Gene TNIK (Human)

TNIK

Species: Human
Alias: TNIK, ZC2
External Links:
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: MSN

Sequence

Name Sequence Type Origin Length Description Download
TNIK.AA Protein None 1360 None Fasta, JSON
TNIK.NA RNA None 5816 None Fasta, JSON
TNIK.kin_dom Protein Kinase Domain None 265 None Fasta, JSON

Protein domain

Protein domains of TNIK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TNIK.AA MSN 25-289 88 1.1e-209 698.95 In-house 1-265 (265) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-265/265
Sequence Identity: 88% (235 aa)

FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT
|||||.||||||||||||||||||||||||||||. ||||||||||||||||||||||||||||||||.|||.|.|||.|||||||||||||.|.|||..
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQS

LKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAI
|||.|||||||||||||.||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||..|||||.|||||
LKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITAI

EMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI
|||||.|||||||||||||||||||.|.||||||||||..|.|.||.||..|||.|||..|||||
EMAEGQPPLCDMHPMRALFLIPRNPPPKLKSKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase TNIK.AA STE20 25-289 52 3.7e-172 578.22 In-house 1-288 (288) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-288/288
Sequence Identity: 52% (153 aa)

FELVELVGNGTYGQVYKGRHVKTGQL----AAIKVMDVTG-----DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD
.||.| .|.|.||.|||..|..||..    .|||.|..       ||.|.|..||...|..  | || .|||...|....  ||.||.|||.||.||.||
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTC--DDELWIVMEYCGGGSLTD

LIKN--TKGN-----TLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR----TVG-RRNTFIGTPYWMAPEVIACD
..|.  ..|.     ...||.|||||||.|.||..||....||||||..|.||||..||||.||||.|||..    | . .||||.|||||||||||.|.
IMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCM

ENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIP--RNPAPRLK---SKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI
|.||  ||.|.| ||||||||||||| ||..|||||||.|.||  .|| |.||   ..|||..|. |...||.|. ..|| ..||.|||||
EGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase TNIK.AA STE 25-289 37 5.69999999999e-142 477.96 In-house 1-359 (359) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-359/359
Sequence Identity: 37% (138 aa)

FELVELVGNGTYGQVYKGRHVK---------------TGQLAAIKVMDVTG------------------DEEEEIKQEINMLKKYSH-HRNIATYYGAFI
.|..| .|.|..|.|||....|               ||.. |||.|..                    .|...|..||...||..| | || .|||...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KKNPP-GMDDQLWLVMEFCGAGSVTDLIKN--TKGNTLK----------EEWIAYICREILRG-LSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSA
|.... . ||.||..||....||..|.||.   .|..|.          |..||||||.||.| |..||.|..||||||..|.||     |||.||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLDR---------------TVG-RRNTFIGTPYWMAPEVIACDENP-DATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN-----------
||.                | . .||||.||| ||||||| ..... |  ||.|.| ||||.|.||||.| ||..|||||||.|.||.|           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----PAPRLKS------------------KKWSKKFQSFIESCLVKNHSQRPATEQLMK--HPFI
    | |.|..                  .|||..|. ||. ||.|. ..|| ..||.|  ||||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase TNIK.AA YSK 25-289 49 5.3e-131 396.82 In-house 1-257 (257) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-257/257
Sequence Identity: 49% (132 aa)

FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE--EEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKG
|   | .| | .| ||||  ..|..  |||. |   .|.  | | |||. |       .|  |||.. |      |  || .||.|| ||. ||.|    
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSP-YITKYYGSYLK------DTKLWIIMEYCGGGSCLDLMKPKYV

NTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIAC--DENPDATYDFKSDLWSLG
. . |. || | |||| ||. ||. ..||||||  ||||.|. .||| ||||..|.  |. .||||.||||||||||| .  ..     |||| | ||||
GQFDEKYIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSY-----YDFKADIWSLG

ITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI
|||.||| | ||.||.||||..|||| |. |.|. ...|| |  |.| ||.|. .|||  ..| || ||
ITAYEMAKGEPPYCDYHPMRVMFLIPKNNPPKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase TNIK.AA NinaC 25-289 51 7.89999999999e-130 437.62 In-house 1-267 (267) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-267/267
Sequence Identity: 51% (139 aa)

FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKN--TKG
.| .| .| |||| |.|    . ||.||.|...   | .|||  | | |..|. | |.  .|| . || . .  ||||.|||.|  |||||..|     |
WEIYETIGKGTYGKVFKVKNKDNGQIAAVKIQHYIHDHDEEIEAEYNILRDYCDHPNVVRFYGMYYKKDKCNG-DQLWFVMEYCNGGSVTDMVKGLLKCG

NTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGIT
  ..|| |||| .| ..|| |||...|||||.|| |.||| .  |||.||||||||| | .|||| .|||.||||||||| .  | .||   | ||||||
RRMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPDYDARCDVWSLGIT

AIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI
|||.. | ||. |||||||.| ||||| |.|    .|...|  ||  || |.  .||   ....||||
AIELGDGDPPFADMHPMRAMFKIPRNPPPTLMHPENWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI
Kinase TNIK.AA MST 25-289 49 1.3e-117 375.44 In-house 1-254 (254) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-254/254
Sequence Identity: 49% (134 aa)

FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSHHRNIATYYGAFI--KKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK
|..||. | | ||.|||  | .||.. |||.. |  .|  .||. ||....      .| .||| ..  |      . ..|.|||.||.||| |..| |.
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQC-KSKYIVKYYGSYFDAK------NNHCWIVMEYCGMGSVCDIMKITQ

GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGI
  || |. || |..  |.||  ||. | ||||||  | || .  | || |||||.||  | . |||.||||||||||||         || | | |||||
-RTLNEQQIACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQ-----EIKYDCKADIWSLGI

TAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI
|||||||| ||. | |||||.|.|| .| | .|   .||  |  |. .||.|| .||.  ||| .||||
TAIEMAEGMPPYSDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase TNIK.AA KHS 25-289 48 1.2e-105 356.31 In-house 1-258 (258) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-258/258
Sequence Identity: 48% (130 aa)

FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV-TGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGN
.||.  || ||||.||| |......|||.||. .  ||. . |.||| |.|.  .| ||  |.|.....      |.||..||.||.||. |. . |   
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKD-CRHPNIVAYFGSYLRR------DKLWICMEYCGGGSLQDIYHVT--G

TLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITA
 |.|  |||.|||.|.|| .||... .|||||| |.|||.. .||| |||||||.  |...|  |||||||||||| | . .    |.   |.|..||||
PLSELQIAYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERK--GGYNQLCDIWAVGITA

IEMAEGAPPLCDMHPMRALFLIPRNP--APRLKSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI
||.||  ||. |.||||||||. .     |.|| | |||..|  |.  .|.||  .||. |.|..|||.
IELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase TNIK.AA PAKA 25-289 41 6.6e-101 341.54 In-house 1-260 (260) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-260/260
Sequence Identity: 41% (112 aa)

FELVELVGNGTYGQVYKGRHVKTGQL--AAIKVMDVTGDEEE-EIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK
.. .| .| |  |.||..  .||.|    |||.|..  .     |. || ..|. ..| ||  |. ...      .||.||.|||. ..|. ||.|... 
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKE-CKHKNIVNYIDSYL------VDDELWVVMEYMEGGCLTDVITQCC

---GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWS
    |...|. |||.|||.|.||. .|....||||||  |.||  ...||. |||  ||| .   .|||  |||||||||||   .     || | | ||
NIQCNYMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQ-----YDEKVDIWS

LGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI
||| ||||.|| ||  .. | ||..||  | .| .|.. |||..|. | . || ..  .|. ...|..|||.
LGIMAIEMIEGEPPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase TNIK.AA S_TKc 25-289 32 7.5e-99 335.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-231/231
Sequence Identity: 32% (90 aa)

FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGA--GSVTDLIKNTKG
.|.....| |..|.|||.||.|||.. |||...      | |..||..|||  || || ..|..|         | |..|||.|.   |.. |.||. ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGR

NT----LKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDF-KSDLW
.     . | ........|...| ..|.|..||||.| .|.||.|  ..|. |||...||       .||.|||..|||||.         |.. |.| |
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL--------GYGKCKCDWW

SLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMK-------HPFI
|.|.. .||. | || .  .... . .|             |. . .||. ||.|. ..||   ....       ||..
SCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TNIK.AA PAKL 25-289 43 1.4e-96 327.15 In-house 1-256 (256) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-256/256
Sequence Identity: 43% (117 aa)

FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD-EEEEIKQEINMLKKYSHHRNIATYYGAFIKK-NPPGMDDQLWLVMEFCGAGSVTDLIKNTKG
||. |  | | || |||. |  |.   ||||. ..   | ..|  ||..|||     ||  |.|    | |      ..|  |..| .||. |... . .
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKK-CKCPNIVSYFGSIQQKLN------HYWILMDYCSLGSINDMMESC-C

NTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG-RRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGI
 ||.|. |. | .  |.||  ||.  .||||||  |.||.| . ||. ||||| ||. . .   |  ||||||||||.|       . |. | | |||||
KTLNEKQISVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINK-----QNYNNKCDIWSLGI

TAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI
||||||.| ||. || ||||.  ||. | | ..  |.||. | .|.  |.||   .|.   .|  ||||
TAIEMADGFPPHYDMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase TNIK.AA SLK 25-289 42 4.1e-91 307.63 In-house 1-259 (259) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-259/259
Sequence Identity: 42% (114 aa)

FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGN
.|..  .|.| .|.||| .|  ....|| |....  .|| |.   ||..| .   | ||   |.|.       .|..||...|||. | | | |    . 
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECK-HPNIVKLYEAYY------YDNKLWMMIEFCDGGAV-DNIMVELEH

TLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITA
.|.|. |.|.|.... .| .||..||||||.|  |.|.| . .|.| ||||||.. .|. .| |||||||||||||..|.   |. ||.|.|.|||||| 
PLTEDQIQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITL

IEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI
||||.. ||  .| ||| |. | .   |.|.   .|||.|. |.. ||||.  .|..|.|||.|...
IEMAQMEPPHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase TNIK.AA Pkinase 25-289 27 3e-84 290.98 Pfam 1-293 (293) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-293/293
Sequence Identity: 27% (85 aa)

FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQ-----EINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAG----SVTD
..... .| |..|.|||..|..||.. |.|.... ...... ..     || ..|.  .| || ..|..|        .| ...|||.|. |    .  |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFD

LIKNTKGNTL--KEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEV----KLVDFGVSAQL-DRTVGRRNTFIGTPYWMAPEVIACDENPDA
.|.  .....   |. .  ....||||| ..|....||||.| .|.|. .| ..    |. |||...|.     .  .|| |||..||||||      . 
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQ

TYDFKSDLWSLGITAIEMAEGAPPLCDM----HPMRALFLIPRNPAPRLKSKKW----------------------SKKFQSFIESCLVKNHSQRPATEQ
 |. |.| ||.|.. .||. | || ..     . .. ...| |.  |.|..  .                      |. ...||..|| |. ..||  ||
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

LMKHPFI
...||..
ILQHPWF
Kinase TNIK.AA Pkinase_Tyr 25-245 27 8.6e-37 125.23 Pfam 1-228 (270) Show / Hide 
Range on Protein: 25-245
Range on HMM: 1-228/270
Sequence Identity: 27% (64 aa)

FELVELVGNGTYGQVYKGRHV----KTGQLAAIKVM--DVTGDE--EEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDL
 .. .  | | .|.||||.      .|..  |.|..  . . ..   |.  .|....|.. || ||  .||. ...  |.   |...|||..  |.  | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLLDY

IKNT--KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL---DRT-VGRRNTFIGTPYWMAPEVIACDENPDATY
 ..    .. |. ...  .|..| .|...|.... ||||.   |.|.|||  ||  ||| .  .   |   . | ..      |||||.|.  .     .
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGK-----F

DFKSDLWSLGITAIEMAE-GAPP-LCDMHPMRALFLI
  ||| || |..  |.   |. |   .| . . . .|
TTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI
Kinase TNIK.AA TyrKc 25-289 23 9e-18 64.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKY-SHHRNIATYYGAFIKK--NPPGMDDQLWLVMEFCGAGSVTDLIKNTK
 .| .  |.| .|.||||.     .  |.|..      .|.. .|.....|.  || ||   ||. ...  |    ...|..|||..  |.  | .....
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRKHR

GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT--------VGRRNTFIGTP-----YWMAPEVIACDENPDA
.. |. .   ..|  | .| ..||....||||.   |.|..||  ||  ||| |  ..          . |  .  |.       |||||.|      . 
PK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----NYG

TYDFKSDLWSLGITAIEMAE-GAPPLCD-----MHPMRALFLIPRNPAPRLKSK-------KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI
.. .||| || |..  |.   |..|  .     | . ... .. .   ..             ...  . ...|   . ..||  ...  | ..
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
CNH TNIK.AA CNH 1042-1340 26 1e-119 404.93 SMART 1-375 (375) Show / Hide 
Range on Protein: 1042-1340
Range on HMM: 1-375/375
Sequence Identity: 26% (100 aa)

YKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQ------GKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNR------------IL
........|.|..|||..|||||| |...|....|      |... .. ||....|.|.|..|.|..||||| .|....|.||...             .
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMISGKKPHLYSHPLVWLFQKYRTQGMTPHIQDHM

HNDPEVEKKQGW-ITVGDLEG-CIHYKV-VKYER--IKFLVIALKNAVEIYAWAPKPYHKFMAFKS----------------FADLQHKPLLVDLTVEEG
.|.  |..|..| ....|..| |.|..| ....|  |.||. |.. .|.||.....|.|||| .||                |. . . |..|...... 
CNHHLVPRKNVWTTKIPDTKGNCHHCCVKCNGKRTGIIFLCHAMQHSVQIYNQWYNPMHKFMCWKSSNNILNNEIEMFKHFRFPEIFPVPVFVCFHHDSF

QRLKVIFGSHT------GFHVIDVD-------------SGNSYDIYIPSHIQGNI------TPHAIVILPKTDG---MEMLVCYEDEGVYVNTYG---RI
.|.....|. .      |||.....             . | .|.......|  .      .||...... .||   .. |.||...||.||.||   | 
ERPWICIGCDKPVGGMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTCKPHQVHQVQQSDGGQRDMYLLCYDNFGVFVNCYGSEWRR

TKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHL-DGVFMHK---RAQRLKFLCE---RNDKVFFASVR
.....|.|..||...||.  ..||......|.||...||.. ....|..   .......||.   |..|.|..| .
WRNPILHWEFMPEYFAYHY-PYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFRLLCTCECRDRKIFYCSQP
CNH TNIK.AA CNH 1051-1331 22 7.3e-91 312.97 Pfam 1-336 (336) Show / Hide 
Range on Protein: 1051-1331
Range on HMM: 1-336/336
Sequence Identity: 22% (76 aa)

LCAALWGVNLLVG-TENGLMLLDR------SGQGKVYNLINRRRFQQMDVLEGLNVLVTI--SGKKNKLRVYYLSWLRNRILHNDPEVEKKQ--------
.|.. ||..|||| |. ||.....      ....... ...| |..|..|.| .|.|..|  ..| ..|.|..|.|| ........ . .|.        
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSR-RVTQIYVIEEFNILIMISGCDKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHRIER

-------GWITVGDLEGCIHYK--VVKYERIKFLVIALKN-----AVEIYAWAP--KPYHKF-------MAFKSFAD-LQHK----PLLVDLTVEEGQRL
       .|....|. .|....  ...|.....|..|.|.      . .| |..  |..||.       ..|. | . ...     .. ..... . ...
IMPRKFAMWQKLPDTKHCHFFCWIRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFKGNQEWFRKFRECFYIPLPPMTECFSMHWLPQEKP

KVIFGSHTGFHVIDVD-SGNSYDIYIPSHIQ---------GNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGR-ITK--DVVLQWGEMPTSVAYIHSN
|...|.  |||....| .| ......|..            |..|.... ...  . |.|.||....||||..|. ...  |....| .||.|.|. ...
KLCVGCQKGFHIVNLDGTGQPWWLHDPADHSVQQDFMARRENCKPICMHRINDD-E-EFLLCYDECCVYVNKQGWPRSRKHDWEIMWEGMPQSFAC-CYP

QIMGWGEKAIEIRSVETG-HLDGVFMHKRAQRLKFLCERN
..... ...||||.|||| ..|..... ..|...||....
YLLAFHPNFIEIRHVETGSEWDACVQCIPGQNIRFLHSGS