Gene ACTR2 (Sea Urchin)

ACTR2

Species: Sea Urchin
Alias: Spk325, SPU_000814, ACTR2, SpActivinR
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: STKR
Subfamily: STKR2

Sequence

Name Sequence Type Origin Length Description Download
ACTR2.AA Protein None 562 None Fasta, JSON
ACTR2.kin_dom Protein Kinase Domain None 283 None Fasta, JSON

Protein domain

Protein domains of ACTR2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Activin_recp ACTR2.AA Activin_recp 44-132 17 3.2e-07 25.28 Pfam 1-121 (121) Show / Hide 
Range on Protein: 44-132
Range on HMM: 1-121/121
Sequence Identity: 17% (22 aa)

QECE-KDGTK------CG--NTT-----EECDNKEAE------IPSCYVLWKNETSSGGGVDVMMR----GCWQNQGDCLD---MDYCMS------SSPA
 .|.  .| .      |.  ...     ..| .           ..|||.| .   ..  . .. |    |||.  ..| .   . .| |      ....
LKCYFCNGYWEYDYQICHENENNFEIPVHTCETHPDKMCFYCYDGQCYVSWEYNDDEE-DTEQHQRMHMYGCWSLNENCPQCHPF-MCKSYKHTHSPPHR

DQNLFFC-CCVGNLCNMNFSFLP
. . ..| || ...|| |.. .|
HGHNHECWCCETDYCNRNLTPPP
Kinase ACTR2.AA Type2 212-501 59 4.1e-215 716.99 In-house 1-315 (315) Show / Hide 
Range on Protein: 212-501
Range on HMM: 1-315/315
Sequence Identity: 59% (187 aa)

IQLLEIKARGRFGAVWKASCLND-----IVAVKVFPIQDRNSWANEREIYSLP-HMHHENLLHFIATEK---HGEGLEVEYWLISEFHHHGSLCDYLKAN
|||.|....||||.||||.. |.     .||||.||.||..||.||..||||| ||.|||.|.||..||   |......||||..||||.||||||||..
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVKIFPEQDKQSWQNEKDIYSLPYHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLKQH

VISWKELCGIAFSMAKGLAYLHEDIPPTTAIPFVKHSVAHRDFKSKNVLIKNNTTACIADFGLACVFEAGKNP--------GDTH--GQVGTRRYMAPEV
.|.|.|.|..|.|||.|||.|||.|.... ....|...||||.||||||.||..|.||||||||..|..||.|        ||||  |||||||||||||
TIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAPEV

LEGAIQFK--RDAFLRIDMYAFGLVLWELVTRCTVQD--GPVPEYRLPFEEELGQG-TSLEDMQEWVVVKRKRPVISDHWLKHRGLE-LLCETIEECWDQ
||||..|.  ||||...||||.||||||.|.|||...  ..||||..|||||.||  .|.|||||.|| |||||...|||..|.|.. .||||||.|||.
LEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRCTDHYPDDEVPEYQMPFEEEVGQHDPSFEDMQELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDCWDH

DAEARLSAGCVEERI
||||||.|.||.||.
DAEARLTAQCVQERM
Kinase ACTR2.AA STKR 212-501 48 6.00000000001e-195 635.12 In-house 1-312 (312) Show / Hide 
Range on Protein: 212-501
Range on HMM: 1-312/312
Sequence Identity: 48% (152 aa)

IQLLEIKARGRFGAVWKASCLN----DIVAVKVFPIQDRNSWANEREIYSLPHMHHENLLHFIATE-KHGEGLEVEYWLISEFHHHGSLCDYLKANVISW
|||.|....||.|.|||... .    . ||||.||..|..|| .|.|||..|.|.|||.|.||| . ||.||....||||.|.|..||||||||...|.|
IQLIECIGKGRYGEVWKGKWRGNGEKETVAVKIFPSRDEQSWFRETEIYQTPMMRHENILQFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRHTIDW

KELCGIAFSMAKGLAYLHEDIPPTTAIPFVKHSVAHRDFKSKNVLIKNNTTACIADFGLACVFEAGKNPGDTHG---------QVGTRRYMAPEVLEGAI
.|.|..|.|||.|||.||..|....   . |...||||.||||.|.||. |.||||||||.......|..|.|.         ||||.||||||||.||.
HEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVLDGAM

QFK--RDAFLRIDMYAFGLVLWELVTRCTVQD-----GPVPEYRLPFEEELGQGTSLEDMQEWVVVKRKRPVISDHWL-KHRGLELLCETIEECWDQDAE
.|.  ..||.|.||||.|||.||...|||. .     ..||||..||......  |.||||..|..||.|| |...|. .| ... .|.|.|||||.|.|
NFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNHPSFEDMQKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEECWDHDPE

ARLSAGCVEERI
|||.| ||....
ARLTALCVKKTM
Kinase ACTR2.AA Type1 212-501 38 2.4e-114 311.03 In-house 1-290 (290) Show / Hide 
Range on Protein: 212-501
Range on HMM: 1-290/290
Sequence Identity: 38% (114 aa)

IQLLEIKARGRFGAVWKASCLNDIVAVKVFPIQDRNSWANEREIYSLPHMHHENLLHFIATEKHGEGLEVEYWLISEFHHHGSLCDYLKANVISWKELCG
||..|.  .||.| ||...   . ||||.|   |  || .|.|||.   | ||| | |||    ..|   . |||...| |||| |||. .... .... 
IQMIECIGKGRYGEVWRGKWRGENVAVKIFFSRDERSWFRETEIYQTVMMRHENILGFIAADMKDNGSWTQLWLITDYHEHGSLYDYLNRHTLDTQQMLR

IAFSMAKGLAYLHEDIPPTTAIPFVKHSVAHRDFKSKNVLIKNNTTACIADFGLACVFEAGKNPGD--THGQVGTRRYMAPEVLEGAIQFKR-DAFLRID
.|.|.| |||.|| .|  |    | |  .||||.||||...|.| . ||||.|||  ..  ..  |  .  .|||.||||||||.  ....  ... . |
LAYSCACGLAHLHMEIFGTQE--FGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRHQQDTDQIDIGQNPRVGTKRYMAPEVLDETMNMNCFESYKMAD

MYAFGLVLWELVTRCTVQDGPVPEYRLPFEEELGQGTSLEDMQEWVVVKRKRPVISDHWLKHRGLELLCETIEECWDQDAEARLSAGCVEERI
.|.||||.||   || | .  | .|.||. .   .  | |||.. | |.. || |   | .|  .. .    .||| | ..||..|  .   .
IYSFGLVMWEIARRCEVGG-IVEDYQLPYYDWVPNDPSFEDMRKVVCVRKLRPNIPNRWQSHPCMRHMAKLMKECWYQNPHARHTALRIKKTL
Kinase ACTR2.AA TKL 218-501 25 2.6e-94 319.65 In-house 1-364 (364) Show / Hide 
Range on Protein: 218-501
Range on HMM: 1-364/364
Sequence Identity: 25% (96 aa)

KARGRFGAVWKASCLN----------DIVAVKVFPIQD-------------------------RNSWANEREIYSLPHMH---HENLLHFIA---TEKHG
  .|.|| |.|. . .            ||||.|....                          .||....|.. . .|.   |.|...|..    ...|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

E------GLEVEYWLISEFHHHGSLCDYLKANVISWKELCGIAFSMAKGLAYLHEDIP-PTTAIPFVKHSVAHRDFKSKNVLIKNNTT------------
.      | . ..... |....|||..||      |  .| .| ..|.|..||| ..| . |     |  ..||| ||||.|...| |            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT-----KPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--ACIADFGLACVFEAGKNPGD-----------------THGQVGTRRYMAPEVLEGAIQFK-----------RDAFLRIDMYAFGLVLWELVTRCTVQD
  ..|.||||. ...  .|  |                 |. |.|| |.||||||.|.....           .... ..|.|.||.||||..|||.   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

GPVPEYRLPFEEELGQGTSLEDMQEWVVVKRKRPVISDHWLK-------HRGLELLCETIEECWDQDAEARLSAGCVEERI
   |.| .|......|   .|.|...|..|..|| | ..|.        .  .. ... ...|||.|.|.|.|. .. .|.
---PYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ACTR2.AA Pkinase 212-501 20 4e-64 224.13 Pfam 1-293 (293) Show / Hide 
Range on Protein: 212-501
Range on HMM: 1-293/293
Sequence Identity: 20% (69 aa)

IQLLEIKARGRFGAVWKASCLND--IVAVKVFPIQDRNSWANER-----EIYSLPHMHHENLLHFIATEKHGEGLEVEYWLISEFHHHG----SLCDYLK
......  .| || |.|.   ..  |||||... ....|| ...     ||. . ...|.| . .. .       . ..... |.. .|    .|.||..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

---ANVI--SWKELCGIAFSMAKGLAYLHEDIPPTTAIPFVKHSVAHRDFKSKNVLIKNNTTA----CIADFGLACVFEAGKNPGDTHGQVGTRRYMAPE
    ...  |..|.. ..  ...||.|.|.             .. ||| |. |.||.|| .     .|.|||||..|.   | . ... .||..|||||
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM------------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPE

VLEGAIQFKRDAFLRIDMYAFGLVLWELVTRCTVQDGPVPEYRLPFEEELGQGTSLEDMQEWVVVKRKRPVISDHWLKHRGL-----------------E
|    |.. ..   ..||...|..|.|....            .|| ..  .  .  |... .. ....|. .| . ....                  |
V----IRGGQYYGPKVDMWSCGCILYEMLCGR-----------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSE

LLCETIEECWDQDAEARLSAGCVEER--I
 ... |. |...| . |..| .. .   .
ECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ACTR2.AA MLK 212-422 26 2e-33 113.38 In-house 1-232 (291) Show / Hide 
Range on Protein: 212-422
Range on HMM: 1-232/291
Sequence Identity: 26% (65 aa)

IQLLEIKARGRFGAVWKASCLNDI-----VAVKVFP-------IQDRNSWANEREIYSLPHMHHENLLHFIATEKHG-EGLEVEYWLISEFHHHGSLCDY
||..|.   | ||.|||. . | .     |||| .        . .  .|. |.|.. | .. |.|    |   ...    . .. ...|.  .|||...
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LKAN---------------VISWKELCGIAFSMAKGLAYLHEDIPPTTAIPFVKHSVAHRDFKSKNVLIKN------NTTACIADFGLACVFEAG-KNPG
|...               |..   .  .|. .|.|..|||.. |..         . ||| ||.|.|| .      ..|. |.|||... .    .|  
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKP---------IIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTN--

DTHGQVGTRRYMAPEVLEGAIQFKRDAFLRI-DMYAFGLVLWELVTR
   .. || ..|||||..   ||. . . .  |.. .|.||||..||
-MMSNAGTYAWMAPEVIQ---QFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase ACTR2.AA S_TKc 212-505 18 8.4e-27 96.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 212-505
Range on HMM: 1-231/231
Sequence Identity: 18% (57 aa)

IQLLEIKARGRFGAVWKASCLN--DIVAVKVFPIQDRNSWANEREIYSLPHMHHENLLHFIATEKHGEGLEVEYWLISEFHHH--GSLCDYLKANV----
 ..|..  .| || |.|.   .   |||.|. .    ..  .|..| .    ||.|. ... .  .      ..... |.  .  |.| ||.| .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---ISWKELCGIAFSMAKGLAYLHEDIPPTTAIPFVKHSVAHRDFKSKNVLIKNNTTACIADFGLACVFEAGKNPGDTHGQVGTRRYMAPEVLEGAIQFK
   ..  . . ..  ....|.|.|.            | . ||| |  |.|. .  .  |.|||||...         . ..||. |||||||       
RFPFPE-HARFYMYQICCALEYCHS------------HGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL-------

RDAFLRIDMYAFGLVLWELVTRCTVQDGPVPEYRLPFEEELGQGTSLEDMQEWVVVKRKRPVISDHWLKHRGLELLCETIEECWDQDAEARLSAGCVEE-
   . ..|....| .|.|......  .                   .. | . ..                  . ... |. |.. | | |..|  . . 
GYGKCKCDWWSCGCILYEMLCGYPPFP------------------QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQD

----RIAQFS
    .. .. 
EWDIKCHPWF
Kinase ACTR2.AA TKL-Unique 220-491 26 2.7e-20 68.38 In-house 7-280 (290) Show / Hide 
Range on Protein: 220-491
Range on HMM: 7-280/290
Sequence Identity: 26% (81 aa)

RGRFGAVWKASCLNDIVAVKVFPI--QDRNSWAN--EREIYSLPHMH-HENLLHFIATEKHGEGLEVEYWLISEFHHHGSLCDYLK-----------ANV
.| .|.| |.    ..||.|.| .    .|.     |.|.  .   | |.|..|.... .     . .. ...|.  .||| |.|             . 
EGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCK

ISWKELCGIAFSMAKGLAYLHEDIPPTTAIPFVKHSVAHRDFKSKNVLIKNN-----TTACIADFGLACVFEAG-KNPGDTH------GQVGTRRYMAPE
....    .|  .|.|. |||  .||..          ||| ||.|.|. ||       . |.||||. .     |..  .|      . .|. |.||||
LNMQQRVKMAIDIAQGMYYLHHCEPPII----------HRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE

VLEGA-IQFKRDAFLRIDMYAFGLVLWELVTRCTVQDGPVPEYRLPFEEELGQGTSLEDMQEWVVV--KRKRPVISDHWLKHRGLELLCETIEECWDQDA
||..   |. .     .| |.|| ||||..||.         |. |.     || . |   | | .  ...|| |..|. |      . . |..||..| 
VLRMNFCQYSE----KSDVYSFGIVLWEIATRKITK-----TYKKPY-----QGMDQEQWCEMVHYMEENYRPPIPNHCPK-----EYRDLIQQCWHHDP

EAR
. |
SQR
Kinase ACTR2.AA CMGC 212-393 17 3.6e-19 58.77 In-house 1-297 (513) Show / Hide 
Range on Protein: 212-393
Range on HMM: 1-297/513
Sequence Identity: 17% (54 aa)

IQLLEIKARGRFGAVWKASC----------------LNDIVAVKVFPIQDRNSWANE-------------REIYSLPHM-----------------HHEN
 . ..   .| .| |.|. .                 | |||.| .  .  . .                |||  | |.                 ||.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LLHFIATEKH----GEGLE---------VEYWLISEFHHHGSLCDYLKANV-----------------------------ISWKELCGIAFSMAKGLA--
... .   .|    |.. |         ..  |. |.  | .|..|.| |                              ..      ... . .||.  
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDH-DLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

YLHEDIPPTTAIPFVKHS--VAHRDFKSKNVLIKNNTTA--------------------CIADFGLACVFEAGKNPGD-------------------THG
|.|            .|   . ||| |  |.|| .|..                      |.|||||. ..  ... .                      
YCH------------SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTH

QVGTRRYMAPEVL
.| || | |||.|
YVVTRWYRAPEIL
Kinase ACTR2.AA TK 212-394 13 2.3e-16 50.64 In-house 1-358 (486) Show / Hide 
Range on Protein: 212-394
Range on HMM: 1-358/486
Sequence Identity: 13% (49 aa)

IQLLEIKARGRFG---AVWKASCLND---------------------------IVAVKVFP--IQDRNSW------------------ANEREIYSLPHM
|.|..   .| ||    |.|.   ..                            ||||.      .                      |.|... ..   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHENLLHFIA-TEKHGE-------GLEVEYWLISEFHHHGS----LCDYLKANV----------------------------------------------
||.|......   ....        ..  .... |. .||.    | |||...                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------ISWKELCGIAFSMAKGLAYLHED---IPPTTAIPFVKHSVAHRDFKSKNVLIKNNTT-----------A
                               .. ..|. ...  |.|..|||.             .   . |||    |.|. .| .           .
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEF--------I-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVC

CIADFGLA------CVFEAGKNPGDTHGQ-VGTRR-------------------------YMAPEVLE
 ||||||.         . ...   .  .  ||.|                         .||||.|.
KIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLN
Kinase ACTR2.AA STE 212-421 18 4.7e-16 53.28 In-house 1-263 (359) Show / Hide 
Range on Protein: 212-421
Range on HMM: 1-263/359
Sequence Identity: 18% (53 aa)

IQLLEIKARGRFGAVWKASCL-----------------NDIVAVKVFPIQD------------------RNSWANEREIYSLPHMH--HENLLHFIATEK
 ...|.  .| || | || .                  ..|.|.|. ....                   .    ..||  . ...  |.|  ... .. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HG---EGLEVEYWLISEFHHHGSLCDYLKAN---------------VISWKELCGIAFSMAKG-LAYLHEDIPPTTAIPFVKHSVAHRDFKSKNVLIKNN
..   .. . | |.. |.   ||| | .| .               ... .... |...  || |.|||            .| . ||| |. |.|.   
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLH------------SHHIIHRDIKPANILL---

TTACIADFGLACVFEA---GKNPGD--------THG-----QVGTRRYMAPEVLEGAIQF-KRDAFLRIDMYAFGLVLWELVT
  . ..|||..  ..    ..            | .      |||  .|||||...  |  . .   . |.. .|....|..|
--VKLCDFGVCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMAT
Kinase ACTR2.AA Dicty4 312-393 32 7.7e-16 49.47 In-house 117-189 (277) Show / Hide 
Range on Protein: 312-393
Range on HMM: 117-189/277
Sequence Identity: 32% (27 aa)

IAFSMAKGLAYLHEDIPPTTAIPFVKHSVAHRDFKSKNVLIKNNTTACIADFGLACVFEAGKNPGD-THGQVGTRRYMAPEVL
.||. |.|...||. .|           . ||| || | |.  | .. ..||||. ..  ... .| . ...||  .|||||.
MAFDAARGMNWLHCCNP----------VIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVM
Kinase ACTR2.AA TyrKc 212-501 20 5.5e-14 3.47 SMART 1-280 (280) Show / Hide 
Range on Protein: 212-501
Range on HMM: 1-280/280
Sequence Identity: 20% (67 aa)

