Gene N11 (M.brevicollis)

N11

Species: M.brevicollis
Alias: N11
External Links:
Annotation:

Classification

Group: TK-assoc
Family: SH2
Subfamily: PKCa-SH2

Sequence

Name Sequence Type Origin Length Description Download
N11.AA Protein None 732 None Fasta, JSON

Protein domain

Protein domains of N11.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C2 N11.AA C2 92-182 30 6.7e-21 73.76 Pfam 1-90 (90) Show / Hide 
Range on Protein: 92-182
Range on HMM: 1-90/90
Sequence Identity: 30% (28 aa)

LACTVKQGRDLLAMN--KNNTATPFVKAYITPELKDKSSKRKTQPRKNTVNPMYNEQFSWEIRANTDLDAMKLHIEVYEHAVLRRSQFMGSMA
| ..|...|.| .|.  || .. |.|| |. .. ||..  .||   ||| || .||.| ...  ..  .  .|...|. .  ..| .|.|   
LRVHVIEARNLPPMDWDKNGKSDPYVKVYLGGDPKDTQK-YKTKVIKNTLNPVWNETFTFDVPPPDLQH--TLRFTVWDWDRFGRDDFIGQCC
C2 N11.AA C2 91-197 22 7.4e-17 63.24 SMART 1-92 (92) Show / Hide 
Range on Protein: 91-197
Range on HMM: 1-92/92
Sequence Identity: 22% (28 aa)

VLACTVKQGRDLLAMNKNNTATPFVKAYITPELKDKSSKRKTQPRKNTV---NPMYNE---QFSWEIRANTDLDAMKLHIEVYEHAVLRRSQFMGSMAFP
.| ......|.|          |.|| |            ||   |||    || .||   .|  ..          |..||..|      .|.|   .|
TLTVHIIEARNLP--------DPYVKVY------------KTKVVKNTLSGFNPVWNEWMETFYFDVHP------Q-LRFEVWDH------DFIGHCCIP

--------------LAEIFEGGSLQGW
              | .|  |.   .|
PNNPHWHQWDGCIHLSDIL-GYRH-WW
Kinase N11.AA PKC 289-547 61 6.9e-181 591.24 In-house 1-262 (262) Show / Hide 
Range on Protein: 289-547
Range on HMM: 1-262/262
Sequence Identity: 61% (161 aa)

FKFLKVLGQGSFGKVLLAEEKATKEVFAVKVLKKTVVVEDDDVECTMIERRVLELAGGSPFLTNLVATFQTPEHLYFVMEMVTGGDLMFHIQKKRRFPTE
|.|||||| ||||||.||| | |.|..|.||||| |...||||||||.|.|||.||.  ||||.|  .|||...|.|||| | |||||||||. |||. |
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

LTRFYTGEICLGLWFLHKSGVLYRDLKLDNVMLAGDGHIKIADFGMCKENMWGAATTTTFCGTPGYLAPEIIKELPYGASVDWWSLGVLIFEMLLGDSPF
 .|||  ||...| |||. |. |||||||||.|  .||||||||||||||||. .||.|||||| |.||||... .||.|||||..||| .||..| |||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

EGEDEDELFNEILTKKLSYPPRLAPEAKALLDGFLQRDPSKRLGCGRDG---KKDIMEHPFF
.||||||||. |.... .||  |. ||.... ||....|.|||||....   ..||.|||||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase N11.AA AGC 289-547 32 4.8e-177 462.45 In-house 1-395 (395) Show / Hide 
Range on Protein: 289-547
Range on HMM: 1-395/395
Sequence Identity: 32% (131 aa)

FKFLKVLGQGSFGKVLLAEEK------ATKEVFAVKVLKKTV-VVEDD--DVECTMIE------------RRVLELAGG---------SPFLTN-LVATF
|.||||.|.|||||| |...|      .|....|.||||| . .|...  .||.||.|            |..||.. .         .||... |  .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTPEH--LYFVMEMVT---------GG-DLMFHIQ---KKRRFPTELTRFYTGE-------ICLGLWFLHK-SGVLYRD-LKLDNVMLAGDGHIKIADFG
|...|  |||||| .          || .|..|.|   |..||. | .|||. |       |.|.| .||.  |. .|| ||..|..|  |||||..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MCKENMWGA--------------------------------------------------ATTTTFCG--TPGYLAPEIIKELPYGASVDWWS--LGVLIF
.|||.| .                                                   ..|.||||  || |.||||.    || ..||||  ||.|..
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLLGDSPFEGE----------DEDELFNEIL------TKKLSYP----------PRLAPEAKALLDGFLQRDPSKRLGCGRD-----GKKDIMEHPFF
||| | .|| |.          ...|.|. |.      ..|. .|          . . |||| |. ..|..||.||||||..     | ..|..||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase N11.AA Alpha 289-547 61 1.5e-154 519.75 In-house 1-259 (259) Show / Hide 
Range on Protein: 289-547
Range on HMM: 1-259/259
Sequence Identity: 61% (160 aa)

