Gene ank1 (Sea Urchin)

ank1

Species: Sea Urchin
Alias: ank1, SPU_011264, Spk202
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: RIPK

Sequence

Name Sequence Type Origin Length Description Download
ank1.AA Protein None 520 None Fasta, JSON
ank1.kin_dom Protein Kinase Domain None 182 None Fasta, JSON

Protein domain

Protein domains of ank1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank ank1.AA Ank 110-142 42 4e-09 37.15 Pfam 1-33 (33) Show / Hide 
Range on Protein: 110-142
Range on HMM: 1-33/33
Sequence Identity: 42% (14 aa)

DGNTALYSASKQGHLHVVEYLVGQGAQVEKVDN
||.|.|  |.. ||. ||..|...|| |  .|.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank ank1.AA Ank 209-241 36 8e-09 36.08 Pfam 1-33 (33) Show / Hide 
Range on Protein: 209-241
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

HGDTPIHAASGNGHLAIVRYLVRQGAEIERTDN
.|.|| | |. .||. .|..|. .||..  .|.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank ank1.AA Ank 44-76 39 1e-08 35.69 Pfam 1-33 (33) Show / Hide 
Range on Protein: 44-76
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

DGNTPLLYASTNRYLGVVQYLVDQGADVDKGNI
||.||| .|. . .. ||..|...||||.  . 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank ank1.AA Ank 143-175 42 1.7e-08 34.89 Pfam 1-33 (33) Show / Hide 
Range on Protein: 143-175
Range on HMM: 1-33/33
Sequence Identity: 42% (14 aa)

KGSTSLIIASAKGHIDVVKYLISKGANINKPDV
 | | | .|. .||..|||.|...||..|  | 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank ank1.AA Ank 77-109 42 2.2e-07 30.87 Pfam 1-33 (33) Show / Hide 
Range on Protein: 77-109
Range on HMM: 1-33/33
Sequence Identity: 42% (14 aa)

GGSTPLHFASGWGFLDVVQCLVGNKAKINKLDD
 | |||| |. .| ..||..|... | .|  ||
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank ank1.AA Ank 176-208 36 7e-06 25.57 Pfam 1-33 (33) Show / Hide 
Range on Protein: 176-208
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

DGKTPIYGASLKGRLHVVQYLVGQGALIENCDN
|| ||   |...|.. ||..|...|| .   |.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank ank1.AA Ank 15-43 31 0.000721 18.21 Pfam 5-33 (33) Show / Hide 
Range on Protein: 15-43
Range on HMM: 5-33/33
Sequence Identity: 31% (9 aa)

ALHLAAANGDVNEVQYLIGQGTHIDTYDE
.||||. .|... |..|...|  ..  | 
PLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank ank1.AA Ank 242-262 57 0.005744 14.96 Pfam 1-21 (33) Show / Hide 
Range on Protein: 242-262
Range on HMM: 1-21/33
Sequence Identity: 57% (12 aa)

AGHTPLLLATGHGHIEVVEYL
 | ||| ||  .||.|||..|
DGFTPLHLACRCGHTEVVKML
Kinase ank1.AA RIPK 312-519 52 8e-123 414.35 In-house 1-212 (290) Show / Hide 
Range on Protein: 312-519
Range on HMM: 1-212/290
Sequence Identity: 52% (117 aa)

LGGGSFGEVFKAVHAVHGDVAVKLAKPGKERQLEMYKKQVVMYQKEAQKHENSLKCEHIVPIKGFVQCEDKACDCELFGIVIQYMKNGSLWNFRTTKWRQ
.|||.|||||||.|...||...|..||.|... .| ..|..|||||..||...|.|||||||.||.|||...|||.|.|||..||.|||||.|..|||..
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHM-DDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPY

HPDHLDFRTTKLLHHPDLWPLTNRMVYQISRGMHFLHSKY--IIHRDLKLENVLVDRNLNVKIADLGLATNLQTSSGKG--C-------------YGTDS
            .||||.|||..||...||.||..|||..  |||||||.||.|||.|..|||||.||||....|. ..  |              ||.|
------------QHHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLS

HKPPEAFRTDIPNSTKVVTPKYDVY
..|||.|||| ....||||||||||
YMPPEHFRTDNKKPIKVVTPKYDVY
Kinase ank1.AA TKL 312-519 22 5.1e-54 185.78 In-house 1-273 (364) Show / Hide 
Range on Protein: 312-519
Range on HMM: 1-273/364
Sequence Identity: 22% (66 aa)

LGGGSFGEVFKAVHAVHG---------DVAVKLAKPGKERQLEM-------------------YKKQVVMYQKEAQKHENSLKCEHIVPIKGFVQCEDKA
.| |.||||.|...  .|         |||||  |   .   ..                     ..     .|  .. ..|....||...|...|... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

CDCE-------LFGIVIQYMKNGSLWNFRTTKWRQHPDHLDFRTTKLLHHPDLWPLTNRMVYQISRGMHFLHSKY--------IIHRDLKLENVLVDRNL
| |.        ..|| .|...|||... .                       |... |....|.|||..|||.         ||||||| .|.|||.|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENW

N--------------VKIADLGLATNLQTSSGKGC---------------------YGTDSHKPPEAFRTDIPNSTKV----------VTPKYDVY
.              .||.|.||......|... .                      ||  . .||..| ..... ||           ..| |||
TNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVY
Kinase ank1.AA TK 306-478 18 9.9e-23 72.36 In-house 1-298 (486) Show / Hide 
Range on Protein: 306-478
Range on HMM: 1-298/486
Sequence Identity: 18% (55 aa)

DHEGCHLGGGSFG---EVFKAVHAVHG--------------------------DVAVKLAKPGKERQLEMYKKQVVM----------YQKEAQKHEN-SL
 . |  || | ||   ||.|.    ..                          .||||  |.| . . |. . .. .             |...  .  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KCEHIVPIKG-FVQCEDKA-----CDCELFGIVIQYMKNGS--------LWNFRTTKWRQHPDHLDFRTTKLLH--------------------------
....|| . |  .| | |      .. | . ||  ||..|.        |.. | ..  . .   ... ... .                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------HPDLWPLTNR------------------MVYQISRGMHFLHSK------YIIHRDLKLENVLVDRNLN-----------VKIADLGLA
            ... | ..                  | .||..|| .||||       ..||||   |.||..|..           .|||| ||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS
Kinase ank1.AA Dicty4 430-483 45 8.5e-19 59.47 In-house 108-166 (277) Show / Hide 
Range on Protein: 430-483
Range on HMM: 108-166/277
Sequence Identity: 45% (27 aa)

WPLTNR---MVYQISRGMHFLHS--KYIIHRDLKLENVLVDRNLNVKIADLGLATNLQT
|||  |   |   . |||  ||.    |||||||  | ||| |..||..|.||..  ..
WPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKK
Kinase ank1.AA CAMK 435-499 25 1.3e-18 55.93 In-house 183-290 (425) Show / Hide 
Range on Protein: 435-499
Range on HMM: 183-290/425
Sequence Identity: 25% (27 aa)

RMVYQISRGMHFLHSKYIIHRDLKLENVLVDRN-----------------LNVKIADLGLATNLQTSSGKG-------------------------CYGT
|.. ||  ..|..||. |.|||||.||.|.| |                  |.||.| |.|. .. ...                           . ||
RYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGT

DSHKP-PE
 .  . ||
PEYMAAPE
Kinase ank1.AA PLK 437-481 55 4.8e-18 55.46 In-house 106-150 (258) Show / Hide 
Range on Protein: 437-481
Range on HMM: 106-150/258
Sequence Identity: 55% (25 aa)

