Gene CTKB1 (M.brevicollis)

CTKB1

Species: M.brevicollis
Alias: CTKB1
External Links:
Annotation:

Classification

Group: TK
Family: CTKB

Sequence

Name Sequence Type Origin Length Description Download
CTKB1.AA Protein None 422 None Fasta, JSON
CTKB1.kin_dom Protein Kinase Domain None 154 None Fasta, JSON

Protein domain

Protein domains of CTKB1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CTKB1.AA CTKB 2-158 73 9.20000000001e-139 467.29 In-house 113-269 (269) Show / Hide 
Range on Protein: 2-158
Range on HMM: 113-269/269
Sequence Identity: 73% (115 aa)

VMAADAAEGMAYLASKKIVHRDLAARNALVHQDYRVCIGDFGISRDVYMREYYVMSAAAALPIRWMAVESLNDGVFSSASDVWSFGVLLWEIMTFGKMPY
.||||.|.||||.|||.||||||||||.||||..|||||||||||||||||||.|.|...||||||..||.||||....|||||.|...||||||.||||
LMAADVADGMAYIASKRIVHRDLAARNCLVHQNWRVCIGDFGISRDVYMREYYKMQASNPLPIRWMSPESINDGVYTTQSDVWSYGIVIWEIMTFAKMPY

PEYETNQEVVEKVCDEDLRMWKPEGCPDAIYDLMMQCWEEEPDERPSFKALHESLTA
||||||.||||..||||.|||.|..|||..||||||||.||||.|.|||.|||..  
PEYETNMEVVERICDEDYRMWQPKECPDEFYDLMMQCWDEEPDDRISFKELHEKTLL
Pkinase_Tyr CTKB1.AA Pkinase_Tyr 1-156 51 1.2e-89 304.24 Pfam 114-270 (270) Show / Hide 
Range on Protein: 1-156
Range on HMM: 114-270/270
Sequence Identity: 51% (82 aa)

LVMAADAAEGMAYLASKKIVHRDLAARNALVHQDYRVCIGDFGISRDVYMREYY-VMSAAAALPIRWMAVESLNDGVFSSASDVWSFGVLLWEIMTFGKM
| |... |.||.||.||...|||||||| ||. .  | |.||| .||.|  .|| ...  . |||.||| |..|.|.|...|||||||||.|||.|.|..
LQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQ

P-YPEYETNQEVVEKVCDEDLRMWKPEGCPDAIYDLMMQCWEEEPDERPSFKALHESL
| ||.  .|.||.|.. ..  || .||.||| |||||.|||...|..||.|...|| |
PTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase CTKB1.AA TK 1-156 33 7.9e-82 273.98 In-house 238-486 (486) Show / Hide 
Range on Protein: 1-156
Range on HMM: 238-486/486
Sequence Identity: 33% (83 aa)

LVMAADAAEGMAYLASK------KIVHRDLAARNALVHQDYR-----------VCIGDFGIS--------RDVYMREYYVMSA-----------------
| |....|.||.||.||      ..||||||||| ||.....           . |.||| |        ||.| ...|. .                  
L-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQ

-------AAALPIRWMAVESLNDGV---------FSSASDVWSFGVLLWEIMTFGKMPYPEYETN---------QEVVEKVCDE-----------DLRMW
        . ||||||| |.|||.|         |...|||||||||.|||.|.|..||... .|         |||.|.....             || 
DYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMR

KP--EGCP--------------DAIYDLMMQCWEEEPDERPSFKALHESL
.|  ..||              ...||||.|||...|..||.|..||| |
MPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase CTKB1.AA UTK 1-156 42 1.4e-75 257.44 In-house 121-296 (296) Show / Hide 
Range on Protein: 1-156
Range on HMM: 121-296/296
Sequence Identity: 42% (76 aa)

LVMAADAAEGMAYLASKKIVHRDLAARNALVHQD-------YRVCIGDFG---ISRDVY---------MREYYVMSAAAALPIRWMAVESLNDG-VFSSA
| ||.| |.||.||.|...||||||||| |||..       . . |.|||    ||.|.           .|| .. . ..|||||| |.|...  |...
LCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTK

SDVWSFGVLLWEIMTFGKMPYPEYETNQEVVEKVCDED-LRMWKPEGCPDAIYDLMMQCWEEEPDERPSFKALHESL
||||||||..|||.|.|..|||.. .|..|.. ||. . .|| .|..||...|.||..||. .|.|||.|. | . .
SDVWSFGVVCWEIWTWGRLPYPGM-SNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase CTKB1.AA InsR 3-158 48 2e-69 232.32 In-house 124-278 (278) Show / Hide 
Range on Protein: 3-158
Range on HMM: 124-278/278
Sequence Identity: 48% (76 aa)

MAADAAEGMAYLASKKIVHRDLAARNALVHQDYRVCIGDFGISRDVYMREYYVMSAAAALPIRWMAVESLNDGVFSSASDVWSFGVLLWEIMTFGKMPYP
|||. . ||||||.|| ||||||.|| .| .|. | |||||  ||.|   ||  .    ||.|||| ||| ||||...||||||||.|||. |.|  || 
MAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGVFTTHSDVWSFGVVLWEMVTLGEQPYQ

