N8

Species: M.brevicollis
Alias: N8
External Links:
Annotation:

Classification

Group: TK-assoc
Family: SH2
Subfamily: Myo-SH2

Sequence

Name Sequence Type Origin Length Description Download
N8.AA Protein None 945 None Fasta, JSON

Protein domain

Protein domains of N8.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
MYSc N8.AA MYSc 12-716 35 2.4e-263 882.06 SMART 1-771 (771) Show / Hide
Range on Protein: 12-716
Range on HMM: 1-771/771
Sequence Identity: 35% (278 aa)

VAPGQC---DNLTALADLNEDTLLKELEIRYNRDVIYTYVGEILVAVNPYFRIPELYDQSQKLKYR-----GGIDRESLPPHIFAVADAAVSALQSTGKN
. | ..   | .. | .|||...|  |..||..| |||| | ...||||| ..|..| ...  .||      |  |. .||||||.||.|  .. . ..|
MNPPKFEGVDDMCMLTYLNEPAVLHNLKKRYMNDQIYTYIGPVCIAVNPYKQLPPIYTPDVIKQYRNRKFDDGKHRYEMPPHIFAIADNAYRNMLNDKEN

QVCVISGESGAGKTESAKLFLQHIIDLSAGSETEGIADKIIAVNPLLEAFGNASTLMNDNSSRFGKYLDLQFTENFTVRGALITEYLLEKSRVTYQADGE
| ..|||||||||||..|. .|..  .|.  ..|.. ..|.. ||.||||||| |. |.|||||||| ...| |. ...|| |. ||||||||.||..||
QCIIISGESGAGKTENTKKIMQYLAAVSG--QVERVEQQILQSNPILEAFGNAKTVRNNNSSRFGKYMEIHFDEKGKICGAKIENYLLEKSRVVYQNKGE

QNFHIFYYIFAGLDASAKAQYELG----SAEDHGYINGNA---------EALAFIGTKECRDMWQE----VSACFDLVGFSQGEKDNLFAILSGVLWLGD
 |.||||.. ||...  | .. |.    ..||  |.| ..          .   . .    . ..|    .   .. .|||  |... | |....|.|| 
RNYHIFYQLCAGASEEQKQEFHLKPFSHNPEDYHYLNQGGHYWNNKRHQSQCFTVDGIDDAEEFKETCEQTCNAMRVMGFSEEEQEWIFRIVAAILHLGN

VLFDGE----DHASI----VSPSSILEAACNQLGLEVGVMEAALVEQILITGGE---ETTKALRTDQAVDVRDATAKALYGRAFTWIIKRVNSLTGPKGR
. |  .    | ...    |.   .|..||  ||... ..| .|.  .. ||.|   . ||.|   ||.. ||| |||.|.| | ||.||.|.       
IEFEQGRNQYDNQAVCSEKVKDEEELQNACELLGVDPEDLEKWLTHRKMKTGHEGGTWITKPLNVEQAIYARDALAKAIYSRLFDWIVKRINQSM-----

GTGQIISFLDIFGFEHFDDNSLEQLCINLANEQLQSFFNSHIFQMELDEYKKEGIDGSQVSFT--DNQATLDMLLSR--RPPGILAIMDEQAIM---PRS
 .   |. |||.|||.|. ||.||.||| .||.|| ||| |.| .| .||..|||. . . |.  |||...| .  .  ||.||....||.  .   |..
-HNYFIGVLDIYGFEIFEHNSFEQFCINYCNEKLQQFFNHHMFKLEQEEYQREGIEWTFIDFFMYDNQPCCDLIEKKGKRPMGIFSLLDEECMFHAQPKG

TDQTMVEKF-----HETFGSHSSYIKP-----------RSNDAIFTIRHYAGDVCYNADGFLEKNRDTLAMDVLGALRMSENSLVRELFDGDADDAKAAK
||||..||      | ....|. . ||           |  .. |.|.||||||.||..|.||||.|||  |..  .. | |.....||. ..|......
TDQTFLEKLNKQDYHQHHKNHPHFSKPHKSHRCCKPKKRMGRTHFIIKHYAGDVTYNVEGWLEKNKDTLFDDLIQLMQSSKNPFIKQLFPEYEDQTSQTP

GKRGKRGGGRGLSRNNMRMSVKK--ARAAEAKKQRKSVGATFKESLEKLMTSLNSSAPHFIRCIKPNQSKQKHMYADQLVKNQLRYTGMLETTRIRKEGY
..... .|.....|..  | .    .     ||  ..||. || .|..||. |||. ||.|||||||  |. . . |.||..|||. |.||. |||..|.
QEKSS-QGKNKSRRKKR-M-MQMKKT-C-MQKKRFPTVGFQFK-QLNELMETLNSCHPHYIRCIKPNEEKKPWDFDDDLVLHQLRCCGVLENIRIRRAGF

AVRPTFEDFLHRYMPLTF-AWGIGQ--------SANAGACRMLLEKAK---------LKDWQIGKTKVFLR-YYHPDELNDLVKP
..| ....|..||  | .  |  ..        .    ||...|.. .          ...|.||||||.| ...  .| .. . 
PYRWPYQEFYQRYKMLCPPTWPNWGNPWKNQLFGDPKKACEAILQQLGEYIQHQNWDPDMYQFGKTKVFFRNPGQLFHLEEMRER

Myosin_head N8.AA Myosin_head 17-703 32 3e-231 779.3 Pfam 1-765 (765) Show / Hide
Range on Protein: 17-703
Range on HMM: 1-765/765
Sequence Identity: 32% (258 aa)