FKFLKVLGQGSFGKVLLAEEKATKEVFAVKVLKKTVVVEDDDVECTMIERRVLELAGGSPFLTNLVATFQTPEHLYFVMEMVTGGDLMFHIQKKRRFPTE
| ||.||| ||||||.||| | |.| .|.|.||| |.. ||||||||.|.||| | |  |||. .  .|||.  |||||| |.|||||.|||.  .|   
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

LTRFYTGEICLGLWFLHKSGVLYRDLKLDNVMLAGDGHIKIADFGMCKENMWGAATTTTFCGTPGYLAPEIIKELPYGASVDWWSLGVLIFEMLLGDSPF
   ||  ||  || |||. |..||||||||||| ..||||||||||||||||. .|| |||||| |.|||||   ||| |||||. ||| .||. |  ||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

EGEDEDELFNEILTKKLSYPPRLAPEAKALLDGFLQRDPSKRLGCGRDGKKDIMEHPFF
.||||||||  |  .. |||  .  ||...  ||| . |.||||||.||..|| |||||
DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase N11.AA Delta 289-547 62 4.90000000001e-137 461.56 In-house 1-259 (259) Show / Hide 
Range on Protein: 289-547
Range on HMM: 1-259/259
Sequence Identity: 62% (161 aa)

FKFLKVLGQGSFGKVLLAEEKATKEVFAVKVLKKTVVVEDDDVECTMIERRVLELAGGSPFLTNLVATFQTPEHLYFVMEMVTGGDLMFHIQKKRRFPTE
|.|.||||.||||||.||| | ... .|.| ||| ||.|||||||||.||||| ||  .|||. |. |||| |||.|||| . |||||.|||...||  .
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

LTRFYTGEICLGLWFLHKSGVLYRDLKLDNVMLAGDGHIKIADFGMCKENMWGAATTTTFCGTPGYLAPEIIKELPYGASVDWWSLGVLIFEMLLGDSPF
 .|||. || .|| |||| |..|||||||||.|  |||||||||||||||| | ... |||||| |.||||||   | .|||||| |||..|||.| |||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

EGEDEDELFNEILTKKLSYPPRLAPEAKALLDGFLQRDPSKRLGCGRDGKKDIMEHPFF
.||||||||. |.  .  ||  .  ||| .| . ..||| ||||  .  | || .|.||
HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase N11.AA Eta 289-547 57 1.5e-136 459.9 In-house 1-261 (261) Show / Hide 
Range on Protein: 289-547
Range on HMM: 1-261/261
Sequence Identity: 57% (149 aa)

FKFLKVLGQGSFGKVLLAEEKATKEVFAVKVLKKTVVVEDDDVECTMIERRVLELAGGSPFLTNLVATFQTPEHLYFVMEMVTGGDLMFHIQKKRRFPTE
|.|.||||.||||||.||| | | ||.|.||||| |.. |||||||| |.|.| ||   ||||.| ..|||.. |.|||| | ||||||.||. |.|   
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

LTRFYTGEICLGLWFLHKSGVLYRDLKLDNVMLAGDGHIKIADFGMCKENMWGAATTTTFCGTPGYLAPEIIKELPYGASVDWWSLGVLIFEMLLGDSPF
 .|||  |. . | |||. ||.||||||||..|  .|| |.|||||||| .    ||||||||| |.||||..|. ||.||||| .|||..||. | .||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

EGEDEDELFNEILTKKLSYPPRLAPEAKALLDGFLQRDPSKRLGCGR--DGKKDIMEHPFF
| . ||.||. ||     ||  |  || ..| .|. . |.|||||    .| ..| .||||
EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase N11.AA Akt 289-547 44 8e-133 426.95 In-house 1-264 (264) Show / Hide 
Range on Protein: 289-547
Range on HMM: 1-264/264
Sequence Identity: 44% (119 aa)

FKFLKVLGQGSFGKVLLAEEKATKEVF-AVKVLKKTVVVEDDDVECTMIERRVLELAGGSPFLTNLVATFQTPEHLYFVMEMVTGGDLMFHIQKKRRFPT
| ||||||.||||||.|...|.|.... | ||||| . .. . || |. ||..|.    .||..||.  |||...|||||. . ||.| .|.|.||||. 
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

ELTRFYTGEICLGLWFLHKSGVLYRD-LKLDNVMLAGDGHIKIADFGMCKEN-MWGAATTTTFCGTPGYLAPEIIKELPYGASVDWWS-LGVLIFEMLLG
. .|||  || |.. .||.... ||| ||. |...  ||||...|||.|||| .    .|.|||||| ||||||..   .. .||||. ||....||. |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

DSPFEGEDEDELFNEILTKKLSYP--PRLAPEAKALLDGFLQRDPSKRLGCGRDGKKDIMEHPFF
  ||  .| ...|  |..... .|  ... ||.| |. | |..||.|||| | .. ..|..||.|
RPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase N11.AA SGK 289-547 39 3.3e-116 360.47 In-house 1-283 (283) Show / Hide 
Range on Protein: 289-547
Range on HMM: 1-283/283
Sequence Identity: 39% (111 aa)

FKFLKVLGQGSFGKVLLAEEKAT------------------KEVFAVKVLKKTVVV-------EDDDVECTMIERRVLELAGGSPFLTNLVATFQTPEHL
|.||||.|.||||||.... |..                  . ..|.|||.|  ..           .  .|.|| |.     .||. ||   |||.. |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YFVMEMVTGGDLMFHIQKKRRFPTELTRFYTGEICLGLWFLHKSGVLYRDLKLDNVMLAGDGHIKIADFGMCKENMWGAATTTTFCGTPGYLAPEIIKEL
||||. | ||.. .|.|. ..||    |||. || . |  ||.. . ||||| .|..|  .||... ||| |||..    ||.|||||| |||||...  
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

PYGASVDWWSLGVLIFEMLLGDSPFEGEDEDELFNEILTKKLSYPPRLAPEAKALLDGFLQRDPSKRLGCGRDGKKDIMEHPFF
|.. .||||.|| . .||. |  ||.  .  ...  |. ..|  ||   ..|. |. | ||.||.||||  ||.  .| .||||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDF-MEIKNHPFF
Kinase N11.AA Iota 289-547 50 9.69999999999e-112 373.56 In-house 1-271 (271) Show / Hide 
Range on Protein: 289-547
Range on HMM: 1-271/271
Sequence Identity: 50% (137 aa)

FKFLKVLGQGSFGKVLLAEEKATKEVFAVKVLKKTVVVEDDDVECTMIERRVLELAGGSPFLTNLVATFQTPEHLYFVMEMVTGGDLMFHIQKKRRFPTE
|. ..|.| ||. |||..| |.|. ..|.||.|| .| .|.|..    |. | | |   |||  | . |||.  |.||.| | |||||||.|..|. | |
FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPEE

LTRFYTGEICLGLWFLHKSGVLYRDLKLDNVMLAGDGHIKIADFGMCKENMWGAATTTTFCGTPGYLAPEIIKELPYGASVDWWSLGVLIFEMLLGDSPF
  |||..|||| | |||. |..|||||||||.|  .||||. |.|||||..    || |||||| |.||||..   || ||||| ||||.|||. | |||
HARFYSAEICLALNFLHERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF

E--G-------EDEDELFNEILTKKLSYPPRLAPEAKALLDGFLQRDPSKRLGCGRDG---KKDIMEHPFF
.  |         || ||  || |..  |  |.  |  .| ||| .||  |||| ..     .|| |||||
DIVGNMDNPDQNTEDYLFQVILEKQIRIPRSLSVRAAHVLKGFLNKDPKERLGCHPQTNEGFMDIKEHPFF
Kinase N11.AA RSK 292-547 41 8.9e-106 357.71 In-house 1-278 (278) Show / Hide 
Range on Protein: 292-547
Range on HMM: 1-278/278
Sequence Identity: 41% (114 aa)

LKVLGQGSFGKVLLAEEK---ATKEVFAVKVLKK-TVVVEDDDVECTMIERRVLELAGGSPFLTNLVATFQTPEHLYFVMEMVTGGDLMFHIQKKRR---
|||||||..||| |  ..   .|. ..|.||||| ..|. . |.. || ||..||. ...||. .|  .|||...|| .|| . ||.|  |.||...   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FPTELTRFYTGEICLGLWFLHKSGVLYRDLKLDNVMLAG---DGHIKIADFGMCKENMWG-AATTTTFCGTPGYLAPEIIK---ELP-YGASVDWWSLGV
|  .  .||  || | . .||. |. .||||..|....    .||||. ||| ||..       | |||.|  |.|||..|       .....|||||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LIFEMLLGDSPFEG---EDEDELFNEILTKK--LSYP--PRLAPEAKALLDGFLQRDPSKRLGCGRDGKKDIMEHPFF
|..||| | .|| |   .. .|... |...|  |. |  . | .||| |. . |.|||.||||||... ..| .||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase N11.AA PKN 289-547 48 2.6e-103 349.52 In-house 1-260 (260) Show / Hide 
Range on Protein: 289-547
Range on HMM: 1-260/260
Sequence Identity: 48% (127 aa)