IQLLEIKARGRFGAVWKASCLNDIVAVKVFPIQDRNSWAN-EREIYSLPHM--HHENLLHFIATEKHG-------EGLEVEYWLISEFHHHGSLCDYLKA
|.|...  .| || |.|.      ||||.         .   ||.  . .   ||.|.. ...   ..       | |    ... |.  ||.| |||..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPL----MIVMEYMPHGDLKDYLRK

NV--ISWKELCGIAFSMAKGLAYLHEDIPPTTAIPFVKHSVAHRDFKSKNVLIKNNTTACIADFGLACVFEAG----KNPGDTHGQV--GTR-----RYM
.   ...|.|. ...  |.| .|||.              . |||    |.|...| |. |.||||.   . .     .    . .   |..     | |
HRPKLCMKDLLSFCWQIACGMEYLHSK------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

APEVLEGAIQFKRDAFLRI-----DMYAFGLVLWELVTRCTVQDGP-----VPEYRLPFEEELGQGTSLEDMQEWVVVKRKRPVISDHWLKHRGLELLCE
|||..          . ..     | ..|| ..||. |..           .. ...   | . ||  .. ...        | .|      .  . . .
APECI----------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEV--IEYVKQGYRMPQPPNDY------P-MSF----VCCPDEMYQ

TIEECWDQDAEARLSAGCVEERI
 ...||. |.| | .   . |..
IMKQCWHEDPEDRPTFSEIHECF
Kinase ACTR2.AA Pkinase_Tyr 212-325 23 1.2e-09 33.34 Pfam 1-129 (270) Show / Hide 
Range on Protein: 212-325
Range on HMM: 1-129/270
Sequence Identity: 23% (31 aa)

IQLLEIKARGRFGAVWKASCL------NDIVAVKVF--PIQDRN--SWANEREIYSLPHM-HHENLLHFIATEK-HGE-GLEVEYWLISEFHHHGSLCDY
|....   .| || |.|. .       .  ||||.      ...  . .  ||.  . .. ||.|.. ...    .|| .   ..... |.  ||.| ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLLDY

LKAN-----VISWKELCGIAFSMAKGLAYLHE
|...      .. |.|.....  |||..||..
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase ACTR2.AA Dicty4 408-422 66 0.000953 8.57 In-house 199-213 (277) Show / Hide 
Range on Protein: 408-422
Range on HMM: 199-213/277
Sequence Identity: 66% (10 aa)

DMYAFGLVLWELVTR
| | ||.||||..||
DVYSFGIVLWEILTR
Kinase ACTR2.AA Pkinase_Tyr 342-366 48 0.005525 10.73 Pfam 134-158 (270) Show / Hide 
Range on Protein: 342-366
Range on HMM: 134-158/270
Sequence Identity: 48% (12 aa)

HRDFKSKNVLIKNNTTACIADFGLA
|||   .|.|...| .. |.|||||
HRDLAARNCLVTENNVVKICDFGLA
Kinase ACTR2.AA TK 408-436 12 0.015701 3.44 In-house 376-438 (486) Show / Hide 
Range on Protein: 408-436
Range on HMM: 376-438/486
Sequence Identity: 12% (8 aa)

DMYAFGLVLWELVTRCTVQDGP-VPE---------------------------------YRLP
|...|| ..||..|.. .. .. ..                                  .|.|
DVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMP
Kinase ACTR2.AA Dicty4 212-242 32 0.021383 4.0 In-house 1-31 (277) Show / Hide 
Range on Protein: 212-242
Range on HMM: 1-31/277
Sequence Identity: 32% (10 aa)

IQLLEIKARGRFGAVWKASCLNDIVAVKVFP
|.  ..  .| || | |...   .||||...
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLN
Kinase ACTR2.AA Pkinase_Tyr 408-423 37 0.989027 3.1 Pfam 196-211 (270) Show / Hide 
Range on Protein: 408-423
Range on HMM: 196-211/270
Sequence Identity: 37% (6 aa)

DMYAFGLVLWELVTRC
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DVWSFGVLMWEIFTYG
Kinase ACTR2.AA Pkinase_Tyr 482-501 30 6.726003 0.28 Pfam 251-270 (270) Show / Hide 
Range on Protein: 482-501
Range on HMM: 251-270/270
Sequence Identity: 30% (6 aa)

ECWDQDAEARLSAGCVEERI
.||..|.| | .   . |..
QCWHYDPEDRPTFSEIHEQL