CDNLTALADLNEDTLLKELEIRYN-RDVIYTYVGEILVAVNPYFRIPELYDQSQKLKYRGGIDRESLPPHIFAVADAAVSALQSTGKNQVCVISGESGAG
 .....|  |||...|  |. ||.  | ||||.| ....|||| ..| .| |.   .|||   |. .||||||.||.|  .. . ..|| ..|.||||||
VEDMVMLTYLNEPSVLHNLKKRYMTGDLIYTYSGHFCISVNPYKQLP-IYTQDMIQEYRGKH-RYEMPPHIFAIADEAYRHMRHDRENQCIIICGESGAG

KTESAKLFLQHIIDLSAGSE---TEGIADKIIAVNPLLEAFGNASTLMNDNSSRFGKYLDLQFTENFTV----RGALITEYLLEKSRVTYQADGEQNFHI
|||..|. .|..  .|....    . . ..|.. ||.||||||| |. |.||||||||. ..|..  ..     |. |. ||||||||.||. || ||||
KTENTKYVMQYFASVSGSNPGVNMGRVEQQILQSNPILEAFGNAKTTRNNNSSRFGKYMEIHFDKTGKINPTAVGGNIENYLLEKSRVVYQTPGERNFHI

FYYIFAGLDASA-KAQYELG--SAEDHGYINGNA-EALAFI-GTKECRDMWQEVSACFDLVGFSQGEKDNLFAILSGVLWLGDVL-FDGED--HASIVSP
||.. ||..... |. . |.  ...|  | | ..     ..  .    .. |..   .|..||.. |.  .| |....| || .  |  ..   ...|. 
FYQLLAGASQQEEKKELHLTSADPKDYHYLNQSGTNPCYTVDDGIDDAEEFQHTRNAMDIIGFTHEEQRSIFRIVAAILHLGNMKGFKQDQNEEQAVVDD

SS-ILEAACNQLGLEVGVMEAALVEQILITG----GEETTKALRTDQAVDVRDATAKALYGRAFTWIIKRVNSLTGPKG---------------------
.  |.|..|  .|. ....|..|.. .. ||     |  ||.. ..|| . ||| |||.|.| | ||..|.|     |                      
TEEICEIICELMGVDPEEFEKWLCYRRIKTGGGKRREWVTKPQNCEQAMYARDALAKAIYSRMFDWIVNRINQAICHKTQNTDDSDGQAAQWDDTVSITV

--------RGTGQIISFLDIFGFEHF-DDNSLEQLCINLANEQLQSFFNSHIFQMELDEYKKEGIDGSQVSF-TDNQATLDMLLSR-RPPGILAIMDEQA
        . .. .|  |||.|||.| . ||.||.||| .||.|| ||| |.|. | .||..|||. ... . .|||.. | |.   .|.|||...||. 
VDVPDPAFDKRNYFIGVLDIYGFEIFCEKNSFEQFCINYCNEKLQQFFNHHMFKLEQEEYVREGIQWTFIDYGFDNQPCCD-LIEKKKPMGILSLLDEEC

IMPRSTDQTMVEKFHETF-GSHS--SY-IKP-R------SNDAIFTIRHYAGDVCYNADGFLEKNRDTLAMDVLGALRMSEN-SLVRELFDG--------
..|..||||...| ..|. . |.   .  || |        .. |.|.||||||.||..|.||||.|.|  |...... | . ....|||.         
WFPKATDQTFLQKLYQTHSSKHPRLHFAQKPGRFYKRHRQGNTHFIIKHYAGDVWYNCEGWLEKNKDPLFDDLIELMWCSWDNPFMQELFPDWEWAEWAH

---------DADDAKAAKGKRGKRGGGRGLSRNNMRMSVKKARAAEAKKQRKSVGATFKESLEKLMTSLNSS---APHFIRCIKPNQSKQKHMYADQLVK
         . ...|.. ...|.  |..| . ..|                . |.. |||.. .||. |..     ||..||||||  || ..  ...|.
MQIDFEADFHEEEFKRRYNRNGCQKGKQGKKKWFM----------------QTVWFQFKEQCNHLMKWLYQCAWWHPHYVRCIKPNENKQPWQFDNSMVL

NQLRYTGMLE-TTRIRKEGYAVRPTFEDFLHRYMPLTF-AWGIG-----QSANAGACRMLLEKA---KL--KDWQIGKTKVFLR
.|||. |.|| . ||. .|.. |.|. .|..||  |.. .|...       .   .|...|..    ..  ...|.||||.|.|
HQLRCNGVLEINIRICRAGFPYRWTYDEFFQRYRILCPKTWWSWIWPEWNGDTKQGCEKILQHLSWGNMDKEEYQFGKTKIFFR

SH2 N8.AA SH2 843-918 41 1.7e-30 91.39 Pfam 1-81 (81) Show / Hide
Range on Protein: 843-918
Range on HMM: 1-81/81
Sequence Identity: 41% (34 aa)

WFHGVVSRVHSESLLGK--QPVGTFLIRVAETRF-GYSLSVRTPA---RIKHFMIDQSPDGQYMVVGNDRLFPSLNDLVTHY
|.|| .||   | || .  .| ||||.|  |.   .|.||||.     |.||. | . ..|.| . |... |.||..|| ||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHK-FCSLQELVEHY

SH2 N8.AA SH2 841-924 42 8.8e-27 96.21 SMART 1-87 (87) Show / Hide
Range on Protein: 841-924
Range on HMM: 1-87/87
Sequence Identity: 42% (37 aa)

AKWFHGVVSRVHSESLLGK--QPVGTFLIRVAET-RFGYSLSVRTPARIKHFMIDQSPDGQYMVVG-NDRLFPSLNDLVTHYRHSPLT
  |.|| .||   |.|| .  .| |.||.|  |. . .|.||||.  ..||. | ...||.| . . ..| |||| .|| ||.| || 
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG