Gene N20 (M.brevicollis)

N20

Species: M.brevicollis
Alias: N20
External Links:
Annotation:

Classification

Group: TK-assoc
Family: SH2
Subfamily: Myo-SH2

Sequence

Name Sequence Type Origin Length Description Download
N20.AA Protein None 835 None Fasta, JSON

Protein domain

Protein domains of N20.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
MYSc N20.AA MYSc 1-699 34 2e-253 849.1 SMART 8-771 (771) Show / Hide 
Range on Protein: 1-699
Range on HMM: 8-771/771
Sequence Identity: 34% (272 aa)

QTDNLTELENLNEETLLNELKARYDRDQIYTYVGEILVAVNPFKTIDGIYSDAKAAIYK-----DLGDRSVAPPHIFAVADAAFSAMINNTGEAANQVAV
 .| ...|..|||...|. || ||..|||||| | ...||||.| ...||..  .. |.     |   |.  ||||||.||.|. .| |   .  ||  .
GVDDMCMLTYLNEPAVLHNLKKRYMNDQIYTYIGPVCIAVNPYKQLPPIYTPDVIKQYRNRKFDDGKHRYEMPPHIFAIADNAYRNMLN---DKENQCII

ISGESGAGKTESAKLFMKHVIYLSSLVAGGLEEKIIQLNPLLEAWGNAATLRNDNSSRFGKFVQLRFNDQHQIQGAVMADYLLEKSRVVSQGEGERNFHV
|||||||||||..|. |..  ..|.  ....|..|.| ||.||| ||| |.||.|||||||.... |..   |.||..  |||||||||.| .||||.|.
ISGESGAGKTENTKKIMQYLAAVSG-QVERVEQQILQSNPILEAFGNAKTVRNNNSSRFGKYMEIHFDEKGKICGAKIENYLLEKSRVVYQNKGERNYHI

FYLMFAGMNPDELEKYNLV----DAAEHAYLNGNN---------EAIAEIKSPQMKALYKE----LADCIEDVGFTTEEKNDMWAILAGVLLTGDIEFAG
|| . || .........|     .. . .||| ..          .  .. .   .. .||    .    . .||. ||..... |.|..|. | |||. 
FYQLCAGASEEQKQEFHLKPFSHNPEDYHYLNQGGHYWNNKRHQSQCFTVDGIDDAEEFKETCEQTCNAMRVMGFSEEEQEWIFRIVAAILHLGNIEFEQ

EDE--AYVVS------ADDVMNKACTQLGIVQDALTEALTC-SINIMRG---KAFRKYKPFEAEGARDAMSKALYGKTFRWIVRRVNQLLGPKRKSKALT
...  ... .      .... ..||  ||. .. | ..||  ..   ..   .  . ... .|. ||||..||.|.. | |||.|.|| .         .
GRNQYDNQAVCSEKVKDEEELQNACELLGVDPEDLEKWLTHRKMKTGHEGGTWITKPLNVEQAIYARDALAKAIYSRLFDWIVKRINQSM---------H

DKDIGILDIFGFECFDLNSFEQLLINLANERLQQFFNNFIFKMELDEYAKEGIDGSQIDYE--DNEELLQMIMAK---PAGLLSLCDEEAKM---PKGSD
.. ||.|||.|||.|. |||||. || .||.||||||. .||.| .|| .|||. . ||.   || . .  |..|   | |..|| ||| ..   |||.|
NYFIGVLDIYGFEIFEHNSFEQFCINYCNEKLQQFFNHHMFKLEQEEYQREGIEWTFIDFFMYDNQPCCDLIEKKGKRPMGIFSLLDEECMFHAQPKGTD