FKFLKVLGQGSFGKVLLAEEKATKEVFAVKVLKKTVVVEDDDVECTMIERRVLELAG--GSPFLTNLVATFQTPEHLYFVMEMVTGGDLMFHIQKKRRFP
|... ||| | ||||||.. | | |..|.|.|||  .|  |.||  |.|.|..| ..  . ||| ||.| ||| || .|||| . ||||| || .   |.
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHED-VFS

TELTRFYTGEICLGLWFLHKSGVLYRDLKLDNVMLAGDGHIKIADFGMCKENMWGAATTTTFCGTPGYLAPEIIKELPYGASVDWWSLGVLIFEMLLGDS
   ..||.  . ||| .||.  ..||||||||..|  .|..||||||.|||.|     | |||||| .||||.. .  |   |||| |||||.||| |..
EPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGEC

PFEGEDEDELFNEILTKKLSYPPRLAPEAKALLDGFLQRDPSKRLGCGRDGKKDIMEHPFF
|| |.||.|.|. |. .   ||  |. || |..   |.. | .||| |     ||  .|||
PFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase N11.AA S_TKc 289-547 35 9.5e-99 335.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 289-547
Range on HMM: 1-231/231
Sequence Identity: 35% (96 aa)

FKFLKVLGQGSFGKVLLAEEKATKEVFAVKVLKKTVVVEDDDVECTMIERRVLELAGGSPFLTNLVATFQTPEHLYFVMEMVTG--GDLMFHIQKKRR--
...|...|.|.|||| .. .| |....|.|..|          | .. |...|.   . |.. .|  .||. .|||.|||.. |  |||. .|.|..|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FPTELTRFYTGEICLGLWFLHKSGVLYRDLKLDNVMLAGDGHIKIADFGMCKENMWGAATTTTFCGTPGYLAPEIIKELPYGA-SVDWWSLGVLIF
    ||   .|||. .||..| ..|. |...|||| .|..|    ||||.|||....        ||||||| |.|||..   .||  ..||||.|....
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLLGDSPFEGEDEDELFNEILTKKLSYPPRLAPEAKALLDGFLQRDPSKRLGCGRDGK--KDIMEHPFF
||| |  ||.  .....|. |.           |||| .... ||.||.||...    .   ||. ||.|
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase N11.AA Pkinase 289-547 29 2.2e-86 298.08 Pfam 1-293 (293) Show / Hide 
Range on Protein: 289-547
Range on HMM: 1-293/293
Sequence Identity: 29% (90 aa)

FKFLKVLGQGSFGKVLLAEEKATKEVFAVKVLKKTVVVEDDDVECTM-IERRVLELAGGSPFLTNLVATFQTPEHLYFVMEMVTGG----DLMFHIQ--K
.......|.||||.| .. .| | ...|||..||    .. |.. .   | ...    ..|.   |  .|... |.|.||| . ||    ||. .|.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

KRRF--PTELTRFYTGEICLGLWFLHKSGVLYRDLKLDNVMLAGDGHI----KIADFGMCKEN-MWGAATTTTFCGTPGYLAPEIIK-ELPYGASVDWWS
...|  . .  .||  .|. || ..|. |...||||..|...  .|||    ||.||| .|         .|||||||.|.|||.|.   .|| .||.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVLIFEMLLGDSPFEGE------DEDELFNEILTKKLSYPPRLA---------------------PEAKALLDGFLQRDPSKRLGCGRDGKKDIMEHPF
.|....|||.|  || |.      |.......|. ..|...                         .|.| .... |..||.||..      ..|..||.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPW

F
|
F
Kinase N11.AA S_TK_X 548-611 35 7.8e-19 69.82 SMART 1-79 (79) Show / Hide 
Range on Protein: 548-611
Range on HMM: 1-79/79
Sequence Identity: 35% (28 aa)

SSIDWAKLER--REVKPPYVPETR----DPREAANFDPEFTEADTSLTPSDPYDIANIDQGV---------FSKFSYVN
..||| ||..  .|..||..|. .    .|. . ||||||||.. .||| ||  .....|           |  |.||.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase N11.AA TyrKc 289-542 20 5.8e-15 19.23 SMART 1-280 (280) Show / Hide 
Range on Protein: 289-542
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

FKFLKVLGQGSFGKVLLAEEKATKEVFAVKVLKKTVVVEDDDVECTMIER--RVLELAG-GSPFLTNLVATFQTP-------EHLYFVMEMVTGGDLMFH
 ...|.|| | ||.| ... |   .  |||.||.            .. |  |..   |   | . .|..   ..       | |. ||| . .|||  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IQKKRR-FPTELTRFYTGEICLGLWFLHKSGVLYRDLKLDNVMLAGDGHIKIADFGMCKENMWG----AATTTTFC----GTPG-----YLAPEIIKELP
..|.|. ....    .   |. |  .||. ..  |||   |.... ....||.|||....   .    ... .       |. .      .||| |..  
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YGASVDWWSLGVLIFEML-LGDSPFEG-----EDEDELFNEILTKKLSYPPRL---------APEAKALLDGFLQRDPSKRLGCGRDGKKDIM
.    | || ||...|.. .|..| .|      . .|... . . .   .|            .|   .     ..||..|        ....
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase N11.AA Pkinase_C 567-613 38 2.7e-11 43.03 Pfam 1-46 (46) Show / Hide 
Range on Protein: 567-613
Range on HMM: 1-46/46
Sequence Identity: 38% (18 aa)

ETRDPREAANFDPEFTEADTSLTPSDPYDIANIDQGVFSKFSYVNEG
. ..|. . |||||||... ..||.|.  . ..||  |  |.|||. 
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase N11.AA Pkinase_Tyr 361-436 26 1.2e-08 29.9 Pfam 78-159 (270) Show / Hide 
Range on Protein: 361-436
Range on HMM: 78-159/270
Sequence Identity: 26% (22 aa)

EH--LYFVMEMVTGGDLMFHIQK----KRRFPTELTRFYTGEICLGLWFLHKSGVLYRDLKLDNVMLAGDGHIKIADFGMCK
|.  .| ||| . .|||  . .|    |......    .  .|. |. .|.  .   |||   |.... ....||.|||...
EPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase N11.AA Pkinase_Tyr 289-323 41 0.000116 16.41 Pfam 1-39 (270) Show / Hide 
Range on Protein: 289-323
Range on HMM: 1-39/270
Sequence Identity: 41% (16 aa)

FKFLKVLGQGSFGKVLLAEEK----ATKEVFAVKVLKKT
 .|.|.||.|.||.| ... |     ||   |||.|| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG
Kinase N11.AA Pkinase_Tyr 472-514 28 0.779594 3.45 Pfam 198-243 (270) Show / Hide 
Range on Protein: 472-514
Range on HMM: 198-243/270
Sequence Identity: 28% (13 aa)

WSLGVLIFEMLL-GDSP-FEGEDEDELFNEI-LTKKLSYPPRLAPE
|| |||..|..  |..| ..| .  |... |        .|...|.
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPD
SH2 N11.AA SH2 634-714 33 1.1e-19 59.64 Pfam 1-81 (81) Show / Hide 
Range on Protein: 634-714
Range on HMM: 1-81/81
Sequence Identity: 33% (29 aa)

WYRPDLPRDEAARQLKG--QEVGTFFVRESSTQPGCYAIAMVSENNKIWNGLVTP---SVTGDGRVLYKLFVKQKFESLPELVTYY
|| ....| || |.|.   .. ||| ||||...||.|..  . ...   .  |.      |..|   | .. ..||.||.||| .|
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP---GDRVKHYRIQRTDNG--GYYITGRHKFCSLQELVEHY
SH2 N11.AA SH2 632-720 27 5.4e-17 63.71 SMART 1-87 (87) Show / Hide 
Range on Protein: 632-720
Range on HMM: 1-87/87
Sequence Identity: 27% (26 aa)

YAWYRPDLPRDEAARQLKG--QEVGTFFVRESSTQPGCYAIAMVSENNKIWNGLVTPSVTGDGRVLYKLFV--KQKFESLPELVTYYTQHPVT
. ||  ...|.|| . ||.  .. |.| ||.|...||.|.. . .. .|. . .. .. .      | .    . ||.|| ||| .|...|  
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-GKVKHYRIRRNDD----GKYYIDETWRRKFPSL-ELVNHYQHNPLG