQADPSQRPSFRVLVHEL
..|. || .  |..|   |||||||||.|.| .| .|| ||. ..| ... .| |. .|..|||| || .|. ||..|| ||| |  | . |
IKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase TSPK1.AA Pkinase_Tyr 1110-1262 25 5.5e-35 119.1 Pfam 1-152 (270) Show / Hide 
Range on Protein: 1110-1262
Range on HMM: 1-152/270
Sequence Identity: 25% (41 aa)

IELEQEIAEGAYGSIHRAGVWLPGQKEDEEPTSILIKVLNRNVSPTS--KAAYLQEIETMKKLKAHPNVIAFVGCCT-KSDP--FFMILEYASKGPLQTF
|.. ... |||.|.... |.| .  ..|.. .   .|.|. . ..    ... ..|...||.|  |||.. ..|.|| ...|   ....||. .| | ..
ITFGKKLGEGAFGEVYK-GTWKG--DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LRRNRPGTPGAKPPPAEIFLRFAIHTAKGMTFLQTQKVAHGELTSRNILLNDYLRAKV
||..|   .. .|.. .  | ...  |||| .|  ..  |  |  ||.|... . .|.
LRKHR---EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKI
Kinase TSPK1.AA FGFR 1276-1372 41 9.5e-35 115.83 In-house 196-293 (293) Show / Hide 
Range on Protein: 1276-1372
Range on HMM: 196-293/293
Sequence Identity: 41% (41 aa)

TQGRMGVRWMGPEVLGGGSYTPANDVWSFGILLWELVCFGATPYTGMS-SRDVKTRIPAGHRLEQPPQCPDETYELMKSCWQADPSQRPSFRVLVHEL
| ||  . || || |    ||   ||||.|.||||   .| .|| .     .  .    |||.| |..|. | | .| .|| . |.|||.|  || .|
TNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase TSPK1.AA EGFR 1278-1373 39 1.1e-34 112.49 In-house 163-258 (258) Show / Hide 
Range on Protein: 1278-1373
Range on HMM: 163-258/258
Sequence Identity: 39% (38 aa)

GRMGVRWMGPEVLGGGSYTPANDVWSFGILLWELVCFGATPYTGMSSRDVKTRIPAGHRLEQPPQCPDETYELMKSCWQADPSQRPSFRVLVHELE
|.| ..||  |..  . || . ||||.|. .|||. ||. || |.. |..   .  | ||.||| |    | .| .|| .|.  || |. |..|..
GKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase TSPK1.AA UTK 1110-1264 24 8.6e-21 67.86 In-house 1-168 (296) Show / Hide 
Range on Protein: 1110-1264
Range on HMM: 1-168/296
Sequence Identity: 24% (42 aa)

IELEQEIAEGAYGSIHRAGVWLPGQKED--EEPTSILIKVLN-RNVSPTSKA---AYLQEIE---TMKKLKAHPNVIAFVGCCTKSDPFFMILEYASKGP
..| ... .||.| .|.| .    ....  ..     .||.. . .......     . |      ||... ||||. .|| ||.. |. ...||...| 
VQLGRQLGQGAFGEVHKARF----TQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGD

LQTFLRRNRPGTPGAKPPPAEI-FLRFAIHTAKGMTFLQTQKVAHGELTSRNILLNDY-------LRAKVNN
|...|||.|| .|..     .   | .| . | || .| .... |. |  ||.|...        . .|...
LRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIAD
Kinase TSPK1.AA Src 1145-1262 27 7.8e-20 64.02 In-house 28-138 (255) Show / Hide 
Range on Protein: 1145-1262
Range on HMM: 28-138/255
Sequence Identity: 27% (32 aa)

IKVLNRNVSPTSKAAYLQEIETMKKLKAHPNVIAFVGCCTKSDPFFMILEYASKGPLQTFLRRNRPGTPGAKPPPAEIFLRFAIHTAKGMTFLQTQKVAH
.|.| .     | .|.|||...||||. |.....    |.. .|.. . || |.| |...|..    ..  .  . .. . .| . |.|| .|  ... |
VKTLKPGT--MSPEAFLQEAQIMKKLR-HEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIH

GELTSRNILLNDYLRAKV
  |  ||.| .. . .||
RDLAARNVLVGENNVCKV
Kinase TSPK1.AA FGFR 1110-1256 25 2e-16 52.43 In-house 1-171 (293) Show / Hide 
Range on Protein: 1110-1256
Range on HMM: 1-171/293
Sequence Identity: 25% (44 aa)

IELEQEIAEGAYGSIHRAGVW-LPGQKEDEEPTSILIKVLNRNVSPTSKAAYLQEIETMKKLKAHPNVIAFVGCCTKSDPFFMILEYASKGPLQTFLRRN
  | . . ||..| . .| .  .. .....| . . .| |  | . .  .    |.|.||    |.|.|   ||||   | . | ||...| |  ||| .
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKE-ITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRAR

RPGT----PGAK-------PPPAEI-------------FLRFAIHTAKGMTFLQTQKVAHGELTSRNILLND
||.     . ..        .|..                ..|   |.|| .|  .|. |  |  ||.|  |
RPPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTD
Kinase TSPK1.AA Pkinase 1283-1372 22 3.8e-16 58.18 Pfam 176-293 (293) Show / Hide 
Range on Protein: 1283-1372
Range on HMM: 176-293/293
Sequence Identity: 22% (27 aa)

RWMGPEVLG-GGSYTPANDVWSFGILLWELVCFGATPYTGM----SSRDVKTRIPAGHRLEQPPQCP-----------------------DETYELMKSC
..| |||.  |  |.|. |.||.|..|.|..| | .|. |     . .| . .|    . . . ..|                       .|  ...|.|
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

WQADPSQRPSFRVLVHE--L
.. ||..||... ...   .
LCKDPKKRPTAEQILQHPWF
Kinase TSPK1.AA S_TKc 1110-1381 18 6.2e-16 56.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 1110-1381
Range on HMM: 1-231/231
Sequence Identity: 18% (51 aa)

IELEQEIAEGAYGSIHRAGVWLPGQKEDEEPTSILIKVLNRNVSPTSKAAYLQEIETMKKLKAHPNVIAFVGCCTKSDPFFMILEYASK--GPLQTFLRR
 |. ..| .||.|. ... ..              ||...           ..||. .||   |||.. . ...   | ..|..||..   | | .....
YEILRKIGKGAFGKVYKC-RHKK------TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

NRPGTPGAKPPPAEIFLRFAIHTAKGMTFLQTQKVAHGELTSRNILLNDYLRAKV---NNSYRIRTPTDIVTQGRMGVRWMGPEVLGGGSYTP-ANDVWS
.... .. . |. ..  ...  ..... ..  ... |  |   ||||..  . |.     . ..       |       .| ||||   .|.. . |.||
RGRHGLRFPFPE-HA-RFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWS

FGILLWELVCFGATPYTGMSSRDVKTRIPAGHRLEQPPQCPDETYELMKSCWQADPSQRPSFRVLVHELEKLAPQDFI
.|..|.|..| | .|.      ..  ..            ..|  .... |.| ||..||.   . .. .. .   ..
CGCILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TSPK1.AA EGFR 1110-1262 24 3e-14 43.54 In-house 1-142 (258) Show / Hide 
Range on Protein: 1110-1262
Range on HMM: 1-142/258
Sequence Identity: 24% (37 aa)

IELEQEIAEGAYGSIHRAGVWLPGQKEDEEPTSILIKVLNRNVSPTSKAAYLQEIETMKKLKAHPNVIAFVGCCTKSDPFFMILEYASKGPLQTFLRRNR
. . .    ||.| .. .|.| |  ..   |  . ||||. . .| .. . |.|   |  .. ||...  .| | .|.   ..  |   | |. ..| ..
LKKVKVLGSGAFGTVY-KGIWIPEGENVKIP--VAIKVLREQTGPKANEEMLDEAYVMASVD-HPHLVRLLGVCMHSQ-MQLVTQYMPYGCLLDYVRQHK

PGTPGAKPPPAEIFLRFAIHTAKGMTFLQTQKVAHGELTSRNILLNDYLRAKV
 .. |..       | ...  |||| .|  ... | .|  ||.|.    . |.
-DNIGSQ-----HLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKI
Kinase TSPK1.AA Pkinase 1110-1210 19 1e-09 35.48 Pfam 1-102 (293) Show / Hide 
Range on Protein: 1110-1210
Range on HMM: 1-102/293
Sequence Identity: 19% (21 aa)

IELEQEIAEGAYGSIHRAGVWLPGQKEDEEPTSILIKVLNRNVSPTSKAAYLQ---EIETMKKLKAHPNVIAFVGCCTKSDPFFMILEYASKG----PLQ
..... | .|..|.  . ...   .|         .|....     .|  ..    ||. ||.|. |||.. . .... .|   |..||. .|     | 
YHIGRKIGSGSFGCV-YKCHHKGTGK------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

TFLR--RNRP
....  |...
DYISTWRHGC