VYQISRGMHFLHSKYIIHRDLKLENVLVDRNLNVKIADLGLATNL
.|||  |.  ||.. |||||||| |.. ..|..|||.| |||| |
MYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRL
Kinase ank1.AA Pkinase 435-492 41 1.1e-17 63.57 Pfam 112-170 (293) Show / Hide 
Range on Protein: 435-492
Range on HMM: 112-170/293
Sequence Identity: 41% (26 aa)

RMVYQISRGMHFLHSKYIIHRDLKLENVLVDRNLNV----KIADLGLATNLQTSSGKGCYGT
...||| ||. ..||. |||||||.||.|.|.| ..    ||.| |||  ..    .. . |
FYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTT
Kinase ank1.AA Ciliate-E2 438-502 21 1.7e-17 56.58 In-house 152-260 (365) Show / Hide 
Range on Protein: 438-502
Range on HMM: 152-260/365
Sequence Identity: 21% (24 aa)

YQISR---------------GMHFLHSKY-IIHRDLKLENVLVDRNLNVKIADLGLATNLQTSSGKG---------------------------------
.|| .               ....||||  |||||.|.||.|.     .||.|.||........ ..                                 
KQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNT

CYGTDSHKPPEAFR
..||   ..|| ..
ICGTPGYMAPEILN
Kinase ank1.AA UTK 436-485 32 3.7e-17 55.26 In-house 123-190 (296) Show / Hide 
Range on Protein: 436-485
Range on HMM: 123-190/296
Sequence Identity: 32% (22 aa)

MVYQISRGMHFLHSKYIIHRDLKLENVLVDRN-------LNVKIADLG---LATNLQT--------SS
|...|.|||..|||. ..||||   |.||...       . .||||.|   .. ...|        .|
MAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWES
Kinase ank1.AA LISK 440-478 48 1.3e-16 50.33 In-house 110-152 (296) Show / Hide 
Range on Protein: 440-478
Range on HMM: 110-152/296
Sequence Identity: 48% (21 aa)

ISRGMHFLHSKYIIHRDLKLENVLVDRN----LNVKIADLGLA
|..|| .|||. |||||||  |.||..|     ..|..|.|.|
IACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFA
Kinase ank1.AA Src 439-478 52 1.3e-14 46.04 In-house 105-144 (255) Show / Hide 
Range on Protein: 439-478
Range on HMM: 105-144/255
Sequence Identity: 52% (21 aa)

QISRGMHFLHSKYIIHRDLKLENVLVDRNLNVKIADLGLA
|...|| .| |. .|||||   ||||. |. .|.|| |||
QVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLA
Kinase ank1.AA Pkinase_Tyr 436-478 55 9.2e-14 47.23 Pfam 116-158 (270) Show / Hide 
Range on Protein: 436-478
Range on HMM: 116-158/270
Sequence Identity: 55% (24 aa)

MVYQISRGMHFLHSKYIIHRDLKLENVLVDRNLNVKIADLGLA
| .||..|| .|.|| .|||||   |.||..|. |||.| |||
MCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase ank1.AA TyrKc 306-512 18 3.3e-11 -41.55 SMART 1-280 (280) Show / Hide 
Range on Protein: 306-512
Range on HMM: 1-280/280
Sequence Identity: 18% (58 aa)

DHEGCHLGGGSFGEVFKAVHAVHGDVAVKLAKPGKERQLEMYKKQVVMYQKEAQKHENSL--KCEHIVPIKGFVQCEDKACDC---ELFGIVIQYMKNGS
 . |  || | ||||.|..     .||||  |...          . .  .||.   . |  . ..|| . | .  .         |   ||  ||..|.
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA----------REDFMREARIMCK-LGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGD

LWNFRTTKWRQHPDHLDFRTTKLLHHPDLWPLTNRMVYQISRGMHFLHSKYIIHRDLKLENVLVDRNLNVKIADLGLATNLQTS----------------
| ..   . ..                  ..    . .||..|| .|||| .|||||   |.||..|. |||.| ||. ..                   
LKDYLRKHRPK----------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHK

SGK---------------GCYGTDS----------------HKPPEA------------------FRTDIPNS---------------------------
.||               |.. | |                 .|..                   .| ..| .                           
GGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPED

-------TKVV
        .  
RPTFSEIHECF
Kinase ank1.AA S_TKc 306-519 18 3.7e-10 -27.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 306-519
Range on HMM: 1-231/231
Sequence Identity: 18% (50 aa)

DHEGCHLGGGSFGEVFKAVHAV-HGDVAVKLAKPGKERQLEMYKKQVVMYQKEAQKHENSLKCEHIVPIKGFVQCEDKACDCELFGIVIQYMKN--GSLW
 . . ..| |.||.|.|..|   .  ||.|  |               . ..| | ...  ....|| .... |        . . .|  |. .  |.| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK--HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLF

NFRTTKWRQHPDH-LDFRTTKLLHHPDLWPLTNRMVYQISRGMHFLHSKYIIHRDLKLENVLVDRNLNVKIADLGLATNLQTSSGKGC----------YG
 .   . |. ... ..  ...            ...||| ... ..||. ||||||| ||.|.|.  ..||.| |||. |  ..  |           ||
DYIKKRGRHGLRFPFPE-HAR------------FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--TTFCGTPWYMAPEVLGYG

T----------------------DSHKPPEAFRTDIPNSTKVV---------TPK----------------YDVY
.                      .   . . |.     |  .           |.                    
KCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase ank1.AA Src 312-339 50 3.5e-05 13.52 In-house 7-34 (255) Show / Hide 
Range on Protein: 312-339
Range on HMM: 7-34/255
Sequence Identity: 50% (14 aa)

LGGGSFGEVFKAVHAVHGDVAVKLAKPG
|| | ||||....   . .||||  |||
LGQGQFGEVWMGYWNGNTKVAVKTLKPG
Kinase ank1.AA CAMK 311-334 29 7.3e-05 10.81 In-house 1-37 (425) Show / Hide 
Range on Protein: 311-334
Range on HMM: 1-37/425
Sequence Identity: 29% (11 aa)

HLGGGSFGEVFKAVHAVHGD-------------VAVK
 || ||||.|....|   .              ||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIK
Kinase ank1.AA Pkinase 307-404 25 0.000189 16.82 Pfam 2-94 (293) Show / Hide 
Range on Protein: 307-404
Range on HMM: 2-94/293
Sequence Identity: 25% (26 aa)

HEGCHLGGGSFGEVFKAVHAVHGD-VAVKLAKPGKERQLEMYKKQVVMYQKEAQKHENSLKCEHIVPIKGFVQCEDKACDCELFGIVIQYMKNG----SL
| |  .| ||||.|.|..|   |. ||||  |  |... .  ... .    |.| . .  ....|| ...... .|. .      .|  |. .|    .|
HIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIK--KRHEKSWKDQTHRRL-SEIQIMKRL-NHPNIVRLYDWFEDKDHIY------MVMEYCEGGLYVMDL

WNF
. .
FDY
Kinase ank1.AA Pkinase_Tyr 307-339 39 0.000931 13.35 Pfam 2-39 (270) Show / Hide 
Range on Protein: 307-339
Range on HMM: 2-39/270
Sequence Identity: 39% (15 aa)

HEGCHLGGGSFGEVFKAVHA-----VHGDVAVKLAKPG
. |  || |.||||.|..        . .||||  |.|
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG
Kinase ank1.AA LISK 311-325 46 0.001744 6.96 In-house 1-15 (296) Show / Hide 
Range on Protein: 311-325
Range on HMM: 1-15/296
Sequence Identity: 46% (7 aa)

HLGGGSFGEVFKAVH
 .| |.||.|.|  |
EIGKGFFGKVYKGTH
Kinase ank1.AA Dicty4 312-323 66 0.104435 1.67 In-house 7-18 (277) Show / Hide 
Range on Protein: 312-323
Range on HMM: 7-18/277
Sequence Identity: 66% (8 aa)

LGGGSFGEVFKA
.|.||||||.|.
IGKGSFGEVYKG