VSMTEKF-----HAELGSNKGYTRP-----------RGNDLKFTIHHYAGKVEYSSDGFLDKNRDTLPIDVVGALRLSDNNLVRSLFDGDADDAKAAKKG
 ...||      |  ..... .. |           |  . .|.|.||||.|.|. .|.|.||.|||. |..  .. |.| ....||. ..|........
QTFLEKLNKQDYHQHHKNHPHFSKPHKSHRCCKPKKRMGRTHFIIKHYAGDVTYNVEGWLEKNKDTLFDDLIQLMQSSKNPFIKQLFPEYEDQTSQTPQE

KAK---RDVANARKSLRMSMKKAAKQAAKSNKKTVGLEFKESLVSLMDEMSKASPHFVRCIKPNHAKKPAIFQNDMVTDQLRYTGMLETTRIRKEGYAFR
| .   . .....  . | | | .    | ...|||  || .| .||. ... .||..||||||. ||| .| .|.| .|||. |.||. |||..|...|
KSSQGKNKSRRKKR-M-MQM-KKTC-MQKKRFPTVGFQFK-QLNELMETLNSCHPHYIRCIKPNEEKKPWDFDDDLVLHQLRCCGVLENIRIRRAGFPYR

PTFGDFLNRFKMLGFPFGVNP---------PVNEVSCGKVLDVAG---------CKGWQVGKTKVFLR----YFHMDELNEK
 .. .|..|.||| .|.  |.              .| ..|   |          ...|.||||||.|     || .|. |.
WPYQEFYQRYKMLCPPTWPNWGNPWKNQLFGDPKKACEAILQQLGEYIQHQNWDPDMYQFGKTKVFFRNPGQLFHLEEMRER
Myosin_head N20.AA Myosin_head 2-689 33 3.1e-222 749.38 Pfam 1-765 (765) Show / Hide 
Range on Protein: 2-689
Range on HMM: 1-765/765
Sequence Identity: 33% (258 aa)

TDNLTELENLNEETLLNELKARYD-RDQIYTYVGEILVAVNPFKTIDGIYSDAKAAIYKDLGDRSVAPPHIFAVADAAFSAMINNTGEAANQVAVISGES
......|..|||...|. || ||.  |.||||.| ....|||.|... ||..   ..|.    |. .||||||.||.|  .| .   .. ||  .|.|||
VEDMVMLTYLNEPSVLHNLKKRYMTGDLIYTYSGHFCISVNPYKQLP-IYTQDMIQEYRGKH-RYEMPPHIFAIADEAYRHMRH---DRENQCIIICGES

GAGKTESAKLFMKHVIYLSSLVA----GGLEEKIIQLNPLLEAWGNAATLRNDNSSRFGKFVQLRFNDQHQI----QGAVMADYLLEKSRVVSQGEGERN
||||||..|. |... ..|.  .    | .|..|.| ||.||| ||| |.||.|||||||. .. |.   .|     |... .||||||||| | .||||
GAGKTENTKYVMQYFASVSGSNPGVNMGRVEQQILQSNPILEAFGNAKTTRNNNSSRFGKYMEIHFDKTGKINPTAVGGNIENYLLEKSRVVYQTPGERN

FHVFYLMFAGMNPDE-LEKYNLV--DAAEHAYLNGNN-EAIAEI-KSPQMKALYKELADCIEDVGFTTEEKNDMWAILAGVLLTGDIE-FAGED--EAYV
||.|| . || .. | .....|   |.   .||| ..     ..       . .... .    .||| ||..... |.|..|. | .. |. ..  |. |
FHIFYQLLAGASQQEEKKELHLTSADPKDYHYLNQSGTNPCYTVDDGIDDAEEFQHTRNAMDIIGFTHEEQRSIFRIVAAILHLGNMKGFKQDQNEEQAV

VSADDV-MNKACTQLGIVQDALTEALTCSINIMRGKAFRKYK------PFEAEGARDAMSKALYGKTFRWIVRRVNQLLGPKR-----------------
|. ...  ...|  .|. .  .. .| |.  |  | ..|. .      . .|  ||||..||.|.. | |||.|.|| .  |.                 
VDDTEEICEIICELMGVDPEEFEKWL-CYRRIKTGGGKRREWVTKPQNCEQAMYARDALAKAIYSRMFDWIVNRINQAICHKTQNTDDSDGQAAQWDDTV

