Gene n508 (Tetrahymena)
n508
Species: Tetrahymena
Alias: n508, 3701.m00158, 508
External Links:
Annotation:
Sequence
Protein domains of n508.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PI3Kc | n508.AA | PI3Kc | 492-743 | 23 | 5.4e-71 | 243.09 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 492-743
Range on HMM: 1-336/336
Sequence Identity: 23% (78 aa)
AVIFKGGDDLRQEILAMQLIYKFQKIFMDA----GLKLWLRPYEILVLSASSGILEFLPDTLSIDALKK-------------------------------
|||||.||||||. ..||.. ..|| . ...|..||| ..... .|..|. |.. .. ..|
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
------------------------------KVDGFTNLYDFYQDTFGDY---FDEAQKNFIESLAGYSIVSYLLQFKDRHNGNILIN-NEGRLIHIDFGF
.. . |||. ...|.|. . ||..||. |.|||..|.|.|. .||||.||.. ..| ..|||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
MFSISPGNMNW-----ENAPFKLTKEYVQLMG--GQQSDQYSYYKDLLFMGFQAILEKVEDIIFMVQIMQEDSDLPCFKYF--DQQVFRQRFRED-LKNN
.|. .|... | .||.||...| .|| |..|... |.... ...|. . . |. ....|. |. .||.. . | .. |||||.| | .
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE
DVGVKYQM-----ILSDTFQINFQQKQQLRQYVEKL
.. . . ..... . .. . ... ... ..
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| PI3_PI4_kinase | n508.AA | PI3_PI4_kinase | 489-694 | 20 | 9.1e-39 | 139.91 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 489-694 Range on HMM: 1-300/300 Sequence Identity: 20% (61 aa) QCRAVIFKGGDDLR--QEILAMQLI-----------------------YKFQKIFMDAGLKLW----LRPYEILVLSASSGILEFLPDTLSIDALKKKVD . ..||||||||| |. . ||.| . |. . |. . ..|| .. .. .|..|..|...... . .. WY-PFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYM --GF---------------------------------------TNLYDFYQDTFGDY---FDEAQKNFIESLAGYSIVSYLLQFKDRHNGNILI---NNE . ||.. ....| ..|| .||..|.||...|.|.|. ||||.||.. VKCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTT GRLIHIDFGFMFS--ISPGNMNWENAPFKLTK------EYVQLMGG----QQSDQYSYYKDLLFMGFQAILEKVEDIIFMV-------QIMQEDSDLPCF | |.|||||..| ... ...| ||..|. ..| .||| .| | ..|... ..|. . . .. . ..| .| . . GHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWR K . S |
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| Kinase | n508.AA | ATR | 579-684 | 25 | 3.4e-11 | 33.96 | In-house | 163-267 (267) | Show / Hide |
Range on Protein: 579-684 Range on HMM: 163-267/267 Sequence Identity: 25% (27 aa) AQKNFIESLAGYSIVSYLLQFKDRHNGNILINN-EGRLIHIDFGFMFSISPGNMNWENAPFKLTKEYVQLMGGQQSDQYSYYKDLLFMGFQAILEKVEDI ...|.. | | ...| |.. ||| ||||. | ..|.|. .| | ||.||. | || .. | .. . . . .. .|| SRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKT--YGLFRRACEVIMMCMRDHRDDI IFMVQIM . ... MSVWDCF |
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| Kinase | n508.AA | ATM | 586-649 | 44 | 1.5e-09 | 26.22 | In-house | 143-207 (304) | Show / Hide |
Range on Protein: 586-649 Range on HMM: 143-207/304 Sequence Identity: 44% (29 aa) SLAGYSIVSYLLQFKDRHNGNILINNEG-RLIHIDFGFMFSISPGNMNWENAPFKLTKEYVQLMG | | ||| |.| ||| ||||| |.||| | | | ||.||.. | || SVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMG |
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| Kinase | n508.AA | PIKK | 578-624 | 41 | 1.5e-07 | 23.98 | In-house | 184-231 (290) | Show / Hide |
Range on Protein: 578-624 Range on HMM: 184-231/290 Sequence Identity: 41% (20 aa) EAQKNFIESLAGYSIVSYLLQFKDRHNGNILINNE-GRLIHIDFGFMF |. .|.. |.| ..| | | ||| ||.|. . | ..|||||. | ERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCF |
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| Kinase | n508.AA | FRAP | 582-621 | 43 | 1e-06 | 20.79 | In-house | 139-179 (251) | Show / Hide |
Range on Protein: 582-621 Range on HMM: 139-179/251 Sequence Identity: 43% (18 aa) NFIESLAGYSIVSYLLQFKDRHNGNILIN-NEGRLIHIDFG |. ||| |.. |.| ||| ||... |...||||| NYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG |
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| Kinase | n508.AA | PIKK | 495-554 | 23 | 0.070769 | 3.07 | In-house | 35-98 (290) | Show / Hide |
Range on Protein: 495-554 Range on HMM: 35-98/290 Sequence Identity: 23% (15 aa) FKGGDDLRQEILAMQLIYKFQKIFMDA----GLKLWLRPYEILVLSASSGILEFLPDTLSIDAL .||..||||. |||. ... .| .| | . .| .|..| ....... .. CKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEI |
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