EYETNQEVVEKVCDEDLRMWKPEGCPDAIYDLMMQCWEEEPDERPSFKALHESLTA
.   | .| . .  .   . .||.||.. ..|||.||   |  ||.|. . ..|  
GL-SNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase CTKB1.AA Src 3-156 46 9.6e-66 222.33 In-house 102-255 (255) Show / Hide 
Range on Protein: 3-156
Range on HMM: 102-255/255
Sequence Identity: 46% (73 aa)

MAADAAEGMAYLASKKIVHRDLAARNALVHQDYRVCIGDFGISRDVYM--REYYVMSAAAALPIRWMAVESLNDGVFSSASDVWSFGVLLWEIMTFGKMP
|||  ||||||| |....|||||||| || ..  . ..|||  | . .   . |...  | .||.|.| | .| |.|.  |||||||.||.||.|.|..|
MAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YPEYETNQEVVEKVCDEDLRMWKPEGCPDAIYD-LMMQCWEEEPDERPSFKALHESL
||   ||.||...| .   || .|..||| .|. .|.|||...|..|| |. |.. |
YPGM-TNHEVLQQV-ERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase CTKB1.AA FGFR 8-156 52 2e-62 211.57 In-house 146-293 (293) Show / Hide 
Range on Protein: 8-156
Range on HMM: 146-293/293
Sequence Identity: 52% (78 aa)

AEGMAYLASKKIVHRDLAARNALVHQDYRVCIGDFGISRDVYMREYYVMSAAAALPIRWMAVESLNDGVFSSASDVWSFGVLLWEIMTFGKMPYPEYETN
| || ||||.|..|||||||| ||  ||   | ||| .||.   .||       ||| ||| |.| | |. . |||||.|||||||||.|  |||     
ARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSV

QEVVEKVCDEDLRMWKPEGCPDAIYDLMMQCWEEEPDERPSFKALHESL
 |   |   |  || ||. |.  || .| ||| ..|..||.|| | |.|
EELY-KYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase CTKB1.AA Trk 1-156 45 2.1e-62 210.35 In-house 120-275 (275) Show / Hide 
Range on Protein: 1-156
Range on HMM: 120-275/275
Sequence Identity: 45% (72 aa)

LVMAADAAEGMAYLASKKIVHRDLAARNALVHQDYRVCIGDFGISRDVYM-REYYVMSAAAALPIRWMAVESLNDGVFSSASDVWSFGVLLWEIMTFGKM
|  | . | || |.||  .||||.|.|| || |.  | ||||| |||||   .|| .    .||||||  ||     |.  |||||||| .||..|.|| 
LWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKFTYESDVWSFGVVMWECFTYGKQ

PYPEYETNQEVVEKVCDEDLRMWKPEGCPDAIYDLMMQCWEEEPDERPSFKALHESL
|.     |.||.| .    .|. .|..||  .||.|. ||  || .| . | .|. .
PWYQL-SNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase CTKB1.AA CTKA 3-156 44 4.3e-62 207.37 In-house 136-290 (290) Show / Hide 
Range on Protein: 3-156
Range on HMM: 136-290/290
Sequence Identity: 44% (70 aa)

MAADAAEGMAYLASKKIVHRDLAARNALVHQDYRVCIGDFGISRDVYMR-EYYVMSAAAALPIRWMAVESLNDGVFSSASDVWSFGVLLWEIMTFGKMPY
||...| || |||.  .||||||.|| |. |   . | ||| .|       ||..|    .|.|||| | |  | ||.|||||.|||||||||..|. |.
MAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPW

PEYETNQEVVEKVCDE-DLRMWKPEGCPDAIYDLMMQCWEEEPDERPSFKALHESL
    . |||.. .      |   |  ||. .| .|  ||  || .||.|  | ..|
RHM-SDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase CTKB1.AA TK-Unique 4-156 48 7.2e-62 211.86 In-house 137-294 (294) Show / Hide 
Range on Protein: 4-156
Range on HMM: 137-294/294
Sequence Identity: 48% (78 aa)

AADAAEGMAYLAS--KKIVHRDLAARNALVHQDYRVCIGDFGISRDVYMREYYVMSAA-AALPIRWMAVESLN--DGVF-SSASDVWSFGVLLWEIMTFG
| . | ||.||||  ||||||||.||| |.  |... |.|||..|||| .. |.|.     .|||||| |||   .|.. .. |||||||||.|||.|.|
AWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLG

KMPYPEYETNQEVVEKVCDEDLRMWKPEGC-PDAIYDLMMQCWEEEPDERPSFKALHESL
..|||..   . ..|.. |   || .||.| ....| || .|| .||.||||| ..   |
ACPYPGMPWKD-IMECIRDG-YRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase CTKB1.AA VEGFR 8-156 45 1.4e-61 210.91 In-house 183-332 (332) Show / Hide 
Range on Protein: 8-156
Range on HMM: 183-332/332
Sequence Identity: 45% (69 aa)

AEGMAYLASKKIVHRDLAARNALVHQDYRVCIGDFGISRD-VYMREYYVMSAA-AALPIRWMAVESLNDGVFSSASDVWSFGVLLWEIMTFGKMPYPEYE
| || .|||.|..|||||||| |.  .. | | ||| .|.  |    || .   . |||.||| ||. | |... |||||.||.|||| . |. |||   
ARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPYPGVQ

TNQEVVEKVCDEDLRMWKPEGCPDAIYDLMMQCWEEEPDERPSFKALHESL
 ..|   .   .  || .|. |. .||. | .|| .|| |||.| .| | |
IDEEFCNRL-KDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase CTKB1.AA TyrKc 1-156 28 3e-39 137.63 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-156
Range on HMM: 1-280/280
Sequence Identity: 28% (79 aa)

LV--------------------------------------------------------------------------------------------------
..                                                                                                  
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

----MAADAAEGMAYLASKKIVHRDLAARNALVHQDYRVCIGDFGISRDVYMR-------EYYVM----SAAAALPIRWMAVESLNDGVFSSASDVWSFG
    .. ..|.||.||.||...|||||||| ||. ...| |.||| |||.|         .||..    .. . ||||||| |..|.|.|...|||||||
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFG

VLLWEIMTFGKMPYPEY----ETNQEVVEKVCDEDLRMWKPEG--------CPDAIYDLMMQCWEEEPDERPSFKALHESL
|..|||.|.|..|||.      .||||.|.| ..  || .|.         |||..|..| |||.|.|..||.|...|| .
VCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV-KQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase CTKB1.AA Pkinase 8-156 19 1.8e-18 66.43 Pfam 118-293 (293) Show / Hide 
Range on Protein: 8-156
Range on HMM: 118-293/293
Sequence Identity: 19% (35 aa)

AEGMAYLASKKIVHRDLAARNALVHQDYRV----CIGDFGISRDV-YMREYYVMSAAAALPIRWMAVESLN-DGVFSSASDVWSFGVLLWEIMTFGKMPY
..|..|. |..|.||||   | |..... .    .|.|||... . | .    .. .  .  ..|| | .. .   ....|.||.|..|.| .. |. |.
LRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP--WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPF

P------EYETNQEVVEKVCDEDLRMWKPEGCP-------------------DAIYDLMMQCWEEEPDERPSFKALHES--L
|      .  . ....... . .|.   |. |.                   ..  |..  |..  | .||... . ..  .
PGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CTKB1.AA S_TKc 1-157 13 1.7e-07 -66.91 SMART 17-231 (231) Show / Hide 
Range on Protein: 1-157
Range on HMM: 17-231/231
Sequence Identity: 13% (34 aa)

LVMAAD------------------------------------------------A--------------------------------AEGMAYLASKKIV
..   .                                                                                 .....|. |..|.
KCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSHGII

HRDLAARNALVHQDYRVCIGDFGISRDVYMREYYVMSAAAALPIRWMAVESLNDGVFSS-ASDVWSFGVLLWEIMTFGKMPYPEYETNQEVVEKVCDEDL
||||   | |. .  .. |.|||..| .                 .|| | |    ..  ..|.||.|..|.| .. |. |.|   . |.. .|..    
HRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG----

RMWKPEGCPDAIYDLMMQCWEEEPDERPSFKALHE--------SLT
        ..   |....|.. .|..||.   . .           
--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
CH CTKB1.AA CH 312-415 22 3.2e-20 77.46 Pfam 1-119 (119) Show / Hide 
Range on Protein: 312-415
Range on HMM: 1-119/119
Sequence Identity: 22% (27 aa)

AQVMIAWVENVTGKT---KPEGA--DM-HAWLKDGQILCELMNKLQPGS-I-SKVA-TG-NR--AFHHLENISKFVSAVGD-LGVRAADRFDGVDLFE--
 . ...|......|    .      ..   ...||..|| |..|..||. |  |   .. .|  .||..|||....... . ||..  ..||  |...  
EKAFLRWCNRHLEKYGHWGVPITPVNFFFTDWRDGVALCALIHKYCPGLLIDWKKVFPPRMRKMPFHCMENINYALDFCEKKLGCPCVNLFDPEDIVYMP

GINMHQVTNCLASLHKVAV
. |...|  .|..| ..  
DGNPKSVMTYLWQLMHHFQ
CH CTKB1.AA CH 311-410 25 7e-20 73.29 SMART 1-100 (100) Show / Hide 
Range on Protein: 311-410
Range on HMM: 1-100/100
Sequence Identity: 25% (28 aa)

AAQVMIAWVENVTGKTKPEGADMHAWLKDGQILCELMNKLQP-GSISKVATGNRAFHHLENISKFVSAVGDL----GVRAADRFDGVDLFEG----INMH
. .    |.....        . ....||| .||.|.||..| .||...     .||..|||  |...  ..    ||   . ||..|...|     .. 
QEETFLRWCNSHL-----PVNNFSTDWKDGVVLCQLINKIRPQDSIDWWH----RFHCMENINYFLNFCEKYGMFLGVCCVVNFDPEDIVDGNNNRKDIL

QVTNCLASL
.|  || .|
GVIWCLMQL