------------KSKALTDKDIGILDIFGFECF-DLNSFEQLLINLANERLQQFFNNFIFKMELDEYAKEGIDGSQIDY-EDNEELLQMIMA-KPAGLLS
             .....   ||.|||.|||.| . |||||. || .||.||||||. .|| | .|| .|||. ..|||  ||      | . ||.|.||
SITVVDVPDPAFDKRNYF---IGVLDIYGFEIFCEKNSFEQFCINYCNEKLQQFFNHHMFKLEQEEYVREGIQWTFIDYGFDNQPCCDLIEKKKPMGILS

LCDEEAKMPKGSDVSMTEKFHAEL-GSNK--GY-TRP-R------GNDLKFTIHHYAGKVEYSSDGFLDKNRDTLPIDVVGALRLSDN-NLVRSLFDGDA
| ||| ..||..| ....| .    . .    .  .| |      . . .|.|.||||.|.|. .|.|.||.|.|. |...... |.. .....||. ..
LLDEECWFPKATDQTFLQKLYQTHSSKHPRLHFAQKPGRFYKRHRQGNTHFIIKHYAGDVWYNCEGWLEKNKDPLFDDLIELMWCSWDNPFMQELFPDWE

D--------DAKAAKKGKAKRDVANARKSLRMSMKKAAKQAAKSNK-KTVGLEFKESLVSLMDEMSKA---SPHFVRCIKPNHAKKPAIFQNDMVTDQLR
         |..|... . .   .|...      .. .||. |... .||.  |||.. .||  ...    .||.|||||||. |.|  | |.|| .|||
WAEWAHMQIDFEADFHEEEFKRRYNRNG------CQKGKQGKKKWFMQTVWFQFKEQCNHLMKWLYQCAWWHPHYVRCIKPNENKQPWQFDNSMVLHQLR

YTGMLE-TTRIRKEGYAFRPTFGDFLNRFKMLGFPF-GVN-P----PVNEVSCGKVLDVA---GC--KGWQVGKTKVFLR
. |.|| . ||. .|...|.|...|..|...|.. . ... .    .  .  | |.|.     .   . .|.||||.|.|
CNGVLEINIRICRAGFPYRWTYDEFFQRYRILCPKTWWSWIWPEWNGDTKQGCEKILQHLSWGNMDKEEYQFGKTKIFFR
IQ N20.AA IQ 713-733 42 0.000179 18.36 Pfam 1-21 (21) Show / Hide 
Range on Protein: 713-733
Range on HMM: 1-21/21
Sequence Identity: 42% (9 aa)

LFAATTLSKMARGYLARRRLR
  ||... .. ||||||...|
HRAAIKIQAWWRGYLARKHYR
SH2 N20.AA SH2 777-835 50 4e-24 72.64 Pfam 1-63 (81) Show / Hide 
Range on Protein: 777-835
Range on HMM: 1-63/81
Sequence Identity: 50% (32 aa)

WFHGVITRKDAEALLQG--SKPGTFLVRVSESRF-GYSLSHMVRG-GGRIKHYMIDQTPNGQY
|.|| |.|..|| ||.    ..|||||| |||   .|.||..  | | |.||| | .|.||.|
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGY
SH2 N20.AA SH2 775-835 29 2.6e-10 41.5 SMART 1-87 (87) Show / Hide 
Range on Protein: 775-835
Range on HMM: 1-87/87
Sequence Identity: 29% (26 aa)

EEWFHGVITRKDAEALLQG--SKPGTFLVRVSES-RFGYSLSHMVRGGGRIKHYMIDQTP-------------------------NGQY
..|.|| |.|..||.||..   ..|.|||| ||| . .|.|| ...  |..||| | ...                         | ..
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK--GKVKHYRIRRNDDGKYYIDETWRRKFPSLELVNHYQHNPLG